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Extragenital pathology and
pregnancy
Content
 The course of pregnancy and childbirth in diseases of the
cardiovascular system.
 Kidney diseases and pregnancy
 The course of pregnancy and childbirth in diseases of the
endocrine system
 The course of pregnancy and childbirth in diseases of the
respiratory and digestive system
CARDIOVASCULAR DISEASES
 Cardiovascular diseases hold first place out of all extragenital pathology
among pregnant women.
 Pregnant women heart disease detection frequency varies from 0,4 to 4,7%.
 Pregnancy worsens the cardiovascular diseases and can lead to extreme
conditions that require immediate actions, not only from an obstetrician, but
also from the therapist, cardiologist, surgeon.
Among heart diseases,
most commonly
encountered are:
 Rheumatism
 acquired and congenital heart diseases
 anomalies of great vessels
 myocardial disease
 surgical heart arrhythmias
Rheumatism
 Rheumatism among pregnant women occurs in the 2,3 -
6,3%. While rheumatism aggravation appears in 2,5 - 25%
of cases, usually within the first 3 and last 2 months of
pregnancy, as well as during first year after childbirth.
 Acquired rheumatic heart diseases account for 75-90% of
all heart lesions in pregnant women.
 Of all forms of rheumatic origin defects the most often
are observed mitral valvular insufficiency and a
combination of stenosis of the left atrioventricular
openings.
To predict the outcomes of pregnancy and
childbirth
 The following factors are important:
 Activity of rheumatoid process
 Form and stage of rheumatic defects
 Compensation or decompensation of blood circulation
 The degree of pulmonary hypertension
 Cardiac arrhythmias
 Joining obstetrics pathology
Risk classification of adverse pregnancy
outcome in patients with heart defects
 1 degree - Pregnancy in heart defects without
marked signs of heart failure and acute rheumatic
process.
 2 degree - Pregnancy with heart defects with initial
symptoms of heart failure (shortness of breath,
tachycardia), evidence rheumatism active phase
symptoms (A.I. Nesterov,degree A 1)
 3 degree - Pregnancy in decompensated heart defect
with signs of the predominance of right heart failure,
presence of the active phase of rheumatism (A 2), atrial
fibrillation, pulmonary hypertension.
 4 degree - Pregnancy in decompensated heart defect with signs of left
ventricular failure, atrial fibrillation, thromboembolic manifestations of
pulmonary hypertension.
 According to this scheme continuation of the pregnancy is permissible, with
1 and 2 degree of risk, only under the supervision of an outpatient and
cardioobsterical facility and with a 3 time hospitalization
Pregnancy and childbirth in arterial
hypertension
 Arterial hypertension detected in 5% of pregnant women:
 70% of hypertension in pregnant women
 15-25% - hypertensive disease
 2-5% - secondary hypertension
Complications:
 Violations of the functions of the placenta:
 leads to hypoxia
 Syndrome of intrauterine growth retardation
 death fetal
 Placental Abruption
Therapy
 Hypertension treatment includes the creation of emotional rest for a patient
 strict observance of day regimen
 diet
 medication
 and physiotherapy
Kidney disease
 Kidney disease and urinary tract infections hold second
place after diseases of the cardiovascular system among
extragenital pathology of pregnant women and pose a
risk for both mother and fetus.
 During pregnancy: hypotension and increased
pyelocaliceal system and ureters is observed
 uterus is deflected to the right
Infection enters the urinary tract:
 ascending path (from the bladder)
 descending - lymphogenous (from the intestine, especially
during constipation)
 haematogenous (for various infectious diseases)
Pathogens:
 Escherichia coli,
 gram-negative enterobacteria,
 Pseudomonas aeruginosa,
 Proteus, enterococcus,
 golden stafilakokk,
 streptococci,
 fungi such as Candida.
Clinical forms
 Common clinical forms should be noted-pyelonephritis, hydronephrosis,
asymptomatic bacteriuria
 Rarely-glomerulonephritis, tuberculosis kidney, urolithiasis, developmental
anomalies of the urinary tract.
 Pyelonephritis - is the most frequent disease during pregnancy (from 6 to 12%),
its when concentrating ability of the kidneys suffers.
 Pyelonephritis has a negative effect on pregnancy and the fetus.
