HEVnet network & database.
A global network of scientists sharing molecular & epidemiological data on hepatitis E virus.
Presented by Agnetha Hofhuis, on behalf of HEVnet.
@hev expert meeting ECDC November 2018
Presentation from the ECDC expert consultation on Whole Genome Sequencing organised by the European Centre of Disease Prevention and Control - Stockholm, 19 November 2015
Whole Genome Sequencing (WGS) for food safety management: Perspectives from K...ExternalEvents
http://tiny.cc/faowgsworkshop
Use of genome sequencing technology on food safety management- Kenya's Perspectives. Presentation from the FAO expert workshop on practical applications of Whole Genome Sequencing (WGS) for food safety management - 7-8 December 2015, Rome, Italy.
Presentation from the 3rd Joint Meeting of the Antimicrobial Resistance and Healthcare-Associated Infections (ARHAI) Networks, organised by the European Centre of Disease Prevention and Control - Stockholm, 11-13 February 2015
This document discusses using a One Health approach and consensus PCR to develop a new diagnostic paradigm for detecting unknown illnesses. It summarizes work done through the PREDICT project, which used low-tech surveillance methods to safely sample over 56,000 animals across Asia and Africa. This led to the detection of 812 novel and 147 known viruses in animals, and 3 novel and 31 known viruses in humans. The approach aims to preempt disease emergence at its source in a cost-effective manner. It has enhanced field and lab capacities globally and built intersectoral cooperation between governments.
Presentation by Jens Lundgren, Rigshospitalet, University of Copenhagen - European AIDS Clinical Society, Denmark, at AIDS 2018 conference during the joint ECDC and EACS satellite "Getting to 90: Addressing inequalities in the HIV continuum of care in Europe and Central Asia"
Presentation by Daniel Simões, HIV in Europe, Portugal , at AIDS 2018 conference during the joint ECDC and EACS satellite "Getting to 90: Addressing inequalities in the HIV continuum of care in Europe and Central Asia"
Blockchain can be applied in several use cases such as data management in electronic medical records, healthcare data security, and management of genomics at the point of care. To know more details and information about use cases, you can visit the below websites:
https://dhealth.network/use-cases/
https://dhealth.network/2021/01/11/health-certificates-on-blockchain/
https://dhealth.network/2021/01/07/hemophilia/
https://dhealth.network/2020/12/10/rabies-vaccine-tracking-with-blockchain-in-mali-and-ivory-coast/
https://dhealth.network/2020/12/01/management-of-respiratory-diseases-with-the-centiva-life-app/
The document summarizes the current situation of hepatitis E virus (HEV) in Ireland. While HEV infections are likely underdiagnosed, available data indicates low prevalence in humans. Limited testing has been conducted in animals and foods. The National Virus Reference Laboratory conducts HEV diagnostic testing and is validating a genotyping assay. HEV will become a notifiable disease, and enhanced surveillance, guidelines, collaboration between agencies, and increased awareness are recommended to improve understanding and monitoring of HEV in Ireland.
Presentation from the ECDC expert consultation on Whole Genome Sequencing organised by the European Centre of Disease Prevention and Control - Stockholm, 19 November 2015
Whole Genome Sequencing (WGS) for food safety management: Perspectives from K...ExternalEvents
http://tiny.cc/faowgsworkshop
Use of genome sequencing technology on food safety management- Kenya's Perspectives. Presentation from the FAO expert workshop on practical applications of Whole Genome Sequencing (WGS) for food safety management - 7-8 December 2015, Rome, Italy.
Presentation from the 3rd Joint Meeting of the Antimicrobial Resistance and Healthcare-Associated Infections (ARHAI) Networks, organised by the European Centre of Disease Prevention and Control - Stockholm, 11-13 February 2015
This document discusses using a One Health approach and consensus PCR to develop a new diagnostic paradigm for detecting unknown illnesses. It summarizes work done through the PREDICT project, which used low-tech surveillance methods to safely sample over 56,000 animals across Asia and Africa. This led to the detection of 812 novel and 147 known viruses in animals, and 3 novel and 31 known viruses in humans. The approach aims to preempt disease emergence at its source in a cost-effective manner. It has enhanced field and lab capacities globally and built intersectoral cooperation between governments.
Presentation by Jens Lundgren, Rigshospitalet, University of Copenhagen - European AIDS Clinical Society, Denmark, at AIDS 2018 conference during the joint ECDC and EACS satellite "Getting to 90: Addressing inequalities in the HIV continuum of care in Europe and Central Asia"
Presentation by Daniel Simões, HIV in Europe, Portugal , at AIDS 2018 conference during the joint ECDC and EACS satellite "Getting to 90: Addressing inequalities in the HIV continuum of care in Europe and Central Asia"
Blockchain can be applied in several use cases such as data management in electronic medical records, healthcare data security, and management of genomics at the point of care. To know more details and information about use cases, you can visit the below websites:
https://dhealth.network/use-cases/
https://dhealth.network/2021/01/11/health-certificates-on-blockchain/
https://dhealth.network/2021/01/07/hemophilia/
https://dhealth.network/2020/12/10/rabies-vaccine-tracking-with-blockchain-in-mali-and-ivory-coast/
https://dhealth.network/2020/12/01/management-of-respiratory-diseases-with-the-centiva-life-app/
The document summarizes the current situation of hepatitis E virus (HEV) in Ireland. While HEV infections are likely underdiagnosed, available data indicates low prevalence in humans. Limited testing has been conducted in animals and foods. The National Virus Reference Laboratory conducts HEV diagnostic testing and is validating a genotyping assay. HEV will become a notifiable disease, and enhanced surveillance, guidelines, collaboration between agencies, and increased awareness are recommended to improve understanding and monitoring of HEV in Ireland.
