This document summarizes a study presented at the American Public Health Association Annual Meeting on using state legislation to decrease obesity by increasing access to healthy foods. The study analyzed laws in the National Cancer Institute's State Cancer Legislative Database related to reimbursable school meals. It found that some states mandate school participation in federal meal programs, while others require school breakfast programs in high-poverty schools. However, the database does not include all state-level regulations and policies related to food access and obesity prevention.
En la unidad curricular Arquitectura y Patrimonio el estudiante identificara y reconocerá el patrimonio histórico del estado. Así mismo,
comprenderá la utilidad de las normativas de protección y preservación para desarrollar actitudes de defensa de la identidad nacional, la
memoria histórica de los pueblos y el patrimonio cultural, con el objeto de profundizar el adecuado concepto de manejo, preservación y
promoción de las edificaciones y sitios de interés patrimonial
How to tell an engaging and concise business storyStuart Collins
Often, presenters arrive at their conference or the rehearsal with an intention of what they want to communicate in mind. And it's great stuff! However, their talking points and visuals often obfuscate their intention. Have you ever been Powerpointed to death?
I've worked my company's employees and our customer presenters to pull out the intention of the speaker and turn busy slides and speaking tangents into a clear and powerful talk.
Given how important speaking engagements are to our goals, I'd like to offer one of the fundamental structures for telling an engaging and concise business story. This is the 4-point story. Use a 4-point story to establish the main points of what you wish to say. Pretty soon you can deliver a coherent and powerful talk that fulfills on what you set out to communicate.
I initially used these slides in a 60min workshop with local business owners in San Leandro, CA in 2016.
INDIAN ECONOMY LOOKING FOR DIRECTION FOR INDIA TO SHINE AGAINNeha Sharma
The Indian economy is in the threshold of a big leap towards India shining once again, but the main stumbling block being a sense of confusion about government policies, scarcity of low cost adequate money for funding further investments and most importantly India Inc. awaiting for specific policy decisions and creative actions in the areas which has been adversely impacted due to lack of policy initiative.
COMPANIES ACT, 2013 - CORPORATE GOVERNANCE IN NEW DIRECTIONSNeha Sharma
The Government of India has already notified 98 sections of the new Companies Act and has also announced draft rules in 1st phase as well as in 2nd phase on most of the chapters of Companies Act, 2013. It may be an interesting debate to examine certain issues having wider implications.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
En la unidad curricular Arquitectura y Patrimonio el estudiante identificara y reconocerá el patrimonio histórico del estado. Así mismo,
comprenderá la utilidad de las normativas de protección y preservación para desarrollar actitudes de defensa de la identidad nacional, la
memoria histórica de los pueblos y el patrimonio cultural, con el objeto de profundizar el adecuado concepto de manejo, preservación y
promoción de las edificaciones y sitios de interés patrimonial
How to tell an engaging and concise business storyStuart Collins
Often, presenters arrive at their conference or the rehearsal with an intention of what they want to communicate in mind. And it's great stuff! However, their talking points and visuals often obfuscate their intention. Have you ever been Powerpointed to death?
I've worked my company's employees and our customer presenters to pull out the intention of the speaker and turn busy slides and speaking tangents into a clear and powerful talk.
Given how important speaking engagements are to our goals, I'd like to offer one of the fundamental structures for telling an engaging and concise business story. This is the 4-point story. Use a 4-point story to establish the main points of what you wish to say. Pretty soon you can deliver a coherent and powerful talk that fulfills on what you set out to communicate.
I initially used these slides in a 60min workshop with local business owners in San Leandro, CA in 2016.
INDIAN ECONOMY LOOKING FOR DIRECTION FOR INDIA TO SHINE AGAINNeha Sharma
The Indian economy is in the threshold of a big leap towards India shining once again, but the main stumbling block being a sense of confusion about government policies, scarcity of low cost adequate money for funding further investments and most importantly India Inc. awaiting for specific policy decisions and creative actions in the areas which has been adversely impacted due to lack of policy initiative.
