Ibogaine: Treatment Acceptability
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This document summarizes the history and background of various medications used to treat opioid addiction, including methadone, buprenorphine, and the experimental medication ibogaine. It discusses how methadone maintenance therapy was established in the 1960s, while buprenorphine was developed in the 1970s-2000s and approved for opioid addiction treatment. Ibogaine's anti-addictive effects were discovered in 1962, but it remains experimental. The document compares early generations of patients using these medications to later generations, and discusses issues of stigma, discrimination, and profitability regarding their development and availability.
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Mesmo sendo derivada de uma planta, certos cuidados devem ser tomados. Não é toda medicação derivada de plantas que é "tranquila" ou "fraquinha", quem fala isso demonstra que não entende do assunto.
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From the Department
Psychiatry & Psychology
(T.A.R.) and Departmen
Internal Medicine (M.C.
Mayo Clinic, Rochester
and Department of Inte
Medicine, Mayo Clinic,
sonville, FL (N.L.D.).
344
How Good Intentions Contributed to Bad
Outcomes: The Opioid Crisis
of
t of
B.),
, MN;
rnal
Jack-
Teresa A. Rummans, MD; M. Caroline Burton, MD; and Nancy L. Dawson, MD
Abstract
The opioid crisis that exists today developed over the past 30 years. The reasons for this are many. Good
intentions to improve pain and suffering led to increased prescribing of opioids, which contributed to
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providers or from illegal sources. Illegal, unregulated sources of opioids are now a factor in the increasing
death rate from opioid overdoses. Stopping the opioid crisis will require the engagement of all, including
health care providers, hospitals, the pharmaceutical industry, and federal and state government agencies.
ª 2017 Mayo Foundation for Medical Education and Research n Mayo Clin Proc. 2018;93(3):344-350
T
here is no debate that the United
States is in the midst of an opioid
crisis. Between 1999 and 2014, drug
overdose deaths nearly tripled.1 In 2016,
more than 60,000 people died from drug
overdoses, and opioids were responsible for
most of these deaths.2 For the first time since
1999, life expectancy decreased for US citizens
compared with citizens of other developed
countries, and opioid overdoses were a factor.3
This crisis includes both prescription and
nonprescription (illegal) use of opioid drugs.
Prescription opioids include natural and semi-
synthetic opioids such as codeine and
morphine, and synthetic opioids such as
methadone, fentanyl, and tramadol. Many of
the synthetic agents such as fentanyl are man-
ufactured and distributed illegally. With the
increased availability of both prescribed and
illegally obtained opioids over the past 30
years, there has been an increase in misuse
and deaths (Figure).4
Various opioids have been available for
more than a century, and opioid misuse has
occurred during that time. Following the Civil
War, veterans who suffered severe injuries
were given morphine for pain relief. In the
late 1800s, pharmaceutical companies began
Mayo Clin Proc. n March 201
www.m.
Peter VanPelt
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National Rx Drug Abuse Summit 4-10-12
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Não confie em locais que usam, como diferencial para fazer propaganda, o argumento de que não é necessária internação, nem exames e nem abstinência prévia. Pelo menos 60 dias de internação são necessárias sim, para inclusive proteger o paciente de qualquer evento adverso .
Não confie em locais e sites que dão a entender que a ibogaína é a "cura" da dependência química, isso é simplificar demais um problema sério.
Desde que se descobriram os efeitos anti-dependência da ibogaína, em 1962, ocorreram cerca de 20.000 tratamentos em todo o mundo. Nestes 20.000 tratamentos, ocorreram 19 mortes, todas relacionadas a problemas de saúde prévios ( que teriam sido detectados se o paciente tivesse feito um check-up antes do procedimento) e também a uso de drogas muito perto do uso da ibogaína ( o que teria sido evitado se o paciente estivesse sob vigilância especializada).
Então, não confie em pessoas que menosprezam o poder da substância, que não entendem do assunto e visam apenas lucro.
Não confie tambem em locais que indicam a ibogaína como uma panacéia, que cura tudo, desde a dependência até queda de cabelo. Claramente, isso é uma tentativa de angariar mais pacientes e aumentar os lucros.
Mesmo sendo derivada de uma planta, certos cuidados devem ser tomados. Não é toda medicação derivada de plantas que é "tranquila" ou "fraquinha", quem fala isso demonstra que não entende do assunto.
