This webinar covered oral chemotherapy options for colorectal cancer. The speaker discussed the commonly used drugs capecitabine and regorafenib. Capecitabine is an oral form of 5-FU that is given twice daily and can be used as adjuvant therapy or for metastatic disease. Regorafenib is used for metastatic colorectal cancer that has progressed on other therapies. Side effects and considerations for each drug were reviewed. An experimental drug, TAS-102, was also mentioned as showing promising results in clinical trials. The summary emphasized that oral chemotherapy is not suitable for all patients but can be a good option when the risks and benefits are considered individually.
El documento describe tres valores importantes para una persona correcta: la tolerancia, el respeto y la puntualidad. Define cada valor de la siguiente manera: la tolerancia es la aceptación de opiniones y culturas diversas; el respeto es la consideración especial hacia los demás basada en la reciprocidad; y la puntualidad es necesaria para dotar de carácter, orden y eficacia a la personalidad. El documento también menciona que los valores humanos son muy importantes para la sociedad y dependen de la educación que recibimos de nuestras familias.
La carrera de Administración de Empresas desarrolla habilidades empresariales y de gestión. Los egresados pueden trabajar en áreas financieras, de recursos humanos, control de gestión u operaciones en empresas nacionales e internacionales u organizaciones. El estudio de esta carrera brinda conocimientos teóricos y prácticos sobre administración, economía, contabilidad y otras materias para administrar o crear organizaciones de manera competitiva y con visión internacional.
The document provides an overview and wireframes for a guest services application. It includes:
1) Descriptions of the different service options - guest services, security, and medical - and how users can make requests that get added to queues.
2) Details on how operators can view and manage requests in the queues, communicate with users, and dispatch field responders as needed.
3) Wireframes of the operator interface showing how it would allow operators to view request logs, active chats, priority queues, and dispatch medical responders to assist users.
The Elysia Park Residence will be making its presence felt in Medini soon. Sprawled across 7.82 acres of land in Medini, Nusajaya, the development is expected to garner much attention and interest.
Residents who value the presence of greenery will certainly appreciate the 4.8-acre park that is right next to the development. It has also been designed to offer a garden that is no ordinary one but is in fact a Sky Garden that redefines the concept of “taking a walk in the garden”.
There are eight unit layouts to choose from with built-up sizes that range from 515 sq ft to 1,251 sq ft which are ideal for first-time homeowners, young couples and small families. All in all, there are a total of 961 units available and the leasehold tenure for the development is 129 years long.
The Elysia Park Residence will be launched in the second half of 2015.
This document provides an overview of a UX strategy redesign for a mobile app called Unite4Good. It includes goals for users, design, and research. Key aspects are delivering positive content to engage users in contests and content creation. Research included end user interviews and a comparative analysis of competitors. The MVP includes rich content delivery, completing contests, redeeming points, and social sharing.
The document describes the launch of a new smartwatch called the EBAR14. The EBAR14 functions as a stylish watch, blood pressure monitor, heart rate checker, calorie counter, music player, and provides weather reports and emergency alerts. It continuously monitors the user's blood pressure, heart rate, and detects any abnormalities. Additional features include calculating calories burned, providing alerts for bad weather or pollution levels. The document outlines the product specifications, target markets, pricing and promotional strategies for the EBAR14 launch.
The document discusses implementing PCIe Address Translation Services (ATS) in ARM-based systems-on-chips (SoCs). It describes an example ARM server system with various components like CPUs, memory controllers, and I/O devices. It then explains how ATS works to improve memory access performance by allowing devices to cache address translations locally instead of relying solely on the IOMMU. The document outlines the typical components involved in ATS like the address translation cache, translating agent, and address translation protection table. It also describes how the ARM System MMU (SMMU) implements ATS and supports distributed address translation caching by endpoints.
IEC 60101-1 is basic certificate for the general purpose as below items :
MEDICAL ELECTRICAL EQUIPMENT
MEDICAL ELECTRICAL SYSTEMS: Assembled by several medical electrical equipment
Components that is used in above equipment
El documento describe tres valores importantes para una persona correcta: la tolerancia, el respeto y la puntualidad. Define cada valor de la siguiente manera: la tolerancia es la aceptación de opiniones y culturas diversas; el respeto es la consideración especial hacia los demás basada en la reciprocidad; y la puntualidad es necesaria para dotar de carácter, orden y eficacia a la personalidad. El documento también menciona que los valores humanos son muy importantes para la sociedad y dependen de la educación que recibimos de nuestras familias.
