Fac 2006 plowe 2
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This document summarizes key mutations in the PfCRT transmembrane protein that are associated with chloroquine resistance in Plasmodium falciparum. It identifies 10 mutation sites, including K76T, A220S, N326D, I356T, and R371I. These mutations are located in different transmembrane domains and confer different levels of chloroquine resistance when present individually or in combination. Studies have found that the K76T mutation is most strongly associated with clinical resistance while other mutations can modulate the level of resistance.
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NRI Report
1) The White House Neighborhood Revitalization Initiative Report recognizes the interconnected challenges in high-poverty neighborhoods and calls for a unified approach to address poverty, failing schools, and broken homes.
2) Developing strategic and accountable partnerships leads to lasting change by sustaining comprehensive change efforts.
3) Maintaining a results focus supported by data presents a strategy for achieving specific objectives, and can lead to a common data set to measure progress.
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