This document outlines ECDC's strategic framework for integrating molecular and genomic epidemiology data into public health operations from 2019-2021. It demonstrates new features for molecular surveillance in the TESSy database and a prototype web interface for genomic analysis. Priority diseases are identified for whole genome sequencing-based typing, including carbapenem-resistant Enterobacteriaceae, Listeria monocytogenes, Salmonella enterica, and Neisseria meningitidis. Improved tools will provide automated quality control feedback and detection of matches to outbreak clusters when sequence data is uploaded.
Genome sequencing for animal health - input and impactFAO
This document discusses how genome sequencing can be used for animal health monitoring and disease control. It provides examples of how sequencing has been used to monitor virus distribution and evolution, evaluate vaccine matching, and improve molecular epidemiology and diagnostic assays. The document also gives examples of impacts in Indonesia and Egypt, such as informing avian influenza control policies and improving knowledge of circulating H5N1 viruses. It concludes that sequence data is a key component of disease control and that sharing sequences is important, and FAO is working to build sequencing capacity and promote data sharing.
HealthMap is a system that monitors disease outbreaks around the world by processing over 20,000 news and unstructured web sites every hour using text clustering, matching, filtering and other algorithms. It provides a "heat index" alert system to identify potential disease outbreaks based on the number and recency of reports from different locations. While most alerts currently come from English language sources, the system also covers Spanish, French and Russian. It is used as a public health monitoring and response tool by various organizations and sees 500-600 daily users. Future work aims to improve algorithms, add more languages and collaborate with other health networks.
Session Two: Barriers to investment in research to find a disease modifying therapy or cure for dementia
Dr Neil Buckholtz , Director of Neuroscience, the National Institute on Aging (NIA), National Institutes of Health (NIH)
Work Package (WP) 12 – PEARL Barriers In search for an inventory and assessme...ExternalEvents
http://www.fao.org/about/meetings/wgs-on-food-safety-management/en/
International challenges regarding the future sharing of sequence data. Presentation from the Technical Meeting on the impact of Whole Genome Sequencing (WGS) on food safety management and GMI-9, 23-25 May 2016, Rome, Italy.
Hepatitis E virus infection has been increasing in France since 2002. Surveillance data shows most cases are autochthonous, in males aged 55 in southern regions. Consumption of raw pork-liver products is a major risk factor. Small outbreaks have been linked to these products. A national study in 2010 found 74% of cases were subtype 3f, which is commonly associated with pig-liver consumption. Further research is ongoing to better quantify the risk from raw pig-liver and identify other potential transmission routes.
PEDV - Research Update - Dr. Lisa Becton, National Pork Board, from the 2014 World Pork Expo, June 4 - 6, 2014, Des Moines, IA, USA.
More presentations at http://www.swinecast.com/2014-world-pork-expo
This document summarizes research on hepatitis E virus (HEV) infections in England and Wales. Key points include:
- HEV is now recognized as the most common cause of acute hepatitis in England and Wales.
- A case-control study suggests an association between consuming pork products and HEV infection. HEV has been found in pork production chains.
- While most HEV infections are imported, indigenous cases are increasing, associated with the emergence of a new virus clade not previously common.
- Surveys found high HEV seroprevalence in UK pigs, though indigenous pig viruses differ from most human infections, suggesting an outside source. Collaboration across Europe aims to link human and pig virus
(1) Cyprus established a successful national prevention program for beta-thalassemia that reduced expected cases from over 50 births annually to less than 5 through population-wide carrier screening, counseling, and prenatal diagnosis. (2) Key factors in Cyprus's success included a small, homogeneous population; strong social support networks; and dedicated diagnostic and counseling centers. (3) Maintaining prevention efforts remains challenging as society changes and awareness declines in younger generations who have never seen the impacts of untreated thalassemia.
MRF funded research into barriers to treating acute bacterial meningitis (ABM) in Malawi. They found recognition barriers like misdiagnosis of other illnesses and not recognizing severity. Action barriers included prioritizing maternal health, negative views of healthcare, and financial/decision constraints. To address this, MRF is training health workers to use WHO triage systems to identify severely ill children for treatment or referral. They are also using radio, mobile apps, and transport bikes to raise awareness and improve access to care. The goal is to reduce delays, prioritize treatment, and improve outcomes for children with meningitis.
Novel and innovative approaches for measuring influenza VE - Anke Stuurman P95DRIVE research
The document discusses 14 proposed novel methods for measuring influenza vaccine effectiveness (IVE). Experts from the DRIVE project brainstormed and prioritized the methods. Rapid near patient diagnostic tests, estimating IVE against non-specific influenza outcomes, and using high-dimensional propensity scores were deemed high priority. Methods like case-only studies and adaptive design were lower priority. The document also lists potential sites for implementing the methods during the 2018/19 influenza season.
One Health Epidemic Risk Management in Kazakhstan With Open-source Eidss Al...Global Risk Forum GRFDavos
Kazakhstan faces risks from diseases such as plague, tularemia, and anthrax. The authors propose developing a Regional Sanitary-Epidemiological Passport (RSEP) to assess epidemic risks in each district of Kazakhstan. The RSEP would use data on infectious disease rates, population counts, and other factors to generate forecasts of risk levels for diseases over 1-2 years. An open-source Electronic Integrated Disease Surveillance System (EIDSS) would collect case data to feed into the RSEP models. The authors plan to develop and validate the RSEP approach over several stages focused on different regions of Kazakhstan.