COMPANIES ACT, 2013 - CORPORATE GOVERNANCE IN NEW DIRECTIONSNeha Sharma
The Government of India has already notified 98 sections of the new Companies Act and has also announced draft rules in 1st phase as well as in 2nd phase on most of the chapters of Companies Act, 2013. It may be an interesting debate to examine certain issues having wider implications.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Best Ayurvedic medicine for Gas and IndigestionSwastikAyurveda
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
1. National Cancer Institute’s State Cancer Legislative Database (SCLD):
Decreasing obesity and promoting healthy communities by increasing
access to healthy foods through state food policy
Jamie Weinstein, M.P.H.1, Jennifer Noll Folliard, R.D., M.P.H.1, Monica Holloway1, Shereitte C. Stokes IV, Ph.D., M.P.H.1, Regina el Arculli, M.A.2
Presented at the American Public Health Association Annual Meeting Washington, DC November 1, 2011
1
The MayaTech Corporation 2National Cancer Institute
Methods and Limitations States’ Efforts to Increase Access to
Community Demographic of Farmers' Markets: Community Demographic of Farmers' Markets: Community Demographic of Farmers' Markets:
Reimbursable Meals: Laws Covered in the SCLD Education, California Poverty, California Race, California
Approach: The SCLD Program utilizes: (1) a standard approach to identifying and abstracting relevant state
legislation and adopted resolutions; (2) data dictionary and hierarchical keyword system; (3) quality control Percent Less Than a
procedures; and (4) multiple data output formats. • Mandatory includes laws addressing the requirement that schools serve reimbursable meals. 4-Year College Degree
(Age 25-64) Percent Below Poverty Level Percent of Minority Population
by Census Tract by Census Tract by Census Tract
Limitations: The SCLD does not contain state-level regulations; executive orders; measures implemented by - States that mandate school participation in a federal reimbursable meal program, such as Arizona 0.0 - 18.3 0.0 - 13.0 0.0 - 19.4
counties, cities, or other localities; opinions of Attorneys General; or data addressing the implementation of (Ariz. Rev. Stat. § 15-242), OR 18.4 - 26.4 13.1 - 23.0 19.5 - 33.8
26.5 - 33.8 23.1 - 34.0 33.9 - 49.2
state laws. Although coverage of Medicaid and Medicare law is not comprehensive, some SCLD records include 33.9 - 42.0 34.1 - 49.0
- Virginia, in which school boards must establish school breakfast programs in public schools in which Sacramento 42.0 - 100.0 Sacramento 49.1 - 100.0 Sacramento
49.3 - 67.0
these data. 67.1 - 100.0
25% or more of enrolled school-age children were eligible to receive free or reduced-price
meals in the federally funded lunch program during the previous school year. (Va. Code Ann. § 22.1-207.3) Stockton Stockton Stockton
San Francisco San Francisco
Background
San Francisco
• Reimbursable Meals Expansion includes laws addressing the expansion of the NSLP, NSBP or Snack Programs by: Oakland Oakland Oakland
Fresno Fresno Fresno
1. increasing state funds or adding new components to the programs; or 2. increasing access to and
San Jose San Jose San Jose
• Excess body weight has been linked to chronic diseases including certain cancers. implementation of the program(s).
