1. The traditional definition of well-being is outdated and needs a "silent transformation" to account for modern pressures on mental well-being from things like increased choice, complexity, and individualism.
2. Everyday life presents a "problem of choice" that can undermine sense of coherence and well-being through short-termism, selfishness, and lack of purpose from competing roles and priorities.
3. Individual decisions have small negative impacts, but these accumulate over many people and time into significant problems, so policies are needed to manage variety and enhance individual capacity for coherent living.
Bibliotheken im Spannungsfeld zwischen Nutzungsmessung und DatenschutzJan Lüth
Der Vortrag bietet einen Überblick zu technischen Verfahren, mit denen das Nutzerverhalten elektronischer Dienste im Internet gemessen und veranschaulicht wird und welche gesetzlichen Schranken bei der Erfassung und Verwendung von Nutzerdaten bestehen. Ziel ist es Bibliothekarinnen und Bibliothekare in diesem Zusammenhang für das Thema Datenschutz zu sensibilisieren und Handlungsempfehlungen, wie die Anonymisierung von Daten oder transparente Service-Policies, aufzuzeigen.
Bibliotheken im Spannungsfeld zwischen Nutzungsmessung und DatenschutzJan Lüth
Der Vortrag bietet einen Überblick zu technischen Verfahren, mit denen das Nutzerverhalten elektronischer Dienste im Internet gemessen und veranschaulicht wird und welche gesetzlichen Schranken bei der Erfassung und Verwendung von Nutzerdaten bestehen. Ziel ist es Bibliothekarinnen und Bibliothekare in diesem Zusammenhang für das Thema Datenschutz zu sensibilisieren und Handlungsempfehlungen, wie die Anonymisierung von Daten oder transparente Service-Policies, aufzuzeigen.
The state in global health (focus on LICs/MICs)Albert Domingo
A report/presentation on the changing dynamics of the power of the state viz. external actors in formulating health policy, particularly in low income countries and middle income countries.
We’re getting serious about poverty
What we have done in the past has not been too successful: a search for something more effective
Initially: “direct impact on the poor”
Later: a more analytical understanding
Collins Center's VP for health initiatives, Dr. Leda Perez presented to the Florida Department of Health on 2 June 2011 about Community Health Workers in the state and future implications.
This discussion, covened by the Dubai Future Foundation, focusses on identifying the significance of the concept of well-being for social-science and policy; and the opportunities to measure it at scale.
Prof. Frank Snyder presents at the Doctoral Midwifery Research Society Alcohol & Medication in Pregnancy Conference about 'Modifiable risk in Pregnancy & Health behaviour change: Utilising the Theory of Triadic Influence (TTI)'
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
The state in global health (focus on LICs/MICs)Albert Domingo
A report/presentation on the changing dynamics of the power of the state viz. external actors in formulating health policy, particularly in low income countries and middle income countries.
We’re getting serious about poverty
What we have done in the past has not been too successful: a search for something more effective
Initially: “direct impact on the poor”
Later: a more analytical understanding
Collins Center's VP for health initiatives, Dr. Leda Perez presented to the Florida Department of Health on 2 June 2011 about Community Health Workers in the state and future implications.
This discussion, covened by the Dubai Future Foundation, focusses on identifying the significance of the concept of well-being for social-science and policy; and the opportunities to measure it at scale.
Prof. Frank Snyder presents at the Doctoral Midwifery Research Society Alcohol & Medication in Pregnancy Conference about 'Modifiable risk in Pregnancy & Health behaviour change: Utilising the Theory of Triadic Influence (TTI)'
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
1. Silent transformation of well-being Timo Hämäläinen, Ph.D., Dos. Glasgow Centre for Population Health Seminar Series, 13th April 2011, Glasgow
2. Agenda Ourold definition of well-being is outdated (”silenttransformation”) ”Problem of choice” in everyday life Pressures on Sense of coherence and mentalwell-being Accumulatingimpacts of short-term and selfishdecisions Law of requisitevariety & well-being Policyimplications Well-being and economiccompetitivenessarenotcontradictory Vision of a sustainablewell-beingsociety 12/04/2011
26. Physiological needs (thirst, hunger,…) RESOURCES AND CAPABILITIES - Income & wealth - Knowledge & skills - Physical & mental health - Social capital - Information - Time - Politicalpower - Naturalresources
55. Manageability making problems, short-termism (hurry), competing loyalties 12/04/2011
56. Antonovsky’s sense of coherence (SOC) Increasing uncertainty & complexity Comprehensibility Problem of choice Manageability Subjective well-being, QoL, mental health Sense of coherence Individualism, normlessness, selfishness, consumerism, materialism & instrumentalism Meaningfulness Source: Aaron Antonovsky; Monica Eriksson & Bengt Lindström Sources: Aaron Antonovsky (1987); Lindström & Erickson (2005)
57. Sense of coherence, mental health and well-being “The [empirical] evidence shows that SOC is strongly and negatively related to anxiety, burnout, demoralization, depression and hopelessness, and positively with hardiness, mastery, optimism, self-esteem, good perceived health, quality of life and well-being.” Source: Bengt Lindstrom & Monica Eriksson (2005): “The Salutogenic Perspective and Mental Health”, in Promoting Mental Health, WHO)
58. Growing mental pressures and demands of working life Pressures on sense of coherence Health Illness grey area Demands of working life
59. Sicknesspensionsdue to depression in Finland, 1983–2006 (privatesector) Number 3 500 3 000 2 500 2 000 1 500 1 000 500 0 83 85 87 89 91 93 95 97 99 01 03 05 Source: Finnish centre for pensions
60. Key problems in decision making Short-termism Selfishness 12/04/2011
61.