Whole Genome Sequencing (WGS) for food safety management: A vision from UruguayExternalEvents
http://tiny.cc/faowgsworkshop
Use of genome sequencing technology on food safety management- Uruguay. Presentation from the FAO expert workshop on practical applications of Whole Genome Sequencing (WGS) for food safety management - 7-8 December 2015, Rome, Italy.
What the new hepatitis C protease inhibitors Incivek and Victrelis mean for people coinfected with HIV & HCV and for health departments. Presented at the NASTAD annual meeting 5/23/11.
This document discusses how web 2.0 tools can be used in healthcare for purposes like staying informed, medical education, collaboration, managing diseases, and sharing data for research. It provides examples of how RSS feeds, podcasts, search tools, and online communities allow medical professionals and the public to access medical information and resources. The document also describes how patients can become "e-patients" by using the internet to gather health information and manage their conditions, and how tools like personal health records and electronic health records fit into the model of "Health 2.0".
Lessons from COVID-19: How Are Data Science and AI Changing Future Biomedical...Jake Chen
: COVID-19 has profoundly impacted all our lives. Not all such impacts in science are negative. For example, how we adapt to online learning, remote mentorship, and online teamwork may become new “norms” of future scientific collaborations, breaking down institutional boundaries to communication. The COVID-19 pandemic has united the scientific community more than ever, through more than 3600 clinical trials, 60,000 peer-reviewed publications, 80,000 SARS-CoV-2 genome sequences, 100,000 COVID-19 open software tools, and a global community of scientists, with which all of us are working hard to find epidemiological patterns, diagnosis, therapeutics, and vaccines in a “War Against COVID-19”. In this talk, I will define and characterize data-driven medicine primarily through my personal journey in the past ten months, having witnessed the rapid “weaponizing of data science tools” in our community’s fight against COVID-19 (including ours, at http://covid19.ubrite.org/). I will review up-to-date COVID-19 literature, especially those related to how biomedical informatics, data science, and artificial intelligence have been applied in accelerating COVID-19 breakthrough discoveries, from basic research to clinical practice. I will end by sharing my thoughts on how the future of medicine in cancer and other translational areas can benefit from the proactive incorporation of new “data science engines.”
InfCareHIV is a clinical decision support system and quality assurance registry for HIV care in Sweden. It covers over 99% of HIV patients nationally, with data on 7838 living patients and 12936 total patients registered. The system is used at each patient visit to automatically transfer lab and quality of life data between clinics. It produces real-time statistics on HIV care in Sweden and delivers anonymized data to international collaborators for research. InfCareHIV also supports pharmaceutical studies through patient identification and data sharing.
The ECDC aims to establish whole genome sequencing (WGS) as the standard method for microbial pathogen typing in the EU by 2020. This will improve disease surveillance and outbreak investigation by providing more accurate transmission data. The ECDC's WGS support strategy includes mapping initiatives, integrated data analysis, guidance, and pilot studies. Priority diseases for 2016-2018 are Listeria monocytogenes, Neisseria meningitidis, carbapenemase-producing Enterobacteriaceae, and antibiotic-resistant Neisseria gonorrhoeae. The roadmap will be revised in 2018-2019 to expand WGS-based surveillance to additional diseases like Salmonella, STEC, and multidrug-resistant tuberculosis, depending on member state capacity
Dr. Shweta Bansal - Modeling Emerging Disease in the US Swine HerdJohn Blue
Modeling Emerging Disease in the US Swine Herd - Dr. Shweta Bansal, PhD, Assistant Professor, Department of Biology at Georgetown University, from the 2015 NIAA Annual Conference titled 'Water and the Future of Animal Agriculture', March 23 - March 26, 2015, Indianapolis, IN, USA.
More presentations at http://www.trufflemedia.com/agmedia/conference/2015_niaa_water_future_animal_ag
Pestforecast: Surveillance and early warning systems for climate sensitive di...ILRI
Presentation by Hu Suk Lee at the CGIAR Research Program on Climate Change, Agriculture and Food Security (CCAFS) annual meeting in Southeast Asia, Hanoi, Vietnam, 30 November 2016.
Participatory epidemiology in animal and human healthILRI
Hendrickx, S. and Pissang, C. 2010. Participatory epidemiology in animal and human health. Paper presented at a symposium on intersectoral collaboration between the medical and veterinary professions in low-resource societies, "Where medics and vets join forces”, Institute of Tropical Medicine, Antwerp, Belgium, 5 November 2010.
This document outlines ECDC's strategic framework for integrating molecular and genomic epidemiology data into public health operations from 2019-2021. It demonstrates new features for molecular surveillance in the TESSy database and a prototype web interface for genomic analysis. Priority diseases are identified for whole genome sequencing-based typing, including carbapenem-resistant Enterobacteriaceae, Listeria monocytogenes, Salmonella enterica, and Neisseria meningitidis. Improved tools will provide automated quality control feedback and detection of matches to outbreak clusters when sequence data is uploaded.
