HEADACHE
Submitted to- Dr. Sreelakshmi Nair
Assistant professor
Submitted by - Kritika Sehrawat
Diksha Samyani
Albina Abraham
Simran Luthra
Vaibhav Sharma
Doctor of Pharmacy
4th year
What is Headache?
• A headache is a painful and disabling
feature of primary headache disorders.
• Headaches are one of the top reasons
people visit doctors or emergency rooms,
making up more than 1% of visits.
• As one of the top 10 presenting complaints
in ambulatory medical care
• The most common of the primary headache
disorders, occurs during the most productive
years of life (20 to 55 years of age)
Secondary Headache
(Symptomatic of organic
disease)
• Sinus Headache
Primary Headache
• Tension- type headache
• Migraine
• Cluster Headache
Types of Headache
Tension- type headache
1
Migraine
2
3
Sinus Headache
4
Cluster Headache
CLUSTER HEADACHE
• Cluster headache, the most severe of the primary
headache disorders
• It is characterized by attacks of severe, unilateral
head pain
• Cluster headache occur in series lasting for weeks
or months (i.e., cluster periods) with 1-2 headache
per day during the cluster
• Cluster headaches can be episodic or chronic.
• Men are more likely than women to have cluster
headache, and onset generally occurs in those
older than 20 years of age.
PATHOPHYSIOLOGY
• Severe Pain: The hallmark of cluster headaches is their severe, stabbing
pain (worst pain)
• Unilateral Pain: one-sided pain and concentrated around the eye.
• Tearing and Redness: Affected eye may tear excessively, become red, and
droop.
• Nasal Congestion: Blocked or runny nose on the same side as the
headache.
• Restlessness and agitation are common during an episode.
CLINICAL MANIFESTATION
Migraine is a familial disorder
characterized by recurrent attacks of
headache widely variable in intensity,
frequency, and duration. Attacks are
commonly unilateral and usually
associated with nausea, anorexia and
vomiting.
MIGRAINE
Etiology
1. Causes are not fully
understood
2. may be hereditary
3.pre-existing condition like
depression or epilepsy
Risk Factors
1. Stress and anxiety
2.sleep disruption
3.Hormonal changes
4.Skipped meals
5.Dehydration
6. Bright lights and loud noise
Migraines attack tend to be
recurrent and each attack last
upto 3 days.
Types of Migraine
1.Migraine without Aura(most common)- >5 attacks lasting for
4-72 hours.
a. Nausea, vomiting, photophobia, phono phobia
b. > 2 of following unilateral > pulsating> aggravated by routine
activity.
2. Migraine with Aura- >2 attacks with
a. Aura(visual, sensory)
b. Unilateral progression of symptoms over >5 minutes but
<60minutes.
c. Headache within 60minutes of aura.
PATHOPHYSIOLOGY
DIAGNOSIS
• Clinical evaluations (based on
symptoms, normal physical
examination, neurological
examination)
• Red flag findings, that
suggest an alternate
diagnosis include- pain that
reaches peak intensity with in
few seconds or less
• Headaches that increase in
intensity or frequency for
weeks or longer.
• History of cancer(brain
metastasis)
or an immunosuppressive
disorder
• fever, meningitis or altered
mental status
• papilledema
CLINICAL
MANIFESTATION
• Pain in eyes, face or
neck
• Headache can be acute,
frequent or throbbing
• sensitivity to light ,
distorted vision , seeing
flashes of light
• Irritability, nasal
congestion or scalp
tenderness
SEVERITY DRUG THERAPY
MILD Simple analgesics/NSAIDs or combination (+/-antiemetics)
MODERATE
NSAIDs combinations/ergot
alkaloids/sumatriptan(+antiemetic)
SEVERE
Ergot alkaloids/sumatriptan/rizatriptan (+antiemetic)
+prophlaxis - 1. Propranolol/ beta-blockers
2. Amitriptyline/other tricyclic
antidepressants
3. Flunarizine/other Ca2+ channel
blockers
4. Valproate/Topiramate
TREATMENT
NON-
PHARMACOGICAL
TREATMENT
• Yoga and meditation
• Acupuncture
• Neuromodulation
therapy
• using icepacks on
forehead
• Resting in dark ,
quiet place
• Tension type headache is the most common type of primary headache
• It is usually of mild or moderate intensity.
• It is more common in women in adulthood.
• Tension type headche is subcategorize as:
1.Infrequent episodic
2.frequent episodic
3.chronic
Tension Type Headache
Pathophysiolog
y
The pain of episodic tension headaches originate from myofascial factors and peripheral
sensitization of nociceptors
1.Premonitory symptoms and aura are absent with tension-type
headache.
