How to design and conduct a complex literature search
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A complex literature search involves several steps: 1) Defining the research question using PICO (Population, Intervention, Comparator, Outcome); 2) Reviewing background literature such as systematic reviews, HTA reports, and specific databases; 3) Searching information resources including bibliographic databases like Medline and Embase, as well as grey literature from trial registers. The document provides details on searching Medline to find studies on vedolizumab for Crohn's disease, and emphasizes the importance of searching grey literature since many negative trials are not published.
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How to design and conduct a complex literature search
This document provides guidance on how to design and conduct a complex literature search to review information on the use of vedolizumab for Crohn's disease. It outlines researching the question using PICO (population, intervention, comparator, outcome), reviewing background literature like systematic reviews and clinical trials, searching relevant bibliographic databases like Medline and grey literature sources, and provides an example search strategy and results for Medline. The goal is to conduct a thorough search across multiple information sources to identify all relevant evidence on this topic.
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10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
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How to design and conduct a complex literature search
- 1. How to design and conduct a complex literature search Rocio Rodriguez Lopez 30/03/2016
- 2. 1. Research Question: PICO P: Population/Disease Crohn Disease I: Intervention Vedolizumab C: Comparator O: Outcome
- 3. 2. Background Literature •Key papers •Synonyms •Drug manufacturer •Specific Databases •Introduction and discussion
- 4. 2. Background Literature Systematic Reviews HTA Reports DARE Regulatory Agencies
- 5. 3. Information resources • CORE Databases: Medline, Embase, WoS. • Specific Databases: NORD. • Grey Literature : Trial Registers. • Manual Searching, Internet Searching, Citation Searching.
- 6. 3.a Bibliographic Databases: Medline 1 Crohn Disease/ (30767) 2 (crohn* or ileocolitis or "inflammatory bowel disease 1" or ((regional or granulomatous or terminal) adj2 (ileitis or ileitides or enteritis or colitis))).ti,ab. (34122) 3 or/1-2 (41222) 4 (vedolizumab* or entyvio* or LDP02 or GTPL7437 or LDP-02 or MLN-02 or MLN-0002).af. (100) 5 3 and 4 (55) 6 randomized controlled trial.pt. (381906) 7 controlled clinical trial.pt. (88467) 8 random*.ti,ab. (737022) 9 placebo.ab. (156936) 10 clinical trials as topic.sh. (170332) 11 trial.ti,ab. (373881) 12 or/6-11 (1209799) 13 exp animals/ not humans.sh. (3972666) 14 12 not 13 (1099744) 15 and/5,14 (26)
- 7. 3.c Grey Literature 59% of negative trials are NOT published Hopewell S, Loudon K, Clarke MJ, Oxman AD, Dickersin K. Publication bias in clinical trials due to statistical significance or direction of trial results. Cochrane Database of Systematic Reviews 2009, Issue 1. Art. No.: MR000006.
- 8. 3.c Grey Literature CENTRAL International Associations and Conferences Conference Proceedings Citation Index
Editor's Notes
- What kind of evidence? Good comunication with the research Team/ Good feedback. Understand their needs.
- Clinical Evidence Regulatory Agencies FDA, EMA, MHRA NICE, UKMI, SR Cochrane, DARE HTA reports HTA, Websites, Google Free text Why?
- National Organisation for Rare Disorders
- Communication/Adaptable to the information needs Iterative Sensitive Explicit Keep all the details