1. CURRICULUM VITAE
Name: William M. Coplin
Degree(s): MD (FCCM) Birth: Feb 1963
Medical School: Baylor College of Medicine Date of Graduation: May 1989
Residency: Neurology, University of Washington Date of Graduation: June 1993
Fellowships: Crit Care Med & Neurosurg Crit Care, UW Date of Graduation: June 1996
Certification(s):
ABPN Neurology Date: Dec 2008
UCNS Neurocritical Care Date: Dec 2010
Active State Licensure(s):
Michigan, Colorado
Date(s): Current
Immediate Past Academic Positions: Associate Professor, Neurology
& Neurological Surgery, Wayne State University
Date Assumed these Positions: Sep 1996
Hospital Appointments: Director, Neurocritical Care, St. Anthony
Hospital & Neurosciences Medical Director, Centura Health
Date of Appointment: May 2013
Teaching/curricular experience, administrative experience/appointments:
Neurosciences Medical Director and Neurocritical Care at St. Anthony Hospital and Centura Health
system, May 2013-present. Conceiving and executing Neurocritical Care clinical care and designing
MD fellowship and RN residency training programs for neuroemergency, neurotrauma, and
neurocritical care. Program Director for Neurocritical Care clinical care and neurosciences
administrative responsibilities for neurosciences for the 15-hospital and 8-primary affiliate Centura
Health system, and its flagships, St. Anthony Hospital (Denver metropolitan area) & Penrose
Hospital (Colorado Springs). These duties also include medical direction of regional cerebrovascular
and neurotrauma coordination of care for Colorado and surrounding state affiliates in Kansas and
New Mexico.
Member of faculty at Wayne State University, Sep 1996-Oct 2012. Conceived and executed
Neurocritical Care training program for neurotrauma, neurocritical care, and pulmonary and critical
care medicine fellows, neurology, neurosurgery, and emergency medicine residents and years 3 and 4
medical students. Have been involved in year 2 didactic course as well as years 3 and 4 clinical course
development and teaching. Program Director for Neurotrauma and Neurocritical Care fellowships
since shortly after arrival at DMC/Wayne State University. Also involved in development of school
of medicine year 3 Clinical Clerkship neurology ICU component as well as in development of the
year 4 clinical externship elective in neurocritical care. Multiple teaching awards from WSU/DMC
neurology residents (most recent in Jun 2009) and from WSU School of Medicine (first in Jun 2003).
Professional Appointments
2013-present Director, Neurocritical Care, St. Anthony Hospital & Neurosciences Medical
Director, Centura Health, Denver, CO
1997-2011 Director, Neurotrauma and Neurocritical Care fellowships, Wayne State University
1998-2011 Executive Committee, Intraventricular Thrombolysis Trial, NACABI
1998-2011 Medical Director, Neurotrauma Center Intensive Care Unit, Detroit Receiving
Hospital
1998-2010 Sedation and Analgesia Practice Parameters Committee, Society of Critical Care
Medicine
1999-2011 Chief of Neurology, Detroit Receiving Hospital
1999-2005 Member, CDIN (formerly BDCN-3) study section, National Institutes of Health

2. 2000-2005 Steering Committee, Interventional Management of Stroke study
2000-2012 Executive Committee, AANS/CNS Joint Section on Neurotrauma & Critical Care,
critical care liaison
2001-2009 Executive Committee, American Academy of Neurology Emergency/Critical Care
Section; Chair: 2005-2007
2002-present Board of Directors, founding member, organizing committee, Neurocritical Care
Society; Past: Co-Chair, Accreditation Committee; Chair, Long-range Planning
Committee
2004-2006 Chair, Neuroscience Section, Society of Critical Care Medicine
2004-2009 Program Planning Committee, Society of Critical Care Medicine
Hospital Committees:
2104-present Trauma Peer Review & Performance Improvement Patient Safety Committees,
Penrose Hospital, Colorado Springs, CO
2013-present Level-One Trauma, Trauma Morbidity and Mortality, and Trauma Quality
Improvement Operations Committees, St. Anthony Hospital, Lakewood, CO
2013-present Neurosciences (co-chair), Trauma, and Spine Councils, Centura Health, Colorado
2013-present Pharmacy & Therapeutics Committee, St. Anthony Hospital, Lakewood, CO
2013-present Critical Care Practice Council, St. Anthony Hospital, Lakewood, CO
2013-present Stroke Peer Review Committee, St. Anthony Hospital, Lakewood, CO
2013-present Growth & Innovation Committee, Centura Health, Englewood, CO
2013-present Comprehensive Stroke Research Committee, Penrose Hospital, Colorado Springs,
CO
2013-present Neurosciences Committee, Littleton Adventist Hospital, Littleton, CO
2013-present Neurosciences & Spine Committees, Parker Adventist Hospital, Parker, CO
2013-present TBI Committee, St. Anthony Summit Medical Center, Frisco, CO
1996-2012 Level-One Trauma and Trauma Morbidity and Mortality Committees, Detroit
Receiving Hospital
1996-2012 Special Care Committee, Detroit Receiving Hospital
1998-2012 Physician Champion, Organ Donation Protocol Committee, Detroit Receiving
Hospital
1998-2012 Ethics Committee, Detroit Receiving Hospital
1999-2012 Pharmacy and Therapeutics Committee, Detroit Medical Center hospitals
2009-2012 System-Wide Critical Care Committee, Detroit Medical Center hospitals
2009-2012 System-Wide Stroke Committee, Detroit Medical Center hospitals
2010-2012 Resuscitation Committee, Detroit Medical Center hospitals
Professional Organizations: Neurocritical Care Society, Society of Critical Care Medicine,
American Associations of Neurological Surgeons, Congress of Neurological
Surgeons, American Stroke Association, American Academy of Neurology,
American Neurological Association
Editorial Responsibilities:
Editorial board: Neurocritical Care
Ad hoc reviews: Neurosurgery, Stroke, Critical Care Medicine, New England Journal of Medicine,
Respiratory Care, Journal of the Neurological Sciences
Recent & representative publications in journals (selected from > 65). Does not include
presentations, abstracts, book chapters, or articles ‘in preparation’ or ‘submitted.’
