High value care balances both quality and cost, with quality meaning benefit to patients and cost encompassing both financial and non-financial harms. Despite the United States spending more than any other wealthy nation on healthcare, it has poorer health outcomes and over 1/3 of healthcare spending is considered waste. Excess costs in the US healthcare system amount to nearly $1 trillion annually and stem from sources like missed prevention opportunities, inflated prices, unnecessary services, and excessive administrative costs. Physician-driven waste accounts for over half of this, with unnecessary medical tests and treatments being commonly over-ordered by physicians due to factors like discomfort with diagnostic uncertainty, duplicating observed behaviors, lack of knowledge around costs and harms, and defensive medicine.