La carrera de Administración de Empresas desarrolla habilidades empresariales y de gestión. Los egresados pueden trabajar en áreas financieras, de recursos humanos, control de gestión u operaciones en empresas nacionales e internacionales u organizaciones. El estudio de esta carrera brinda conocimientos teóricos y prácticos sobre administración, economía, contabilidad y otras materias para administrar o crear organizaciones de manera competitiva y con visión internacional.
The document provides an overview and wireframes for a guest services application. It includes:
1) Descriptions of the different service options - guest services, security, and medical - and how users can make requests that get added to queues.
2) Details on how operators can view and manage requests in the queues, communicate with users, and dispatch field responders as needed.
3) Wireframes of the operator interface showing how it would allow operators to view request logs, active chats, priority queues, and dispatch medical responders to assist users.
The Elysia Park Residence will be making its presence felt in Medini soon. Sprawled across 7.82 acres of land in Medini, Nusajaya, the development is expected to garner much attention and interest.
Residents who value the presence of greenery will certainly appreciate the 4.8-acre park that is right next to the development. It has also been designed to offer a garden that is no ordinary one but is in fact a Sky Garden that redefines the concept of “taking a walk in the garden”.
There are eight unit layouts to choose from with built-up sizes that range from 515 sq ft to 1,251 sq ft which are ideal for first-time homeowners, young couples and small families. All in all, there are a total of 961 units available and the leasehold tenure for the development is 129 years long.
The Elysia Park Residence will be launched in the second half of 2015.
This document provides an overview of a UX strategy redesign for a mobile app called Unite4Good. It includes goals for users, design, and research. Key aspects are delivering positive content to engage users in contests and content creation. Research included end user interviews and a comparative analysis of competitors. The MVP includes rich content delivery, completing contests, redeeming points, and social sharing.
The document describes the launch of a new smartwatch called the EBAR14. The EBAR14 functions as a stylish watch, blood pressure monitor, heart rate checker, calorie counter, music player, and provides weather reports and emergency alerts. It continuously monitors the user's blood pressure, heart rate, and detects any abnormalities. Additional features include calculating calories burned, providing alerts for bad weather or pollution levels. The document outlines the product specifications, target markets, pricing and promotional strategies for the EBAR14 launch.
The document discusses implementing PCIe Address Translation Services (ATS) in ARM-based systems-on-chips (SoCs). It describes an example ARM server system with various components like CPUs, memory controllers, and I/O devices. It then explains how ATS works to improve memory access performance by allowing devices to cache address translations locally instead of relying solely on the IOMMU. The document outlines the typical components involved in ATS like the address translation cache, translating agent, and address translation protection table. It also describes how the ARM System MMU (SMMU) implements ATS and supports distributed address translation caching by endpoints.
IEC 60101-1 is basic certificate for the general purpose as below items :
MEDICAL ELECTRICAL EQUIPMENT
MEDICAL ELECTRICAL SYSTEMS: Assembled by several medical electrical equipment
Components that is used in above equipment
From bowel frequency, pain, and more, many colorectal cancer treatments lead to digestive side effects. Join this webinar with Dr. Cathy Eng to learn all about the digestive system, the side effects that are common due to CRC treatment, and how to manage those side effects.
This patient has stage IV colon cancer that has progressed on initial chemotherapy with CapeOx, bevacizumab, and capecitabine. Appropriate next steps include continuing palliative treatment with the goals of reducing symptoms, avoiding complications, and prolonging survival. Regorafenib monotherapy or with FOLFIRI is recommended based on clinical trials demonstrating improved progression-free and overall survival. Close monitoring is needed due to potential adverse effects like hand-foot skin reactions, fatigue, and liver toxicity.
Many colorectal cancer patients take chemotherapy as part of their treatment plan. Join Ashley Glode, Pharm.D, as she discusses chemo information and education, supportive care management for patients, and toxicity monitoring. She will discuss the importance of communicating with your doctors and care team to ensure you stay safe and comfortable throughout your treatment plan.
This document provides information about Person-Centered Planning and self-advocacy for people with disabilities. It discusses how Person-Centered Planning began in 1974 as an alternative to the terms "retarded" and "handicapped." The planning process focuses on the individual, learning about their preferences, needs, and goals. It emphasizes that the person with a disability should be at the center of their plan, not their parents or other family members. Examples of self-advocacy stories are also mentioned. Resources for Person-Centered Planning and disability rights are listed at the end.
What to expect before and after lung transplantSandra Tindle
This document outlines what to expect before and after receiving a lung transplant. It discusses the rigorous evaluation process before transplant approval. It describes rehabilitation and testing in the hospital after surgery, including bronchoscopies to monitor the lungs. Recovery takes 1-4 weeks, and patients must stay near the transplant center for 3 months while undergoing frequent testing. Lifelong commitments include taking multiple medications on schedule to prevent rejection and infection.
