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Goldstein and brown were lucky. If they had used the JD allele to compare with wild type rather
than an allele that results in complete loss of the LDLr protein, the graph of _____ would look
much different.LDL binding
Solution
Answer is LDL import.
NPVY domain recruits clathrin and other proteins responsible for the endocytosis of LDL,
therefore this mutation inhibits LDL internalization. "JD" mutant results from a single point
mutation in the NPVY domain

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Goldstein and brown were lucky. If they had used the JD allele to co.pdf

  • 1. Goldstein and brown were lucky. If they had used the JD allele to compare with wild type rather than an allele that results in complete loss of the LDLr protein, the graph of _____ would look much different.LDL binding Solution Answer is LDL import. NPVY domain recruits clathrin and other proteins responsible for the endocytosis of LDL, therefore this mutation inhibits LDL internalization. "JD" mutant results from a single point mutation in the NPVY domain