How to Lose Weight Are you tired of carrying around extra pounds You can learn the basics of weight loss, as well as ways to eat healthier, get more exercise, and keep yourself motivated to keep the pounds off the healthy way Write down
you track your eating over time. Choose to eat lean proteins such as chicken breast, salmon, or tofu; a wide variety of green and leafy vegetables; as well as a selection of fruits and whole grains. Swap out unhealthy fats like butter for healthy choices like olive oil. Avoid alcoholic beverages, which are high in calories, and can also stimulate your appetite. Try eating several small meals throughout the day instead of a few larger meals. This will help keep your energy levels up and prevent you from getting too hungry. Also, drink plenty of cool water to stay hydrated, which can help keep you fuller longer. Avoid juice, soda, and other sweetened drinks. It is important to reduce your daily calorie intake, but don't eat fewer than 1200 calories a day, which can trigger your body's starvation response and slow your weight loss. Also, aim for a minimum of 30 minutes of moderate-to-vigorous exercise each day. Depending upon your level of fitness, you can get the exercise you need by walking, running, swimming, cycling, or taking a class at the gym. Mix things up with strength training. You don't need any special equipment – body weight exercises such lunges, squats, and push-ups can all help you get toned and burn fat. Find friends or family to work on losing weight with you so that you can support each other. With consistent attention to diet and exercise, you'll lose weight in a healthy, sustainable, way. To learn more from our Dietitian co-author, like how to make a meal plan, keep reading!
Eat more fruits and vegetables. Fruit helps to satisfy your sweet tooth thanks to its natural sugars, while fresh vegetables help your stomach fill up more quickly. Fruits and vegetables contain fiber to help you feel full quickly.
Build Your Health and Your Body by Eating Right, Not Less! Inside
this eBook, you will discover the topics about healthy eating habits
tips, food quantities and weight loss, a balanced diet in weight loss,
the blood type principle of weight loss, the science of weight loss, the
magic bullet of protein, meal timing, calorie counting is dead and
benefits of right food to health.
This course teaches you how to lose weight without the customary
calorie counting that is often the basis of most weight-loss diets. To
be sure, low-calorie diets are too fast but it is a well-known fact that
they pose special hardships and gains are hard to sustain. Composed
of 10 chapters, this course provides you with a greater understanding of
the needs of your body and how this knowledge helps you follow a diet
that induces weight loss and sustains your gains without effort.
Weight
Introducing Eat More, Not Less to Lose Weight! –Build Your Health and Your Body by Eating Right, Not Less! Inside this
eBook, you will discover the topics about healthy eating habits tips, food quantities and weight loss, a balanced diet in weight loss, the blood type principle of weight loss, the science of weight loss, the magic bullet of protein, meal timing, calorie counting is dead and benefits of right food to health.
you track your eating over time. Choose to eat lean proteins such as chicken breast, salmon, or tofu; a wide variety of green and leafy vegetables; as well as a selection of fruits and whole grains. Swap out unhealthy fats like butter for healthy choices like olive oil. Avoid alcoholic beverages, which are high in calories, and can also stimulate your appetite. Try eating several small meals throughout the day instead of a few larger meals. This will help keep your energy levels up and prevent you from getting too hungry. Also, drink plenty of cool water to stay hydrated, which can help keep you fuller longer. Avoid juice, soda, and other sweetened drinks. It is important to reduce your daily calorie intake, but don't eat fewer than 1200 calories a day, which can trigger your body's starvation response and slow your weight loss. Also, aim for a minimum of 30 minutes of moderate-to-vigorous exercise each day. Depending upon your level of fitness, you can get the exercise you need by walking, running, swimming, cycling, or taking a class at the gym. Mix things up with strength training. You don't need any special equipment – body weight exercises such lunges, squats, and push-ups can all help you get toned and burn fat. Find friends or family to work on losing weight with you so that you can support each other. With consistent attention to diet and exercise, you'll lose weight in a healthy, sustainable, way. To learn more from our Dietitian co-author, like how to make a meal plan, keep reading!
Eat more fruits and vegetables. Fruit helps to satisfy your sweet tooth thanks to its natural sugars, while fresh vegetables help your stomach fill up more quickly. Fruits and vegetables contain fiber to help you feel full quickly.