Levy AS, Salottolo K, Coplin WM, Smith R, Santos P, Bar-Or D. Pharmocologic
Thromboprophylaxis Reduces the Odds of Venous Thromboembolism In Patients With

3. Hemorrhagic Stroke. Stroke. 2014 – presented at 2014 International Stroke Conference, San Diego
Levy AS, Salottolo K, Coplin WM, Orlando A, Smith R, Santos P, Bar-Or D. Association Between
Pharmacologic Thromboprophylaxis And Hemorrhage Progression In Patients With Hemorrhagic Stroke.
Stroke. 2014 – presented at 2014 International Stroke Conference, San Diego
Coplin WM. Traumatic Spinal Cord Injury. Neurocritical Care Society. 2013.
Liu-Deryke X, Levy PD, Parker D Jr, Coplin W, Rhoney DH. A Prospective Evaluation of Labetalol Versus
Nicardipine for Blood Pressure Management in Patients with Acute Stroke. Neurocrit Care. 2013;19:41-7.
Bhattacharya P, Kansara A, Chaturvedi S, Coplin W. What drives the increasing utilisation of
hemicraniectomy in acute ischaemic stroke? J Neurol Neurosurg Psychiatry. 2013; 84(7):727-31.
Nagaraja N, Bhattacharya P, Norris G, Coplin W, Narayanan S, Xavier A, et al. Arrival by ambulance is
associated with acute stroke intervention in young adults. J Neurol Sci. 2012;316(1-2):168-9.
Coplin WM. Critical care management of acute ischemic stroke. Neurology. Continuum (Minneap Minn).
2012;18(3):547-59.
Naff N, Williams MA, Keyl PM, Tuhrim S, Bullock MR, Mayer SA, et al. Low-dose recombinant tissue-type
plasminogen activator enhances clot resolution in brain hemorrhage: the intraventricular hemorrhage
thrombolysis trial. Stroke. 2011;42(11):3009-16.
Kullar R, Chin JN, Edwards DJ, Parker D, Coplin WM, Rybak MJ. Pharmacokinetics of single-dose
daptomycin in patients with suspected or confirmed neurological infections. Antimicrob Agents Chemother.
2011;55(7):3505-9.
Rhoney DH, Coplin WM, Lin Y, Frankel M, Lyden PD, Levine SR. Time of day, outcome, and response to
thrombolytic therapy: the National Institute of Neurological Disorders and Stroke Recombinant Tissue
Plasminogen Activator Stroke Trial experience. J Stroke Cerebrovasc Dis. 2010;19(1):40-8.
Browning L, Parker D, Jr., Liu-DeRyke X, Shah A, Coplin WM, Rhoney DH. Possible removal of topiramate
by continuous renal replacement therapy. J Neurol Sci. 2010;288(1-2):186-9.
Zwienenberg-Lee M, Hartman J, Rudisill N, Madden LK, Smith K, Eskridge J, et al. Effect of prophylactic
transluminal balloon angioplasty on cerebral vasospasm and outcome in patients with Fisher grade III
subarachnoid hemorrhage: results of a phase II multicenter, randomized, clinical trial. Stroke.
2008;39(6):1759-65.
Ramappa P, Thatai D, Coplin W, Gellman S, Carhuapoma JR, Quah R, et al. Cardiac troponin-I: a predictor
of prognosis in subarachnoid hemorrhage. Neurocrit Care. 2008;8(3):398-403.
Liu-Deryke X, Janisse J, Coplin WM, Parker D, Jr., Norris G, Rhoney DH. A comparison of nicardipine and
labetalol for acute hypertension management following stroke. Neurocrit Care. 2008;9(2):167-76.
Chang CW, Torbey MT, Diringer MN, Coplin W, Mayer SA, Hemphill EC, et al. Neurointensivists: part of
the problem or part of the solution? Crit Care Med. 2008;36(10):2963-4; author reply 5.
Benson RR, Meda SA, Vasudevan S, Kou Z, Govindarajan KA, Hanks RA, et al. Global white matter analysis
of diffusion tensor images is predictive of injury severity in traumatic brain injury. J Neurotrauma.
2007;24(3):446-59.

4. Murugappan A, Coplin WM, Al-Sadat AN, McAllen KJ, Schwamm LH, Wechsler LR, et al. Thrombolytic
therapy of acute ischemic stroke during pregnancy. Neurology. 2006;66(5):768-70.
Mayer SA, Coplin WM, Chang C, Suarez J, Gress D, Diringer MN, et al. Core curriculum and competencies
for advanced training in neurological intensive care: United Council for Neurologic Subspecialties guidelines.
