This study evaluated the efficacy of levetiracetam and sodium valproate treatments for 195 patients with benign childhood epilepsy with centrotemporal spikes (BECTS) over 2 years. The study found that monotherapy, particularly with levetiracetam, was associated with normalization of EEG patterns and prevention of cognitive decline. Polytherapy, especially those including sodium valproate, was linked to poorer cognition. Early treatment to control electrical status epilepticus in sleep may help reduce cognitive issues in BECTS patients.
REVIEWpublished 24 June 2015doi 10.3389fnhum.2015.003.docxmalbert5
REVIEW
published: 24 June 2015
doi: 10.3389/fnhum.2015.00359
Pathophysiology of ADHD and
associated problems—starting points
for NF interventions?
Björn Albrecht*, Henrik Uebel-von Sandersleben, Holger Gevensleben and
Aribert Rothenberger
Department of Child and Adolescent Psychiatry, University Medical Center Göttingen, Göttingen, Germany
Edited by:
Martijn Arns,
Research Institute Brainclinics,
Netherlands
Reviewed by:
Roumen Kirov,
Institute of Neurobiology, Bulgarian
Academy of Sciences, Bulgaria
Leon Kenemans,
Utrecht University, Netherlands
*Correspondence:
Björn Albrecht,
Department of Child and Adolescent
Psychiatry, University Medical Center
Göttingen, von Siebold Straße 5,
37075 Göttingen, Germany
[email protected]
Received: 06 October 2014
Accepted: 02 June 2015
Published: 24 June 2015
Citation:
Albrecht B, Uebel-von Sandersleben
H, Gevensleben H and Rothenberger
A (2015) Pathophysiology of ADHD
and associated problems—starting
points for NF interventions?
Front. Hum. Neurosci. 9:359.
doi: 10.3389/fnhum.2015.00359
Attention deficit hyperactivity disorder (ADHD) is characterized by severe and
age-inappropriate levels of hyperactivity, impulsivity and inattention. ADHD is a
heterogeneous disorder, and the majority of patients show comorbid or associated
problems from other psychiatric disorders. Also, ADHD is associated with cognitive and
motivational problems as well as resting-state abnormalities, associated with impaired
brain activity in distinct neuronal networks. This needs to be considered in a multimodal
treatment, of which neurofeedback (NF) may be a promising component. During NF,
specific brain activity is fed-back using visual or auditory signals, allowing the participants
to gain control over these otherwise unaware neuronal processes. NF may be used
to directly improve underlying neuronal deficits, and/or to establish more general self-
regulatory skills that may be used to compensate behavioral difficulties. The current
manuscript describes pathophysiological characteristics of ADHD, heterogeneity of
ADHD subtypes and gender differences, as well as frequently associated behavioral
problems such as oppositional defiant/conduct or tic disorder. It is discussed how NF
may be helpful as a treatment approach within these contexts.
Keywords: Neurofeedback (NF), ADHD, ODD/CD, tic disorder, comorbidity, children, neurobiology
Introduction
Difficulties with Inattention or Hyperactivity and Impulsivity as the core symptoms of Attention
deficit Hyperactivity disorder (ADHD) are a frequent psychosocial burden. With an early onset
during childhood, ADHD is often persisting throughout life. It is a heterogeneous disorder, and a
challenge to treat. In light of this heterogeneity, the most promising treatment approach should
be multimodal in nature (Taylor et al., 2004; Swanson et al., 2008). Pharmacological interventions
particularly with stimulants such as methylphenidate and amphetamine sulfate, as well as non-
s.
This document summarizes research on cognitive and behavioral effects in epilepsy. It finds that cognitive impairment is more common in epileptic patients compared to the general population, and the degree of impairment varies depending on the epilepsy syndrome. Behavioral changes are also more common in people with epilepsy, especially those with drug-resistant epilepsy or frequent seizures. For children, factors like epilepsy itself, epilepsy treatment, underlying structural brain abnormalities, and epilepsy syndromes can predict behavioral changes. The document reviews several studies on cognition and behavior in childhood epilepsy and factors linked to changes like structural brain abnormalities, progressive cognitive impairment, and effects of epilepsy treatment.
Epilepsy is a chronic neurological disorder which is caused by various factors which may vary according to the age of patients which results in asynchronization of neurons. Cognitive functional impairment is mostly seen in epileptic patients compared to the general population, and the degree of its impairment varies from one another according to the epilepsy syndrome. Behavioral changes are more seen in epileptic people and people with drug-resistant epilepsy, frequent seizures, and associated neurological or mental abnormalities. In children and adults, many data suggest a correlation between behavior/cognition and some other specific epilepsy syndromes. The major predictors of such behavioral changes in children with epilepsy are epilepsy itself, treatment, the underlying structural lesion, and epilepsy treatment.
This review article discusses cognition and behavioral effects in epilepsy. It notes that cognitive impairment and behavioral changes are commonly seen in epileptic patients compared to the general population. The degree of impairment varies depending on the epilepsy syndrome. In children, behavioral disorders like depression, anxiety and anger are more frequent in epileptic individuals. Several factors are linked to cognitive and behavioral changes in epilepsy patients, including structural brain abnormalities, progressive cognitive impairment from the epilepsy itself, and adverse effects of epilepsy treatment with some antiepileptic drugs. The major predictors of behavioral changes in children are the epilepsy, its treatment, any underlying structural brain lesions, and treatment effects.
This review article discusses cognition and behavioral effects in epilepsy. It finds that cognitive impairment and behavioral changes are more common in epileptic patients compared to the general population. The degree of impairment varies based on the epilepsy syndrome. In children, behavioral disorders like depression and anxiety are more frequent in epileptic children. Several factors are linked to cognitive and behavioral changes in epilepsy patients, including structural brain abnormalities, progressive cognitive impairment from the epilepsy itself, and adverse effects of epilepsy treatment with some antiepileptic drugs. Managing epilepsy and treating with appropriate medications can help reduce these symptoms.
Levetiracetam is a novel antiepileptic drug that has been approved for use in children as an add-on treatment for various seizure types. Two prospective studies found it effective at reducing partial seizure frequency in children, with over 40% of children experiencing a 50% or greater reduction in seizures. Additional open-label studies found levetiracetam reduced both partial and generalized seizure types in children, with 30-50% of children experiencing a 50% or greater reduction in total seizures. Levetiracetam was generally well-tolerated in pediatric studies, with sedation being the most commonly reported side effect.
This document summarizes information about refractory epilepsy. It begins by defining refractory epilepsy as persistent seizures under antiepileptic drug treatment. It then discusses predictive factors of refractory epilepsy like epileptic syndrome, response to previous drugs, age at onset, and structural brain abnormalities. The document outlines evaluation and management approaches including optimizing medical treatment, surgical options like resection or palliation procedures, and other therapies like the ketogenic diet.
Over the past few decades, the prognosis of neonatal seizures has experienced considerable enhancement due to the improvement in neonatal and infant care. The mortality rate of neonatal seizures has fallen from 40% to 20%, and the relationship between electro encephalogram (EEG) and prognosis has become quite clear. The underlying cause of seizures is a major determinant of the outcome of the disease. For example, patients with secondary seizures and hypoxic-ischemic encephalopathy have only 50% chance of normal development and total recovery, while newborns with secondary seizures and subarachnoid hemorrhage or better hypocalcemia have higher chances of recovery. Searches were conducted by two independent researchers in international (PubMed, Web of Science, Scopus, and Google Scholar) and national (SID and Magiran) databases for related studies from the inception of the databases to September 2017 (without time limitation) in English and Persian languages. It is possible to achieve accurate diagnosis through checking the history before birth and performing a thorough physical examination in some rare cases. Depending on the case, tests or additional actions can be done. EEG is the primary means for diagnosis and may exhibit paroxysmal activity in the difference between seizures or may produce electrographic seizures in cases where seizure is hidden or latent. One of the most important points in the treatment of neonatal seizures is the diagnosis of underlying cause (such as hypoglycemia, meningitis, drug deprivation, and trauma) because such diagnosis facilitates different approaches to control neonatal seizures. Most experts agree to control all clinical and electrographic seizures. Some others focus merely on clinical seizures. Most centers prefer the first approach. An important point before starting an anticonvulsant drug is to decide if the patient needs intravenous and luteinizing treatment with an initial bolus dose, or it can be easy to start treatment with a prescription for a long-acting medication based on the severity of seizure, duration, and frequency.