Build Your Health and Your Body by Eating Right, Not Less! Inside
this eBook, you will discover the topics about healthy eating habits
tips, food quantities and weight loss, a balanced diet in weight loss,
the blood type principle of weight loss, the science of weight loss, the
magic bullet of protein, meal timing, calorie counting is dead and
benefits of right food to health.
This course teaches you how to lose weight without the customary
calorie counting that is often the basis of most weight-loss diets. To
be sure, low-calorie diets are too fast but it is a well-known fact that
they pose special hardships and gains are hard to sustain. Composed
of 10 chapters, this course provides you with a greater understanding of
the needs of your body and how this knowledge helps you follow a diet
that induces weight loss and sustains your gains without effort.
Weight
Introducing Eat More, Not Less to Lose Weight! –Build Your Health and Your Body by Eating Right, Not Less! Inside this
eBook, you will discover the topics about healthy eating habits tips, food quantities and weight loss, a balanced diet in weight loss, the blood type principle of weight loss, the science of weight loss, the magic bullet of protein, meal timing, calorie counting is dead and benefits of right food to health.
Udar Arogya is an Ayurvedic Remedy for all your stomach problems. Medicine is a proprietary Ayurvedic solution made from a mixture of various specific herbs in their purified extracted form for general wellbeing of gastrointestinal system.
https://udararogya.com/
How to lose weight in simple steps it's a quick guide to weight loss for beginners.
In this short document, you can find ideeas and articles like simple solutions for quick weight loss, 9 super foods to help weight loss, about if there are any weight loss wonders, about the beginning your weight loss journey and being in the mood for weight loss, how to burn calories for weight loss and common myths about weight loss.
If you have tried before quick weight loss and experienced an even quicker weight gain back, there are some things that could be done and starts from a healthy life, with nutrient foods, with some exercises – regarding diets, that should not exist anymore, the change must be profound for an active life style, with energy from healthy food.
build your health and body by eating right not less, you will discover the topics health eating habit tips, food quantities and weight loss,the blood type principle of weight lose
Weight loss is simple now - New Editionmanojmohanan9
Your weight loss is now made simple with effective food and exercise patterns. Being the most common issue, weight loss have become a major problem for people globally due to change in lifestyle and culture. This book give you guidance for weight loss naturally and effectively. The contents cover the food, exercises, commonly asked questions and facts of weight loss.
DISCOVER THE“NEAR-MAGICAL”METHOD TO LOSE
UNWANTED BELLY FAT NATURALLY AND SAFELY WHILE YOU SLEEP
(WITHOUT Starving Yourself And WITHOUT Doing Any
Exercise More Strenuous Than Making A Cup Of Tea!)
The book is about healthy eating habits. It addresses the following topics : Food Quantities and Weight Loss,
A Balanced Diet In Weight Loss, The Blood Type Principle of Weight Loss, The Science of Weight Loss and Meal Timing. The book is highly recommended for anyone struggling with weight.
Yes it is possible to lose weight quickly and yet stay healthy. You will need to follow a healthy diet and exercise plan.
For you to learn how to lose weight quickly make sure that you eat healthy you will need to change your general nutrition and lifestyle habits and then stick to a number of simple dietary and behavioral changes which will assist in your weight loss journey.
The smoothie diet review 21-day smoothie diet plan for weight lossSalah Fringe
It was a 21-day smoothie diet is an e-book prepared by Drew Sgoutas which contains a schedule and recipes for three weeks instructing what smoothies to be taken for each day.
This diet will help you shed approximately 2 or 3 pounds per week. You should expect to get rid of up to 50-70 pounds if you repeat this diet plan several times.
Water retention is a body's response to a change in hormones, environment, or disease. It's not uncommon to experience excess fluids in your body causing bloating and weight gain
The first chapter of this course is focused on how changing lifestyle
gain good health, and why starving yourself to lose weight is unnecessary and even dangerous. Chapters 9 to 10 are about healthy eating habits, food combinations and quantities that promotes weight loss, the science of losing weight, contribution of protein to getting fit, timing your meals, and the health benefits of eating the right foods. Get all the info you need here.
Eat More, Not Less To Lose Weight! Build Your Health And Your Body By Eating Right, Not Less!
