The global animal health care market grew steadily from $XX billion in 2006 to $XX billion in
2011, registering a CAGR of 6%. North America and Europe contributed around 50-55% of total
sales in 2011. However, Europe's contribution declined due to reduced meat consumption. Asia-
Pacific and Latin America contributed around 20-25% each in 2011 and their contributions grew
by 2-3% due to rising demand for animal health care products.
Asia Pacific Animal Health Care Market Outlook to 2016 - Compelling Potential...AMMindpower
The report titled “Asia Pacific Animal Health Care Market Outlook to 2016 –compelling potential in vaccine segment” provides a comprehensive analysis of market size of global and Asia pacific animal health care industry, market segmentation of Asia Pacific animal health care industry by geography, pharmaceuticals, vaccines, medical feeds and on the basis of animals. The report also provides competitive landscape and profile of major players operating in the animal health care industry.
For more information on the research report please refer to the below mentioned link:
http://www.ammindpower.com/report.php?A=299&T=D&S=91
Japan pharmaceutical industry & forecast focus on otc and prescription drugs...AMMindpower
The report offer detailed study of OTC and prescription drugs market, key trends, driving forces and recent Mergers and acquisitions. The report also talks about future outlook of overall Japanese Pharmaceutical industry and demand for prescription and OTC drugs in coming years.
The animal health care market in the world has grown remarkably over the past few years due to the growth in the emerging markets such as China, India, Indonesia, Thailand, Malaysia and Taiwan followed by US and Europe. The animal health industry’s SWOT analysis provides animal health solutions to society depends on its in-depth knowledge of both cutting-edge technologies and classical veterinary science to innovate and keep up with the animal and human health challenges of new and emerging diseases. The main finding of this project indicates India is one of the important markets and can be seen as a key growth area in global animal health care industry.
- The Indian animal healthcare industry is responsible for maintaining the health and productivity of the over 640 million livestock and 2 billion poultry in India and ensuring the wholesomeness and abundance of the food they produce. Apart from, the industry must also cater to the health and well being of companion animals. Despite this, the global animal healthcare market is 50 times larger than the Indian animal healthcare combined market for all nonhuman species. In spite of this India’s largest milk and 3rd largest meat producer, and blessed with largest cattle population 20% of the world population, and largest buffalo more than 50% of the world. Veterinary Pharmaceutical is yet not considered as big industry as compared to Human Pharmaceutical. The reality is that the global animal health market is very complex, operating under stringent and increasingly strict regulations similar to those for human health, yet the market opportunities are considerably smaller. In an increasingly risky environment for new product development and innovation, the difference between success and failure in the future usually lies in successfully identifying the next growth segment, developing the right product candidates and being the first to market. The situation in developing countries like India is varied and economic and institutional framework of the live stock is often quite different in several respects to that encounter in developed world.
A challenging aspect of the overall market is within the animal food industry as consumers continue to express concern about the conditions under which their daily food is produced. Indian consumers are becoming more health conscious, willing to pay any amount and demanding healthy and balanced diets. By implementing a feeding plan that provides vitamins and supplements, consumers enjoy additional nutritional benefits. Additionally, healthy feeding results in minimized impact on the environment.
Asia Pacific Animal Health Care Market Outlook to 2016 - Compelling Potential...AMMindpower
The report titled “Asia Pacific Animal Health Care Market Outlook to 2016 –compelling potential in vaccine segment” provides a comprehensive analysis of market size of global and Asia pacific animal health care industry, market segmentation of Asia Pacific animal health care industry by geography, pharmaceuticals, vaccines, medical feeds and on the basis of animals. The report also provides competitive landscape and profile of major players operating in the animal health care industry.
For more information on the research report please refer to the below mentioned link:
http://www.ammindpower.com/report.php?A=299&T=D&S=91
Japan pharmaceutical industry & forecast focus on otc and prescription drugs...AMMindpower
The report offer detailed study of OTC and prescription drugs market, key trends, driving forces and recent Mergers and acquisitions. The report also talks about future outlook of overall Japanese Pharmaceutical industry and demand for prescription and OTC drugs in coming years.
The animal health care market in the world has grown remarkably over the past few years due to the growth in the emerging markets such as China, India, Indonesia, Thailand, Malaysia and Taiwan followed by US and Europe. The animal health industry’s SWOT analysis provides animal health solutions to society depends on its in-depth knowledge of both cutting-edge technologies and classical veterinary science to innovate and keep up with the animal and human health challenges of new and emerging diseases. The main finding of this project indicates India is one of the important markets and can be seen as a key growth area in global animal health care industry.