REVIEWpublished 24 June 2015doi 10.3389fnhum.2015.003.docxmalbert5
REVIEW
published: 24 June 2015
doi: 10.3389/fnhum.2015.00359
Pathophysiology of ADHD and
associated problems—starting points
for NF interventions?
Björn Albrecht*, Henrik Uebel-von Sandersleben, Holger Gevensleben and
Aribert Rothenberger
Department of Child and Adolescent Psychiatry, University Medical Center Göttingen, Göttingen, Germany
Edited by:
Martijn Arns,
Research Institute Brainclinics,
Netherlands
Reviewed by:
Roumen Kirov,
Institute of Neurobiology, Bulgarian
Academy of Sciences, Bulgaria
Leon Kenemans,
Utrecht University, Netherlands
*Correspondence:
Björn Albrecht,
Department of Child and Adolescent
Psychiatry, University Medical Center
Göttingen, von Siebold Straße 5,
37075 Göttingen, Germany
[email protected]
Received: 06 October 2014
Accepted: 02 June 2015
Published: 24 June 2015
Citation:
Albrecht B, Uebel-von Sandersleben
H, Gevensleben H and Rothenberger
A (2015) Pathophysiology of ADHD
and associated problems—starting
points for NF interventions?
Front. Hum. Neurosci. 9:359.
doi: 10.3389/fnhum.2015.00359
Attention deficit hyperactivity disorder (ADHD) is characterized by severe and
age-inappropriate levels of hyperactivity, impulsivity and inattention. ADHD is a
heterogeneous disorder, and the majority of patients show comorbid or associated
problems from other psychiatric disorders. Also, ADHD is associated with cognitive and
motivational problems as well as resting-state abnormalities, associated with impaired
brain activity in distinct neuronal networks. This needs to be considered in a multimodal
treatment, of which neurofeedback (NF) may be a promising component. During NF,
specific brain activity is fed-back using visual or auditory signals, allowing the participants
to gain control over these otherwise unaware neuronal processes. NF may be used
to directly improve underlying neuronal deficits, and/or to establish more general self-
regulatory skills that may be used to compensate behavioral difficulties. The current
manuscript describes pathophysiological characteristics of ADHD, heterogeneity of
ADHD subtypes and gender differences, as well as frequently associated behavioral
problems such as oppositional defiant/conduct or tic disorder. It is discussed how NF
may be helpful as a treatment approach within these contexts.
Keywords: Neurofeedback (NF), ADHD, ODD/CD, tic disorder, comorbidity, children, neurobiology
Introduction
Difficulties with Inattention or Hyperactivity and Impulsivity as the core symptoms of Attention
deficit Hyperactivity disorder (ADHD) are a frequent psychosocial burden. With an early onset
during childhood, ADHD is often persisting throughout life. It is a heterogeneous disorder, and a
challenge to treat. In light of this heterogeneity, the most promising treatment approach should
be multimodal in nature (Taylor et al., 2004; Swanson et al., 2008). Pharmacological interventions
particularly with stimulants such as methylphenidate and amphetamine sulfate, as well as non-
s.
This document summarizes research on cognitive and behavioral effects in epilepsy. It finds that cognitive impairment is more common in epileptic patients compared to the general population, and the degree of impairment varies depending on the epilepsy syndrome. Behavioral changes are also more common in people with epilepsy, especially those with drug-resistant epilepsy or frequent seizures. For children, factors like epilepsy itself, epilepsy treatment, underlying structural brain abnormalities, and epilepsy syndromes can predict behavioral changes. The document reviews several studies on cognition and behavior in childhood epilepsy and factors linked to changes like structural brain abnormalities, progressive cognitive impairment, and effects of epilepsy treatment.
Epilepsy is a chronic neurological disorder which is caused by various factors which may vary according to the age of patients which results in asynchronization of neurons. Cognitive functional impairment is mostly seen in epileptic patients compared to the general population, and the degree of its impairment varies from one another according to the epilepsy syndrome. Behavioral changes are more seen in epileptic people and people with drug-resistant epilepsy, frequent seizures, and associated neurological or mental abnormalities. In children and adults, many data suggest a correlation between behavior/cognition and some other specific epilepsy syndromes. The major predictors of such behavioral changes in children with epilepsy are epilepsy itself, treatment, the underlying structural lesion, and epilepsy treatment.
This review article discusses cognition and behavioral effects in epilepsy. It notes that cognitive impairment and behavioral changes are commonly seen in epileptic patients compared to the general population. The degree of impairment varies depending on the epilepsy syndrome. In children, behavioral disorders like depression, anxiety and anger are more frequent in epileptic individuals. Several factors are linked to cognitive and behavioral changes in epilepsy patients, including structural brain abnormalities, progressive cognitive impairment from the epilepsy itself, and adverse effects of epilepsy treatment with some antiepileptic drugs. The major predictors of behavioral changes in children are the epilepsy, its treatment, any underlying structural brain lesions, and treatment effects.
This review article discusses cognition and behavioral effects in epilepsy. It finds that cognitive impairment and behavioral changes are more common in epileptic patients compared to the general population. The degree of impairment varies based on the epilepsy syndrome. In children, behavioral disorders like depression and anxiety are more frequent in epileptic children. Several factors are linked to cognitive and behavioral changes in epilepsy patients, including structural brain abnormalities, progressive cognitive impairment from the epilepsy itself, and adverse effects of epilepsy treatment with some antiepileptic drugs. Managing epilepsy and treating with appropriate medications can help reduce these symptoms.
Levetiracetam is a novel antiepileptic drug that has been approved for use in children as an add-on treatment for various seizure types. Two prospective studies found it effective at reducing partial seizure frequency in children, with over 40% of children experiencing a 50% or greater reduction in seizures. Additional open-label studies found levetiracetam reduced both partial and generalized seizure types in children, with 30-50% of children experiencing a 50% or greater reduction in total seizures. Levetiracetam was generally well-tolerated in pediatric studies, with sedation being the most commonly reported side effect.
This document summarizes information about refractory epilepsy. It begins by defining refractory epilepsy as persistent seizures under antiepileptic drug treatment. It then discusses predictive factors of refractory epilepsy like epileptic syndrome, response to previous drugs, age at onset, and structural brain abnormalities. The document outlines evaluation and management approaches including optimizing medical treatment, surgical options like resection or palliation procedures, and other therapies like the ketogenic diet.
Over the past few decades, the prognosis of neonatal seizures has experienced considerable enhancement due to the improvement in neonatal and infant care. The mortality rate of neonatal seizures has fallen from 40% to 20%, and the relationship between electro encephalogram (EEG) and prognosis has become quite clear. The underlying cause of seizures is a major determinant of the outcome of the disease. For example, patients with secondary seizures and hypoxic-ischemic encephalopathy have only 50% chance of normal development and total recovery, while newborns with secondary seizures and subarachnoid hemorrhage or better hypocalcemia have higher chances of recovery. Searches were conducted by two independent researchers in international (PubMed, Web of Science, Scopus, and Google Scholar) and national (SID and Magiran) databases for related studies from the inception of the databases to September 2017 (without time limitation) in English and Persian languages. It is possible to achieve accurate diagnosis through checking the history before birth and performing a thorough physical examination in some rare cases. Depending on the case, tests or additional actions can be done. EEG is the primary means for diagnosis and may exhibit paroxysmal activity in the difference between seizures or may produce electrographic seizures in cases where seizure is hidden or latent. One of the most important points in the treatment of neonatal seizures is the diagnosis of underlying cause (such as hypoglycemia, meningitis, drug deprivation, and trauma) because such diagnosis facilitates different approaches to control neonatal seizures. Most experts agree to control all clinical and electrographic seizures. Some others focus merely on clinical seizures. Most centers prefer the first approach. An important point before starting an anticonvulsant drug is to decide if the patient needs intravenous and luteinizing treatment with an initial bolus dose, or it can be easy to start treatment with a prescription for a long-acting medication based on the severity of seizure, duration, and frequency.