Aim for a slow, steady weight loss by decreasing calorie intake while maintaining an adequate nutrient intake and increasing physical activity. You can cut calories without eating less nutritious food. The key is to eat foods that will fill you up without eating a large amount of calories. ! See more detail below (https://tinyurl.com/wkn697yw )
Inside this eBook, you will discover the topics about healthy eating habits tips, food quantities, and weight loss, a balanced diet in weight loss, the blood type principle of weight loss, the science of weight loss, the magic bullet of protein, meal timing, calorie counting is dead and benefits of right food to health.
Udar Arogya is an Ayurvedic Remedy for all your stomach problems. Medicine is a proprietary Ayurvedic solution made from a mixture of various specific herbs in their purified extracted form for general wellbeing of gastrointestinal system.
https://udararogya.com/
How to lose weight in simple steps it's a quick guide to weight loss for beginners.
In this short document, you can find ideeas and articles like simple solutions for quick weight loss, 9 super foods to help weight loss, about if there are any weight loss wonders, about the beginning your weight loss journey and being in the mood for weight loss, how to burn calories for weight loss and common myths about weight loss.
If you have tried before quick weight loss and experienced an even quicker weight gain back, there are some things that could be done and starts from a healthy life, with nutrient foods, with some exercises – regarding diets, that should not exist anymore, the change must be profound for an active life style, with energy from healthy food.
build your health and body by eating right not less, you will discover the topics health eating habit tips, food quantities and weight loss,the blood type principle of weight lose
Weight loss is simple now - New Editionmanojmohanan9
Your weight loss is now made simple with effective food and exercise patterns. Being the most common issue, weight loss have become a major problem for people globally due to change in lifestyle and culture. This book give you guidance for weight loss naturally and effectively. The contents cover the food, exercises, commonly asked questions and facts of weight loss.
DISCOVER THE“NEAR-MAGICAL”METHOD TO LOSE
UNWANTED BELLY FAT NATURALLY AND SAFELY WHILE YOU SLEEP
(WITHOUT Starving Yourself And WITHOUT Doing Any
Exercise More Strenuous Than Making A Cup Of Tea!)
The book is about healthy eating habits. It addresses the following topics : Food Quantities and Weight Loss,
A Balanced Diet In Weight Loss, The Blood Type Principle of Weight Loss, The Science of Weight Loss and Meal Timing. The book is highly recommended for anyone struggling with weight.
Yes it is possible to lose weight quickly and yet stay healthy. You will need to follow a healthy diet and exercise plan.
For you to learn how to lose weight quickly make sure that you eat healthy you will need to change your general nutrition and lifestyle habits and then stick to a number of simple dietary and behavioral changes which will assist in your weight loss journey.
The smoothie diet review 21-day smoothie diet plan for weight lossSalah Fringe
It was a 21-day smoothie diet is an e-book prepared by Drew Sgoutas which contains a schedule and recipes for three weeks instructing what smoothies to be taken for each day.
This diet will help you shed approximately 2 or 3 pounds per week. You should expect to get rid of up to 50-70 pounds if you repeat this diet plan several times.
Water retention is a body's response to a change in hormones, environment, or disease. It's not uncommon to experience excess fluids in your body causing bloating and weight gain
The first chapter of this course is focused on how changing lifestyle
gain good health, and why starving yourself to lose weight is unnecessary and even dangerous. Chapters 9 to 10 are about healthy eating habits, food combinations and quantities that promotes weight loss, the science of losing weight, contribution of protein to getting fit, timing your meals, and the health benefits of eating the right foods. Get all the info you need here.
Eat More, Not Less To Lose Weight! Build Your Health And Your Body By Eating Right, Not Less!
Aim for a slow, steady weight loss by decreasing calorie intake while maintaining an adequate nutrient intake and increasing physical activity. You can cut calories without eating less nutritious food. The key is to eat foods that will fill you up without eating a large amount of calories. ! See more detail below (https://tinyurl.com/wkn697yw )
Inside this eBook, you will discover the topics about healthy eating habits tips, food quantities, and weight loss, a balanced diet in weight loss, the blood type principle of weight loss, the science of weight loss, the magic bullet of protein, meal timing, calorie counting is dead and benefits of right food to health.