Neurocrit Care. 2006;5(2):159-65.
Mayer SA, Coplin WM, Chang C, Suarez J, Gress D, Diringer MN, et al. Program requirements for fellowship
training in neurological intensive care: United Council for Neurologic Subspecialties guidelines. Neurocrit
Care. 2006;5(2):166-71.
Esper DH, Coplin WM, Carhuapoma JR. Energy expenditure in patients with nontraumatic intracranial
hemorrhage. JPEN J Parenter Enteral Nutr. 2006;30(2):71-5.
Borsody M, Burke A, Coplin W, Miller-Lotan R, Levy A. Haptoglobin and the development of cerebral artery
vasospasm after subarachnoid hemorrhage. Neurology. 2006;66(5):634-40.
Albers GW, Thijs VN, Wechsler L, Kemp S, Schlaug G, Skalabrin E, et al. Magnetic resonance imaging
profiles predict clinical response to early reperfusion: the diffusion and perfusion imaging evaluation for
understanding stroke evolution (DEFUSE) study. Ann Neurol. 2006;60(5):508-17.
Barrett RJ, Hussain R, Coplin WM, Berry S, Keyl PM, Hanley DF, et al. Frameless stereotactic aspiration and
thrombolysis of spontaneous intracerebral hemorrhage. Neurocrit Care. 2005;3(3):237-45.
Larive LL, Rhoney DH, Parker D, Jr., Coplin WM, Carhuapoma JR. Introducing hypertonic saline for
cerebral edema: an academic center experience. Neurocrit Care. 2004;1(4):435-40.
Rhoney DH, Tam VH, Parker D, Jr., McKinnon PS, Coplin WM. Disposition of cefepime in the central
nervous system of patients with external ventricular drains. Pharmacotherapy. 2003;23(3):310-4.
Pilitsis JG, Coplin WM, O'Regan MH, Wellwood JM, Diaz FG, Fairfax MR, et al. Free fatty acids in
cerebrospinal fluids from patients with traumatic brain injury. Neurosci Lett. 2003;349(2):136-8.
Pilitsis JG, Coplin WM, O'Regan MH, Wellwood JM, Diaz FG, Fairfax MR, et al. Measurement of free fatty
acids in cerebrospinal fluid from patients with hemorrhagic and ischemic stroke. Brain Res. 2003;985(2):198-
201.
Carhuapoma JR, Gupta K, Coplin WM, Muddassir SM, Meratee MM. Treatment of refractory fever in the
neurosciences critical care unit using a novel, water-circulating cooling device. A single-center pilot
experience. J Neurosurg Anesthesiol. 2003;15(4):313-8.
Rhoney DH, Parker D, Jr., Formea CM, Yap C, Coplin WM. Tolerability of bolus versus continuous gastric
feeding in brain-injured patients. Neurological Res. 2002;24(6):613-20.
Pilitsis JG, Coplin WM, O'Regan MH, Wellwood JM, Diaz FG, Fairfax MR, et al. Free fatty acids in human
cerebrospinal fluid following subarachnoid hemorrhage and their potential role in vasospasm: a preliminary
observation. J Neurosurg. 2002;97(2):272-9.
Narayan RK, Michel ME, Ansell B, Baethmann A, Biegon A, Bracken MB, et al. Clinical trials in head injury.
J Neurotrauma. 2002;19(5):503-57.

5. Kraus JJ, Metzler MD, Coplin WM. Critical care issues in stroke and subarachnoid hemorrhage. Neurol Res.
2002;24 Suppl 1:S47-57.
Jacobi J, Fraser GL, Coursin DB, Riker RR, Fontaine D, Wittbrodt ET, et al. Clinical practice guidelines for
the sustained use of sedatives and analgesics in the critically ill adult. Crit Care Med. 2002;30(1):119-41.
Coplin WM, Rhoney DH, Rebuck JA, Clements EA, Cochran MS, O'Neil BJ. Randomized evaluation of
adverse events and length-of-stay with routine emergency department use of phenytoin or fosphenytoin.
Neurol Res. 2002;24(8):842-8.
Tirschwell DL, Coplin WM, Becker KJ, Vogelzang P, Eskridge J, Haynor D, et al. Intra-arterial urokinase for
acute ischemic stroke: factors associated with complications. Neurology. 2001;57(6):1100-3.
Pilitsis JG, Diaz FG, Wellwood JM, Oregan MH, Fairfax MR, Phillis JW, et al. Quantification of free fatty
acids in human cerebrospinal fluid. Neurochem Res. 2001;26(12):1265-70.
Joshi N, Chaturvedi S, Coplin WM. Poor prognosis of acute stroke patients denied thrombolysis due to early
CT findings. J Neuroimaging. 2001;11(1):40-3.
Coplin WM, Cullen NK, Policherla PN, Vinas FC, Wilseck JM, Zafonte RD, et al. Safety and feasibility of
craniectomy with duraplasty as the initial surgical intervention for severe traumatic brain injury. J Trauma.
2001;50(6):1050-9.
Coplin WM, Cochran MS, Levine SR, Crawford SW. Stroke after bone marrow transplantation: frequency,
aetiology and outcome. Brain. 2001;124(Pt 5):1043-51.