This document provides a review of the diagnosis and treatment of neonatal seizures. It discusses several key points:
1) The prognosis for neonatal seizures has improved due to advances in neonatal care, with mortality falling from 40% to 20%. EEG is useful for diagnosis and prognosis.
2) The underlying cause of seizures is a major determinant of outcome, with hypoxic-ischemic encephalopathy associated with poorer outcomes than other causes like subarachnoid hemorrhage.
3) Diagnosis involves thorough physical exam, tests like bloodwork and lumbar puncture, and EEG to detect clinical and subclinical seizures. Treatment focuses on identifying and treating the underlying cause, with medications like lorazepam,
This document provides a review of the diagnosis and treatment of neonatal seizures. It discusses several key points:
1) The prognosis for neonatal seizures has improved due to advances in neonatal care, with mortality falling from 40% to 20%. EEG is useful for diagnosis and prognosis.
2) The underlying cause of seizures is a major determinant of outcome, with hypoxic-ischemic encephalopathy associated with poorer outcomes than other causes like subarachnoid hemorrhage.
3) Diagnosis involves thorough physical exam, tests like bloodwork and lumbar puncture, and EEG to detect clinical and subclinical seizures. Treatment focuses on identifying and treating the underlying cause, with medications like lorazepam,
This study compared the efficacy and safety of intravenous levetiracetam versus phenobarbitone in treating neonatal seizures. It found that levetiracetam was more effective in controlling seizures, with 86% of neonates becoming seizure-free within 24 hours compared to 62% for phenobarbitone. Levetiracetam also had a better safety profile, with no adverse events observed, while 10 neonates experienced hypotension, bradycardia or increased ventilation needs with phenobarbitone. The study concludes that levetiracetam achieves better seizure control than phenobarbitone with fewer adverse effects and could be a safer first-line treatment for neonatal seizures.
This document provides an overview of the neuropsychiatric aspects of epilepsy. It defines key terms like seizure and epilepsy and discusses classifications of seizures and epilepsies. It covers the prevalence, etiology, investigations, and various neuropsychiatric aspects of epilepsy like disorders related to seizure occurrence such as preictal, ictal, peri-ictal, and postictal. It also discusses management approaches aimed at adequate seizure control and patient safety.
Genetic epilepsy results from known or presumed genetic mutations where seizures are a core symptom. About 30% of epilepsies are genetic in origin. The term "genetic epilepsy" was recently introduced to replace "idiopathic epilepsy". Genetic epilepsies are diverse, with most underlying genes still unknown. They can be identified through family history patterns, clinical research in patient populations, or molecular genetics identifying single gene or copy number variants. The best known example is Dravet Syndrome, where over 80% of patients have mutations in the SCN1A gene affecting sodium channels. Genetic does not necessarily mean inherited, as de novo mutations can also cause genetic epilepsies.
Continuous Spike Web during Sleep - (CSWS)Sanjida Ahmed
Sami, a 6-year-old girl, was admitted with a 1.5 year history of recurrent seizures that had been progressively worsening. An EEG showed continuous spike wave discharges in her sleep. She was diagnosed with epilepsy with continuous spike wave during sleep (CSWS). Treatment with steroids improved her EEG findings. Her diagnosis and treatment for CSWS were then summarized.
Objective: To describe cognitive disorders in patients with epilepsy attending neurology consultations in the city of Ouagadougou. Methodology: This was a prospective cross-sectional multicenter study carried on patients with epilepsy during the period from 1erJanuary 2018 to 30 April 2019. All the patients were screened using mini-mental state examination (MMSE). Results: The study included 102 patients with a mean age of 33.28 ± 15.55 years. The sample was consisted of 54 (52.9%) men and 48 (47.1%) women. The majority of patients had secondary level (55.7 %). Generalized seizures were more common (74.5%). The most common causes of epilepsy was head trauma (24.5%). A great number of patients were treated by phenobarbital (49%). The overall mean MMSE score was 25.65 ± 5.07. The frequency of cognitive disorders was 61.8%, including cognitive impairment (25.5%), mild dementia (25.5%), moderate dementia (7.8%) and severe dementia (3%). The domains most affected were calculation and attention
deficit (48%) followed by memory disorders (27.5%) and copying (12.8%). Head trauma and phenobarbital were signifi cantly associated to cognitive. Cognitive disorders were less frequent in young adult aged of 26-35 years.
Prof. Dr. Vladimir Trajkovski - Health issues and health care in ASD Vladimir Trajkovski
Prof. Dr. Vladimir Trajkovski presented topic: Health issues and health care in persons with autism spectrum disorders at international autism conference held in Krakow September 27th, 2018.
The document summarizes a study investigating clinical and electroencephalography (EEG) features of patients with nonconvulsive status epilepticus (NCSE). The study reviewed 45 patients over 5 years. The most common etiologies were acute symptomatic (58%) and cerebrovascular disease (49%). EEG patterns were classified using the Salzburg Consensus Criteria, with 25 definite, 30 possible, and 6 no NCSE. In-hospital mortality was high at 33%. Prognostic factors associated with mortality included potentially fatal etiology, refractory NCSE, use of anesthetics, multiple EEG patterns, and nonreactive EEGs. The criteria had high diagnostic accuracy but did not affect prognosis.
Parkinson's disease is a brain disorder that progressively affects a person’s ability to control body movements, caused by a disorder of certain nerve cells in a part of the brain that produces dopamine, a chemical messenger the brain uses to help direct and control body movement.
Early diagnosis of Parkinson's disease gives you the best chance of a longer, healthier life. This presentation covers the information about biomarkers for Parkinson Diseases which include biological, physiological and imagine candidate / novel biomarkers.
Early signs and symptoms of childhood onset neuronal ceroid lipofuscinosis (NCL) subtypes were identified through a literature review. The most common age of onset is between two and five years. Early symptoms include neurological regression, speech delay, ataxia, and seizures. Facilitators of early diagnosis include parents identifying subtle symptoms and increased awareness among healthcare professionals, while lack of awareness and subtle initial symptoms can hinder diagnosis.
Dr. kristen park kcnq2 Cure summit parent track learn more at kcnq2cure.orgscottyandjim
1. The document discusses the classification and treatment of epilepsies, focusing on epileptic encephalopathies like KCNQ2E.
2. Epileptic encephalopathies are characterized by frequent seizures, abnormal EEG patterns, developmental impairment, and are often resistant to treatment.
3. Treatment aims to minimize seizures and side effects while optimizing quality of life, and may include medications, dietary therapies, devices, and early intervention.
- Epilepsy is the most common neurological disorder affecting children, with between 5-10% of children experiencing a seizure before age 20.
- Most children with epilepsy test within the average range on IQ tests and attend regular schools, but they are at higher risk for learning and behavioral challenges.
- Learning disabilities and conditions like ADHD are commonly overlooked co-morbid conditions for children with epilepsy. Thorough evaluation of language, memory, and executive functions is important for proper intervention.
Mini-mental state examination in patients with hepatic encephalopathy and liv...Enrique Moreno Gonzalez
Mini-Mental State Examination (MMSE) is one of the most commonly used methods in the assessment of cognitive mental status. MMSE has been used in hepatology but its usefulness in the evaluation of hepatic encephalopathy (HE) has never been properly assessed. The aim of the study was to investigate the value of MMSE in detection of HE in atients with cirrhosis.
