The Rion-Antirion Bridge in Greece withstood the 2008 Mw 6.5 Achaia-Ilia earthquake without structural damage. The bridge's seismic design included energy dissipation devices and sacrificial fuses that were activated during the quake as intended. Post-earthquake inspections confirmed yielding of all lateral fuses while minor non-structural damage occurred. Data from the bridge's monitoring system was analyzed to evaluate the bridge's response and performance of the seismic design elements during the strong shaking event.