Understand the concept of Colorectal Cancer clinical trials and the differences across the phases. Presented by Dr. Sam J. Lubner MD, FACP University of Wisconsin Carbone Cancer Center
Nutrition is an important part of any cancer treatment plan, especially for those individuals who are undergoing colorectal cancer treatment and have had surgery to remove part of the colon. Another important consideration for patients who have had surgery to remove part of the colon is avoiding a bowel obstruction. Knowing which foods you should and shouldn’t eat can be a helpful part of the treatment and the surgery recovery process. In this webinar, we will talk about how nutrition and avoiding bowel blockages can be helpful to you after a colorectal cancer treatment procedure and what foods to eat as we enter the holiday season.
Margaret Martin, RD, MS, LDN, CDE is a Licensed Dietitian and Nutritionist in the State of Tennessee and James D. Waller, Jr., MD present this lively session.
The document provides medical advice and information for volunteers going overseas including how to prevent and treat common illnesses like malaria, travelers diarrhea, and rabies. It discusses recommended vaccines, medications to bring, and what medical expenses the organization covers. It also addresses potential mental health issues and maintaining wellness while abroad.
1.5 - Clinical Pharmacists in General Practice - A necessity, not a luxuryNHS England
- Clinical pharmacists can take significant workload from GPs by handling medication reviews, prescription queries, and patient consultations, allowing GPs to focus on more complex cases.
- The speaker describes their work transforming prescribing practices at Westbourne Medical Centre, where they conduct 47 hours per month of medication reviews and 32 hours per month of patient consultations, saving GPs substantial time.
- Key proposals include streamlining the prescription query process, focusing on high-risk medications, and implementing a color-coded system to prioritize diabetes patients for appointments based on health metrics and medication usage. Other clinicians praise the positive impact of the clinical pharmacist role.
The Prague Medical Institute offers various obesity treatment procedures such as gastric balloons, gastric plication, gastric banding, and sleeve gastrectomy. Patients must have a BMI over 35 with obesity-related health issues or over 40 to be eligible. Preparation involves arranging time off work and support for recovery. Possible complications include pain, difficulty exercising, and vitamin deficiencies. The institute has experienced experts and contracts top Czech professionals without relying on hospitals.
Pain is a common side effect of colorectal cancer treatment that can be hard to manage. If you or someone you know is experiencing pain, Dr. Ann Navarro-Leahy from the University of Colorado Hospital will cover reasons for pain, different types of pain, and ways to treat and control pain. http://fightcrc.org/Webinar
PROMACTA is a once-daily tablet that may help raise platelet counts in patients with chronic immune thrombocytopenia (cITP) when other treatments have not worked well enough. In clinical studies, PROMACTA increased and maintained platelet counts within the target range for most patients. It is important for patients taking PROMACTA to be monitored by their doctor and to report any side effects like liver problems, high platelet counts, eye problems or blood clots right away. Financial assistance and support programs are available for patients prescribed PROMACTA.
This document provides information about chemotherapy treatment and managing common side effects to patients at the Lions Gate Hospital Dr. Paul Klimo Medical Oncology Clinic. It discusses what chemotherapy is, how it is administered, potential side effects that can affect normal cells like bone marrow, blood counts, mouth sores, fatigue, and tips for managing side effects like nausea, vomiting, diarrhea and constipation. It also provides contact information for the oncology clinic and doctors responsible for patients' cancer care.
This document provides information about chemotherapy treatment and common side effects to patients at the Lions Gate Hospital Dr. Paul Klimo Medical Oncology Clinic. It discusses how chemotherapy works, potential side effects that can affect normal cells like bone marrow, mouth, nerves, reproductive organs and hair follicles. It also outlines signs of low blood cell counts and provides tips for managing common side effects like nausea, vomiting, diarrhea, constipation and fatigue. Patients are advised to contact the oncology clinic about fever, infections or other concerning symptoms.
This document provides an overview of Nancy Fischer's marketing and design services, including:
1) Campaign branding, magazine advertising, website design, annual reports, marketing kits, packaging, PowerPoint presentations, and logo/icon design.
2) Concepts and final designs created for the Diprospan® brochure campaign branding.
3) Concepts developed for rebranding the Elecon® campaign, including strategic taglines and designs.
4) Multiple concepts and the final solution created for the Puregon® campaign branding.
The document discusses limiting acetaminophen (APAP) in combination opioid products due to safety concerns. It notes that APAP overdoses are common and can cause liver injury. It recommends designating several oral APAP/opioid combination products as non-formulary and having pharmacists automatically interchange orders for these combinations to the separate components instead. The goal is to limit total daily APAP intake and improve safety.