Using the VEP for Better Patient Outcomes in Mild Traumatic Brain InjuryDiopsys, Inc.
An optimal VEP test protocol can differentiate objectively between visually normal patients and those with mild traumatic brain injury.
BY KENNETH J. CIUFFREDA, OD, PhD; NAVEEN YADAV, BSOptom, MS, PhD; AND DIANA P. LUDLAM, BS, COVT
This guideline reviews evidence and recommendations for the management of status epilepticus (SE) in adults. SE is defined as prolonged seizure activity that risks neuronal injury. The preferred treatment for generalized convulsive SE is intravenous lorazepam or diazepam followed by phenytoin. Refractory SE requires anaesthetic doses of medications. Initial therapy for complex partial SE follows generalized convulsive SE treatment. Subtle SE often requires intravenous anaesthesia. Evidence supports benzodiazepines as first-line treatment but second-line options are based on observational studies and expert opinion due to lack of high-quality evidence.
The document summarizes the process of presurgical evaluation for epilepsy patients. It discusses how modern imaging techniques like video EEG monitoring, high-resolution MRI, fMRI, PET and SPECT are used to localize the epileptogenic zone noninvasively in most patients. When noninvasive methods are insufficient, invasive EEG monitoring using subdural or depth electrodes may be used. The goal is to precisely identify the brain area responsible for seizure generation to allow its surgical resection, while avoiding damage to critical functions. A classical example where surgery is often curative is mesial temporal lobe epilepsy.
1179journal.publications.chestnet.org Th e PathophysSantosConleyha
The document discusses the pathophysiology of insomnia across multiple levels of analysis, with a focus on hyperarousal as a central theme. It summarizes current knowledge on insomnia's genetic, molecular, cellular, and neurological underpinnings. The document proposes a model integrating evidence that insomnia may involve heightened physiological, cognitive, and emotional arousal that interferes with disengagement from the environment and the ability to fall asleep. Understanding insomnia's pathophysiology could provide insights into how and why it develops and is maintained.
Cardiovascular, respiratory, and nervous systems neonatal pathology in premature babies leads to systemic and organ hypoxia, which is one of the main risk factors for premature retinopathy (PR) development. Among the certain neuron-specific proteins, the most studied and adequately characterizing the blood-brain barrier (BBB) proper membrane function is neuro-specific enolase (NSE), which is currently used to diagnose acute conditions characterized by cerebral ischemia and brain hypoxia, occurring with impaired BBB function. by D.I. Tashkhanova and M.Kh. Karimova 2020. The nse predictive value in pr development. International Journal on Integrated Education. 3, 11 (Nov. 2020), 5-7. DOI:https://doi.org/10.31149/ijie.v3i11.813. https://journals.researchparks.org/index.php/IJIE/article/view/813/779 https://journals.researchparks.org/index.php/IJIE/article/view/813
Walmart Business+ and Spark Good for Nonprofits.pdfTechSoup
"Learn about all the ways Walmart supports nonprofit organizations.
You will hear from Liz Willett, the Head of Nonprofits, and hear about what Walmart is doing to help nonprofits, including Walmart Business and Spark Good. Walmart Business+ is a new offer for nonprofits that offers discounts and also streamlines nonprofits order and expense tracking, saving time and money.
The webinar may also give some examples on how nonprofits can best leverage Walmart Business+.
The event will cover the following::
Walmart Business + (https://business.walmart.com/plus) is a new shopping experience for nonprofits, schools, and local business customers that connects an exclusive online shopping experience to stores. Benefits include free delivery and shipping, a 'Spend Analytics” feature, special discounts, deals and tax-exempt shopping.
Special TechSoup offer for a free 180 days membership, and up to $150 in discounts on eligible orders.
Spark Good (walmart.com/sparkgood) is a charitable platform that enables nonprofits to receive donations directly from customers and associates.
Answers about how you can do more with Walmart!"
How to Setup Warehouse & Location in Odoo 17 InventoryCeline George
In this slide, we'll explore how to set up warehouses and locations in Odoo 17 Inventory. This will help us manage our stock effectively, track inventory levels, and streamline warehouse operations.
This document provides a review of the diagnosis and treatment of neonatal seizures. It discusses several key points:
1) The prognosis for neonatal seizures has improved due to advances in neonatal care, with mortality falling from 40% to 20%. EEG is useful for diagnosis and prognosis.
2) The underlying cause of seizures is a major determinant of outcome, with hypoxic-ischemic encephalopathy associated with poorer outcomes than other causes like subarachnoid hemorrhage.
3) Diagnosis involves thorough physical exam, tests like bloodwork and lumbar puncture, and EEG to detect clinical and subclinical seizures. Treatment focuses on identifying and treating the underlying cause, with medications like lorazepam,
This document provides a review of the diagnosis and treatment of neonatal seizures. It discusses several key points:
1) The prognosis for neonatal seizures has improved due to advances in neonatal care, with mortality falling from 40% to 20%. EEG is useful for diagnosis and prognosis.
2) The underlying cause of seizures is a major determinant of outcome, with hypoxic-ischemic encephalopathy associated with poorer outcomes than other causes like subarachnoid hemorrhage.
3) Diagnosis involves thorough physical exam, tests like bloodwork and lumbar puncture, and EEG to detect clinical and subclinical seizures. Treatment focuses on identifying and treating the underlying cause, with medications like lorazepam,
This study compared the efficacy and safety of intravenous levetiracetam versus phenobarbitone in treating neonatal seizures. It found that levetiracetam was more effective in controlling seizures, with 86% of neonates becoming seizure-free within 24 hours compared to 62% for phenobarbitone. Levetiracetam also had a better safety profile, with no adverse events observed, while 10 neonates experienced hypotension, bradycardia or increased ventilation needs with phenobarbitone. The study concludes that levetiracetam achieves better seizure control than phenobarbitone with fewer adverse effects and could be a safer first-line treatment for neonatal seizures.
This document provides an overview of the neuropsychiatric aspects of epilepsy. It defines key terms like seizure and epilepsy and discusses classifications of seizures and epilepsies. It covers the prevalence, etiology, investigations, and various neuropsychiatric aspects of epilepsy like disorders related to seizure occurrence such as preictal, ictal, peri-ictal, and postictal. It also discusses management approaches aimed at adequate seizure control and patient safety.
Genetic epilepsy results from known or presumed genetic mutations where seizures are a core symptom. About 30% of epilepsies are genetic in origin. The term "genetic epilepsy" was recently introduced to replace "idiopathic epilepsy". Genetic epilepsies are diverse, with most underlying genes still unknown. They can be identified through family history patterns, clinical research in patient populations, or molecular genetics identifying single gene or copy number variants. The best known example is Dravet Syndrome, where over 80% of patients have mutations in the SCN1A gene affecting sodium channels. Genetic does not necessarily mean inherited, as de novo mutations can also cause genetic epilepsies.
Continuous Spike Web during Sleep - (CSWS)Sanjida Ahmed
Sami, a 6-year-old girl, was admitted with a 1.5 year history of recurrent seizures that had been progressively worsening. An EEG showed continuous spike wave discharges in her sleep. She was diagnosed with epilepsy with continuous spike wave during sleep (CSWS). Treatment with steroids improved her EEG findings. Her diagnosis and treatment for CSWS were then summarized.
