Hormones are distributed throughout the body in blood and other body fluids. Why don’t all tissues/cells respond to all hormones? Solution The “endocrine glands” are ductless glands, which release the hormones into the blood and are transported to a site distant from its origin where it produces its action. It is known as endocrine signalling. Though the endocrine hormones travel throughout the blood, only specific tissues respond to each hormone because hormones bind to specific receptors to produce physiological effects. For example, the insulin released by pancreas binds to the insulin receptor. The luteinizing hormone (LH) and follicle-stimulating hormone (FSH) acts on receptors prominent in ovaries and uterus..