2.Bilateral Pain is most common
pain pattern -headband
3.Mild photophobia-sensitivity to light
phonophobia-Sensitivity to sound
Clinical Manifestation
Treatment
Non Pharmacological
Therapy
Pharmacological therapy
Psychophysiologic
Therapy
Physical
Therapy
• Reassurance
• Counselling
• Stress Management
• Biofeedback
• electrical nerve
• stimulation
• Exercise
• Massage
• acupuncture
Acute treatment
First line-Simple analgesics and NSAIDs
Second line -ASA+APAP+ caffeine ,butalbital
containing products
Limit acute treatment to 2 days per week
Preventive treatment (chronic
TTH)
TCA are prescribed most often
(Considered if headache frequency more than
2 per week and
duration greater than 3-4 hrs )
SINUS HEADACHE
A sinus headache is a symptom of sinus infections (sinusitis). Sinus
headaches make your face hurt. You may feel a constant, dull ache
behind the eyes or in your cheekbones, forehead and the bridge of
your nose. The pain gets worse when you move your head suddenly or
you bend over. Typically, sinus headaches go away once a sinus
infection runs its course.
SIGNS AND
SYMPTOMS
Nasal congestion
An uncomfortable pressure behind
the forehead
Weakened sense of smell
Green or yellow nasal discharge
Fever
Pain getting worse while leaning
forward
Runny nose
What causes sinus
headache ?
The sinuses are air-filled cavities situated around your eyes and on either side of your nose.
These cavities play an important role in warming and moistening the air you breathe. Healthy
sinuses allow mucus to drain and air to circulate throughout the nasal passages.
Sinuses are prone to inflammation, known as sinusitis, which may lead to the common
symptoms of pressure and pain. The most common cause of sinusitis is a viral infection, but
both bacteria and fungi can be the culprits. Allergies can also cause sinus inflammation.
Less often, sinus pain and pressure are triggered by exposure to secondhand smoke,
perfume, or other inhaled chemicals. Structural issues, like nasal polyps or a deviated
septum, can prevent the sinuses from draining properly and allow inflammation to take hold.
Sudden changes in air pressure can also cause pain without inflammation.
decongestant
antihistamines
nasal steroid sprays
Pharmacological treatment
pain killers
antibiotics
saline nasal sprays
• Drink plenty of water to keep mucus thin and
loose.
• Apply a warm compress to your face.
• Inhale steam. Spend time in a hot shower, or
boil water and inhale the steam from a pot.
Even steam inhaled from hot tea or chicken
soup can help. Aim to inhale steam three to
four times a day.
• A neti pot or another sinus rinsing system
may provide relief. Always use distilled,
purified, or boiled water that is allowed to
cool.
• Elevate your head while sleeping. If the pain
is on one side, sleep on the pain-free side.
• Use saline nasal sprays to loosen mucus and
rinse the sinuses
Non-
pharmacological
treatment
Thank you!

Headache theapeutics pharm d students.pptx

  • 1.
    HEADACHE Submitted to- Dr.Sreelakshmi Nair Assistant professor Submitted by - Kritika Sehrawat Diksha Samyani Albina Abraham Simran Luthra Vaibhav Sharma Doctor of Pharmacy 4th year
  • 2.
    What is Headache? •A headache is a painful and disabling feature of primary headache disorders. • Headaches are one of the top reasons people visit doctors or emergency rooms, making up more than 1% of visits. • As one of the top 10 presenting complaints in ambulatory medical care • The most common of the primary headache disorders, occurs during the most productive years of life (20 to 55 years of age)
  • 3.
    Secondary Headache (Symptomatic oforganic disease) • Sinus Headache Primary Headache • Tension- type headache • Migraine • Cluster Headache Types of Headache Tension- type headache 1 Migraine 2 3 Sinus Headache 4 Cluster Headache
  • 4.
    CLUSTER HEADACHE • Clusterheadache, the most severe of the primary headache disorders • It is characterized by attacks of severe, unilateral head pain • Cluster headache occur in series lasting for weeks or months (i.e., cluster periods) with 1-2 headache per day during the cluster • Cluster headaches can be episodic or chronic. • Men are more likely than women to have cluster headache, and onset generally occurs in those older than 20 years of age.
  • 5.
  • 6.
    • Severe Pain:The hallmark of cluster headaches is their severe, stabbing pain (worst pain) • Unilateral Pain: one-sided pain and concentrated around the eye. • Tearing and Redness: Affected eye may tear excessively, become red, and droop. • Nasal Congestion: Blocked or runny nose on the same side as the headache. • Restlessness and agitation are common during an episode. CLINICAL MANIFESTATION
  • 8.
    Migraine is afamilial disorder characterized by recurrent attacks of headache widely variable in intensity, frequency, and duration. Attacks are commonly unilateral and usually associated with nausea, anorexia and vomiting. MIGRAINE
  • 9.
    Etiology 1. Causes arenot fully understood 2. may be hereditary 3.pre-existing condition like depression or epilepsy Risk Factors 1. Stress and anxiety 2.sleep disruption 3.Hormonal changes 4.Skipped meals 5.Dehydration 6. Bright lights and loud noise Migraines attack tend to be recurrent and each attack last upto 3 days.
  • 10.