Genome sequencing for animal health - input and impactFAO
This document discusses how genome sequencing can be used for animal health monitoring and disease control. It provides examples of how sequencing has been used to monitor virus distribution and evolution, evaluate vaccine matching, and improve molecular epidemiology and diagnostic assays. The document also gives examples of impacts in Indonesia and Egypt, such as informing avian influenza control policies and improving knowledge of circulating H5N1 viruses. It concludes that sequence data is a key component of disease control and that sharing sequences is important, and FAO is working to build sequencing capacity and promote data sharing.
HealthMap is a system that monitors disease outbreaks around the world by processing over 20,000 news and unstructured web sites every hour using text clustering, matching, filtering and other algorithms. It provides a "heat index" alert system to identify potential disease outbreaks based on the number and recency of reports from different locations. While most alerts currently come from English language sources, the system also covers Spanish, French and Russian. It is used as a public health monitoring and response tool by various organizations and sees 500-600 daily users. Future work aims to improve algorithms, add more languages and collaborate with other health networks.
Session Two: Barriers to investment in research to find a disease modifying therapy or cure for dementia
Dr Neil Buckholtz , Director of Neuroscience, the National Institute on Aging (NIA), National Institutes of Health (NIH)
Work Package (WP) 12 – PEARL Barriers In search for an inventory and assessme...ExternalEvents
http://www.fao.org/about/meetings/wgs-on-food-safety-management/en/
International challenges regarding the future sharing of sequence data. Presentation from the Technical Meeting on the impact of Whole Genome Sequencing (WGS) on food safety management and GMI-9, 23-25 May 2016, Rome, Italy.
Hepatitis E virus infection has been increasing in France since 2002. Surveillance data shows most cases are autochthonous, in males aged 55 in southern regions. Consumption of raw pork-liver products is a major risk factor. Small outbreaks have been linked to these products. A national study in 2010 found 74% of cases were subtype 3f, which is commonly associated with pig-liver consumption. Further research is ongoing to better quantify the risk from raw pig-liver and identify other potential transmission routes.
PEDV - Research Update - Dr. Lisa Becton, National Pork Board, from the 2014 World Pork Expo, June 4 - 6, 2014, Des Moines, IA, USA.
More presentations at http://www.swinecast.com/2014-world-pork-expo
This document summarizes research on hepatitis E virus (HEV) infections in England and Wales. Key points include:
- HEV is now recognized as the most common cause of acute hepatitis in England and Wales.
- A case-control study suggests an association between consuming pork products and HEV infection. HEV has been found in pork production chains.
- While most HEV infections are imported, indigenous cases are increasing, associated with the emergence of a new virus clade not previously common.
- Surveys found high HEV seroprevalence in UK pigs, though indigenous pig viruses differ from most human infections, suggesting an outside source. Collaboration across Europe aims to link human and pig virus
(1) Cyprus established a successful national prevention program for beta-thalassemia that reduced expected cases from over 50 births annually to less than 5 through population-wide carrier screening, counseling, and prenatal diagnosis. (2) Key factors in Cyprus's success included a small, homogeneous population; strong social support networks; and dedicated diagnostic and counseling centers. (3) Maintaining prevention efforts remains challenging as society changes and awareness declines in younger generations who have never seen the impacts of untreated thalassemia.
MRF funded research into barriers to treating acute bacterial meningitis (ABM) in Malawi. They found recognition barriers like misdiagnosis of other illnesses and not recognizing severity. Action barriers included prioritizing maternal health, negative views of healthcare, and financial/decision constraints. To address this, MRF is training health workers to use WHO triage systems to identify severely ill children for treatment or referral. They are also using radio, mobile apps, and transport bikes to raise awareness and improve access to care. The goal is to reduce delays, prioritize treatment, and improve outcomes for children with meningitis.
Novel and innovative approaches for measuring influenza VE - Anke Stuurman P95DRIVE research
The document discusses 14 proposed novel methods for measuring influenza vaccine effectiveness (IVE). Experts from the DRIVE project brainstormed and prioritized the methods. Rapid near patient diagnostic tests, estimating IVE against non-specific influenza outcomes, and using high-dimensional propensity scores were deemed high priority. Methods like case-only studies and adaptive design were lower priority. The document also lists potential sites for implementing the methods during the 2018/19 influenza season.
One Health Epidemic Risk Management in Kazakhstan With Open-source Eidss Al...Global Risk Forum GRFDavos
Kazakhstan faces risks from diseases such as plague, tularemia, and anthrax. The authors propose developing a Regional Sanitary-Epidemiological Passport (RSEP) to assess epidemic risks in each district of Kazakhstan. The RSEP would use data on infectious disease rates, population counts, and other factors to generate forecasts of risk levels for diseases over 1-2 years. An open-source Electronic Integrated Disease Surveillance System (EIDSS) would collect case data to feed into the RSEP models. The authors plan to develop and validate the RSEP approach over several stages focused on different regions of Kazakhstan.
Whole Genome Sequencing (WGS) for food safety management: A vision from UruguayExternalEvents
http://tiny.cc/faowgsworkshop
Use of genome sequencing technology on food safety management- Uruguay. Presentation from the FAO expert workshop on practical applications of Whole Genome Sequencing (WGS) for food safety management - 7-8 December 2015, Rome, Italy.
What the new hepatitis C protease inhibitors Incivek and Victrelis mean for people coinfected with HIV & HCV and for health departments. Presented at the NASTAD annual meeting 5/23/11.