This document provides information about chemotherapy treatment and managing side effects to cancer patients. It discusses what chemotherapy is, how it is administered, potential side effects that affect normal cells like bone marrow, blood cells, mouth, hair etc. It provides guidance on preventing and managing common side effects like infections, fevers, nausea, vomiting, diarrhea, constipation and fatigue. It also lists contact information for the oncology clinic and doctors.
- Cephalosporins are a class of antibiotics used to treat bacterial infections. They work by killing bacteria or preventing their growth.
- Cephalosporins come in both oral and injectable forms and are used to treat infections in many parts of the body. They are sometimes given with other antibiotics or to prevent infections before, during, and after surgery.
- The appropriate dose of cephalosporin depends on the individual medication, age of the patient, infection being treated, and whether it is being taken orally or via injection. Doses are generally taken every 4 to 12 hours and treatment duration is usually 5 to 10 days.
From bowel frequency, pain, and more, many colorectal cancer treatments lead to digestive side effects. Join this webinar with Dr. Cathy Eng to learn all about the digestive system, the side effects that are common due to CRC treatment, and how to manage those side effects.
This patient has stage IV colon cancer that has progressed on initial chemotherapy with CapeOx, bevacizumab, and capecitabine. Appropriate next steps include continuing palliative treatment with the goals of reducing symptoms, avoiding complications, and prolonging survival. Regorafenib monotherapy or with FOLFIRI is recommended based on clinical trials demonstrating improved progression-free and overall survival. Close monitoring is needed due to potential adverse effects like hand-foot skin reactions, fatigue, and liver toxicity.
Many colorectal cancer patients take chemotherapy as part of their treatment plan. Join Ashley Glode, Pharm.D, as she discusses chemo information and education, supportive care management for patients, and toxicity monitoring. She will discuss the importance of communicating with your doctors and care team to ensure you stay safe and comfortable throughout your treatment plan.
This document provides information about Person-Centered Planning and self-advocacy for people with disabilities. It discusses how Person-Centered Planning began in 1974 as an alternative to the terms "retarded" and "handicapped." The planning process focuses on the individual, learning about their preferences, needs, and goals. It emphasizes that the person with a disability should be at the center of their plan, not their parents or other family members. Examples of self-advocacy stories are also mentioned. Resources for Person-Centered Planning and disability rights are listed at the end.
What to expect before and after lung transplantSandra Tindle
This document outlines what to expect before and after receiving a lung transplant. It discusses the rigorous evaluation process before transplant approval. It describes rehabilitation and testing in the hospital after surgery, including bronchoscopies to monitor the lungs. Recovery takes 1-4 weeks, and patients must stay near the transplant center for 3 months while undergoing frequent testing. Lifelong commitments include taking multiple medications on schedule to prevent rejection and infection.
Understand the concept of Colorectal Cancer clinical trials and the differences across the phases. Presented by Dr. Sam J. Lubner MD, FACP University of Wisconsin Carbone Cancer Center
Nutrition is an important part of any cancer treatment plan, especially for those individuals who are undergoing colorectal cancer treatment and have had surgery to remove part of the colon. Another important consideration for patients who have had surgery to remove part of the colon is avoiding a bowel obstruction. Knowing which foods you should and shouldn’t eat can be a helpful part of the treatment and the surgery recovery process. In this webinar, we will talk about how nutrition and avoiding bowel blockages can be helpful to you after a colorectal cancer treatment procedure and what foods to eat as we enter the holiday season.
Margaret Martin, RD, MS, LDN, CDE is a Licensed Dietitian and Nutritionist in the State of Tennessee and James D. Waller, Jr., MD present this lively session.
The document provides medical advice and information for volunteers going overseas including how to prevent and treat common illnesses like malaria, travelers diarrhea, and rabies. It discusses recommended vaccines, medications to bring, and what medical expenses the organization covers. It also addresses potential mental health issues and maintaining wellness while abroad.
1.5 - Clinical Pharmacists in General Practice - A necessity, not a luxuryNHS England
- Clinical pharmacists can take significant workload from GPs by handling medication reviews, prescription queries, and patient consultations, allowing GPs to focus on more complex cases.
- The speaker describes their work transforming prescribing practices at Westbourne Medical Centre, where they conduct 47 hours per month of medication reviews and 32 hours per month of patient consultations, saving GPs substantial time.
- Key proposals include streamlining the prescription query process, focusing on high-risk medications, and implementing a color-coded system to prioritize diabetes patients for appointments based on health metrics and medication usage. Other clinicians praise the positive impact of the clinical pharmacist role.