3) Description:
This course teaches you how to lose weight without the customary calorie counting that is often the basis of most weight loss diets. To be sure, low-calorie diets are too fast but it is a well known fact that they pose special hardships and gains are hard to sustain. Composed of 10 chapters, this course provides you with greater understanding of the needs of your body and how this knowledge help you follow a diet that induces weight loss and sustains your gains without effort.
Introducing eat more, not less to lose weight!- build your health and your body by eating Right, Not less! Inside this eBook, you will discover the topics about healthy eating habits tips, food quantities and weight loss.
LEARN MORE >>https://nplink.net/jrur1itj<<
The blood type principle of weight loss, the science of weight loss and benefit of right food to health.
Inside this eBook, you will discover the topics about healthy eating habits tips, food quantities and weight loss, a balanced diet in weight loss, the blood type principle of weight loss, the science of weight loss, the magic bullet of protein, meal timing, calorie counting is dead and benefits of right food to health.
This course teaches you how to lose weight without the customary
calorie counting that is often the basis of most weight-loss diets. To
be sure, low-calorie diets are too fast but it is a well-known fact that
they pose special hardships and gains are hard to sustain
The first chapter of this course is focused on how changing lifestyle –more healthful diets and more exercises - helps you to lose weight and gain good health, and why starving yourself to lose weight is unnecessary and even dangerous. Chapters 9 to 10 are about healthy eating habits, food combinations and quantities that promote weight loss, the science of losing weight, the contribution of protein to getting fit, timing your meals, and the health benefits of eating the right foods.
Get all the info you need here.
Introducing Eat more, not less to lose weight! Build your health and your body by Eating right not less. Build Your Health And Your Body By Eating Right, Not Less! The first chapter of this course is focused on how changing lifestyle.
The keto diet keeps carbohydrate levels low, but instead of ramping up the amount of protein in your diet, the keto diet increases the amount of fat. A typical keto diet aims for meals with 75% fat, 20% protein, and 5% carbohydrate. Eating a high-fat diet can still mean eating healthy. Keto diet menu items often include seafood, meat, dairy products, eggs, vegetables, and nuts. With the increased popularity of the keto diet, keto recipes are widely available.
Eat more, not less to lose weight! discover how to lose weight by eating moreFAIGALGA
This book teaches you how to lose weight without the customary
calorie counting that is often the basis of most weight loss diets. To
be sure, low-calorie diets are too fast but it is a well-known fact that
they pose special hardships and gains are hard to sustain.
Introducing Eat More, Not Less to Loss Weight - Build Your Health and Your Body by Eating Right, Not Less! Inside this eBook, you will discover the topics about healthy eating habit tips. food quantities and weight loss, a balanced diet in weight loss, the blood type principle of weight loss, the science of weight loss, the magic bullet of protein, meal timing, calorie counting is dead and benefits of right food to health
Introducing Eat More,Not Less To Lose Weight!-Build Your Body by Eating Right, Not Less! Inside This eBook, You Will discover the topics about healthy eating habits tips, food quantities and weight loss , a balanced diet in weight loss , the blood type principal of weight loss, the science of weight loss , the magic bullet of protein , meal timing , calorie counting is dead and benefits of right food to health.
The first chapter of this course is focused on how changing lifestyle –
more healthful diets and more exercises - helps you to lose weight and
gain good health, and why starving yourself to lose weight is
unnecessary and even dangerous. Chapters 9 to 10 are about healthy
eating habits, food combinations and quantities that promotes weight
loss, the science of losing weight, contribution of protein to getting fit,
timing your meals, and the health benefits of eating the right foods.
Get all the info you need here.
Email for Free copy of e-Book onlinecourses247@gmail.com
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
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1. How to Lose Weight
Are you tired of carrying around extra pounds? You can learn the basics of weight loss,
as well as ways to eat healthier, get more exercise, and keep yourself motivated to keep
the pounds off the healthy way.