Diabetes and pregnancy
 The problem of pregnancy in women with diabetes is
relevant throughout the world.
 The course of pregnancy and childbirth in diabetes
mellitus
 It adversely affects:
 -Utero fetal development
 -Increased frequency of malformations
 -High perinatal morbidity and mortality
Types of diabetes
 Type I diabetes - Insulin dependent diabetes mellitus
(IDDM);
 Type II diabetes - insulin-independent diabetes mellitus
(INSD);
 Type III diabetes - gestational diabetes (GD), which
develops after 28 weeks. pregnancy and is transient
violation of glucose utilization in women during
pregnancy.
 The most frequent is insulin dependent diabetes mellitus
(IDDM). The disease is usually diagnosed in girls in
childhood, during puberty.
 Insulin-independent diabetes mellitus (INSD) occurs in
older women (after 30 years), and it proceeds less
seriously.
 Gestational diabetes is diagnosed very rarely.
 I-week pregnancy. The course of diabetes in the majority
of pregnant women remains unchanged.
 II half of pregnancy. Worsens carbohydrate tolerance,
amplified diabetic complaints.
 by the end of pregnancy carbohydrate tolerance
improves again, blood glucose levels and insulin doses
are reduced.
At childbirth
 High hypergikemiya, the state of acidosis and
hypoglycemic state is possible in pregnant women with
diabetes.
Obstetric complications in the second half of
pregnancy:
 hypertension of pregnant
 polyhydramnios
 risk of preterm birth
 fetal hypoxia
 urinary tract infections
The flow of labor is
complicated by:
 presence of a large fetus
 uterine inertia
 prenatal amniorrhea
 increase of fetal hypoxia
 development of functional-narrow pelvis
 shortness of birth shoulder girdle
 development of endometritis in childbirth
 birth injuries of mother and fetus
Contraindications to pregnancy in
diabetes
 The presence of rapidly progressive vascular complications:
 Retinopathy
 Insulineresistent
 Labile forms of diabetes
 Presence of diabetes mellitus in both parents, which
dramatically increases the possibility of disease in children
 The combination of diabetes and Rh-sensitized mother
 Combination of diabetes mellitus and active pulmonary
tuberculosis
Treatment
 Insulin therapy during pregnancy is required even under
mild forms of diabetes
Thyroid disease and pregnancy
 The thyroid gland - is an endocrine organ that produces
hormones essential for organism - thyroxine (or
tetraiodothyronine - T4) and triiodothyronine (T3).
Toxic goiter
 Graves disease (GD) occurs most frequently during
pregnancy (from 0,2 to 8%). It’s mandatory symptoms are
hyperplasia and hyper function of the thyroid gland.
The course of pregnancy
 In the I half-all women have a disease escalation
 In the II half-due to blockade of excess hormones in some
patients with mild thyrotoxicosis there is improvement.
The course of pregnancy
 Hypertension pregnant
 Preterm delivery
 At childbirth
 At childbirth decompensation of the circulatory
system can often occur, and in the postpartum and
early postpartum period - bleeding.
 In the postpartum period
The sharp worsening of postpartum thyrotoxicosis
requires:
 treatment using merkazalil (it passes through the milk
to the fetus)
 suppression of lactation.
Tactics obstetrician-gynecologist and
endocrinologist
 Hospitalization in the early period to 12 weeks for
examination and decision on the possibility of carrying
out the pregnancy.
Pregnancy is contraindicated:
 Pregnancy is contraindicated in the average severity of
diffuse goiter and nodular goiter, if a woman does not
intend to does not intend to have surgery?) in a period of
14 weeks.
 Pregnancy is possible to bear only a mild degree of
thyrotoxicosis a diffuse goiter and positive treatment
diyodtirozin.
Active pulmonary tuberculosis
 Indications for abortion to 12 weeks:
 Common destructive process in the lungs, poorly amenable to treatment;
 aggravation of the process during a previous pregnancy;
 pregnancy less than 2 years after suffering miliary tuberculosis;
Prevention of extra genital
diseases
 Preventive measures of complications of pregnancy and
childbirth during the extra genital diseases - regular
monitoring of pregnant women in antenatal clinic by the
obstetrician-gynecologist, a physician, an
endocrinologist, a mandatory three times hospitalization
and effective outpatient therapy.