Objective: To describe cognitive disorders in patients with epilepsy attending neurology consultations in the city of Ouagadougou. Methodology: This was a prospective cross-sectional multicenter study carried on patients with epilepsy during the period from 1erJanuary 2018 to 30 April 2019. All the patients were screened using mini-mental state examination (MMSE). Results: The study included 102 patients with a mean age of 33.28 ± 15.55 years. The sample was consisted of 54 (52.9%) men and 48 (47.1%) women. The majority of patients had secondary level (55.7 %). Generalized seizures were more common (74.5%). The most common causes of epilepsy was head trauma (24.5%). A great number of patients were treated by phenobarbital (49%). The overall mean MMSE score was 25.65 ± 5.07. The frequency of cognitive disorders was 61.8%, including cognitive impairment (25.5%), mild dementia (25.5%), moderate dementia (7.8%) and severe dementia (3%). The domains most affected were calculation and attention
deficit (48%) followed by memory disorders (27.5%) and copying (12.8%). Head trauma and phenobarbital were signifi cantly associated to cognitive. Cognitive disorders were less frequent in young adult aged of 26-35 years.
Prof. Dr. Vladimir Trajkovski - Health issues and health care in ASD Vladimir Trajkovski
Prof. Dr. Vladimir Trajkovski presented topic: Health issues and health care in persons with autism spectrum disorders at international autism conference held in Krakow September 27th, 2018.
The document summarizes a study investigating clinical and electroencephalography (EEG) features of patients with nonconvulsive status epilepticus (NCSE). The study reviewed 45 patients over 5 years. The most common etiologies were acute symptomatic (58%) and cerebrovascular disease (49%). EEG patterns were classified using the Salzburg Consensus Criteria, with 25 definite, 30 possible, and 6 no NCSE. In-hospital mortality was high at 33%. Prognostic factors associated with mortality included potentially fatal etiology, refractory NCSE, use of anesthetics, multiple EEG patterns, and nonreactive EEGs. The criteria had high diagnostic accuracy but did not affect prognosis.
Parkinson's disease is a brain disorder that progressively affects a person’s ability to control body movements, caused by a disorder of certain nerve cells in a part of the brain that produces dopamine, a chemical messenger the brain uses to help direct and control body movement.
Early diagnosis of Parkinson's disease gives you the best chance of a longer, healthier life. This presentation covers the information about biomarkers for Parkinson Diseases which include biological, physiological and imagine candidate / novel biomarkers.
Early signs and symptoms of childhood onset neuronal ceroid lipofuscinosis (NCL) subtypes were identified through a literature review. The most common age of onset is between two and five years. Early symptoms include neurological regression, speech delay, ataxia, and seizures. Facilitators of early diagnosis include parents identifying subtle symptoms and increased awareness among healthcare professionals, while lack of awareness and subtle initial symptoms can hinder diagnosis.
Dr. kristen park kcnq2 Cure summit parent track learn more at kcnq2cure.orgscottyandjim
1. The document discusses the classification and treatment of epilepsies, focusing on epileptic encephalopathies like KCNQ2E.
2. Epileptic encephalopathies are characterized by frequent seizures, abnormal EEG patterns, developmental impairment, and are often resistant to treatment.
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1. ORIGINAL RESEARCH
published: 06 May 2021
doi: 10.3389/fneur.2021.670958
Frontiers in Neurology | www.frontiersin.org 1 May 2021 | Volume 12 | Article 670958
Edited by:
Edoardo Ferlazzo,
University of Catanzaro, Italy
Reviewed by:
Pasquale Parisi,
Sapienza University of Rome, Italy
Marina Trivisano,
Bambino Gesù Children Hospital
(IRCCS), Italy
*Correspondence:
Fei Yin
yf2323@hotmail.com
†These authors have contributed
equally to this work
Specialty section:
This article was submitted to
Epilepsy,
a section of the journal
Frontiers in Neurology
Received: 22 February 2021
Accepted: 09 April 2021
Published: 06 May 2021
Citation:
Kessi M, Yan F, Pan L, Chen B,
Olatoutou E, Li D, He F, Rugambwa T,
Yang L, Peng J and Yin F (2021)
Treatment for the Benign Childhood
Epilepsy With Centrotemporal Spikes:
A Monocentric Study.
Front. Neurol. 12:670958.
doi: 10.3389/fneur.2021.670958
Treatment for the Benign Childhood
Epilepsy With Centrotemporal
Spikes: A Monocentric Study
Miriam Kessi1,2†
, Fangling Yan1,2†
, Langui Pan1,2†
, Baiyu Chen1,2
, Eleonore Olatoutou1,2
,
Dong Li1,2
, Fang He1,2
, Tibera Rugambwa3
, Lifen Yang1,2
, Jing Peng1,2
and Fei Yin1,2
*
1
Department of Pediatrics, Xiangya Hospital, Central South University, Changsha, China, 2
Hunan Intellectual and
Developmental Disabilities Research Center, Changsha, China, 3
Department of Oncology, Xiangya Hospital, Central South
University, Changsha, China
Background and Purpose: To date, there is no specific treatment guideline for
the benign childhood epilepsy with centrotemporal spikes (BECTS). Several countries
recommend levetiracetam, carbamazepine, sodium valproate, oxcarbazepine, and
lamotrigine as first-line drugs. Nevertheless, some of these drugs are associated with
cognitive decline. Available studies that investigated the efficacy of levetiracetam and
sodium valproate on BECTS involved small sample sizes. This study aimed to evaluate
the efficacy of levetiracetam and sodium valproate on cognition, and to investigate the
prognostic factors for BECTS as whole.
Methods: Clinical data and treatment status of all patients with BECTS at Xiangya
Hospital, Central South University followed from 2008 to 2013 were analyzed
retrospectively. Since electrical status epilepticus in sleep (ESES) has been confirmed
to play a role in cognitive deterioration, in order to evaluate the response to drugs and
their cognitive effects, we created two groups of patients according to the levels of spike
wave index (SWI): group 1; 0–50% SWI and group 2; >50% SWI at the last follow up.
Results: A total of 195 cases were enrolled: 49.7% received monotherapies, 24.1%
duotherapies and 27.2% polytherapies. Medications included; levetiracetam plus other
drug (s) (75.9%), levetiracetam alone (32.8%), sodium valproate plus other drug (s)
(31.3%), and sodium valproate alone (5.1%). After 2 years of treatment and follow up,
71% of the cases had a good seizure outcome, 15.9% had an improvement of SWI, and
91.7% had a normal DQ/IQ. Sodium valproate combined with levetiracetam, and sodium
valproate alone correlated with good improvement of SWI, whereas, focal spikes were
linked with poor improvement. For both groups (group 1 and group 2): monotherapy,
levetiracetam alone, and a normal DQ/IQ at seizure onset correlated with good cognitive
outcomes, in contrast, polytherapy, sodium valproate plus other drug (s), levetiracetam
plus sodium valproate, an initial SWI of ≥85%, and multifocal spikes were linked to
cognitive deterioration.
2. Kessi et al. Treatment for the BECTS
Conclusions: Monotherapy, particularly levetiracetam seems to be a good first-line
therapy which can help in normalizing the electroencephalograph and preventing
cognitive decline. Polytherapy, mostly the administration of sodium valproate seems to
relate with poor cognition, therefore, it is recommended to avoid it.
Keywords: benign childhood epilepsy with centrotemporal spikes, intellectual disability, cognition, levetiracetam,
sodium valporate, treatment
INTRODUCTION
Benign childhood epilepsy with centrotemporal spikes (BECTS)
forms a mild end of epilepsy aphasia spectrum (EAS), and
is characterized by normal cognitive function but some cases
can present with neuropsychological impairment, problems with
cognition and academics (1, 2). It affects 15–25% of children
below 15 years with a male predominance (2). BECTS can
evolve to an atypical form known as atypical benign partial
epilepsy of childhood (ABPE). ABPE is characterized by an
earlier age of onset of seizures which are more severe such as
atonic seizures, epileptic negative myoclonus, typical rolandic
seizures (1), diurnal seizures, persistent seizures or status
epilepticus, electrical status epilepticus in sleep (ESES) pattern
in an electroencephalograph (EEG) and neuropsychological
impairments (2). Neuropsychological impairments include
learning/cognitive, and behavioral problems (3–5) as well as
language deficits (6). Early age at epilepsy onset, presence of
new seizures, and an increased frequency of spikes in EEG
during sleep and daytime can predict evolvement of BECTS
to ABPE (2). Neurocognitive deficits have been correlated
with ESES as it is considered as a factor that negatively
affects the cognitive aspects precisely because it interferes with
the cognitive functions of sleep including memory-learning
process (2, 7).