The Prague Medical Institute offers various obesity treatment procedures such as gastric balloons, gastric plication, gastric banding, and sleeve gastrectomy. Patients must have a BMI over 35 with obesity-related health issues or over 40 to be eligible. Preparation involves arranging time off work and support for recovery. Possible complications include pain, difficulty exercising, and vitamin deficiencies. The institute has experienced experts and contracts top Czech professionals without relying on hospitals.
Pain is a common side effect of colorectal cancer treatment that can be hard to manage. If you or someone you know is experiencing pain, Dr. Ann Navarro-Leahy from the University of Colorado Hospital will cover reasons for pain, different types of pain, and ways to treat and control pain. http://fightcrc.org/Webinar
PROMACTA is a once-daily tablet that may help raise platelet counts in patients with chronic immune thrombocytopenia (cITP) when other treatments have not worked well enough. In clinical studies, PROMACTA increased and maintained platelet counts within the target range for most patients. It is important for patients taking PROMACTA to be monitored by their doctor and to report any side effects like liver problems, high platelet counts, eye problems or blood clots right away. Financial assistance and support programs are available for patients prescribed PROMACTA.
This document provides information about chemotherapy treatment and managing common side effects to patients at the Lions Gate Hospital Dr. Paul Klimo Medical Oncology Clinic. It discusses what chemotherapy is, how it is administered, potential side effects that can affect normal cells like bone marrow, blood counts, mouth sores, fatigue, and tips for managing side effects like nausea, vomiting, diarrhea and constipation. It also provides contact information for the oncology clinic and doctors responsible for patients' cancer care.
This document provides information about chemotherapy treatment and common side effects to patients at the Lions Gate Hospital Dr. Paul Klimo Medical Oncology Clinic. It discusses how chemotherapy works, potential side effects that can affect normal cells like bone marrow, mouth, nerves, reproductive organs and hair follicles. It also outlines signs of low blood cell counts and provides tips for managing common side effects like nausea, vomiting, diarrhea, constipation and fatigue. Patients are advised to contact the oncology clinic about fever, infections or other concerning symptoms.
This document provides an overview of Nancy Fischer's marketing and design services, including:
1) Campaign branding, magazine advertising, website design, annual reports, marketing kits, packaging, PowerPoint presentations, and logo/icon design.
2) Concepts and final designs created for the Diprospan® brochure campaign branding.
3) Concepts developed for rebranding the Elecon® campaign, including strategic taglines and designs.
4) Multiple concepts and the final solution created for the Puregon® campaign branding.
The document discusses limiting acetaminophen (APAP) in combination opioid products due to safety concerns. It notes that APAP overdoses are common and can cause liver injury. It recommends designating several oral APAP/opioid combination products as non-formulary and having pharmacists automatically interchange orders for these combinations to the separate components instead. The goal is to limit total daily APAP intake and improve safety.
This document provides information about chemotherapy treatment and managing side effects to cancer patients. It discusses what chemotherapy is, how it is administered, potential side effects that affect normal cells like bone marrow, blood cells, mouth, hair etc. It provides guidance on preventing and managing common side effects like infections, fevers, nausea, vomiting, diarrhea, constipation and fatigue. It also lists contact information for the oncology clinic and doctors.
- Cephalosporins are a class of antibiotics used to treat bacterial infections. They work by killing bacteria or preventing their growth.
- Cephalosporins come in both oral and injectable forms and are used to treat infections in many parts of the body. They are sometimes given with other antibiotics or to prevent infections before, during, and after surgery.
- The appropriate dose of cephalosporin depends on the individual medication, age of the patient, infection being treated, and whether it is being taken orally or via injection. Doses are generally taken every 4 to 12 hours and treatment duration is usually 5 to 10 days.
Similar to Final oralchemotherapy-fightcrc-3-150311113715-conversion-gate01 (20)
How to Control Your Asthma Tips by gokuldas hospital.Gokuldas Hospital
Respiratory issues like asthma are the most sensitive issue that is affecting millions worldwide. It hampers the daily activities leaving the body tired and breathless.
The key to a good grip on asthma is proper knowledge and management strategies. Understanding the patient-specific symptoms and carving out an effective treatment likewise is the best way to keep asthma under control.
Nano-gold for Cancer Therapy chemistry investigatory projectSIVAVINAYAKPK
chemistry investigatory project
The development of nanogold-based cancer therapy could revolutionize oncology by providing a more targeted, less invasive treatment option. This project contributes to the growing body of research aimed at harnessing nanotechnology for medical applications, paving the way for future clinical trials and potential commercial applications.