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Extragenital pathology and pregnancy.pptx

  • 2. Content  The course of pregnancy and childbirth in diseases of the cardiovascular system.  Kidney diseases and pregnancy  The course of pregnancy and childbirth in diseases of the endocrine system  The course of pregnancy and childbirth in diseases of the respiratory and digestive system
  • 3. CARDIOVASCULAR DISEASES  Cardiovascular diseases hold first place out of all extragenital pathology among pregnant women.  Pregnant women heart disease detection frequency varies from 0,4 to 4,7%.  Pregnancy worsens the cardiovascular diseases and can lead to extreme conditions that require immediate actions, not only from an obstetrician, but also from the therapist, cardiologist, surgeon.
  • 4. Among heart diseases, most commonly encountered are:  Rheumatism  acquired and congenital heart diseases  anomalies of great vessels  myocardial disease  surgical heart arrhythmias
  • 5. Rheumatism  Rheumatism among pregnant women occurs in the 2,3 - 6,3%. While rheumatism aggravation appears in 2,5 - 25% of cases, usually within the first 3 and last 2 months of pregnancy, as well as during first year after childbirth.  Acquired rheumatic heart diseases account for 75-90% of all heart lesions in pregnant women.  Of all forms of rheumatic origin defects the most often are observed mitral valvular insufficiency and a combination of stenosis of the left atrioventricular openings.
  • 6. To predict the outcomes of pregnancy and childbirth  The following factors are important:  Activity of rheumatoid process  Form and stage of rheumatic defects  Compensation or decompensation of blood circulation  The degree of pulmonary hypertension  Cardiac arrhythmias  Joining obstetrics pathology
  • 7. Risk classification of adverse pregnancy outcome in patients with heart defects  1 degree - Pregnancy in heart defects without marked signs of heart failure and acute rheumatic process.  2 degree - Pregnancy with heart defects with initial symptoms of heart failure (shortness of breath, tachycardia), evidence rheumatism active phase symptoms (A.I. Nesterov,degree A 1)
  • 8.  3 degree - Pregnancy in decompensated heart defect with signs of the predominance of right heart failure, presence of the active phase of rheumatism (A 2), atrial fibrillation, pulmonary hypertension.  4 degree - Pregnancy in decompensated heart defect with signs of left ventricular failure, atrial fibrillation, thromboembolic manifestations of pulmonary hypertension.  According to this scheme continuation of the pregnancy is permissible, with 1 and 2 degree of risk, only under the supervision of an outpatient and cardioobsterical facility and with a 3 time hospitalization
  • 9. Pregnancy and childbirth in arterial hypertension  Arterial hypertension detected in 5% of pregnant women:  70% of hypertension in pregnant women  15-25% - hypertensive disease  2-5% - secondary hypertension Complications:  Violations of the functions of the placenta:  leads to hypoxia  Syndrome of intrauterine growth retardation  death fetal  Placental Abruption
  • 10. Therapy  Hypertension treatment includes the creation of emotional rest for a patient  strict observance of day regimen  diet  medication  and physiotherapy
  • 11. Kidney disease  Kidney disease and urinary tract infections hold second place after diseases of the cardiovascular system among extragenital pathology of pregnant women and pose a risk for both mother and fetus.  During pregnancy: hypotension and increased pyelocaliceal system and ureters is observed  uterus is deflected to the right
  • 12. Infection enters the urinary tract:  ascending path (from the bladder)  descending - lymphogenous (from the intestine, especially during constipation)  haematogenous (for various infectious diseases) Pathogens:  Escherichia coli,  gram-negative enterobacteria,  Pseudomonas aeruginosa,  Proteus, enterococcus,  golden stafilakokk,  streptococci,  fungi such as Candida.
  • 13. Clinical forms  Common clinical forms should be noted-pyelonephritis, hydronephrosis, asymptomatic bacteriuria  Rarely-glomerulonephritis, tuberculosis kidney, urolithiasis, developmental anomalies of the urinary tract.  Pyelonephritis - is the most frequent disease during pregnancy (from 6 to 12%), its when concentrating ability of the kidneys suffers.  Pyelonephritis has a negative effect on pregnancy and the fetus.