A ibogaína é muito eficiente, principalmente se comparada aos outros tratamentos disponíveis, mas para atingir bons resultados, é necessária uma expertise que alguns locais que fazem propaganda disseminada não possuem.
Apenas a título de informação, aqui está o link para um trabalho científico comentando essas mortes às quais me referi. Observe como no texto é dito que esses casos todos foram de pacientes com problemas de saúde prévios, usando medicação de origem desconhecida.
SPECIAL ARTICLEFor editorialcomment, seepage 269From.docx
SPECIAL ARTICLE
For editorial
comment, see
page 269
From the Department
Psychiatry & Psychology
(T.A.R.) and Departmen
Internal Medicine (M.C.
Mayo Clinic, Rochester
and Department of Inte
Medicine, Mayo Clinic,
sonville, FL (N.L.D.).
344
How Good Intentions Contributed to Bad
Outcomes: The Opioid Crisis
of
t of
B.),
, MN;
rnal
Jack-
Teresa A. Rummans, MD; M. Caroline Burton, MD; and Nancy L. Dawson, MD
Abstract
The opioid crisis that exists today developed over the past 30 years. The reasons for this are many. Good
intentions to improve pain and suffering led to increased prescribing of opioids, which contributed to
misuse of opioids and even death. Following the publication of a short letter to the editor in a major
medical journal declaring that those with chronic pain who received opioids rarely became addicted,
prescriber attitude toward opioid use changed. Opioids were no longer reserved for treatment of acute
pain or terminal pain conditions but now were used to treat any pain condition. Governing agencies began
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led to dependence. When this occurred, patients sought more in the form of opioid prescriptions from
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death rate from opioid overdoses. Stopping the opioid crisis will require the engagement of all, including
health care providers, hospitals, the pharmaceutical industry, and federal and state government agencies.
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States is in the midst of an opioid
crisis. Between 1999 and 2014, drug
overdose deaths nearly tripled.1 In 2016,
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overdoses, and opioids were responsible for
most of these deaths.2 For the first time since
1999, life expectancy decreased for US citizens
compared with citizens of other developed
countries, and opioid overdoses were a factor.3
This crisis includes both prescription and
nonprescription (illegal) use of opioid drugs.
Prescription opioids include natural and semi-
synthetic opioids such as codeine and
morphine, and synthetic opioids such as
methadone, fentanyl, and tramadol. Many of
the synthetic agents such as fentanyl are man-
ufactured and distributed illegally. With the
increased availability of both prescribed and
illegally obtained opioids over the past 30
years, there has been an increase in misuse
and deaths (Figure).4
Various opioids have been available for
more than a century, and opioid misuse has
occurred during that time. Following the Civil
War, veterans who suffered severe injuries
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Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
ARTHROLOGY PPT NCISM SYLLABUS AYURVEDA STUDENTS
PPT RELATED TO ARTHROLOGY ACCORDING TO NCISM AYURVEDA
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journey
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
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How to Give Better Lectures: Some Tips for Doctors
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Alcohol_Dr. Jeenal Mistry MD Pharmacology.pdf
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
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The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
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Non-respiratory Functions of the Lungs.pdf
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
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Ibogaine: Treatment Acceptability
- 10. Buprenorphine products manufacturer, Reckitt Benckiser will not make current product photographs available
- 13. Noribogaine Liver transforms ibogaine into noribogaine
- 14. 18-methoxycoronaridine molecule 18-MC Synthetic molecule
- 16. Roots bark contain ibogaine
- 17. Pharmaceutical ibogaine experimental medication
- 20. Drs. Dole and Nyswander ca 1976
- 27. Stigma Focuses attention on the victim
- 28. Discrimination: Focuses attention on those who produce rejection and exclusion
- 29. The ibogaine advantage Ibogaine removes the stigmatized condition.
- 33. Ibogaine resources The Ibogaine Dossier An internet library http://www.ibogaine.org http://www.ibogaine.desk.nl
- 34. Manual for Ibogaine Therapy Second Revision Release date Friday, May 9, 2003 http://www.ibogaine.org/manual.html
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- Presented May 5, 2003, NYC Iboga and Ibogaine Forum.
- The principal source of ibogaine is in the bark of the root of Tabernanthe iboga.
- Based on the writing of Link BG & Phelen JC, “On Stigma and Public Health Implications. Columbia University, 2001. <http://www.stigmaconference.nih.gov/papers.html>