This document discusses how web 2.0 tools can be used in healthcare for purposes like staying informed, medical education, collaboration, managing diseases, and sharing data for research. It provides examples of how RSS feeds, podcasts, search tools, and online communities allow medical professionals and the public to access medical information and resources. The document also describes how patients can become "e-patients" by using the internet to gather health information and manage their conditions, and how tools like personal health records and electronic health records fit into the model of "Health 2.0".
Lessons from COVID-19: How Are Data Science and AI Changing Future Biomedical...Jake Chen
: COVID-19 has profoundly impacted all our lives. Not all such impacts in science are negative. For example, how we adapt to online learning, remote mentorship, and online teamwork may become new “norms” of future scientific collaborations, breaking down institutional boundaries to communication. The COVID-19 pandemic has united the scientific community more than ever, through more than 3600 clinical trials, 60,000 peer-reviewed publications, 80,000 SARS-CoV-2 genome sequences, 100,000 COVID-19 open software tools, and a global community of scientists, with which all of us are working hard to find epidemiological patterns, diagnosis, therapeutics, and vaccines in a “War Against COVID-19”. In this talk, I will define and characterize data-driven medicine primarily through my personal journey in the past ten months, having witnessed the rapid “weaponizing of data science tools” in our community’s fight against COVID-19 (including ours, at http://covid19.ubrite.org/). I will review up-to-date COVID-19 literature, especially those related to how biomedical informatics, data science, and artificial intelligence have been applied in accelerating COVID-19 breakthrough discoveries, from basic research to clinical practice. I will end by sharing my thoughts on how the future of medicine in cancer and other translational areas can benefit from the proactive incorporation of new “data science engines.”
InfCareHIV is a clinical decision support system and quality assurance registry for HIV care in Sweden. It covers over 99% of HIV patients nationally, with data on 7838 living patients and 12936 total patients registered. The system is used at each patient visit to automatically transfer lab and quality of life data between clinics. It produces real-time statistics on HIV care in Sweden and delivers anonymized data to international collaborators for research. InfCareHIV also supports pharmaceutical studies through patient identification and data sharing.
The ECDC aims to establish whole genome sequencing (WGS) as the standard method for microbial pathogen typing in the EU by 2020. This will improve disease surveillance and outbreak investigation by providing more accurate transmission data. The ECDC's WGS support strategy includes mapping initiatives, integrated data analysis, guidance, and pilot studies. Priority diseases for 2016-2018 are Listeria monocytogenes, Neisseria meningitidis, carbapenemase-producing Enterobacteriaceae, and antibiotic-resistant Neisseria gonorrhoeae. The roadmap will be revised in 2018-2019 to expand WGS-based surveillance to additional diseases like Salmonella, STEC, and multidrug-resistant tuberculosis, depending on member state capacity
Dr. Shweta Bansal - Modeling Emerging Disease in the US Swine HerdJohn Blue
Modeling Emerging Disease in the US Swine Herd - Dr. Shweta Bansal, PhD, Assistant Professor, Department of Biology at Georgetown University, from the 2015 NIAA Annual Conference titled 'Water and the Future of Animal Agriculture', March 23 - March 26, 2015, Indianapolis, IN, USA.
More presentations at http://www.trufflemedia.com/agmedia/conference/2015_niaa_water_future_animal_ag
Pestforecast: Surveillance and early warning systems for climate sensitive di...ILRI
Presentation by Hu Suk Lee at the CGIAR Research Program on Climate Change, Agriculture and Food Security (CCAFS) annual meeting in Southeast Asia, Hanoi, Vietnam, 30 November 2016.
Participatory epidemiology in animal and human healthILRI
Hendrickx, S. and Pissang, C. 2010. Participatory epidemiology in animal and human health. Paper presented at a symposium on intersectoral collaboration between the medical and veterinary professions in low-resource societies, "Where medics and vets join forces”, Institute of Tropical Medicine, Antwerp, Belgium, 5 November 2010.
This document summarizes the test-negative design study conducted by the Istituto Superiore di Sanità (National Institute of Health, ISS) within the Italian Influenza surveillance network (InfluNet) during the 2018-2019 influenza season. The study aimed to estimate seasonal influenza vaccine effectiveness against laboratory-confirmed influenza in Italy. A total of 2,526 patients presenting with influenza-like illness to participating general practitioners were enrolled. Of those, 1,177 tested positive for influenza and 1,349 tested negative. Preliminary results found significant differences in age distribution between cases and controls, with a higher proportion of cases among children and the elderly. Further analyses will estimate vaccine effectiveness stratified by age, virus subtype, and
This document provides guidelines for conducting population-based surveys to measure national HIV prevalence. It outlines how to plan and implement a new national survey, incorporate HIV testing into existing surveys, and calculate a national HIV prevalence estimate by combining data from surveys and sentinel surveillance. Population-based surveys can provide more representative HIV prevalence data than sentinel surveillance alone. The guidelines aim to help countries obtain accurate national estimates by adjusting prevalence measures from different data sources and accounting for biases.
Сравнение режимов лечения ВИЧ в разрезе различных клинических сценариев.ART...hivlifeinfo
This downloadable slideset summarizes optimal evidence-based antiretroviral therapy management strategies for a series of challenging clinical cases and is based on a satellite symposium presented at HIV Glasgow 2016.
