The document discusses holistic education and its benefits for the economy, health, and reducing stress. It argues that mainstream education focuses too much on superficial goals and neglects students' spiritual and productive development. A more holistic approach integrating a productive domain like crafts, skills, or agriculture into 25% of school time could help make education accessible to all by reducing costs and student stress while preventing issues like dropout rates and unemployment. This holistic model emphasizing self-sufficiency and practical skills could help address global problems like poverty and social strife.
Western Wake Real Estate Professionals PresentationBobby Carroll
While many real estate professionals have taken the plunge in to social media marketing many are sitting on the sidelines wondering if it really works or is it a monumental waste of time. Consumers are talking about real estate and real estate professionals. The question is are you listening to see if home buyers and sellers are going "wall to wall" with their Facebook friends chatting about you or the market? Watch this presentation see why you can longer afford to sit on the sidelines of social media. It's time you listened, connected and engaged with your audience!
Dakno Real Estate Marketing Boot Camp Apps SessionBobby Carroll
Apps for Real Estate Agents on the Go! presented at the Dakno Real Estate Marketing Boot Camp by VP of Sales/Marketing, Bobby Carroll (@rewebcoach). A special treat during this session was the local introduction of the agent-centric GoConnect real estate app developed by Go Realty Founder Zach Schabot. www.goconnectapp.com
Western Wake Real Estate Professionals PresentationBobby Carroll
While many real estate professionals have taken the plunge in to social media marketing many are sitting on the sidelines wondering if it really works or is it a monumental waste of time. Consumers are talking about real estate and real estate professionals. The question is are you listening to see if home buyers and sellers are going "wall to wall" with their Facebook friends chatting about you or the market? Watch this presentation see why you can longer afford to sit on the sidelines of social media. It's time you listened, connected and engaged with your audience!
Dakno Real Estate Marketing Boot Camp Apps SessionBobby Carroll
Apps for Real Estate Agents on the Go! presented at the Dakno Real Estate Marketing Boot Camp by VP of Sales/Marketing, Bobby Carroll (@rewebcoach). A special treat during this session was the local introduction of the agent-centric GoConnect real estate app developed by Go Realty Founder Zach Schabot. www.goconnectapp.com
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
3. Improvement in economy through holistic
education is pivotal to Total Stress
Management i.e. empowerment and
blossoming of an individual, school, nation
and the world.
If you analyze the poverty and associated
globally prevalent issues leading to ubiquitous
stress, with a holistic perspective, then it
would be clear that the innate core (the
spiritual domain that imparts universal
perspective and globally beneficial outlook)
and the productive domain (that empowers);
of people concerned with education; are
4. grossly neglected and remain perennially
deficient.
Mainstream Education System and the
courses and careers in it; revolve around and
serve the grossly petty and superficial
considerations, motivations and interests (I
am referring to what I have been observing
in India for last half a century and guess that
it is not much different in other parts of the
world)! This state of affairs is strongly
protected and strengthened by the political
elements with similar interests! Hence laws,
rules and regulations develop accordingly!
5. Steps to rectify
1. Working physically in different ways and
earning [productive domain] in itself, is not a
burden. It is an opportunity to grow from
within. It is an opportunity to develop self
esteem. It is an opportunity to become self
sufficient.
2. This leads to self sufficiency in schools.
They do not have to depend on heavy fees or
federal grants or donations. This makes the
education institutions
accessible to all and self sufficient!
6. 3. Through productive domain the
hypokinetic stress, emotional stress of being
dependent and intellectual stress
of excessive memorizing would be averted.
4. Due to productive domain, the dropping
out due to lack of earning [as is common in
case of millions of students in many parts of
world] and then turning into helpless,
vulnerable and cheap child labor would come
down.
5. Being empowered, the students would not
go through the stress of unemployment and
7. turn into helpless, frustrated mental wrecks
or criminals.
6. The emphasis on productive (and hence
psychomotor and practical aspects) would
bring down the necessity to “copy” and
associated crimes and corruption in
procedures of examinations, certification,
providing grants presently rampant in many
parts of world.
The caste based reservation for education,
jobs and other faculties; responsible for social
divide and strife in many parts of the world;
(especially India) can be peacefully and
8. advantageously done away with, by
consensus!
This is only a brief sketch of the potential
advantages of productive domain.
The practical aspects of productive domain
can include several crafts and skills and arts
and their sale according to the situations. For
example, planting of
medicinal herbs, rearing of cows, home
flower gardening, production of chalk
sticks, carpentry, pottery, arts such as music,
dance, painting and others.
9. Tips
1. The productive domain should be an
essential ingredient of Mainstream Education
System, but no particular job should be
enforced.
2. The productive domain should constitute
only about twenty five percent of the school
time.
3. The teachers and others should participate
in the productive domain.
Warnings
10. 1. Administrative aspects such as
infrastructural development have to be done
with professional expertise.
2. It should be done with due care and
concern for the physical capacities of the
children and should not be painful and
troublesome.
3. All this should be done with a clear aim of
all-round development of the students,
Teachers and other concerned.
Sources available for free download on
www.superliving.net
1. Stress: Understanding and Management:
Dr. Shriniwas Kashalikar
11. 2. Conceptual Stress: Understanding and
Management: Dr. Shriniwas Kashalikar
3. Hitaguj (Marathi): Dr. Shriniwas
Kashalikar
4. Smiling Sun: Dr. Shriniwas Kashalikar
5. Namasmaran: Dr. Shriniwas Kashalikar
Dr. Shriniwas Kashalikar