• The International Agency for Research on Cancer estimates that obesity and physical inactivity may account for - In Washington, to the extent funds are appropriated, the Superintendent may award grants to school
25 to 30% of several major cancers (Vainio and Bianchini, 2002). Studies estimate that 3.2% of all new cancers districts to: (1) increase participation in school breakfast and lunch programs, (2) improve program
Farmers' Markets Farmers' Markets Farmers' Markets
are linked to obesity (Polednak, 2003) and 14% of deaths from cancer in men and 20% of deaths in women quality, and (3) improve the equipment and facilities used in the programs. WIC/SNAP Accepted WIC/SNAP Accepted
Los Angeles Los Angeles WIC/SNAP Accepted Los Angeles
are due to overweight and obesity (Calle, et al., 2003). Also contingent upon appropriation, the Superintendent must increase state support for school Non WIC/SNAP Accepted Non WIC/SNAP Accepted Non WIC/SNAP Accepted
Santa Ana Santa Ana Santa Ana
breakfasts and lunches. (Wash. Rev. Code Ann. §§ 28A.235.140 and 28A.235.150 to 28A.235.160)
• The problem is exacerbated in underserved populations (Ward et al. 2004, Haynes and Smedley, 1999). Anaheim Anaheim Anaheim
Long Beach Long Beach Long Beach
- The obesity rate for African Americans exceeds 40% in 15 states compared to the rate for Whites, San Diego San Diego San Diego
which exceeds 30% in only four states. State Laws Mandating Reimbursable Meals and
- Individuals who have not completed high school have higher rates of obesity compared to only one-fifth Addressing Reimbursable Meals Expansion
of college graduates. Community Demographic of Farmers' Markets: Community Demographic of Farmers' Markets: Community Demographic of Farmers' Markets:
(Enacted as of June 30, 2011) Education, District of Columbia Poverty, District of Columbia Race, District of Columbia
- Lower income earners have higher obesity rates than those at the highest income levels. NH
WA VT
Centers for Disease Control and Prevention. U.S. Obesity Trends. Trends by State 1985-2010. Available at: www.cdc.gov/obesity/data/trends.html.
ME
Federal Efforts to Address Obesity Prevention MA
by Decreasing Food Disparities MI
PA NJ
RI
OH
IL IN
CA CO
• School Reimbursable Meals – National School Lunch Program (NSLP), National School Breakfast WV VA MD
KS
MO
Program (NSBP), Summer Feeding Program (SFP), After-School Snack Program DC
NC
- Children from families with incomes at or below 130% of the poverty level are eligible for free meals. AZ
NM AR SC
Those with incomes between 130% and 185% of the poverty level are eligible for reduced price meals,
GA Percent Less Than a
for which students can be charged no more than 40 cents. 4-Year College Degree
TX LA (Age 25-64) Percent Below Poverty Level Percent of Minority Population
by Census Tract by Census Tract by Census Tract
• Senior Farmers' Market Nutrition Program (SFMNP) 0.0 - 22.6 0.0 - 10.1 0.0 - 20.5
22.7 - 44.3 10.2 - 22.2 20.6 - 42.9
- Provides low-income seniors with coupons that can be exchanged for fruits, vegetables, herbs and honey Farmers Markets Farmers' Markets
43.0 - 74.9
Farmers' Markets
44.4 - 63.9 22.3 - 34.7
at farmers' markets, roadside stands and community supported agriculture (CSA) programs, and promotes 64.0 - 79.3
WIC/SNAP Accepted 34.8 - 54.5
WIC/SNAP Accepted
75.0 - 91.0 WIC/SNAP Accepted
Non WIC/SNAP Accepted Non WIC/SNAP Accepted Non WIC/SNAP Accepted
the use and expansion of farmers' markets, roadside stands, and CSA programs throughout the country. 79.3 - 100 54.6 - 97.0 91.1 - 100.0
Laws Addressing Reimbursable Laws Mandating State Laws Mandating State Reimbursable Meals and
• WIC Farmers' Market Nutrition Program (FMNP) Meals Expansion (n=5) Reimbursable Meals (n=13) Addressing Reimbursable Expansion (n=10)
- Provides locally grown fruits and vegetables through farmers' markets to WIC participants, and expands the
awareness and use of farmers' markets. States’ Efforts to Increase Access to Healthy Foods: States with Food Environment Laws Addressing Health Disparities The Database
• Supplemental Nutrition Assistance Program (SNAP) Laws Covered in the SCLD (Enacted as of June 30, 2011)
- Helps low-income households put food on the table by providing electronic benefits that are redeemed for Since 1989, the NCI SCLD Program has monitored laws and resolutions covering numerous cancer-related topics.
Number of Laws As of June 30, 2011, the database contained more than 8,000 records divided between general legislation and
food at authorized stores.
• Farmers’ Markets: Laws addressing any public market where farmers or vendors sell their goods directly to the year-end status. General legislation records are abstracts of individual legislative measures (bills, resolutions, and
public consumer. 5
• Let’s Move! ballot measures); year-end status records incorporate a stream of codified legislation related to a particular topic.
