The document summarizes research on the effects of cannabinoids AM404 and cannabidiol (CBD) on fear memory extinction in rats. The study found that AM404 and CBD facilitated the extinction of contextual fear memories. This effect was blocked by a CB1 receptor antagonist, but not a TRPV1 receptor antagonist. AM404 and CBD also produced anti-anxiogenic effects, suggesting they may reduce stress and promote fear memory extinction. The results highlight CBD's potential as a pharmacological tool to reduce anxiety and stress.