Coplin WM, Broderick J, Tomsick TT. Intraarterial recombinant tissue plasminogen activator for ischemic
stroke: an accelerated dosing regimen. Neurosurgery. 2001;49(1):228-9.
Coplin WM. Intracranial pressure and surgical decompression for traumatic brain injury: biological rationale
and protocol for a randomized clinical trial. Neurol Res. 2001;23(2-3):277-90.
Vinas FC, Kazmierczak C, Coplin WM. Active intracerebral hemorrhage from the lateral posterior choroidal
artery. Arch Neurol. 2000;57(6):889-90.
Tipps LB, Coplin WM, Murry KR, Rhoney DH. Safety and feasibility of continuous infusion of remifentanil
in the neurosurgical intensive care unit. Neurosurgery. 2000;46(3):596-601; discussion -2.
Rhoney DH, Tipps LB, Murry KR, Basham MC, Michael DB, Coplin WM. Anticonvulsant prophylaxis and
timing of seizures after aneurysmal subarachnoid hemorrhage. Neurology. 2000;55(2):258-65.
Rebuck JA, Murry KR, Rhoney DH, Michael DB, Coplin WM. Infection related to intracranial pressure
monitors in adults: analysis of risk factors and antibiotic prophylaxis. J Neurol Neurosurg Psychiatry.
2000;69(3):381-4.
Devlin JW, Coplin WM, Murry KR, Rengachary SS, Wilson RF. Nimodipine-induced acute hypoxemia: case
report. Neurosurgery. 2000;47(5):1243-6; discussion 6-7.
Coplin WM, Pierson DJ, Cooley KD, Newell DW, Rubenfeld GD. Implications of extubation delay in brain-
injured patients meeting standard weaning criteria. Am J Respir Crit Care Med. 2000;161(5):1530-6.

6. YEAR ONE: CENTURA NEUROSCIENCES SYSTEM OF CARE:
Mountains and North Denver Operating Group
St. Anthony Hospital
Neurocrit Care, N/NS, Crit Care, (Neuro)trauma, Stroke, MD/RN
Education, Admin, Protocols, Program Development, Research, Centura
Connect, cEEG/LTR, Neuromonitoring, TBI Clinic, Pharmacy
St. Anthony North Hospital
Neurology coverage and transfer/repatriation, Stroke Certification, Nursing
education
Avista Adventist Hospital
Neurology/Stroke coverage, Spine, Neurosurgery, Primary Stroke Center
development
St. Anthony Summit Medical Center
TBI Committee – research, clinical protocols, clinic
Panorama Orthopedics
Spine surgery peri-op and spinal cord injury protocols
New West Physicians
Neurology/stroke
South Denver Operating Group
Littleton Adventist Hospital
N’surg (vascular, trauma, functional), Crit Care Med, (Neuro)trauma, Spine,
Pharmacy, Neurocritical Care, EMU, Research planning, Centura Connect,
Neuromonitoring
Porter Adventist Hospital
Neurology, ENT, EMed, Liver transplantation, Nursing education (2)
Parker Adventist Hospital
Spine, Stroke, Rehab, Neurol, N’surg, Sleep, Infxn Control, Neurocrit Care,
Neuromonitoring
Castle Rock Adventist Hospital
Neurology, Neurosurgery, Stroke, Back Wellness
South State Operating Group
Penrose Hospital
Neurol, Comprehensive Stroke Center development & Research
Committee, Trauma Peer Review & Performance Improvement Patient
Safety Committees, N’surg, Trauma, EMed, Neurocrit Care, Centura
Connect
St. Francis Medical Center
EMed, Stroke, Endovascular, Spine
St. Mary-Corwin Medical Center
RN education, Trauma, Crit Care Med, Neurocrit Care, Stroke, N’surgery,
Centura Connect
St. Thomas More Hospital
Neurology, Neurosurgery, Centura Connect, Stroke, Telehealth
Southwest-Kansas Operating Group
Mercy Regional Medical Center
Neurology, Spine, TBI, Medicine, Lab Med, Pharmacy, MD/RN education,
Research planning, Neuroemergencies, Meningitis, Sports Medicine, Toxic
encephalopathy secondary to ethanol withdrawal, Centura Connect
St. Catherine Hospital
Neurology, Stroke, Neuroemergencies, Primary Stroke Center development
and mock review
Goodland Regional Medical Center (pending 6/12/14)

7. Telestroke
St. Rose Ambulatory & Surgery Center (pending 6/13/14)
Teleneurology
Outreach/Affiliates
Cheyenne Regional Medical Center, WY – trauma (CME), Centura Connect
Denver Health Medical Center – neurocritical care
Aspen Valley Hospital – trauma (CME), therapeutic temperature management for
global cerebral ischemia after cardiac arrest, Centura Connect
St. Vincent’s Hospital, Leadville (2) – trauma (CME), telestroke, Centura Connect
Longmont United Hospital (2) – neurology, neurotrauma, Centura Connect
Platte Valley Medical Center (2) - neurology, neurotrauma, critical care
Good Samaritan Medical Center – endovascular neurosurgery
Heart of the Rockies Regional Medical Center, Salida (2) – neurology (CME),
Centura Connect
San Luis Valley Regional Medical Center, Alamosa (4) – neurology, stroke, rural
trauma, Centura Connect
Rio Grande Hospital, Del Norte (2) – stroke, trauma, Centura Connect
Conejos County Hospital, La Jara – neuroemergencies, Centura Connect
Pagosa Springs Medical Center (2) – neurotrauma, neurosciences
San Juan Regional Medical Center, Farmington, NM – teleneurology,
