This presentation discusses the pharmacotherapeutic approach to headache management, including types of headaches (migraine, tension-type, cluster), underlying mechanisms, clinical features, and evidence-based treatment strategies. It highlights the role of pharmacological agents such as analgesics, triptans, ergot alkaloids, and preventive therapies, along with non-pharmacological considerations. Designed for Pharm.D, pharmacy, and medical students studying pharmacology, therapeutics, and clinical pharmacy.