In addition to ESES, some drugs can accelerate cognitive
decline. Most cases with BECTS have rare seizures which can
be controlled by one antiepileptic drug, however, there are some
cases who need more than one drug especially those with early
onset (below 4 years) (2). In one clinical trial, 10.6% of the
cases received multidrug therapy and the existence of bilateral
abnormalities in EEG was a predictor for the need of multidrug
therapies (8). Several countries recommend the utilization of
levetiracetam, carbamazepine, sodium valproate, oxcarbazepine,
and lamotrigine as first-line drugs (9). Levetiracetam is
more preferred due to its efficacy (in seizure control, EEG
normalization, cognition, speech, and behavior) and less side
effects (10–14). Moreover, as monotherapy, it has been shown
to be effective even in other idiopathic generalized epilepsy,
such as in the absence epilepsy and juvenile myoclonic epilepsy
(15). Among those preferred first-line drugs, exposure to high
dose of sodium valproate has been shown to associate with
poor cognition (16) and has many other adverse effects (17).
Early recognition of BECTS and mitigation of ESES with
therapies that do not interfere with cognition might lower
the rate of neuropsychological impairments. Currently, the
available studies that investigated the efficacy of levetiracetam
and sodium valproate on BECTS involved small sample sizes
(11–14, 18–24).
Thus, in order to prevent further cognitive deterioration for
the cases with BECTS, this study aimed to evaluate the effects of
levetiracetam, sodium valproate and other drugs on cognition for
195 cases followed from 2008 to 2013. Additionally, treatment
outcomes and prognostic factors will be discussed. To the best of
our knowledge, this study has the largest sample size on the aspect
of evaluating the efficacy of levetiracetam and sodium valproate
on cognition. This study will aid clinicians in management issues.
MATERIALS AND METHODS
Ethical Clearance
This study was reviewed and approved by the Institutional Ethics
Committee of Xiangya Hospital Central South University, thus
complying with the treaty agreed to in 1964 in Helsinki by
the World Medical Association on ethical principles of human
research for medical purposes and subsequent revisions of the
same (2013). Both informed and written consents were obtained
from the parents and/or legal guardians for study participation.
Study Design and Participants
BECTS cases attended at the department of pediatric neurology,
Xiangya Hospital, Central South University followed from 2008
to 2013 were recruited retrospectively. We included those who
met the clinical and electroencephalographic diagnostic criteria
for (1) BECTS, (2) ABPE, and (3) follow-up period of at least
2 years. The diagnosis of BECTS was done according to the
International League against Epilepsy (ILAE) criteria (25). The
exclusion criteria included cases with: (1) continuous spike-
and-wave during sleep (ECSWS), (2) Landau-Kleffner syndrome
(LKS), (3) focal epilepsies with secondary bilateral synchronies
not fulfilling the criteria for BECTS, and (4) with follow up
period of <2 years. A thorough history, physical and neurological
examinations, sleep and awake EEGs, and brain magnetic
resonance images (MRIs) were performed for all cases.
The spike wave index (SWI) percentage was obtained as the
total number of minutes of all spike and slow wave abnormalities
divided by the total number of minutes of non-rapid eye
movement sleep (NREM) and multiplied by 100. The follow-up
EEG examinations at 3 months, 6 months, 1 year and 2 years
of the treatment were evaluated. The ranges of SWI considered
were: typical ESES (85–100%) and atypical ESES (<85%).
The EEG response to treatment was summarized as follows:
(1) normalization of the record, (2) improvement of ≥50%
of SWI, (3) improvement of <50% of SWI, and (4) no
Frontiers in Neurology | www.frontiersin.org 2 May 2021 | Volume 12 | Article 670958
3. Kessi et al. Treatment for the BECTS
improvement. The clinical responsiveness to therapy (ies) was
categorized as the following: complete disappearance of clinical
manifestations observed at the time of diagnosis of equal or
more than 50%, and <50%. Follow-up EEGs under different
treatment regimens were evaluated along with cognitive changes.
Clinicians and parents/guardians provided feedback regarding
the cognitive deterioration or improvement. The judgement
about the improvement or deterioration of cognition was done by
senior neurologists. A relapse was defined as a reincrease of the
SWI to half or more of what it was before treatment. A remission
was considered for the cases without any relapse of seizures or
ESES pattern in an EEG for more than a year.
In order to summarize the treatment outcomes after 2 years
of follow-up, several terms were used. The term “good/positive
seizures outcome” was considered for the cases who achieved
seizure freedom plus those who had ≥50% seizure frequency
reductions compared with the baseline frequencies. In contrast
the term “poor/negative seizure outcome” was applied for
the cases without seizures improvement plus those with
<50% seizure frequency reductions. The term “good/positive
improvement of SWI” was used for the cases with normalization
of the EEG record, and those with improvement of ≥50% of SWI.
The term “poor/negative improvement of SWI” was applied to
all cases with improvement of <50% of SWI or no improvement
of SWI or an increased SWI. The term “good/normal cognition”
was considered for the cases with normal intelligence quotient
(IQ)/developmental quotient (DQ) (IQ ≥ 70 plus DQ ≥ 85) while
the term “poor/abnormal cognition” was used for the cases with
abnormal DQ/IQ (IQ < 70 plus DQ < 85).
Diagnosis and Management Protocol
at Our Center
All cases received clinical assessments, EEG and MRI
examinations. Antiepileptic drug particularly levetiracetam
was given first incase patient presented with both seizures
and ESES pattern. Benzodiazepines and/or steroids were given
as add-on therapy (ies) for the cases with ESES worsening.
However, this did not apply to all cases since patients were
attended by different neurologists. Priority of the drug (s)
prescribed changed with time based on the available updates
from the literature at the point of diagnosis.
The diagnosis of intellectual disability (cognitive deficit)
was done according to the diagnostic criteria of the DSM-5
for intellectual disabilities (Diagnostic and Statistical Manual
of Mental Disorders, Fifth Edition, American Psychiatric
Association, 2013). Standardized age-related rating scales,
clinical interview and observations were used for the assessment
of the adaptive functioning. But the diagnosis was often
made based on clinical judgment, rather than on formal
standardized assessments, especially for young patients (26).
Standardized age-related rating scales that were used include:
Gesell Developmental Schedules for patients younger than 2–4
years, Wechsler Preschool and Primary Scale of Intelligence-
Fourth Edition (WPPSI-IV) for patients aged between 4 and
6 years, and Wechsler Intelligence Scale for Children-Fourth
Edition (WISC-IV) for patients who were ≥6 years old. More
details regarding assessment of intelligence can be found in our
previous studies (27, 28).
Clinical Data Collection and Review
Demographic data and clinical information such as sex, the age
of onset of seizures and ESES, pre-natal, natal and post-natal
histories, etiology, neurodevelopment, behavior, history of febrile
seizures, family history of epilepsy, seizure semiology, frequency
of seizures, the DQ/IQ at the diagnosis, the baseline SWI, and the
therapy (ies) used were extracted from the hospital database. In
addition, information regarding seizure frequency, SWI, IQ/DQ,
cognitive status, behavioral changes, treatments and outcomes
were collected at 3 months, 6 months, 1 year and 2 years.
Therefore, all cases received at least 4 EEG examinations.
Individuals with insufficient medical records or lacked
baseline assessments were excluded in this study. All data were
reviewed by two neurologists. Furthermore, at least one neuro-
radiologist reviewed the brain images.