Format: Microsoft PowerPoint (.ppt)
File size: 1.32 MB
Date posted: 11/11/2016
This document summarizes a presentation given by Anastasia Pharris of the European Centre for Disease Prevention and Control on infections among people who inject drugs. It finds that over 30,000 new HIV diagnoses in Europe in 2016 were due to injecting drug use, with most cases concentrated in Eastern Europe. While harm reduction efforts have made progress in some countries, people who inject drugs still face high burdens of HIV, hepatitis C, and other infections. The presentation calls for improved testing, treatment, and prevention programs targeting this group.
The document summarizes the goals and activities of Aviesan, the French Alliance for Life and Health Sciences. It aims to optimize scientific foresight, facilitate research clusters, and promote national projects. It represents major French research organizations and operates through 10 thematic institutes. It also maintains a catalog of 237 French health databases and supports several large research projects and infrastructures through funding from "Investments for the future", totaling billions of euros over 10 years.
Telehealth in Urology: A Systematic Review of the Literature.Valentina Corona
This systematic review identified 45 studies evaluating telehealth applications in urology. The studies covered prostate cancer (11 studies), hematuria management (3 studies), urinary stones (6 studies), urinary incontinence (14 studies), urinary tract infections (5 studies), and other conditions (6 studies). The available evidence indicates that telehealth has been successfully used for decision-making in prostate cancer, follow-up care of prostate cancer and urinary incontinence patients, initial diagnosis of hematuria and urinary tract infections, and management of uncomplicated urinary stones. However, more robust data on long-term outcomes, safety, and cost-effectiveness are still needed. The COVID-19 pandemic is likely
The document discusses the importance of global health information systems and challenges in building sustainable systems in resource-constrained countries. It highlights issues such as lack of integrated interventions and siloed disease-specific systems. It also outlines opportunities for librarians and universities to help address gaps through educational programs, research, and training the next generation of health informatics professionals.
Standards for public health genomic epidemiology - Biocuration 2015Melanie Courtot
A presentation introducing genomic epidemiology and its application in public health. It also explains the need for standards to support the Canadian Integrated Rapid Infectious Disease Analysis platform which implements genomic epidemiology analyses for detection and investigation of infectious disease outbreaks caused by food-borne pathogens.
This document discusses disease surveillance networks and provides examples. It begins by defining key concepts like surveillance, emerging diseases, and networks. It then provides examples of successful surveillance networks, including SISEA/Pasteur in Southeast Asia, the Mekong Basin Disease Surveillance network, and tuberculosis surveillance. These networks improved disease detection and response through established nodes, standardized reporting procedures, and capacity building. The document concludes that interconnected surveillance networks can enhance sensitivity and specificity of disease detection compared to isolated efforts.
Presentation from the 3rd Joint Meeting of the Antimicrobial Resistance and Healthcare-Associated Infections (ARHAI) Networks, European Centre of Disease Prevention and Control - Stockholm, 11-13 February 2015
After several years of decreasing trend, foodborne hepatitis A virus (HAV) infection has re-emerged as a public health problem in EU/EEA since 2011. Several consecutive multi-country foodborne HAV outbreaks were experienced in Europe 2012-2014.
GenomeTrakr: Whole-Genome Sequencing for Food Safety and A New Way Forward in...ExternalEvents
http://www.fao.org/about/meetings/wgs-on-food-safety-management/en/
GenomeTrakr: Whole-Genome Sequencing for Food Safety and A New Way Forward in the Microbiological Testing & Traceability for Foodborne Pathogens. Presentation from the Technical Meeting on the impact of Whole Genome Sequencing (WGS) on food safety management -23-25 May 2016, Rome, Italy.
Introduction to Computational Vaccinology and iVAX by EpiVaxAnnie De Groot
This presentation was developed for Dr. Anna Durbin's vaccine class at Johns Hopkins. It was delivered simultaneously to my vaccine class at URI. Both classes had their first introductory lecture at the same time, so we joined them by webinar. The slides cover the EpiVax approach to computational vaccinology, which is relatively novel as compared to other groups working in the field. A number of case studies, including H7N9, are provided.
The HIV epidemic in Ethiopia remains heterogeneous, with urban areas, large cities, and areas near major transport corridors experiencing higher prevalence rates than rural areas. While national HIV prevalence has remained stable at around 1.5% according to surveys, prevalence is increasing slightly in some large urban areas. HIV incidence appears to have declined based on falling prevalence in younger age groups and ANC surveillance. AIDS-related mortality has also decreased sharply. Behavioral factors like high male circumcision rates and low rates of premarital and extramarital sex have helped keep prevalence low. However, HIV transmission within marriage represents a major source of new infections. The HIV response in Ethiopia has expanded treatment coverage significantly but prevention programs need to be strengthened,
The document summarizes a study that evaluated methods for selecting pregnant or postpartum women with suspected pulmonary embolism (PE) for diagnostic imaging. The study aimed to estimate the accuracy, effectiveness and cost-effectiveness of using clinical features, decision rules and biomarkers to identify which patients need imaging. The study developed a diagnostic model to analyze the performance of these selection methods and assess their ability to safely reduce imaging while maintaining appropriate patient care.
Hepatitis E in the Netherlands, November 2018AgnethaRIVM1
Epidemiology & other studies on hepatitis E in the Netherlands.
Presented at ECDC by Agnetha Hofhuis, on behalf of RIVM.
