Urban-centric lighting is the research topic of an Urban Lighting Task Group, promoted by CICAT, the Spanish Lighting Industry Cluster, and was created to carry out an innovation project of applied research about the influence of exterior lighting in human health. The project that we want to share in Healthy City Design International 2023 is a collaborative effort between companies of the lighting industry ecosystem, an applied research project aimed to foster innovation and share knowledge between the academia, the institutions, the independent consultants, the designers and the industry. The research project is being carried out by a task group formed by professionals from different companies in the form of a real-world experience in public space. Such methods and technologies are an application of evidence-based knowledge in the field of artificial lighting for the sake of health and well-being. There is also a fundamental source of awareness that comes from social sciences about how the built environment design promotes well-being, or else constitutes a hazard for health. The starting point of this search for innovation in lighting for the public realm is the will to address the challenges that contemporary and future urban spaces are facing. These challenges are the direct consequence of the need for healthier, more sustainable, less polluting, and more inclusive urban spaces, and affect the work of all the professionals that design and plan for the public realm. The main purpose of this project is to evaluate and discriminate the objective parameters that will define the lighting design and its features, choosing among the available technological innovation those that are properly grounded on scientific evidence. At the same time, there is research and innovation that come from disciplines such as ecology, environmental psychology, critical urban studies, and sociology, that are strictly necessary to nurture with sense and meaning design decisions in the urban realm. They have given the knowledge for establishing critical approaches such as gender perspective and environmental justice awareness, among others. Such approaches should be included in the toolset for the building of a complete methodological framework following a holistic concept of health and well being. This why we need to identify and evaluate inclusive lighting strategies on urban space, to avoid those that drive in an unequal or unjust result for reason of gender, race, age, or socio-economic status. From the biological perspective, the framework must apply the knowledge and scientific evidence about the non-visual effects of lighting on mental and physical health and has the parameters that involve this interaction identified and quantized. This effects on health and behavior have been studied and demonstrated on humans, animals, insects, and plants, so there is a founded consciousness about the harmful effects of light at night on living organisms.