Grouping of the Patients
Since ESES has been confirmed to play a role in cognitive
deterioration, in order to evaluate the response to drugs and their
cognitive effects, we created two groups of patients according to
the levels of SWI. Group 1 consisted of the cases with a record
of 0–50% SWI at the last follow up. Group 2 consisted of the
cases with a record of >50% SWI at the last follow up. We
then investigated the relationship between the effects of drugs on
cognition for each group.
Statistical Analysis
All analysis were carried out via IBM SPSS Statistics 22.0 software
(IBM, Armonk, NY, USA). We excluded the missing values in
data analysis. Categorical data were summarized in the form of
frequencies and proportions, and analyzed with the Chi-square
test or Fisher’s exact test where applicable. P-value of ≤ 0.05 was
considered statistically significant.
RESULTS
Demographic Characteristics of the Cohort
A total of 195 cases met the inclusion criteria. Males accounted
for 50.8% (99/195) of the cases. The mean age of seizure onset
was 6.50 ± 2.28 SD years (range = 0.17–12.83) while for ESES
was 7.34 ± 2.39 years (range, 2–16). Impaired motor skills were
observed in 1 (0.5%) case, abnormal behavior in 3 (1.5%) cases,
impaired memory in 11(5.6%) cases, language problems in 4
(2.1%) cases, learning problems in 16 (8.2%) cases, and social
problems in 1 (0.5%) case. Of the 181 cases with information
regarding the initial DQ/IQ prior to treatment, 15 (8.3%) had
abnormal findings (Supplementary Table 1).
Seizure Semiology and Spike Wave
Characteristics
Seizure semiologies included partial motor seizures (n = 18,
9.2%), tonic-clonic seizures (n = 85, 43.6%), complex partial
seizures (n = 84, 43.1%), epileptic falls (n = 4, 2.1%), absence
seizures (n = 4, 2.1%), and febrile seizures (n = 7, 3.6%). Of
Frontiers in Neurology | www.frontiersin.org 3 May 2021 | Volume 12 | Article 670958
4. Kessi et al. Treatment for the BECTS
the 185 cases with information regarding the initial SWI, 19
(10.3%) had ≥85%, and the remained (n = 166, 89.7%) had
<85%. For the 193 cases with details about epileptic discharges,
findings were as follows; focal discharges were observed in 108
(56%) cases, multifocal discharges in 18 (9.3%), localized spikes
in 161 (83.4%), and generalized spikes in 25 (13%). Out of the 194
cases with recorded origin of spikes, rolandic accounted for 138
(71.1%) cases, bilateral rolandic origin was noticed in 87 (44.8%),
unilateral rolandic in 51 (26.3%), right rolandic in 26 (13.4%) and
left rolandic in 25 (12.9%) (Supplementary Table 1).
Treatment Strategies
Of the total number of patients, 97 (49.7%) received
monotherapies, 47 (24.1%) duotherapies and 53 (27.2%)
polytherapies (Figure 1). The therapies used were; levetiracetam
plus other drug (s) (n = 148, 75.9%), levetiracetam alone (n =
64, 32.8%), sodium valproate plus other drug (s) (n = 61, 31.3%),
sodium valproate alone (n = 10, 5.1%), oxcarbazepine alone
(n = 14, 7.2%), topiramate plus other drug (s) (n = 7, 3.56%),
zonisamide plus other drug (s) (n = 1, 0.5%), phenobarbital plus
other drug (s) (n = 1, 0.5%), nitrazepam plus other drug (s)
(n = 16, 8.2%), nitrazepam plus other drug (s) (n = 12, 6.2%),
levetiracetam plus oxcarbazepine (n = 25, 12.8%), levetiracetam
plus nitrazepam (n = 40, 20.5%), levetiracetam plus sodium
valproate (n = 41, 21%), antiepileptic drugs plus benzodiazepines
(n = 56, 28.7%), and antiepileptic drugs plus steroids (n = 24,
12.3%) (Figure 2).
Outcome After 2 Years of Treatment and
Follow Up
One hundred and eight six cases had information regarding
seizures outcomes after 2 years of follow up; 116 (62.4%) cases
became seizure free, 54 (29%) cases had ≥50% seizure frequency
reductions compared with the baseline frequencies, and 28
(15.1%) cases had <50% seizure frequency reductions compared
with the baseline frequencies or remained with the same
FIGURE 1 | A summary of number of the therapies used.
frequency. Overall, 132 (71%) cases had good seizure outcomes
(seizure free and ≥50% seizure frequency reductions compared
with the baseline frequencies). Of the 182 cases with information
regarding the final SWI, 21 (11.5%) had normalized EEGs, 82
(45.1%) had no EEG improvement or became worse, and 20
(11%) had increased SWIs. Overall, 29 (15.9%) cases had positive
improvement of SWIs (normalized EEGs plus improvement of
≥50% of SWI). Of the 181 cases with information regarding the
final DQ/IQ, 166 (91.7%) had normal DQ/IQ while 15 (8.3%) had
abnormal DQ/IQ (Supplementary Table 1). Of those 15 cases.
Five had normal baseline DQ/IQ of whom received sodium
valproate plus oxcarbazepine (n = 1), levetiracetam only (n =
1), levetiracetam plus oxcarbazepine plus nitrazepam (n = 1),
sodium valproate plus levetiracetam plus oxcarbazepine plus
carbamazepine (n = 1), and sodium valproate plus levetiracetam
plus nitrazepam plus lamotrigine (n = 1). At the last follow up,
61 cases had seizure remission, and 16 cases had EEG remission.
The mean age of seizure remission was 11.28 ± 1.3 years (range,
10–14.83) while for ESES was 12.12 ± 2 years (range, 10–16).
Determinants of Positive Seizure Outcome
There was no factor that showed correlation with good seizure
outcome. However, sodium valproate (P = 0.066), epileptic falls
(P = 0.074), speech delay (P = 0.074), and multifocal spikes (P =
0.090) showed non-statistically significant association with poor
seizure outcome (Supplementary Table 2).
Determinants of Positive Improvement of
Spike Wave Index
Levetiracetam plus sodium valproate (P = 0.012), and sodium
valproate alone (P = 0.030) showed correlation with positive
improvement of SWI. Whereas, focal spikes (P = 0.025) and
localized spikes (P = 0.031) were linked with poor improvement
of SWI (Supplementary Table 3).
Determinants of Good Cognitive Outcome
After 2 Years of Treatment and Follow Up
Group 1
For the 83 cases with recorded 0–50% SWI at the last follow up,
normal DQ/IQ at seizure onset (P = 0.000) showed statistically
significant association with good cognitive outcome. Whereas,
the utilization of sodium valproate plus other drug (s) (P = 0.027)
and levetiracetam plus sodium valproate (P = 0.056) showed
an association with poor cognition (Supplementary Table 4).
Besides, high proportion of cases with good cognition was
observed for the cases that received monotherapies in contrast
to those who received duotherapies or polytherapies. Notably,
all cases that received levetiracetam alone (n = 33) had good
cognitive outcome (Figure 3).
Group 2
For the 92 cases with recorded >50% SWI at the last follow
up, normal DQ/IQ at seizure onset (P = 0.000), and ≥50%
reduction of seizure frequency (P = 0.013) showed statistically
significant association with good cognitive outcome. Whereas,
initial SWI of ≥85% (P = 0.006), usage of sodium valproate
plus other drug (s) (P = 0.032), utilization of levetiracetam
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5. Kessi et al. Treatment for the BECTS
FIGURE 2 | An overview of the specific drugs utilized in 195 cases. LEV, levetiracetam; VPA, sodium valproate; TPM, topiramate; ZNS, zonisamide; PHB,
phenobarbital; NZP, nitrazepam; LTG, lamotrigine; OXC, oxcarbazepine.