Cancer remains one of the leading causes of death worldwide, prompting the need for innovative treatment methods. Nanotechnology offers promising new approaches, including the use of gold nanoparticles (nanogold) for targeted cancer therapy. Nanogold particles possess unique physical and chemical properties that make them suitable for drug delivery, imaging, and photothermal therapy.
Summer is a time for fun in the sun, but the heat and humidity can also wreak havoc on your skin. From itchy rashes to unwanted pigmentation, several skin conditions become more prevalent during these warmer months.
Know the difference between Endodontics and Orthodontics.Gokuldas Hospital
Your smile is beautiful.
Let’s be honest. Maintaining that beautiful smile is not an easy task. It is more than brushing and flossing. Sometimes, you might encounter dental issues that need special dental care. These issues can range anywhere from misalignment of the jaw to pain in the root of teeth.
5-hydroxytryptamine or 5-HT or Serotonin is a neurotransmitter that serves a range of roles in the human body. It is sometimes referred to as the happy chemical since it promotes overall well-being and happiness.
It is mostly found in the brain, intestines, and blood platelets.
5-HT is utilised to transport messages between nerve cells, is known to be involved in smooth muscle contraction, and adds to overall well-being and pleasure, among other benefits. 5-HT regulates the body's sleep-wake cycles and internal clock by acting as a precursor to melatonin.
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STUDIES IN SUPPORT OF SPECIAL POPULATIONS: GERIATRICS E7shruti jagirdar
Unit 4: MRA 103T Regulatory affairs
This guideline is directed principally toward new Molecular Entities that are
likely to have significant use in the elderly, either because the disease intended
to be treated is characteristically a disease of aging ( e.g., Alzheimer's disease) or
because the population to be treated is known to include substantial numbers of
geriatric patients (e.g., hypertension).
Giloy in Ayurveda - Classical Categorization and SynonymsPlanet Ayurveda
Giloy, also known as Guduchi or Amrita in classical Ayurvedic texts, is a revered herb renowned for its myriad health benefits. It is categorized as a Rasayana, meaning it has rejuvenating properties that enhance vitality and longevity. Giloy is celebrated for its ability to boost the immune system, detoxify the body, and promote overall wellness. Its anti-inflammatory, antipyretic, and antioxidant properties make it a staple in managing conditions like fever, diabetes, and stress. The versatility and efficacy of Giloy in supporting health naturally highlight its importance in Ayurveda. At Planet Ayurveda, we provide a comprehensive range of health services and 100% herbal supplements that harness the power of natural ingredients like Giloy. Our products are globally available and affordable, ensuring that everyone can benefit from the ancient wisdom of Ayurveda. If you or your loved ones are dealing with health issues, contact Planet Ayurveda at 01725214040 to book an online video consultation with our professional doctors. Let us help you achieve optimal health and wellness naturally.
- Video recording of this lecture in English language: https://youtu.be/Pt1nA32sdHQ
- Video recording of this lecture in Arabic language: https://youtu.be/uFdc9F0rlP0
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
2. • Speaker(s): Dr. Anna Varghese
• Archived Webinars: FightColorectalCancer.org/Webinars
• AFTER THE WEBINAR: Expect an email with links to the material &
a survey. If you fill it out, we’ll send you a Blue Star pin.
• Ask a question in the panel on the RIGHT SIDE of your screen
• Follow along via Twitter – use the hashtag #CRCWebinar
Today’s Webinar:
3. Established in 2006, our Lisa Fund has
raised thousands of dollars and directly
funded talented scientists focused on
late-stage (stage III & IV) colorectal
cancer research.
100% of the funds donated go
directly to our research grant.
Learn more or donate:
FightColorectalCancer.org/LisaFund
Funding Science:
5. Disclaimer:
The information and services provided by Fight Colorectal Cancer are for
general informational purposes only. The information and services are not
intended to be substitutes for professional medical advice, diagnoses or
treatment.
If you are ill, or suspect that you are ill, see a doctor immediately. In an
emergency, call 911 or go to the nearest emergency room.
Fight Colorectal Cancer never recommends or endorses any specific
physicians, products or treatments for any condition.
6. Speakers:
Dr. Anna Varghese is an assistant attending in the
Gastrointestinal Oncology Service at Memorial
Sloan-Kettering Cancer Center. She completed
medical school at Case Western Reserve
University in Cleveland, Ohio, her internal
medicine residency at Beth Israel Deaconess
Medical Center in Boston, Massachusetts, and
her medical oncology fellowship training at
MSKCC in New York City. At MSKCC, her clinical
and research interests center on developing new
treatments for patients with colorectal cancers
and cancers of unknown primary.