neurorehabilitation
Southwest Memorial Hospital, Cortez – neuroemergencies, stroke, neurotrauma,
Centura Connect
Lincoln Community Hospital, Hugo – neurotrauma, stroke, blood pressure
management (CME)
Miners’ Colfax Medical Center, Raton, NM – traumatic brain injury (CME)
Kit Carson County Memorial Hospital, Burlington – Stroke, Trauma, Telehealth -
pending 6/11/14
Vail Valley Medical Center – trauma - pending
Middle Park Medical Center (Granby/Kremmling) – pending (CME)
Goodland (KS) – pending
Boulder Community - pending
Walsenburg - pending
Trinidad - pending
La Junta - pending
Springfield - pending
Yuma - pending
Steamboat Springs – pending
FOUNDATION/Catholic Health Initiatives/Adventist Health
Statewide - Two visits, third pending – programmatic funding
Local/Regional – St. Anthony (including Gala planning), St. Mary-Corwin
RECRUITING:
Neurocritical Care – St. Anthony/Penrose/Centura
Neurology – St. Anthony/MNDOG, Penrose/SSOG
Neurosurgery – St. Anthony, Penrose, Avista
Neuroendovascular – St. Anthony, Littleton, Penrose
Neurocritical Care Program Manager – St. Anthony
Stroke Program Manager – St. Anthony
Traumatic Brain Injury & Spine Coordinator – St. Anthony

8. CONFERENCES
 Trauma QI – St. Anthony, monthly
 Stroke – St. Anthony, weekly
 3rd International Neurocritical Care Symposium - Panama – 20-21 June 2013
 ICP Think Tank – Seattle - 6-8 September 2013
 Centura Leadership Training – 25-6 September 2013
 International Multimodality Monitoring Consensus Conference – Philadelphia – 29-
30 September 2013
 Neurocritical Care Society – Board of Directors, Professor’s Rounds, Speaker –
Philadelphia – 1-4 October 2013
 Society of Vascular and Interventional Neurology – Houston – 26-27 October 2013
 Centura Rocky Mountain Neurocritical Care Conference – inaugural – 29-30
October 2013 (course director)
 International Stroke Conference – San Diego – 12-14 February 2014
 American Association of Neurological Surgeons – Speaker – San Francisco – 5-7
April 2014
PROTOCOLS/GUIDELINES/PROGRAM DEVELOPMENT
Stroke – St. Anthony, SAN, LAH, PSF, Centura-wide
Stroke Alert Algorithm – St. Anthony, PSF, Centura-wide
Stroke Coordinators Physician Champion – Centura-wide
Severe TBI – St. Anthony, Littleton, Parker, Centura-wide
Mild TBI/Concussion program – Summit, Mercy
Spine Surgery/SCI – St. Anthony/MNDOG, LAH, PKR, PSF, SMC, MMC, Centura-wide
Spinal Cord Injury Order Set – St. Anthony
Cardiac Arrest – St. Anthony, Littleton, Centura-wide
Status epilepticus – St. Anthony, Centura-wide
Service Line coordination – Neurosciences, Trauma, Cardiology, Oncology, Senior Services
Seniors System of Care Strategic Planning
Pharmacy/CNIO’s office formulary coordination
Neurosciences Nursing Residency/Fellowship Program
Neurocritical Care Fellowship – St. Anthony, Littleton, Penrose
Neurocritical Care Privileging – St. Anthony
Mayo Clinic partnership site visit & due diligence
Neurosciences Strategic Business Plan – Centura (with Patricia Santos)
CASE REVIEWS
Neurology - St. Anthony, Littleton, Porter, Parker, Penrose, St, Francis, Mercy
Stroke/ICH/SAH – St. Anthony, SASMC, LAH, PAH, PKR, Penrose, St, Francis
Neurosurgery- St. Anthony, Littleton, Parker, Porter, Penrose
Trauma – St. Anthony, Littleton, Parker
Neuroradiology – St. Anthony, Summit
Skull Base Surgery/Otolaryngology/Head & Neck Surgery - Porter
Emergency Medicine – St. Anthony, Littleton, Parker, Penrose, St. Francis
RESEARCH
 Pharmacological thromboprophylaxis for venous thromboembolism after
hemorrhagic stroke – St. Anthony co-investigators: A. Stewart Levy, Richard H.
Smith, Patricia L. Santos
 Levetiracetam After Severe Traumatic Brain Injury – St. Anthony, Denver Health

9.  Targeted Temperature Management After Cardiac Arrest – St. Anthony, Littleton
Adventist, Penrose Hospitals
HOSPITAL/SYSTEM COMMITTEES
Trauma Peer Review & Performance Improvement Patient Safety Committees, Penrose
Trauma Committee – St. Anthony, Littleton, Parker
Stroke CET – St. Anthony
Stroke Peer Review – St. Anthony
Pharmacy & Therapeutics – St. Anthony
Critical Care Practice Council – St. Anthony
Neurosciences Committee - Littleton
Spine Committee – Parker
Neurosciences Committee - Parker
TBI Committee - Summit
Centura Neurosciences Telestroke - Centura
Centura Growth & Innovation - Centura
Centura Clinical Content Steering Committee – ad hoc (hypertonic saline, order sets)
Centura Outreach
Centura Trauma Council
Centura Spine Council
Centura Neurosciences Council – Co-Chair
PEER-REVIEWED PUBLICATIONS
Levy AS, Salottolo K, Coplin WM, Smith R, Santos P, Bar-Or D. “Pharmacological
Thromboprophylaxis Reduces Odds Of Venous Thromboembolism In Patients With Hemorrhagic
Stroke”. International Stroke Conference, San Diego, CA. 2/14/14.