FIGURE 3 | Summary of the therapies used and their effects on cognition after 2 years of treatment for the cases with 0–50% SWI at the last follow up. LEV,
levetiracetam; VPA, sodium valproate.
plus sodium valproate (P = 0.055), and multifocal spikes
(P = 0.096) showed correlated with poor cognitive outcome
(Supplementary Table 5). Strikingly, high proportion of the
cases with poor cognitive outcome was observed for those who
received polytherapies (Figure 4).
DISCUSSION
In this study, the most common associated symptoms included
learning problems, impaired memory and language problems.
Abnormal baseline DQ/IQ prior to treatment accounted for 8.3%
of the cases. Cases presented with variable seizure semiologies,
and the commonest subtype was tonic-clonic. Approximately
90% of the cases had atypical ESES (<85% SWI). Almost
3/4 of the cases had spikes concentrated on rolandic region.
Seventy one percent of the cases had good seizure outcome,
and 15.9% had positive improvement of SWI. Similar to the
baseline DQ/IQ prior to treatment, 8.3% of the cases had
abnormal DQ/IQ after 2 years of treatment: 5 cases had normal
findings before but transformed to abnormal after 2 years of
treatment/follow up. The remained 10 cases had abnormal
DQ/IQ from the beginning. Most cases received monotherapies,
and the commonest prescribed drug was levetiracetam. The
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6. Kessi et al. Treatment for the BECTS
FIGURE 4 | Summary of the therapies used and their effects on cognition after 2 years of treatment for the cases with >50% SWI at the last follow up. LEV,
levetiracetam; VPA, sodium valproate.
usage of levetiracetam plus sodium valproate as well as sodium
valproate alone showed correlation with positive improvement
of SWI, whereas, focal spikes and localized spikes were linked
with negative improvement of SWI. For both groups (group
1 and group 2), monotherapy, the utilization of levetiracetam
alone, and normal DQ/IQ at seizure onset seemed to relate
with good cognitive outcome, whereas, polytherapy, utilization of
sodium valproate plus other drug (s), levetiracetam plus sodium
valproate, initial SWI of ≥85%, and the existence of multifocal
spikes were linked to cognitive deterioration.
Most cases received monotherapies and polytherapies. The
most commonly used drugs were levetiracetam alone or
in combination with other drugs such as oxcarbazepine,
sodium valproate and nitrazepam. Other countries recommend
levetiracetam, carbamazepine, sodium valporate, oxcarbazepine,
and lamotrigine as first-line drugs (9). Similar to our findings,
levetiracetam is more preferred due to its efficacy (in seizure
control, EEG normalization, cognition, speech, and behavior)
and less side effects (10–14). In this study, levetiracetam plus
sodium valproate showed statistically significant association with
reduction of SWI. In comparison with carbamazepine and
sodium valproate, levetiracetam was superior in suppressing
rolandic discharges, however, the effects of those three drugs
in controlling seizures were the same according to one
study (29). A randomized controlled trial revealed that
both levetiracetam and sulthiame have beneficial effects on
EEG normalization (23). Besides, our study showed that the
usage of sodium valproate alone correlates with poor seizure
control. Nevertheless, one study showed sodium valproate and
levetiracetam monotherapies are equally effective in controlling
seizures, and sodium valproate was better than levetiracetam in
normalizing EEG which is similar to our study (21).
Moreover, our study has shown that the utilization of
the levetiracetam alone relates with good cognitive outcome
which is similar to one study (18), however, it associates with
poor cognitive outcome when administered along with sodium
valproate. Exposure to high dose of sodium valproate has been
shown to relate with poor cognition (16), and has many other
adverse effects (17). Thus, based on findings from our study
plus previous studies, we recommend levetiracetam as first-line
therapy, and avoidance of sodium valproate whenever possible
to prevent cognitive decline. Overall, 71% cases had good seizure
outcome after 2 years of the treatment. Likewise, 88.3% of the
60 Greek cases became seizure free by 1 or 2 years after seizure
onset (30). In another study, 29 (69%) cases continued to have
seizure after 2 years of receiving antiepileptic drugs (31). Notably,
it is difficult to conclude whether seizure control was related to
antiepileptic drugs or to natural history of the disease since this
condition tend to remit at puberty.
In addition to side effects of drugs, ESES is considered as
a factor that negatively impacts the cognitive aspects precisely
because it interferes with the cognitive functions of sleep
including memory-learning process (7). Even after dividing our
cases in two groups based on final SWI, monotherapies especially
levetiracetam and normal DQ/IQ at seizure onset seemed to
relate with good cognitive outcome. Therefore, it seems like
cases with normal DQ/IQ at seizure onset are more likely to
remain without cognitive problems. However, few cases can
end up with abnormal DQ/IQ after treatment as shown by
this study. Polytherapies, utilization of sodium valproate plus
other drug (s), levetiracetam plus sodium valproate, initial SWI
of ≥85%, and the existence of multifocal spikes correlated
with poor cognitive outcome. Topiramate (32), zonisamide (33),
and phenobarbital (34) have negative side effects on cognitive
function, nevertheless, they did not show any association with
cognitive decline in our study. Thus, our study suggests that
polytherapies, especially inclusion of sodium valproate should
be avoided whenever possible and drugs that mitigate ESES
should be encouraged more. Functional MRI study indicated
that changes of functional brain network caused by the frequent
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7. Kessi et al. Treatment for the BECTS
discharges during slow wave sleep are responsible for cognitive
deficits in patients with BECTS (35). Thus, initial SWI of
≥85% observed in our cases played a major role too in
cognitive deterioration.
Strikingly, one fourth of our cases received polytherapies.
About 10.6% of the cases in another Chinese study used
multidrug therapies (8). Some cases with BECTS can have
uncontrolled seizures, and some of them can progress to epileptic
encephalopathy (8), therefore, there is a possibility that some
of our cases received polytherapies due to inability to control
seizures and/or worsening of EEG while others due to poor
drug compliance.
CONCLUSIONS
Monotherapy, especially levetiracetam seems to be a good
first-line therapy which can help in normalizing the EEG
and preventing cognitive decline. Polytherapy, particularly the
administration of sodium valproate seems to relate with poor
cognition, therefore, it is recommended to avoid it.
LIMITATIONS
Despite the fact that our study has some strengths, it has some
limitations too. It was retrospective single-center thus prone
to bias. The choices of drugs were not uniform for all cases,
and they changed according to the clinical observation and
updates from the literature. All patients received from 1 to
3 drugs which is quite unusual. It was difficult to comment
much on why many cases used polytherapies due to the nature
of the study. Noteworthy, the efficacy of the therapies on
epilepsy should be interpreted with cautions because seizures
could disappear due to natural history of the disease and not
due to treatment. Future prospective multicenter studies can
evaluate the efficacy of levetiracetam in normalizing the EEG and
preventing cognitive decline.
DATA AVAILABILITY STATEMENT
The original contributions generated for this study are included
in the article/Supplementary Material, further inquiries can be
directed to the corresponding author/s.
ETHICS STATEMENT
The studies involving human participants were reviewed and
approved by the Institutional Ethics Committee of Xiangya
Hospital, Central South University. Written informed consent to
participate in this study was provided by the participants’ legal
guardian/next of kin.
AUTHOR CONTRIBUTIONS
MK, FYa, and LP are the first co-authors who collected and
analyzed data, drafted, and wrote the manuscript. BC, EO,
DL, and TR assisted in data collection, analysis as well as in
preparation of tables and figures. FH, LY, JP, and FYi designed the
study, revised the manuscript, and supervised each step involved
in the preparation of the manuscript. All co-authors have read
and agreed to the content of the manuscript.
FUNDING
We are grateful for the support we received from the National
Key Research and Development Program of China (No.
2016YFC1306202) and the National Natural Science Foundation
of China (No. 81771408).
SUPPLEMENTARY MATERIAL
The Supplementary Material for this article can be found
online at: https://www.frontiersin.org/articles/10.3389/fneur.
2021.670958/full#supplementary-material
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