8. Outline
• Commonly used medications for colorectal
cancer
• Standard oral chemotherapy for colorectal
cancer
– Capecitabine
– Regorafenib
• Experimental oral chemotherapy
– TAS-102
9. Commonly used medications for
colorectal cancer
Chemotherapy Brand Name Other Names Intravenous
(IV) or oral
5-Fluorouracil Adrucil ™ 5-FU Intravenous
Oxaliplatin Eloxatin™ Oxali Intravenous
Irinotecan Camptosar™ CPT-11, Irino Intravenous
Cetuximab Erbitux™ Cetux Intravenous
Bevacizumab Avastin™ Bev Intravenous
Panitumumab Vectibix™ P-mab Intravenous
Capecitabine Xeloda™ Cape Oral
Regorafenib Stivarga™ Oral
10. Commonly used medications for
colorectal cancer
Commonly given combinations:
FOLFOX : 5-Fluorouracil + Leucovorin +
Oxaliplatin
FOLFIRI: 5-Fluororuacil + Leucovorin +
Irinotecan
Capeox = XELOX = Capecitabine and Oxaliplatin
Capeiri : Capecitabine and Irinotecan
Chemotherapy
5-Fluorouracil
Oxaliplatin
Irinotecan
Cetuximab
Bevacizumab
Panitumumab
Capecitabine
Regorafenib
11. Commonly used medications for
colorectal cancer
Commonly given combinations:
FOLFOX: 5-Fluorouracil + Leucovorin + Oxaliplatin
FOLFIRI: 5-Fluororuacil + Leucovorin + Irinotecan
Capeox (XELOX): Capecitabine and Oxaliplatin
Capeiri: Capecitabine and Irinotecan
Chemotherapy Brand Name Other Names Intravenous
(IV) or oral
5-Fluorouracil Adrucil ™ 5-FU Intravenous
Oxaliplatin Eloxatin™ Oxali Intravenous
Irinotecan Camptosar™ CPT-11, Irino Intravenous
Cetuximab Erbitux™ Cetux Intravenous
Bevacizumab Avastin™ Bev Intravenous
Panitumumab Vectibix™ P-mab Intravenous
Capecitabine Xeloda™ Cape Oral
Regorafenib Stivarga™ Oral
13. Capecitabine: The Basics
• What is it?
– Oral form of 5-FU
• How is it given?
– Oral
– Tablets
• 150mg or 500mg tablets
• How often do you have to take it?
– Twice a day
– Multiple possible schedules
• 3 week schedule: 2 weeks on / 1 week off
• 2 week schedule: 1 week on / 1 week off
Genentech.com
14. Capecitabine: When can you use it?
• Stage II or Stage III colon cancer
– 6 months of adjuvant chemotherapy
• Oral / IV option: Capeox
• All IV option: FOLFOX
• Stage II or III rectal cancer
– Chemotherapy with FOLFOX or Capeox
– Concurrent radiation therapy and chemotherapy
• Stage IV colorectal cancer
15. Capecitabine: Is the pill as good as the
intravenous form of 5-FU?
• Yes!
• We use these interchangeably.
• Capecitabine is as effective as 5-FU.
– Studies comparing capeox and FOLFOX
demonstrated that capeox is no worse than
FOLFOX in first-line treatment.
16. Capecitabine: What are the common
side effects?
• Lowering of the neutrophil count (neutropenia)
• Lowering of the platelet count (thrombocytopenia)
• Rash on the hands and feet (hand-foot syndrome)
• Nausea and vomiting
• Diarrhea or constipation
• Poor appetite
• Cardiac complications
Ascopost.com
17. Capecitabine: Who should not take it?
• People with poor kidney function.
• People who cannot metabolize the drug.
18. Capecitabine: How do you know if it’s
right for you?
• Your doctor can help you decide, but only you
can know this.
• How do you feel about a mediport?
• How important is it to limit visits to the clinic?
• Are you the kind of person who can take pills
reliably?
• Will the burden of twice daily medications
become overwhelming?
19. Example
• You have just undergone surgery for your
colon cancer and were found to have stage III
colon cancer in which 2 lymph nodes had
evidence of cancer.
• Your doctor has recommended 6 months of
“adjuvant” chemotherapy with either FOLFOX
or Capeox.
• How do you decide which one?
20. Adjuvant Capeox vs. Adjuvant FOLFOX
FOLFOX Capeox
Medications 5-Fluorouracil,
leucovorin, and
oxaliplatin
Capecitabine and oxaliplatin
Method of administration IV
Requires mediport
Oral and IV
Visits Every 2 weeks Every 3 weeks
Number of treatments /
clinic visits
12 8
PROS •Requires a mediport •Does not require a mediport
or 48 hour infusion
•Fewer visits
CONS •Requires a mediport
•More visits
•Fewer doses of oxaliplatin
higher dose of oxaliplatin
increased side effects
•Increased pressure on patient
•Adherence
21. Capecitabine: How do you think you
get it?
