To set up an HTTPS server using a self-signed certificate, you need: 1) A server certificate containing a public key 2) A private key 3) OpenSSL to generate these keys and a self-signed certificate 4) Python code to create an HTTPS server that uses the certificate and key to encrypt communication However, browsers will display certificate errors because self-signed certificates are not trusted; to resolve this, certificates must be obtained from a trusted certificate authority.