Levy AS, Salottolo K, Coplin WM, Orlando A, Smith R, Santos P, Bar-Or D. “Association Between
Pharmacological Thromboprophylaxis And Hemorrhage Progression In Patients With Hemorrhagic
Stroke”. International Stroke Conference, San Diego, CA. 2/14/14
Coplin WM. Traumatic Spinal Cord Injury. Neurocritical Care Society 2013 Practice Update.
Liu-Deryke X, Levy PD, Parker D Jr, Coplin W, Rhoney DH. A Prospective Evaluation of Labetalol
Versus Nicardipine for Blood Pressure Management in Patients with Acute Stroke. Neurocrit Care.
2013;19:41-7.
NATIONAL/INTERNATIONAL COMMITTEES
Brain Death Subcommittee of the Neurocritical Care Society Ethics Committee
External Ventricular Drains Guidelines Committee
PRESENTATIONS
1. Online Live Chat – Stroke Prevention – Centura Health – 5/23/13
2. Stroke in the Emergency Department: What to do… - St. Catherine Hospital (med staff) –
5/29-13
3. Zombie Neurobiology: Are We Ready For The Looming Apocalypse? – University of
Virginia Neurology Grand Rounds – 5/31/13
4. Optimal Glucose Control in Hemorrhagic Stroke – St. Anthony Hospital (MD/RN) –
6/13/13
5. TBI Case Studies – St. Anthony Neuro/Trauma Nursing Staff – monthly x 2, first 6/14/13
6. Brain Injury Management – Grand Rounds Santo Tomas Hospital, Panama – 6/19/13

10. 7. Delayed Brain Injury - 3rd International Neurocritical Care Symposium, Panama – 6/20/13
8. Updates in Neuromonitoring of TBI Patients - 3rd International Neurocritical Care
Symposium, Panama – 6/20/13
9. Brain Tissue Oxygen Based Therapy and Outcome after Severe Traumatic Brain Injury - 3rd
International Neurocritical Care Symposium, Panama – 6/21/13
10. Update in the Management of Traumatic Spinal Cord Injury - 3rd International Neurocritical
Care Symposium, Panama – 6/21/13
11. Traumatic Spinal Cord Injury – St. Anthony Trauma Multidisciplinary QI – 7/1/13
12. Early Goal Directed Therapy for Traumatic Brain Injury – Cheyenne Regional Medical
Center (WY) – 7/9/13
13. Hospital Neurological Assessments – Penrose Hospital (Centura Stroke Coordinators’
monthly meeting) – 7/12/13
14. Traumatic Spinal Cord Injury – Panorama Orthopedics (physician/PA staff) – 7/15/13
15. Controversies in Spine Injury – Parker Adventist Hospital (Spine Committee) – 7/30/13
16. Clearing the Spine in the ED: Exam, Imaging, Gear Removal, and Transition to Further
Care: The Neuro Doc's Perspective – 1st Annual Rocky Mountain Sports Medicine
Symposium, Durango – 8/2/13
17. Hypoxia Unplugged: Altitude and Carbon Monoxide– 1st Annual Rocky Mountain Sports
Medicine Symposium, Durango – 8/3/13
18. Neurological Assessment – St. Anthony North (nursing) – 8/7/13
19. You Won’t Get Far If You Keep On Sticking Your Hand In The Medicine Jar: Steroids
Work, Don’t They? – Littleton Adventist Hospital (trauma) – 8/15/13
20. Transfusion “Requirements” in Traumatic Brain Injury – Littleton Adventist Hospital
(trauma) – 8/15/13
21. Toxic Encephalopathies: Ethanol Withdrawal – Critical Care Karma, Porter Adventist
Hospital – 8/21/13
22. Blood Pressure Management for Different Types of Stroke - St. Anthony Hospital –
8/26/13
23. Severe Traumatic Brain Injury: Initial Assessment and Resuscitation – St. Anthony Hospital
– 8/29/13
24. Use of Clinical Examination Scales in Patients with Neurological Injury: Why All the
Confusion? – St. Anthony Hospital (Neurocritical Care board review series) – 9/9/13
25. Monitoreo Multimodal en Neurointensivo - Asociación Colombiana de Medicina Interna –
Pasto – 9/13/13
26. Presión Tisular de Oxígeno Cerebral - Asociación Colombiana de Medicina Interna – Pasto
– 9/13/13
27. Minimizing Perioperative Spine Surgery Infections: Why All The Confusion? – Parker
Adventist Hospital (Spine Committee) – 9/17/13
28. Traumatic Spinal Cord Injury – Neurocritical Care Society – Philadelphia – 10/2/13
29. General Approach to Ventilating the Comatose Trauma Patient – St. Anthony Hospital