Method 1 of 4: Losing Weight Basics
1/ Write down everything you eat this week. People who keep food diaries, according
to a study published in the Journal of the Academy of Nutrition and Dietetics, lose an
average of 6 pounds (2.75 kg) more than people who don't keep a record of everything
2. that they eat.[1]
So force yourself to write down the good, the bad and the ugly. Keep these
tips in mind:
Be complete. Write it all down, including beverages, condiments, and a description of
how the food was prepared. Don't pretend you didn't have that extra glass of wine after
dinner. If it goes into your stomach, it goes into the journal.
Be accurate. Record your portion sizes in your food diary. Don't eat too little or too much
- keep track. Also, read the ingredients list so that you can be accurate about serving
sizes.
Be consistent. Carry your food journal everywhere that you go. As an alternative, you can
use a diet-tracking app on your smartphone or tablet.
3. 2/ Figure out how many calories you should eat each day to lose weight. Losing
weight isn't all about weight. The more aware you are of the calories in the food you eat,
the more easily you'll be able to eat the right amount of food and do the right amount of
exercise to drop a couple of pounds. Take your food journal and look up each item
individually. Keep a running tally and add up your calorie total for the day.
Next, look up how much a person of your age, height, weight, and energy level needs per
day in calories.
Add about 170 calories to your total. Recent studies estimate that we tend to eat slightly
more than we're able to keep track of in a day.[2]
4. 3/ Make a meal plan, and stick to it. Decide what you're going to eat this week before
you're standing at the fridge and trying to figure it out on the fly. Buy the right healthy
ingredients to eat the way you want to eat, and plan it out by the calorie.
Be realistic. If you like to eat out a lot, don't try to totally eliminate eating out. Instead,
plan on eating home-cooked meals six days a week.
Cut down on the snacking, or try to make them healthy snacks. Fresh vegetables with
guacamole, unsalted almonds, or fruit make for great weight-loss snacks.
Let yourself have treats. Promise yourself that if you can follow this for six weeks and
exercise (if that is one of your goals), you will treat yourself to a restaurant meal one day
of the week.
5. 4/ Eat fewer calories than you burn. The only surefire way to lose weight is to eat less
than you burn over the course of a day. Sounds simple, but it takes work and consistency.
That means exercise. If you want to lose weight and stay healthy, you need to start
exercising. Aim for 30 minutes of exercise 3-5 times a week to get started.
Try to tally your energy-output each day. It's helpful to keep track of these with
pedometers, or other weight-loss tracking apps that you can use to make this easier. Read
the section about exercise for more specific tips.
Set mini-goals. Instead of thinking that you need to lose 20 pounds, think that you want
to lose 1 to 2 pounds this week. Or you can focus on non-pound goals like skipping after-
dinner snacks this week or only drinking alcohol on weekends.
6. 5/ Drink at least 2 liters (0.53 US gal) of water each day. Water has the double effect
of both hydrating your body and filling your stomach with a certain volume of a liquid
that has zero calories. The Institute of Medicine determined that an adequate intake (AI)
for men is roughly 3 liters (0.8 US gal) (about 13 cups) of total beverages a day. The AI
for women is 2.2 liters (about 9 cups) of total beverages a day.
Drinking water about 30 minutes before meals can reduce the amount of calories people
end up consuming, especially in older individuals.
Research showed that dieters who drank half a liter of water before meals lost 44% more
weight over a period of 12 weeks, compared to those who didn’t.
Method 2 of 4: Eating Right
7. 1/ Eat more fresh fruits and vegetables. Fruit helps to satisfy your sweet tooth thanks to
its natural sugars, while fresh vegetables help you fill up more quickly. Fruits and
vegetables contain fiber to help you feel full quickly.[3]
Try some of these tips to introduce
more fruit and vegetables into your diet:
Eat what's in season, and eat fruit and vegetables for snacks, or for desert. When you eat
apples in the fall, for instance, or cherries in late summer, it might as well be an indulgent
desert. Cut up celery, carrots, peppers, broccoli or cauliflower and dip them in a light
salad dressing or hummus.
Use vegetables as a main dish. For example, make a stir-fry or a hearty salad and add just
a few ounces of cooked chicken, salmon or almonds.
8. 2/ Eat more whole grains and cut simple carbs. Whole wheat bread, oatmeal, whole
wheat pasta, sweet potato, and brown rice are all excellent sources of energy and sources
of nutrition. Combined with the right combination of proteins and vegetables, whole
grains are perfect all-around nutrition.[4]
Simple carbs are things like white bread, processed flour, and white sugar. This gives you
energy quickly, but then comes with a crash. It gets transferred into fat very quickly.
