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Fudge SOBP 2016
- 1. Being Vigilant: NewData on BNST Connectivity in the Nonhuman Primate Julie L. Fudge, MD Departments of Neuroscience and Psychiatry No disclosures or conflicts of interest
- 2. Anticipation of futureevents can be pleasant or unpleasant, depending on expectations Past experience shapes expectations of the future Anticipatory anxiety can be adaptive, a mechanism to protect the organism should the past repeat itself
- 3. Hermann MJ Human BrainMapping 2016 Brain activity during anticipation of aversive stimulus
- 4. (A) Activation ofthe right basal forebrain during sustained anticipation of aversion, as overlaid on an anatomical atlas (Mai et al. 1998). Daniel W. Grupe et al. Cereb. Cortex 2013;23:1874-1883 Sustained anticipation of aversion
- 5. Torrisi et al,Human Brain Mapping, 2015 Resting state, 7T Using the BNST as a seed: what is the ‘resting state’ intrinsic activity in normal human subjects
- 6. Neural activations correlatedwith threat responses in monkeys Fox AS et al , PNAS, 2015
- 7. WHAT ARE THECOMPONENTS OF THE ‘THREAT CIRCUIT’ AT A CELLULAR LEVEL?
- 8. BNST is embeddedin the ‘central extended amygdala’ BSTL SLEAc A. CeN SLEAc B. Fudge, 2001
- 9. BSTL CeN SLEAc SLEAc A. B. Fudge, 2001 Lesion/inactivationstudies show functional dissociations between BNST and CeN BNST related to uncertainty, predator odor, unconditioned stimuli such as light (rodents) (Fendt, 2003; Qi , Walker, Lee). CeN is more classically related to conditioned fear responses (Walker and Davis 1997)
- 10. Heimer, Alheid, deOlmos 1988,1999 Johnston, 1923 Given the proposed specific role of the BNST in anticipatory, long lasting threat responses, how does the organization of the extended amygdala make sense?
- 13. amygdala deCampo and Fudge,JCN, 2013
- 22. DOING THE CROSS-CHECK: INJECTINGANTEROGRADE TRACERS INTO RETROGRADELY LABELED SITES
- 23. MULTIPLE ANTEROGRADE INJECTIONSIN AMYGDALA
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- 25. ANTEROGRADE INJECTIONS INAREA 25 (SUBG ACC)
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- 29. Central nucleus projections tothe BSTL--retrograde Oler et al. Brain Structure and Function, 2016
- 30. Central nucleus projections tothe BSTL--anterograde Oler et al. Brain Structure and Function, 2016
- 31. BSTL projections tothe CeN-- retrograde Oler et al. Brain Structure and Function, 2016
- 32. BSTL projections tothe CeN-- anterograde Oler et al. Brain Structure and Function, 2016
- 33. IMMEDIATE FEAR RESPONSES LONG-LASTING ANXIETY-LIKE RESPONSE TO UNCERTAINTY The BNST/CeN can’tbe separated. Anatomy suggests that more fear experiences make you more wary about uncertainty Oler et al. Brain Structure and Function, 2016
- 34. HIPPOCAMPUS CeN BSTL Anticipation of aversive or uncertain events Codedbased on past memories? Sensitized by episodes of fear learning?
- 35. Supported by NIMHR0163291, F30MH 096502 Emily Kelly, PhD Dana Helmreich, PhD Danielle deCampo, PhD Michele Saul, PhD Nancy Bui Julia Iourinets Brian Ho Ben Berg Giovanna Braganza Shahyan Rehman Nanette Alcock FUDGE Laboratory Ned Kalin’s group: Jonathan Oler Andrew Fox Rothem Kovner