(trauma) – 10/7/13
30. Fluids, Electrolytes, Resuscitation Do’s and Don’ts – St. Anthony Hospital (Neurocritical
Care board review series) – 10/10/13
31. Hypercalcemia – Heart of the Rockies Regional Medical Center, Salida – 10/10/13
32. Coagulopathies – Littleton Adventist Hospital (trauma) – 10/17/13
33. Acute Management of Neurological Emergencies – St. Mary-Corwin (nursing) – 10/19/13
34. Neuropharmacology – Rocky Mountain Neurocritical Care Conference – 10/29/13
35. Neuroendocrinology – Rocky Mountain Neurocritical Care Conference – 10/30/13
36. Spinal Cord Injury – Rocky Mountain Neurocritical Care Conference – 10/30/13
37. Natural, Supernatural, and Man-Made Catastrophes – Rocky Mountain Neurocritical Care
Conference – 10/30/13

11. 38. Zombie Neurobiology: Are We Ready For The Looming Apocalypse? – St. Mary’s Medical
Center’s 4th Annual Neuroscience Symposium – Advancements in Neuroscience, Palm
Beach Gardens, FL – 11/2/13
39. Traumatic Intracranial Hemorrhage – Mercy Regional Medical Center Trauma Conference –
11/9/13
40. Traumatic Intracranial Hemorrhage – Mercy Regional Medical Center – 11/11/13
41. Toxic Encephalopathies: Ethanol Withdrawal – Mercy Regional Medical Center – 11/11/13
42. Mild TBI Transfer Algorithm – Mercy Regional Medical Center – 11/13/13
43. Zombie Neurobiology: Are We Ready For The Looming Apocalypse? – Critical Care Karma
- 11/18/13
44. Severe TBI – St. Anthony Hospital (Neurocritical Care board review series) – 11/26/13
45. Workup, Management, and Disposition of Mild Traumatic Brain Injury: Why All The
Confusion? – St. Vincent Hospital, Leadville – 12/2/13
46. Multimodality Monitoring in Neurocritical Care – St. Anthony Hospital (Neurocritical Care
board review series) – 12/5/13
47. Spinal Cord Injury – St. Anthony Hospital (nursing) – 12/6/13
48. There Will Be Blood – Aspen Valley Hospital (trauma) – 12/10/13
49. Workup, Management, and Disposition of Mild Traumatic Brain Injury: Why All The
Confusion? – Mercy Regional Medical Center – 12/11/13
50. “Neuroradiology”. Lecture for RNs. St. Anthony Hospital - 2/20/14
51. “HACA: 33 vs 36C”. CCPSA Journal Club. St. Anthony Hospital - 2/24/14
52. “Traumatic Brain Injury”. Wilz Neuroscience and Trauma Symposium. Pueblo Convention
Center - 3/1/14
53. “Appropriate TBI Admissions and TBI Management, Including Rehab and Follow Up”. San
Luis Valley Regional Medical Center - 3/17/14
54. “Fluid and Electrolyte Management In Critically-Ill Patients After Neurological
Catastrophes”. Neurotrauma Critical Care Review and Update for Practicing Neurosurgeon.
82nd American Association of Neurological Surgeons Annual Scientific Meeting, San
Francisco - 4/5/14
55. “Traumatic Brain Injury”. Miners’ Colfax Medical Center. Raton, NM - 4/10/14
56. “Telestroke” St. Thomas More Emergency Department. Canon City, CO - 4/16/14
57. “Alcohol Withdrawal Syndrome: A New Approach To Prevention and Intervention of
Severe Alcohol Withdrawal Symptoms”. Mercy Regional Medical Center. Durango, CO -
4/17/14
58. “Alcohol Withdrawal Syndrome: Interdepartmental/Interdisciplinary Approach Based on
the Evidence Based Medicine Review”. Mercy Regional Medical Center. Durango, CO -
4/17/14
59. “Alcohol Withdrawal Syndrome: Protocol/Standardization of Treatment in Inpatients, Pre-
ICU, ICU, and ED Patients”. Mercy Regional Medical Center. Durango, CO - 4/17/14
60. “Traumatic Brain Injury”. Platte Valley Medical Center - 4/24/14
61. “Therapeutic Temperature Management after Neurological Catastrophe: Why All the
Confusion?”. Trauma Multidisciplinary Meeting. St. Anthony Hospital - 5/5/14
62. “Hospital Neurological Stroke Assessments”. Mega Nursing Grand Rounds. Porter
Adventist Hospital - 5/6/14
63. “Disability”. Rural Trauma Team Development Course. San Luis Valley Regional Medical
Center - 5/8/14
64. “Zombie Neurobiology: Are We Ready For The Looming Apocalypse?” South State EMS.
