This document reviews the Indian fruit tree Garcinia indica, commonly known as kokum. It discusses the tree's native regions in India, botanical description, phytochemistry, traditional medicinal uses, and validated pharmacological properties. Preclinical studies have shown that kokum and some of its phytochemicals possess anti-inflammatory, antioxidant, anti-obesity, anticancer and other medicinal effects. The review aims to highlight the nutritional and medicinal value of this underutilized indigenous fruit.
This document reviews the Indian fruit tree Garcinia indica, commonly known as kokum. It discusses the tree's native regions in India, botanical description, phytochemistry, traditional medicinal uses, and validated pharmacological properties. Preclinical studies have shown that kokum and some of its phytochemicals possess anti-inflammatory, antioxidant, anti-obesity, anticancer and other medicinal effects. The review aims to highlight the nutritional and medicinal value of this underutilized indigenous fruit.
1. 班級 : 二食營四 A 姓名 : 歐舒萍 指導老師 : 吳幸娟 山竹醇 (Garcinol) 對大鼠胚胎的大腦皮層神經元 及 星形膠質細胞中,自由基的生成與一氧化氮的製造之影響 C.-H. Liao et al. / Biochemical and Biophysical Research Communications 329 (2005) 1306–1314 Effects of garcinol on free radical generation and NO production in embryonic rat cortical neurons and astrocytes
Garcinol 抑制了 ROS 引起的 DNA 鏈斷裂 A 空白組 : 質體核酸培養 在 37 度 for 30 分鐘 with 濃度 100 mM 過氧化氫 and 50 UM 硫酸亞鐵 實驗組 : 添加山竹醇 Y 鬆弛環狀 DNA% X 為編號 鬆弛環狀 DNA% 越高代表抗氧化能力越差 B圖 cambogin 藤黃果衍生物 作三重複 有效果顏色較重
圖 A 抑制 50% 酵素活性所需要的 garcinol 濃度 我們發現在圖 A garcinol 在 52UM 時 Y 軸在 IC50 ,能抑制 50% 的黃嘌呤氧化酶,證明山竹醇有效的能抑制黃嘌呤氧化酶 圖 B
A 細胞有添加及沒添加山竹醇,培養 7 天 ,之後染色 使用山竹醇之後明顯看不見 細胞活性增加 減少影響的毒性
(D) LPS-stimulated cells were treated with garcinol in a dose-dependent manner (1.25, 2.5, and 5 lM). iNOS protein expression in cell lysate was determined by SDS–PAGE for immunoblotting analysis by anti-iNOS antibody By Western blot analysis, the inhibition of LPS-stimulated iNOS production by garcinol was displayed in a dose-dependent manner (1.25, 2.5, and 5 lM) for 24 h (Fig. 4D) 南方墨點法