Doctor writes a
prescription.
Pharmacy
mails drug to
your home.
22. Capecitabine: How should you get it?
Doctor writes a prescription.
Doctor’s office calls your insurance company
to find out what specialty pharmacy to use.
Doctor’s office sends prescription to
specialty pharmacy.
Doctor’s office may need to complete a
prior authorization form.
Pharmacy then coordinates mailing
the drug to your home.
23. Capecitabine: How do you actually
get it?
Doctor writes a prescription.
Doctor’s office calls your insurance company
to find out what specialty pharmacy to use.
Doctor’s office sends prescription to
specialty pharmacy.
Doctor’s office may need to complete a
prior authorization form.
Pharmacy then coordinates mailing
the drug to your home.
Patient calls doctor’s office.
Patient calls insurance.
Patient calls pharmacy.
Patient calls doctor’s office.
Patient calls insurance.
Patient calls pharmacy.
Patient calls doctor’s office.
Patient calls insurance.
Patient calls pharmacy.
24. Capecitabine: How do you take it?
• Twice a day
• Within 30 minutes of eating a meal
• Swallow whole
26. Regorafenib: The Basics
• What is it?
– Blocks several different proteins thought to be
important in cancer growth
• How is it given?
– Oral
– 40mg Tablets
• How often do you have to take it?
– Once a day
– 4 tablets
– 4 week schedule: 3 weeks on / 1 week off
27. Regorafenib: When can you use it?
• Metastatic colorectal cancer that has
progressed or grown despite 5-FU,
capecitabine, oxaliplatin, irinotecan,
cetuximab, and panitumumab
28. Regorafenib: What are the side effects?
• Fatigue and weakness
• Rash on the hands and feet (hand-foot syndrome)
• Bleeding
• High blood pressure (hypertension)
• Neurologic abnormalities
• Bowel perforation
• Impaired wound healing
• Liver damage
29. Regorafenib: How do you know if it’s
right for you?
• Your doctor can help you decide, but only you
can know this.
• Are you the kind of person who can take pills
reliably?
• Will the burden of taking daily medications
become overwhelming?
30. Regorafenib: How do you get it?
Doctor writes a prescription.
Doctor’s office calls your insurance company
to find out what specialty pharmacy to use.
Doctor’s office sends prescription to
specialty pharmacy.
Doctor’s office may need to complete a
prior authorization form.
Pharmacy then coordinates mailing
the drug to your home.
31. Regorafenib: How do you take it?
• Once a day at the same time each day
• Swallow whole
• Take with a meal
32. Oral chemo: How do you remember
to take it?
• Alarms
• Pill box – separate from your other
medications
33. When should you call your doctor or
go to a local Emergency Room?
Question ER or 911 Call your
doctor
If you develop chest pain, chest pressure,
or unexplained shortness of breath?
X
If you develop new neurologic changes? X
If you develop a rash on your hands and
feet?
X
If you develop unexplained fatigue, but
you can still get out of bed and take care of
your personal care?
X
If you develop darkening of your skin, eyes,
or urine, but you still otherwise feel OK?
X
If you are worried about a symptom? XXXXXXX
34. Question Do Don’t
What if I miss my dose? Do skip the dose. Do not take extra or double
the dose.
What if I can’t swallow the
pills?
Do talk to your doctor.
Do take the pills whole.
Do not crush the pills
unless you talk with your
doctor or pharmacist.
What if I’m having side
effects?
Do talk to your doctor. Do not ignore your
symptoms! Trust your
instincts.
Dos and Don’ts of Oral Chemotherapy
36. TAS-102: The Basics
• What is it?
– Inhibits DNA synthesis directly
– Inhibits an enzyme important for DNA replication
• How is it given?
– Oral
– Tablets
38. TAS-102: What side effects have been
seen?
• Fatigue
• Diarrhea
• Nausea and Vomiting
• Poor appetite
• Lowering of the blood counts – neutrophils,
platelets, and hemoglobin
39. Summary
• Oral chemotherapy is an option for patients with
stages II, III, and IV colorectal cancer.
• The two FDA approved oral agents for colorectal
cancer are capecitabine and regorafenib.
• Oral chemotherapy is not right for everyone, but
it can be a good option for the right patient.
• Oral chemotherapy is still chemotherapy and
comes with risks.
40. Question & Answer:
SNAP A
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