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Lakshya J Basumatary DM
Consultant Neurologist
Excelcare Hospitals,Guwahati
Headache Therapy
10 FAQ
disclosure
• Nothing to disclose
Migraine treatment during pregnancy
U.S. Selected practice recommendations
for contraceptive use (CDC 2016)
Curtis et al, MMWR Recomm Rep 2016,65
Mamura et al, Headache 2015
Worthington I et al, Can J neurol Sci 2013
Dodick DW Lancet 2018
Marmura M et al, Headache 2015
Dodick DW, Lancet 2018
Becker WB Continuum 2015
Worthington I, et al. Can J Neurol Sci 2013
Worthington I, et al. Can J Neurol Sci 2013
Chen SP et al. Pain 2016
Oshinsky MI, et al Pain 2014
Akerman S, et al Neurobiol Disc 2017
Chen SP et al. Pain 2016
Oshinsky MI, et al Pain 2014
Akerman S, et al Neurobiol Disc 2017
Chou DE et al, Neuromodulation 2017
Silbertsein SDPract Neurol 2007
Holland S et al. Neurology 2012
Dodick DW Lancet 2018
Significant
interference with
ADL
Risk for progression
Acute medication
Ineffective,
contraindicated, AE,
overused
Uncommon
subtypes
Hemiplegic,
brainstem,
migrainous
infarction,
prolonged aura
Patient preference
When to start?
Silberstein SD et al. Neurology 2012
Silberstein SD et al. Neurology 2012
Simpson DM et al Neurology 2016
Blumenfeld A, J Headache Pain 2018
cefaly
Schoenen J et al, Neurology 2013
Schoenen J et al, Neurology 2013
Starling A, et al. Cephalgia 2018
Any tricks for prevention?
Holland PR Ann Neurol 2012
Afridi SK et al Neurology 2013
Blumenfeld A, et al Headache 2013
Treatment of migraine in ED: by the evidence
Lasmiditan
oral, centrally-penetrant, selective serotonin 5-HT1F
agonist
First oral calcitonin gene-related peptide
(CGRP) receptor antagonist
Attributes of Gepants
Questions??
Lakshya J Basumatary, DM
drbasumatary@gmail.com
99544 80668
@drbasumatary

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headache.pptx

Editor's Notes

  1. Migraine is the most prevalent neurological disorder and is characterized by recurrent headache attacks associated with gastrointestinal symptoms and sensoriphobia. Due to disabling headache and associated symptoms migraine significantly impair quality of life. It is the sixth most disabling diseae worldwide according to global burden of disease study 2013
  2. Becker WB Continuum 2015 Prochlorperazine –stemetil
  3. Worthington I, et al. Can J Neurol Sci 2013
  4. Chen SP et al. Pain 2016 Oshinsky MI, et al Pain 2014 Akerman S, et al Neurobiol Disc 2017
  5. Chou DE et al, Neuromodulation 2017
  6. Silbertsein SDPract Neurol 2007 Holland S et al. Neurology 2012 Dodick DW Lancet 2018
  7. Silberstein SD et al. Neurology 2012
  8. Simpson DM et al Neurology 2016
  9. Blumenfeld A, J Headache Pain 2018
  10. In early march 2014 the FDA approved for use a transcutaneous electric nerve stimulation device for prevention of migraine knowns as cefaly dvice
  11. Schoenen J et al, Neurology 2013
  12. Starling A, et al. Cephalgia 2018
  13. Holland PR Ann Neurol 2012 Afridi SK et al Neurology 2013
  14. Blumenfeld A, et al Headache 2013
  15. Silberstein DS et al, neurology 2012 Holland Et al Neurology 2012 Dussor G et al ACS Chem Neurosci 2014
  16. Newman L. Continuum 2015
  17. Rozen T. Neurology Continuum 2015
  18. 1