Also see: https://www.ncbi.nlm.nih.gov/pubmed/?term=tulen+hofhuis+hepatitis
1. Role of DIC Wates on IVM dan AI Diagnostics.pptxAlfianYusakMuzaki
The document summarizes the role of the Disease Investigation Center (DIC) Wates in Indonesia for influenza virus monitoring. DIC Wates conducts avian influenza virus surveillance in three provinces in Java through risk-based surveillance, wild bird surveillance, and outbreak investigations. It serves as the national reference laboratory for avian influenza, performing diagnostic testing, genetic sequencing and antigenic analysis to identify circulating strains. Through its Influenza Virus Monitoring network, DIC Wates makes recommendations for vaccine strain updates and provides data and analysis to monitor influenza virus evolution in Indonesia.
Similar to HEVnet: Sharing sequences & metadata of hepatitis E virus (20)
Disampaikan pada FGD Kepmen Pertahanan tentang Organisasi Profesi JF Analis Pertahanan Negara
Jakarta, 20 Juni 2024
Dr. Tri Widodo W. Utomo, SH. MA.
Deputi Bidang Kajian Kebijakan dan Inovasi Administrasi Negara LAN RI
Jennifer Schaus and Associates hosts a complimentary webinar series on The FAR in 2024. Join the webinars on Wednesdays and Fridays at noon, eastern.
Recordings are on YouTube and the company website.
https://www.youtube.com/@jenniferschaus/videos
Sponsor a Child for Education & Food.pptxSERUDS INDIA
Every year there are many generous people across the world who wanna help needy children with everything they need. The statistics say that donations worth education and food for more than 500 million children get every year
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Causes Supporting Charity for Elderly PeopleSERUDS INDIA
Around 52% of the elder populations in India are living in poverty and poor health problems. In this technological world, they became very backward without having any knowledge about technology. So they’re dependent on working hard for their daily earnings, they’re physically very weak. Thus charity organizations are made to help and raise them and also to give them hope to live.
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FT author
Amanda Chu
US Energy Reporter
PREMIUM
June 20 2024
Good morning and welcome back to Energy Source, coming to you from New York, where the city swelters in its first heatwave of the season.
Nearly 80 million people were under alerts in the US north-east and midwest yesterday as temperatures in some municipalities reached record highs in a test to the country’s rickety power grid.
In other news, the Financial Times has a new Big Read this morning on Russia’s grip on nuclear power. Despite sanctions on its economy, the Kremlin continues to be an unrivalled exporter of nuclear power plants, building more than half of all reactors under construction globally. Read how Moscow is using these projects to wield global influence.
Today’s Energy Source dives into the latest Statistical Review of World Energy, the industry’s annual stocktake of global energy consumption. The report was published for more than 70 years by BP before it was passed over to the Energy Institute last year. The oil major remains a contributor.
Data Drill looks at a new analysis from the World Bank showing gas flaring is at a four-year high.
Thanks for reading,
Amanda
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New report offers sobering view of the energy transition
Every year the Statistical Review of World Energy offers a behemoth of data on the state of the global energy market. This year’s findings highlight the world’s insatiable demand for energy and the need to speed up the pace of decarbonisation.
Here are our four main takeaways from this year’s report:
Fossil fuel consumption — and emissions — are at record highs
Countries burnt record amounts of oil and coal last year, sending global fossil fuel consumption and emissions to all-time highs, the Energy Institute reported. Oil demand grew 2.6 per cent, surpassing 100mn barrels per day for the first time.
Meanwhile, the share of fossil fuels in the energy mix declined slightly by half a percentage point, but still made up more than 81 per cent of consumption.
Presentation by Rebecca Sachs and Joshua Varcie, analysts in CBO’s Health Analysis Division, at the 13th Annual Conference of the American Society of Health Economists.
HEVnet: Sharing sequences & metadata of hepatitis E virus
1. HEVnet
Sharing sequences &
metadata of hepatitis E virus
Developed & maintained by RIVM
www.HEVnet.nl HEVnet@rivm.nl
Supported by ECDC, EJP, MVNA, RIVM
Sequences provided & analysed
by all HEVnet members
Presented by Agnetha Hofhuis
2. ECDC HEV-expert meeting 2015:
“We need a better understanding
of the emergence of hepatitis E”
“Develop a joint sequence database
accompanied by a metadata set
for the support of molecular
epidemiology investigations”
C. Adlhoch et al, J Clin Vir 2016
3. HEVnet network & database
A global network of scientists sharing molecular &
epidemiological data on HEV.
Developed & maintained by RIVM (NL)
Based on success of HAVnet & Noronet
Virology laboratory
Annelies Kroneman & Harry Vennema
Epidemiology department
Agnetha Hofhuis & Eelco Franz
Financial support:
Cornelia Adlhoch H2020 EJP-project ORION & RIVM
Steering committee: Annelies Kroneman, Cornelia Adlhoch, Ilaria Di Bartolo, Samreen Ijaz,
Sally A. Baylis, Ana Avellón, Wim van der Poel, Eelco Franz, Agnetha Hofhuis
4. HEVnet network
HEVnet members form a voluntary network of HEV experts
across Europe, fostering collaboration to perform
supranational studies between experts from:
– national public health reference laboratories
– veterinary research
– food safety
– blood safety
– environmental research
This zoonosis requires
a One Health approach.
HEV does not cause disease in animals;
is not considered a relevant veterinary issue,
requiring animal disease control measures.
N. Pavio et al,
Vet Res. 2017
5. HEVnet network meetings
October 2017: 1st meeting with all members &
RIVM-HEVnet team, ECDC and EFSA representatives.
March 2019: 2nd meeting with all members.
• Consolidate collaboration & recapitulate achievements.