  • 14. Diabetes and pregnancy  The problem of pregnancy in women with diabetes is relevant throughout the world.  The course of pregnancy and childbirth in diabetes mellitus  It adversely affects:  -Utero fetal development  -Increased frequency of malformations  -High perinatal morbidity and mortality
  • 15. Types of diabetes  Type I diabetes - Insulin dependent diabetes mellitus (IDDM);  Type II diabetes - insulin-independent diabetes mellitus (INSD);  Type III diabetes - gestational diabetes (GD), which develops after 28 weeks. pregnancy and is transient violation of glucose utilization in women during pregnancy.
  • 16.  The most frequent is insulin dependent diabetes mellitus (IDDM). The disease is usually diagnosed in girls in childhood, during puberty.  Insulin-independent diabetes mellitus (INSD) occurs in older women (after 30 years), and it proceeds less seriously.  Gestational diabetes is diagnosed very rarely.
  • 17.  I-week pregnancy. The course of diabetes in the majority of pregnant women remains unchanged.  II half of pregnancy. Worsens carbohydrate tolerance, amplified diabetic complaints.  by the end of pregnancy carbohydrate tolerance improves again, blood glucose levels and insulin doses are reduced.
  • 18. At childbirth  High hypergikemiya, the state of acidosis and hypoglycemic state is possible in pregnant women with diabetes. Obstetric complications in the second half of pregnancy:  hypertension of pregnant  polyhydramnios  risk of preterm birth  fetal hypoxia  urinary tract infections
  • 19. The flow of labor is complicated by:  presence of a large fetus  uterine inertia  prenatal amniorrhea  increase of fetal hypoxia  development of functional-narrow pelvis  shortness of birth shoulder girdle  development of endometritis in childbirth  birth injuries of mother and fetus
  • 20. Contraindications to pregnancy in diabetes  The presence of rapidly progressive vascular complications:  Retinopathy  Insulineresistent  Labile forms of diabetes  Presence of diabetes mellitus in both parents, which dramatically increases the possibility of disease in children  The combination of diabetes and Rh-sensitized mother  Combination of diabetes mellitus and active pulmonary tuberculosis
  • 21. Treatment  Insulin therapy during pregnancy is required even under mild forms of diabetes
  • 22. Thyroid disease and pregnancy  The thyroid gland - is an endocrine organ that produces hormones essential for organism - thyroxine (or tetraiodothyronine - T4) and triiodothyronine (T3).
  • 23. Toxic goiter  Graves disease (GD) occurs most frequently during pregnancy (from 0,2 to 8%). It’s mandatory symptoms are hyperplasia and hyper function of the thyroid gland. The course of pregnancy  In the I half-all women have a disease escalation  In the II half-due to blockade of excess hormones in some patients with mild thyrotoxicosis there is improvement.
  • 24. The course of pregnancy  Hypertension pregnant  Preterm delivery  At childbirth  At childbirth decompensation of the circulatory system can often occur, and in the postpartum and early postpartum period - bleeding.  In the postpartum period The sharp worsening of postpartum thyrotoxicosis requires:  treatment using merkazalil (it passes through the milk to the fetus)  suppression of lactation.
  • 25. Tactics obstetrician-gynecologist and endocrinologist  Hospitalization in the early period to 12 weeks for examination and decision on the possibility of carrying out the pregnancy. Pregnancy is contraindicated:  Pregnancy is contraindicated in the average severity of diffuse goiter and nodular goiter, if a woman does not intend to does not intend to have surgery?) in a period of 14 weeks.  Pregnancy is possible to bear only a mild degree of thyrotoxicosis a diffuse goiter and positive treatment diyodtirozin.
  • 26. Active pulmonary tuberculosis  Indications for abortion to 12 weeks:  Common destructive process in the lungs, poorly amenable to treatment;  aggravation of the process during a previous pregnancy;  pregnancy less than 2 years after suffering miliary tuberculosis;
  • 27. Prevention of extra genital diseases  Preventive measures of complications of pregnancy and childbirth during the extra genital diseases - regular monitoring of pregnant women in antenatal clinic by the obstetrician-gynecologist, a physician, an endocrinologist, a mandatory three times hospitalization and effective outpatient therapy.