62.
63. Crowding of life’s activities; growing hurry, short-termism and procrastination; decreasing commitment and loyalty (”grass greener on the other side…?”).12.4.2011 15
64. Weight of new army servicemen in Finland (kg) Source: Santtila et al., Finnish armed forces 12.4.2011
65. Cooper test results of new army servicemen, 1975 - 2006 Source: Santtila et al., Finnish armed forces
76. Increasing tourism to far-off countries, more driving with cars growing environmental problems22
77. Accumulating impacts of individual decisions in the long-term and in large groups 12.4.2011 23 Environmental, childdevelopment, social relationshipproblems Life management problems (Kahneman, Giddens) Long-term Trafficjams, litter- ing, status compe- tition, etc. (Hirsch, Schelling) Hedonistic instant gratification dominates Short-term One’s own well-being Others’ well-being
96. Need to decentralize power, but then achieving cohesion and synergy becomes a problem.
97. The Viable System Model offers a way of gaining both functional decentralization and cohesion of the whole.
98. Recursive structure: All living systems are composed of a series of sub-systems, each having self-organizing and self-regulatory characteristics.
99. Each viable system requires five elements: operations, coordination, control, intelligence and policy (direction, values, purpose).12/04/2011
100. Individual’s life as a Viable System The everyday life of a human being is a system of subsystems in which different activities take place. Each activity adds value (well-being) and has its own goals, values, rules, languages, etc. The interdependencies and interfaces of each activity must be coordinated to operate synergistically. How well are our everyday activities coordinated? Is the whole system under our control? How does it affect our well-being as a whole? Can we manage our lives? (coordination & control= manageability!) Intelligence: Do we understand what’s going on in the world around us? Or, who we are? (= comprehensibility!) Policy: What’s the direction and purpose of our life? (= meaningfulness!)
101. Ashby (1958): Law of requisite variety The variety of the controller must be equal to that of the controlled. If the variety of disturbances (Vd) grows, old institutional responses/mechanisms (Vr) become inadequate in controlling them, and the variety (uncertainty) of outcomes (Vo) grows. Minimal value of Vo is Vd – Vr Given the variety of disturbances, the “goodness” or value of the outcome depends on the “capacity” (variety of responses) of the regulator (decision maker). Due to “limitation on ‘the capacity of Man’”, there is a limit to the variety (choice) that people can deal with. “Problem of choice” means an overwhelming variety of life options. Due to limited time and cognitive capacity, we cannot deal with this variety anymore. Life management problems!
104. Being more selective in one’s commitments based on their compatibility and personal strengths (downshifting, flow activities, purpose, work & life bal.)
111. policy (direction & purpose = meaningfulness): spiritualism, volunteering, serving others (or society) Transformational human being (O’Hara)?
112.
113. However, the value-added of products and services depends on their contribution to everyday well-being.
114. Superior well-being knowledge supports the development of products and services with more value-added – and hence competitiveness.
115. In addition, it helps: (a) people to live betterlives; (b) publicsector to produceserviceswithmorevalue-added, (c) policymakers to providebetterpublicgoods and institutions (e.g. living environments)
116. An updated and sophisticatedunderstanding of well-beingprovides and overall vision for the development of a new and sustainablesocio-economicmodel.12/04/2011
117. Europe could lead in the road to a sustainable well-being society Environment Everyday well-being (subjective well-being, happiness, good life) Economy (value-added, compe-titiveness, efficiency, productivity, growth) Public sector (public value, efficiency, renewal capacity, social security, equality) Environment Environment Environment Adapted from: Habermas (1987, Vol. 2) Lähde: Habermas (1987, Vol. 2) 30