Substitute whole wheat flour or oat flour into pancakes or baked goods. You might need
to add additional leavening ingredients, like wheat gluten. Put barley in your soup instead
of rice or try a pilaf with barley, wild rice or brown rice.
Eat only naturally-occurring carbohydrates instead of processed carbohydrates. Avoid
processed foods, like white bread, semolina pasta or crackers, or processed sweets like
candy bars or sugary vegetables.[5]
9. 3/ Choose lean proteins instead of fatty ones. Protein is important for organ function
and building muscle while, if you plan on working out. Select lean cuts of beef or extra-
lean ground beef when you're eating red meat. If you use different cuts of chicken, then
remove the skin.[6]
Skip the fatty deli meats like bologna and salami. Choose lean turkey or roast beef as a
replacement.
Vegetarians can get plenty of protein from soy, nuts, beans and seeds. Lentils, legumes,
and beans are excellent sources of fiber and protein.
Eat low-fat dairy for a source of protein, including low-fat cheeses and nonfat yogurt. [7]
10. 4/ Try a formal diet plan. If you like the idea of following a more specific diet and
putting the planning into someone else's hands, try following a new diet and exercise:
Follow a paleo diet and eat grass-produced meat, fish and seafood, fresh fruits and
vegetables, eggs, seeds and nuts, just like paleo-humans did. Eat nothing prepackaged or
processed.[8]
Try sticking to raw foods. The Raw Food Diet requires 75 percent of your dietary intake
to be uncooked. Most people eat a lot of fruits and vegetables, whole grains, nuts and
beans.[9]
Join a commercial diet plan. If you prefer to eat whatever you want and to meet weekly
with other people who are losing weight, then try Weight Watchers. If you prefer
prepared meals so that you don't have to cook, try Jenny Craig or NutriSystem.
11. 5/ Cut the salt from your diet. Eating more sodium causes your body to retain water,
which can cause you to feel bloated and gain more weight. The good news is that you'll
sweat that weight out very quickly, so an easy way of cutting some pounds is to eat less
sodium in your diet.
Instead of salt, try spicing your meals with chili flakes, fresh salsa, or cajun spices and
seasonings.
Lots of people claim that unsalted foods will taste much saltier eventually, if you cut it
out for a while and let your taste-buds re-acclimate.
12. 6/ Don't skip meals. Lots of people think skipping a meal will help to lose weight, but
the same study found that people who ate at least 3 meals per day lost more weight than
people who didn't. When you skip meals, your body stops breaking down fat and starts
breaking down muscle tissue. Muscle tissue burns more calories at rest than other tissues,
so you're actually working against your goals.[10]
Make sure that you don't get hungry by eating small portions throughout the day at
regular intervals. Between your meals, eat a 150-calorie snack to keep your metabolism
burning and to stave off hunger. Be sure that you don't eat a fattening snack such as
sweets or crisps. When you're hungry, your body conserves calories and slows down your
metabolic processes.
13. Method 3 of 4: Exercising
1/ Start doing basic aerobic and cardio exercise. Start with a small goal of 30 minutes,
3 times per week if you aren't exercising at all currently. Try these steps to get yourself
going:[12]
Buy a pedometer. Attach the pedometer to your belt and try to take 5,000 steps daily.
Move up to a goal of 10,000 to 15,000 steps as you get in better shape.
Start by walking. Walking around your neighborhood costs nothing and is a great way to
start moving. You can also try other low-impact exercises like swimming,riding a bike or
slow running.
14. 2/ Try machines at the gym. You can use a treadmill, an elliptical trainer, a stationary
bike, a rowing machine or a stair climber. Start with short sessions and gradually add
minutes as you get more fit. Also, use the settings on the machines to increase the
intensity as you lose weight.
Do a variety of different machines until you find something you like. Consult a personal
trainer to make sure you're using proper form, to avoid injury. They're there to help, not
to intimidate you.