    Types of Migraine 1.Migrainewithout Aura(most common)- >5 attacks lasting for 4-72 hours. a. Nausea, vomiting, photophobia, phono phobia b. > 2 of following unilateral > pulsating> aggravated by routine activity. 2. Migraine with Aura- >2 attacks with a. Aura(visual, sensory) b. Unilateral progression of symptoms over >5 minutes but <60minutes. c. Headache within 60minutes of aura.
  • 13.
  • 14.
    DIAGNOSIS • Clinical evaluations(based on symptoms, normal physical examination, neurological examination) • Red flag findings, that suggest an alternate diagnosis include- pain that reaches peak intensity with in few seconds or less • Headaches that increase in intensity or frequency for weeks or longer. • History of cancer(brain metastasis) or an immunosuppressive disorder • fever, meningitis or altered mental status • papilledema
  • 15.
    CLINICAL MANIFESTATION • Pain ineyes, face or neck • Headache can be acute, frequent or throbbing • sensitivity to light , distorted vision , seeing flashes of light • Irritability, nasal congestion or scalp tenderness
  • 16.
    SEVERITY DRUG THERAPY MILDSimple analgesics/NSAIDs or combination (+/-antiemetics) MODERATE NSAIDs combinations/ergot alkaloids/sumatriptan(+antiemetic) SEVERE Ergot alkaloids/sumatriptan/rizatriptan (+antiemetic) +prophlaxis - 1. Propranolol/ beta-blockers 2. Amitriptyline/other tricyclic antidepressants 3. Flunarizine/other Ca2+ channel blockers 4. Valproate/Topiramate TREATMENT
  • 17.
    NON- PHARMACOGICAL TREATMENT • Yoga andmeditation • Acupuncture • Neuromodulation therapy • using icepacks on forehead • Resting in dark , quiet place
  • 18.
    • Tension typeheadache is the most common type of primary headache • It is usually of mild or moderate intensity. • It is more common in women in adulthood. • Tension type headche is subcategorize as: 1.Infrequent episodic 2.frequent episodic 3.chronic Tension Type Headache
  • 19.
    Pathophysiolog y The pain ofepisodic tension headaches originate from myofascial factors and peripheral sensitization of nociceptors
  • 20.
    1.Premonitory symptoms andaura are absent with tension-type headache. 2.Bilateral Pain is most common pain pattern -headband 3.Mild photophobia-sensitivity to light phonophobia-Sensitivity to sound Clinical Manifestation
  • 21.
    Treatment Non Pharmacological Therapy Pharmacological therapy Psychophysiologic Therapy Physical Therapy •Reassurance • Counselling • Stress Management • Biofeedback • electrical nerve • stimulation • Exercise • Massage • acupuncture Acute treatment First line-Simple analgesics and NSAIDs Second line -ASA+APAP+ caffeine ,butalbital containing products Limit acute treatment to 2 days per week Preventive treatment (chronic TTH) TCA are prescribed most often (Considered if headache frequency more than 2 per week and duration greater than 3-4 hrs )
  • 22.
    SINUS HEADACHE A sinusheadache is a symptom of sinus infections (sinusitis). Sinus headaches make your face hurt. You may feel a constant, dull ache behind the eyes or in your cheekbones, forehead and the bridge of your nose. The pain gets worse when you move your head suddenly or you bend over. Typically, sinus headaches go away once a sinus infection runs its course.
  • 23.
    SIGNS AND SYMPTOMS Nasal congestion Anuncomfortable pressure behind the forehead Weakened sense of smell Green or yellow nasal discharge Fever Pain getting worse while leaning forward Runny nose
  • 24.
    What causes sinus headache? The sinuses are air-filled cavities situated around your eyes and on either side of your nose. These cavities play an important role in warming and moistening the air you breathe. Healthy sinuses allow mucus to drain and air to circulate throughout the nasal passages. Sinuses are prone to inflammation, known as sinusitis, which may lead to the common symptoms of pressure and pain. The most common cause of sinusitis is a viral infection, but both bacteria and fungi can be the culprits. Allergies can also cause sinus inflammation. Less often, sinus pain and pressure are triggered by exposure to secondhand smoke, perfume, or other inhaled chemicals. Structural issues, like nasal polyps or a deviated septum, can prevent the sinuses from draining properly and allow inflammation to take hold. Sudden changes in air pressure can also cause pain without inflammation.
  • 25.
    decongestant antihistamines nasal steroid sprays Pharmacologicaltreatment pain killers antibiotics saline nasal sprays
  • 26.
    • Drink plentyof water to keep mucus thin and loose. • Apply a warm compress to your face. • Inhale steam. Spend time in a hot shower, or boil water and inhale the steam from a pot. Even steam inhaled from hot tea or chicken soup can help. Aim to inhale steam three to four times a day. • A neti pot or another sinus rinsing system may provide relief. Always use distilled, purified, or boiled water that is allowed to cool. • Elevate your head while sleeping. If the pain is on one side, sleep on the pain-free side. • Use saline nasal sprays to loosen mucus and rinse the sinuses Non- pharmacological treatment
  • 27.