The Bandiagara Malaria Project has been conducting malaria vaccine research since 1997. They have completed two malaria vaccine trials and published 20 scientific papers. Their research has focused on two candidate vaccines: RTS,S and AMA-1. RTS,S is a recombinant protein combining the circumsporozoite protein with hepatitis B surface antigen and an adjuvant. It has shown modest efficacy in clinical trials. AMA-1 is based on the apical membrane antigen-1 involved in erythrocyte invasion. Antibodies against AMA-1 can block merozoite invasion into red blood cells. The project is a collaboration between the University of Bamako in Mali, the University of Maryland, and

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10. Current status:
Pre-erythrocytic vaccines
• RTS,S (U.S. Army & GlaxoSmithKline)
–Recombinant CSP combined with hepatitis
B surface antigen
– Immune boosting agents (adjuvant)
• AS02A: QS21, monophosporyl lipid A

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15. Bandiagara Malaria Project
• Started 1997
• University of Bamako / Faculty of Medicine
– Malaria Research & Training Center
• University of Maryland
– Center for Vaccine Development
• US National Institutes of Health
• 20 scientific papers published
• 2 malaria vaccine trials completed

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28. Malaria vaccine AMAMalaria vaccine AMA--11
• P. falciparum apical membrane antigen-1
• Expressed on merozoite surface,
involved in erythrocyte invasion
• Antibodies block invasion of merozoites
into erythrocytes

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