This document provides guidance for a coordinated strategy to abandon female genital mutilation/cutting (FGM/C) in one generation using a human rights-based approach. It examines FGM/C as a social convention and applies game theory to understand the social dynamics that perpetuate the practice. The strategy outlines a vision, goal, communication approach, implementation by subregion, indicators for monitoring and evaluation, and costing approach. The goal is to support large-scale abandonment of FGM/C in affected countries by 2015 through community-led initiatives that stimulate dialogue and collective change without coercion.