Penrose Hospital. Colorado Springs, CO - 5/13/14
65. “Workup, Management, and Disposition of Mild Traumatic Brain Injury: Why All The
Confusion?” Pagosa Springs Medical Center - 5/15/14
66. “Mild Brain Injury – When to Refer; When and Where to Manage”. Brain Injury Alliance of
Colorado Summit County Conference. Beaver Run, CO - 5/16/14

12. BIOGRAPHY
William M. Coplin, MD, FCCM serves as the Neurosciences Medical Director for the Centura
Health system, based in the Denver, CO area. This includes direction of the Neurocritical Care
program. He previously served as an Associate Professor of Neurology and Neurological Surgery at
Wayne State University School of Medicine in Detroit. He is a graduate of the University of Chicago,
received his medical degree from Baylor College of Medicine in Houston, and did his postgraduate
medical training in internal medicine, neurology, the division of pulmonary and critical care medicine
and neurosurgical critical care at the University of Washington in Seattle. Dr. Coplin has published
more than 100 journal articles, book chapters, case reports, and abstracts. He was principal
investigator of the American traumatic brain injury craniectomy clinical trial effort and a local
investigator in the NIH-funded Wayne State University hub of the Neurological Emergencies
Treatment Trials network. He has served as Chief of Neurology and Medical Director of
Neurotrauma and Critical Care at the Detroit Receiving Hospital/Detroit Medical Center for over 12
and 14 years, respectively. He also served as medical director for multiple Wayne State University
neurocritical care projects and is active in research related to neurotrauma, brain edema, therapeutic
hypothermia, neurocardiopulmonary injury, status epilepticus, and multimodality monitoring.
Dr. Coplin is a member of the Board of Directors and a founding member of the Neurocritical Care
Society, a fellow of the American College of Critical Care Medicine, and a board-certified neurologist
and neurointensivist. He is on the editorial board of the journal Neurocritical Care and is a past Chair
of the Critical Care and Emergency Section of the American Academy of Neurology and
Neurosciences Section of the Society of Critical Care Medicine. He sat on the Executive Committee
of the American Association of Neurological Surgeons/Congress of Neurological Surgeons Joint
Section on Neurotrauma and Critical Care for over 12 years. Dr. Coplin is internationally recognized
for his expertise in neurocritical care, lectures widely, and has participated in numerous expert panels.
Dr. Coplin has performed nearly two decades of studies to determine physiological responses to a
variety of therapeutic interventions. These observations have had a major influence on our
understanding of the use of mechanical ventilation and airway care in brain injury, blood pressure
reduction in acute ischemic stroke and intracerebral hemorrhage, the response of the brain to
osmotic therapies, and the role of biomarkers following subarachnoid hemorrhage and other acute
brain injuries.

13. Curriculum Vitae
William M. Coplin, MD, FCCM
1245 Humboldt St. - #208
Tel: 313-702-2202
Email address: wmcoplin@gmail.com
Michigan Lic #4301068197
Colorado Lic #53222
PROFESSIONAL BACKGROUND
5/13 to Present St. Anthony Hospital – Lakewood, CO
- Neurocritical Care
- Trauma Morbidity & Mortality and Multidisciplinary Operations
Committees
- Critical Care Practice Council
- Pharmacy and Therapeutics Committee
- Stroke Clinical Effectiveness Team
Penrose Hospital – Colorado Springs, CO
- Comprehensive Stroke Research Committee
- Trauma Peer Review & Performance Improvement Patient Safety
Committees
St. Anthony Summit Medical Center – Frisco, CO
- TBI Committee
Centura Health – Englewood, CO
- Neurosciences Medical Director
- Neurosciences Council (co-chair)
- Trauma Council
- Spine Council
- Growth and Innovation Council
9/96 to 10/12 Wayne State University School of Medicine – Detroit, MI
- Assistant  Associate Professor, Neurology & Neurological Surgery
9/96 to 5/12 Detroit Receiving Hospital/Detroit Medical Center – Detroit, MI
- Chief of Neurology, Detroit Receiving Hospital
- Medical Director, Neurotrauma & Critical Care
- ATLS instructor
- Level 1 Trauma Committee
- Pharmacy & Therapeutics and Medication Use committees
- Special Care and Systemwide Critical Care committees
- Resuscitation Committee
- Detroit Receiving Hospital Infection Control Committee

14. - Performance Improvement Coordinating Committee
- Detroit Receiving Hospital Medical Staff Operating Committee
- Detroit Receiving Hospital Leadership Committee
- Detroit Receiving Hospital Ethics Committee
- Stroke Practice Group and Systemwide Stroke Committee
- Stroke Team
- Organ Donation Committee, physician champion
- Detroit Receiving Hospital Keystone Committee
- Detroit Receiving Hospital Clinical Excellence Committee
7/93 – 6/96 Neurology/Medicine - University of Washington, Seattle
- Acting Instructor
- Seattle VA Medical Center: ward attending, general neurology, epilepsy, and
neuro-oncology clinics, service-connected disability clinic
- University of Washington Medical Center general neurology clinics
- Fellowship grant writing
EDUCATION
7/95 – 6/96 Neurological Surgery - University of Washington, Seattle
- Senior Fellow
7/94 – 6/96 Pulmonary & Critical Care Medicine - University of Washington, Seattle
- Senior Fellow
7/90 – 6/93 Neurology - University of Washington, Seattle
- Residency
6/89 – 6/90 Internal Medicine - University of Washington, Seattle
- Internship
6/85 – 5/89 Doctor of Medicine Degree, Baylor College of Medicine, Houston, TX
10/81 – 6/85 Bachelor of Arts Degree, University of Chicago, IL
BOARDS AND LICENSURES
• FLEX – completed 1989
• American Board of Psychiatry & Neurology, Neurology – certified 1994
• American Board of Psychiatry & Neurology, Neurology – recertified 2008
• United Council for Neurologic Subspecialties, Neurocritical Care – certified 2010
• State of Washington Medical License – MD00028748 (expired 2/7/97)

15. • State of Michigan Medical License #4301068197
• State of Colorado Medical License #53222