15. 3/ Take an aerobics class. You can take a traditional aerobics class or try any number of
movement-based exercise routines. This are great ways of keeping yourself motivated in
a group, having fun moving around, and losing weight.[13]
Try any of the following:
Kickboxing
Jazzercise
Zumba
Pilates
Yoga
Martial arts
Cross-fit or Bootcamp
16. 4/ Get into strength training. Start small, aiming for one or two 15-minute sessions per
week until you feel motivated to do more. Exercise large muscle groups to burn more
calories and lose weight, instead of focusing on specific muscles. Try some of these
examples:
Start with squats paired with an overhead dumbbell press to work your lower body and
upper body at the same time.
Perform resistance exercises while sitting or reclining on an exercise ball. You'll
strengthen your core while simultaneously working on other areas.
Use machines and free weights. These tools tend to focus on particular muscle groups
like the arms, shoulders, thighs, glutes and upper back. Do these more focused exercises
after you work on exercises for multiple muscle groups.
17. Rest at least one full day between strength training workouts so that your muscles can
recover. Recovery will help you to avoid pain and injury.
5/ Play a sport. If you're not into the idea of exercise for the sake of exercise, try finding
a fun activity that you enjoy, which has the added benefit of getting you moving. Find an
intramural league in your town, or just get together with some friends to play a pick-up
game every now and then.
If you don't like competitive sports, try doing something that you can do by yourself.
Swim, or play golf, or go hiking instead of playing a game with a ball and a net.
Get a bicycle if you want to find a great way to get around and exercise at the same time.
Don't spend all that time sitting down in your car when you could be burning calories.
18. Method 4 of 4: Staying Motivated
1/ Find creative ways to eat less. While doing these things alone won't necessarily make
you lose weight, they can be helpful little tricks to keep you moving on the right path.
Try out the following to help your hunger cravings during the day:
Eat three fewer bites of each meal.
Put your knife and fork down between bites.
Use smaller plates, and fill your plate only once.
Wait to eat until you feel hungry, don't just snack when you're bored.
19. 2.
2/ Find creative ways to manage your cravings. If you're used to big snacks and
indulgent meals, it's no secret that dieting and switching to exercise is less fun. But
learning to manage your cravings for a big slice of cake or a greasy hamburger is
possible, with a little creativity.
Smell fresh fruit when you want a snack, instead of eating something.
"Close" your kitchen between meals.
Don't keep sugary or fattening snacks in the house.
Some studies show that the color blue is an appetite suppressant. Try getting a blue
tablecloth, or blue dishwater to eat on.
20. 3/ Eat at home. Going out to eat makes it too easy to cheat. Food sold at restaurants is
commonly much higher in fat, sodium, and other weight-loss killers. The portions are
also often much larger than what you might usually eat at home, as well. Instead of
heading out, try to make your own meals.
Eat in a small group, instead of a large one. Some research shows that people eating at
big tables tend to eat more than people eating alone.[14]
Don't eat while you do other things, in general. Watching television, or reading, or
working while you eat often causes people to eat much more food than they normally
would.
21. 4/ Eat cereal for breakfast. One recent study revealed that people who eat cereal for
breakfast each day have a much easier time losing weight than people who eat other types
of breakfast. Start your day right with a high-fiber, nutrient rich natural cereal, or
oatmeal.
Switch to skim milk with breakfast and for use in other dishes. Each lower-fat step you
take down, you're losing 20% of the calories. Switching to a low-fat version of milk is an
excellent way to cut down on the calories you're taking in, without having to sacrifice any
of the nutritional benefits.
22. 5/ Decide to lose weight in a group. Commit to losing a certain amount of weight by a
certain date with the caveat that you'll pay up if you don't lose. You may enjoy starting up
a Biggest Loser Club at work or with your friends, or you can investigate a weight loss
betting website.
23. 6/ Give yourself a treat now and then. If you're attending a party or going out for a
special occasion, allow yourself an indulgence. Just make sure that these indulgences
don't become daily habits. Don't let a single slip-up de-rail your diet and exercise plan.
Get back to it, even if you forget for a day or two.
Try using non-food rewards as well. When you do something right with your diet and
exercise, treat yourself to something. Go to a game with a friend, or get a manicure, a
massage or a trip to the movies when you meet your mini-goals. Get yourself that new
shirt that you've been wanting if you meet your goal of losing a pound this week.
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