• Generate ideas on:
– Research for & with HEVnet data
– Funding opportunities, alignment to existing & future
programmes (e.g. EJP One Health, Horizon2020).
– HEVnet advertisement: also attract veterinary, food,
environmental members.
• Identify needs for further harmonization,
e.g. HEV detection & subtyping, nomenclature, WGS & NGS.
6. HEVnet database
● A safe space online (since April 2017); password is granted
after confidentiality agreement.
● Quid pro quo principle for using the HEVnet data.
Data ownership remains with the data provider.
● International repository database for HEV sequences:
– Microbiological data: genetic sequences & typing results.
– Publicly accessible HEV typing tool: standardized typing of
all submitted sequences
– Combined with metadata: source, time, place, clinical info.
– Data can be queried, analysed and visualised with online
tools: phylogenetic tree tool, geographical plot, incidence
plots, pie charts.
8. Typing according to a standardized nomenclature
Sequences of any part of the hepatitis E (HEV) genome can be
assigned to a HEV genotype.
Sequences of other ssRNA viruses are also recognized by the
tool and are assigned to their family.
HEV Genotyping tool
www.hevnet.nl
9. Aims with HEVnet data
1. Trends of human HEV using molecular typing to assess trends in
circulating HEV geno- & subtypes in humans
2. Molecular epidemiology through analysis of the distribution of HEV
subtypes in humans, for a better understanding of the underlying
epidemiology of HEV in Europe
3. Cluster investigation & outbreak detection through
comparison across countries of human HEV sequence data with provided
metadata
4. Source tracing/attribution tracing the most likely reservoirs and
sources of HEV, through identification of connections between human and
nonhuman samples from food, animals and the environment via source
attribution studies
5. Population genetics studies into the spread and evolution of HEV
6. Pathogenicity of strains through relations between viral subtypes
and severity of disease, looking at symptoms, hospitalization and mortality
Higher #aims more meta data needed
12. HEVnet members from 30 institutes in 12 European countries
provide & have access to all sequences.
Nov 2018: 1400 entries from 10 countries.
Varying amount of metadata:
100% sample origin: human/ animal/ food/ environmental
90% sequencing method
69% patient sex, 67% patient year of birth
47% region of sampling
~95% genotype 3
Several new subtypes have been identified
87% human sample, 7% animal, 5% food, 0,3% environment
Sample date 2000-2014, 2015, 2016, 2017, 2018
HEVnet database
16. First descriptive analyses with 1015 HEVnet sequences:
Analysis of the association of hepatitis E virus genotype 3
clade/subtype with gender and age in Europe
Lorenzo Subissi (EUPHEM-fellow), Samreen Ijaz, Jacques Izopet,
Eelco Franz, Harry Vennema, Annelies Kroneman, Steven Van Gucht,
Vanessa Suin, Cornelia Adlhoch, Anna Rita Ciccaglione, Roberto Bruni.
• What is the subtype distribution in Belgium, France, UK,
Netherlands, Italy and Bulgaria?
• Do HEV-3 main clades (3efg versus 3abcjhi) affect different
populations in terms of age and gender?
HEVnet database
17. Thank you for your attention!
HEV expert scientists are invited to join HEVnet
Email to hevnet@rivm.nl with a short explanation:
What can you contribute to the network and database?
Your ideas are welcome:
• Research for & with HEVnet data
• Funding opportunities, alignment to existing & future
programmes (e.g. EJP One Health, Horizon2020).
• Need more veterinary, food, environmental members.
18. List of HEVnet members,
November 2018
Austria Medical University Vienna: Stephan Aberle
Belgium Sciensano: Vanessa Suin & Lorenzo Subissi (EUPHEM)
Denmark SSI: Sofie Midgley
Estonia National Institute for Health Development: Tatiana Kuznetsova
United Kingdom PHE: Samreen Ijaz
Royal Cornwall Hospital: Harry Dalton
France ANSES: Nicole Pavio
Toulouse University Hospital: Jacques Izopet
Germany PEI: Sally A. Baylis & Christel Kamp
University of Veterinary Medicine Hannover: Christine Baechlein
Institute of Virology Charité: Victor M. Corman
RKI: Mirko Faber
BfR: Reimar Johne
IMHR: Jürgen Wenzel
Ireland University College Dublin: Suzie Coughlan
This list continues on the next page…
19. (continued)
List of HEVnet members
November 2018
Italy ISS: Ilaria di Bartolo, Anna Rita Ciccaglione, Elisabetta Suffredini
Bulgarian focal point: Roberto Bruni
Lab of virology INMI Spallanzani IRCCs: Anna Rosa Garbuglia
Netherlands RIVM: Harry Vennema, Annelies Kroneman, Agnetha Hofhuis
NVWA: Ingeborg Boxman
WBVR: Wim van der Poel
Sanquin Blood Supply Foundation: Boris Hogema & Hans Zaaijer
Portugal INSA: Rita de Sousa
Spain isciii: Ana Avellon
Hospital Universitario Valle Hebron: Maria Buti
Vall d'Hebron Institut Research: Josep Quer
Biology University of Barcelona: Rosina Girones
Sweden National Veterinary Institute (SVA): Frederik Widén
Switzerland Vetsuisse, University of Zürich: Claudia Bachofen
Centre Hospitalier Universitaire Vaudois: Sahli Roland
ECDC European Centre for Disease Prevention and Control: Cornelia Adlhoch
EFSA European Food Safety Authority: Valentina Rizzi