- The White House initiative is focused on five pillars: • Demonstration Program: Laws addressing food environment programs of a specific duration that are planned The SCLD Program added obesity prevention as a topic area in July 2010, with a baseline of state laws enacted as
1. Creating a healthy start for children; 2. Empowering parents and caregivers; 3. Providing healthy as a test or a trial in order to assess feasibility, effectiveness, and/or efficacy (e.g., pilot program). of December 31, 2009.
food in schools; 4. Improving access to healthy & affordable foods; and 5. Increasing physical activity
• Access to Healthy Foods: Laws addressing primary cancer prevention/obesity prevention with a goal of 4
reducing health/food disparities by improving access to healthy foods (e.g., fruits and vegetables, nuts, dairy, SCLD Program Resources
Federal – State Partnerships Addressing lean meats, etc.) and/or programs to reduce food insecurity.
Food Disparities • Environmental Risk Prevention: Laws addressing primary cancer prevention programs that include provisions
3
3 3 3 Standard Resources Conference Presentations
to reduce environmental cancer risk factors (e.g., environmental toxins) with a goal of reducing health - SCLD Program Web site Analysis of SCLD data and development of oral and
disparities. poster presentations for scientific and professional
Role of the Federal Government Role of the States - SCLD Update quarterly newsletter and Legislative
Data Byte organization meetings
• Administration of Food Assistance Programs • Financial Incentives: Laws addressing programs that provide primary cancer prevention/obesity prevention
• Sets the agenda for the country’s priorities The Web site is located at www.scld-nci.net.
through implementation of financial incentives to influence people's purchasing behavior with the goal of 2
2 2 2 2 2 - Topical fact sheets and data table
- Through Funding & Program Initiatives • State Interventions reducing health/food disparities.
Acknowledgment: The authors thank Min Qi Wang, Ph.D. , The MayaTech Corporation, for his contributions to the
- State may provide additional funding for NSBP,
• Policy Floor - Nutritional Guidelines • Vouchers: Laws addressing primary prevention programs that include provisions to reduce health disparities demographic data analysis.
NSLP, SNAP, & SFMNP
- WIC, SFMNP, & SNAP and use a type of payment authorization provided by the state to be used only for covered services related to
- May require more stringent nutritional guidelines 1 1 1 1 1 1 1 1 1 1 1 1
primary cancer prevention.
- NSLP and NSBP
Contacts
1
than federal policy floor
• New guidelines for NSLP & NSBP in January 2012 will - May require NSBP, and/or NSLP in schools with Examples
closely mirror 2010 Dietary Guidelines for Americans severe need LA HB 840: Creates the Louisiana Sustainable Local Food Policy Council within the state Department of Regina el Arculli, M.A. Jamie Weinstein, M.P.H.
Agriculture and Forestry, for the purpose of building a local food economy benefiting the state by increasing National Cancer Institute Center for Health Policy and Legislative Analysis
0
consumer access to fresh and nutritious foods, and providing greater food security for all citizens of the Office of Government and Congressional Relations The MayaTech Corporation
y
na
nsas
ia
rado
t
bia
a
ois
a
a
e
s
sk a
lina
ania
s
ton
sin
York
ticu
t
Texa
Iow
id
isian
tuck
Main
state, among other things.
forn
uset
Building 31, Room 10A48 1100 Wayne Avenue, Suite 825
o
Illin
con
olum
Flor
ra
hing
Caro
Ariz
nsylv
Arka
nec
Colo
New
Neb
Ken
31 Center Drive, MSC 2580 Silver Spring, MD 20910
Lou
Cali
sach
Wis
IL HB 4756: Requires the state Department of Human Services and the state Department of Agriculture to
Was
Con
of C
th
Bethesda, MD 20892-2580 Phone: 301.587.1600, Fax: 301.587.0709
Pen
implement a Farmers' Market Technology Improvement Program to increase access to fresh fruits and
M as
Nor
Phone: 301.496.5217, Fax: 301.402.1225 e-mail: scld@mayatech.com
rict
vegetables, quality meat , and dairy for all Illinois residents.
e-mail: elarculli@nih.gov
Dist