This document discusses werewolf syndrome, also known as hypertrichosis, which is a rare medical condition characterized by excessive hair growth. It describes the different types and classes of hypertrichosis, including congenital forms present from birth and acquired forms that develop after birth. The genetics involve mutations on chromosomes 17 and X that are sometimes inherited in an X-linked dominant pattern. While rare, cases have been historically documented as far back as the Middle Ages, with some individuals exhibiting the condition joining circuses. Diagnosis involves examining physical signs and ruling out other potential medical causes or drug-induced cases. Treatment options include cosmetic procedures, lasers, and pharmaceutical interventions.

1. GENETICS OF WEREWOLF SYNDROME.
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2. PRESENTED BY
BAKHTWAR ATTIQUE
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3. INTRODUCTION:
HYPERTRICHOSIS:
This is a medical condition in which
there is excessive hair growth in
areas that normally do not have hair.
It is sometimes called the werewolf
syndrome or Ambras syndrome.
As far back as the middle Ages there have
been documented cases of hypertrichosis in
both women and men.
CLASSIFICATION:
TYPES OF HYPERTRICHOSIS:
1. Generalized hypertrichosis.
2.Localized hypertrichosis.
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4. CLASSES OF HYPERTRICHOSIS:
CONGENITAL
HYPERTRICHOSIS
Present from birth.
This is a rare syndrome.
It has several sub-classes:
Congenital generalized
hypertrichosis is one of the type
of Congenital hypertrichosis
ACQUIRED
HYPERTRICHOSIS
This disorder arises in sufferers
after birth.
It also has several sub-classes.
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5. TYPE OF HAIR:
When a person has hypertrichosis they can
have any of the three different types
of hair.
Vellus:
Terminal:
Lanugo:
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6. GENETICS:
• CGH in its most common form is idiopathic in the absence of underlying endocrine or
metabolic disorders.
• An excess of stimulation of the hair follicles with normal levels of androgen-like
hormones.
• The involvement of chromosome 17.3 with Ambras type, and involvement of chromosome
X at the locus X 17q24.2-q24.3.
• Congenital generalized hypertrichosis (CGH), is the type of X-linked dominant; the gene
that is mutated is found on the X chromosome.
• Hypertrichosis is sometimes considered an atavism a trait that reappears once it has
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8. EPIDEMIOLOGY:
• Congenital forms of hypertrichosis are rare.
• HISTORICAL BACKGROUND
• The first recorded case of hypertrichosis was Petrus
Gonsalvus.
• Julia Pastrana.
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9. CIRCUS LIFE
Circus Life Stephan Bibrowski,
known as Lional the lion faced
man. He like many other people
with this disease joined the
circus. He makes his wealth by
sharing his medical condition
with the world. As time went on
the hair on Stephan's face grew
to an outstanding length of 8in
on his face, and about 4in
everywhere else on his body!
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10. STUDIES ON CONGENTIAL GENERALIZED
HYPERTRICHOSIS:
• Studies show autosomal dominate pattern inheritance with CGH.
• Affected women carry on the trait to both male and female offspring.
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11. MALE AND FEMALE
• Female:
female have patchy pattern of
the disease.
• Male:
Male have the syndrome more
extreme.
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12. DIAGNOSIS:
• PHYSICAL CHANGES
Particular attention should be given to the presence of other anomalies in particular area
of the face, eyes, teeth, hearth, kidneys, bones, and extremities, and at the same time, to
obesity and intellectual disability. The diagnosis directed at identifying the signs
associated with CGH and distinguishing it from the acquired form.
• CHEMICAL CHANGES
Drug induced hypertrichosis, in particular anti-convulsants such as phenytoin and other
drugs, including corticosteroids, cyclosporine and interferon alpha.
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13. CAUSES
• Malnutrition and anorexia nervosa.
• Endocrine disorders.
• Juvenile dermatomyositis and infectious diseases.
• Metabolic diseases such as mucopolysaccharidoses
(Hurler, Hunter, Sanfilippo syndromes).
• Congenital porphyrias.
• Adrenal enzymatic deficiency.
• And Ovarian and adrenal neoplasms.
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14. MANAGEMENT AND TREATMENT OF
HYPERTRICHOSIS:
• There are different approaches to the treatment of excess hair,
including:
• Cosmetic procedures.
• Intense pulsed light source and laser treatment.
• Pharmacological treatment.
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