- The Indian animal healthcare industry is responsible for maintaining the health and productivity of the over 640 million livestock and 2 billion poultry in India and ensuring the wholesomeness and abundance of the food they produce. Apart from, the industry must also cater to the health and well being of companion animals. Despite this, the global animal healthcare market is 50 times larger than the Indian animal healthcare combined market for all nonhuman species. In spite of this India’s largest milk and 3rd largest meat producer, and blessed with largest cattle population 20% of the world population, and largest buffalo more than 50% of the world. Veterinary Pharmaceutical is yet not considered as big industry as compared to Human Pharmaceutical. The reality is that the global animal health market is very complex, operating under stringent and increasingly strict regulations similar to those for human health, yet the market opportunities are considerably smaller. In an increasingly risky environment for new product development and innovation, the difference between success and failure in the future usually lies in successfully identifying the next growth segment, developing the right product candidates and being the first to market. The situation in developing countries like India is varied and economic and institutional framework of the live stock is often quite different in several respects to that encounter in developed world.
A challenging aspect of the overall market is within the animal food industry as consumers continue to express concern about the conditions under which their daily food is produced. Indian consumers are becoming more health conscious, willing to pay any amount and demanding healthy and balanced diets. By implementing a feeding plan that provides vitamins and supplements, consumers enjoy additional nutritional benefits. Additionally, healthy feeding results in minimized impact on the environment.
This is a Equity Research Report on Pharmaceutical Industry.
Various ratios of company is compared with industry ratios and tried to evaluate the potential of the stock of the company whether to buy, sell or hold. This may help you to understand interpretation of various financial ratios.
Global Animal Health Care Market Outlook to 2016 - Growth Opportunity in the ...AMMindpower
The report titled “Global Animal Health Care Market Outlook to 2016 - Growth Ppportunity in the Emerging Asia” provides a comprehensive analysis of market size of animal health care industry on the basis of region such as Asia Pacific, Europe, North America and Latin America, market segmentation by pharmaceuticals, vaccines, medical feeds and on the basis of animals. The report also provides competitive landscape and profile of major players operating in the animal health care industry.
For more information on the research report please refer to the below mentioned link:
This is a Equity Research Report on Pharmaceutical Industry.
Various ratios of company is compared with industry ratios and tried to evaluate the potential of the stock of the company whether to buy, sell or hold. This may help you to understand interpretation of various financial ratios.
Global Animal Health Care Market Outlook to 2016 - Growth Opportunity in the ...AMMindpower
The report titled “Global Animal Health Care Market Outlook to 2016 - Growth Ppportunity in the Emerging Asia” provides a comprehensive analysis of market size of animal health care industry on the basis of region such as Asia Pacific, Europe, North America and Latin America, market segmentation by pharmaceuticals, vaccines, medical feeds and on the basis of animals. The report also provides competitive landscape and profile of major players operating in the animal health care industry.
For more information on the research report please refer to the below mentioned link:
Global crop protection industry outlook to 2016 sample reportAMMindpower
Report includes performance of agrochemical market, herbicides, fungicide, insecticides and bio-pesticides, micro-nutrients and adjuvant segments with coverage of Europe, Asia and NAFTA region and 9 countries including the US, Canada, India, China, Japan, Germany, France, Italy and Spain.
Global crop protection industry outlook to 2016 sample reportAMMindpower
Report includes performance of agrochemical market, herbicides, fungicide, insecticides and bio-pesticides, micro-nutrients and adjuvant segments with coverage of Europe, Asia and NAFTA region and 9 countries including the US, Canada, India, China, Japan, Germany, France, Italy and Spain.
India Animal Health Market PPT: Demand, Trends and Business Opportunities 202...IMARC Group
Looking forward, the india animal health market value is projected to reach a strong growth during the forecast period (2022-2027).
More info:- https://www.imarcgroup.com/india-animal-health-market
Global Healthcare IT Market Outlook to 2016 - Evolving mHealth and PACS MarketAMMindpower
The report titled “Global Healthcare IT Market Outlook to 2016 – Evolving mHealth and PACS Market” provides a comprehensive analysis on the total number of Global healthcare IT market size, segmentation of healthcare IT market, EMR segment, PACS market, Telemedicine market, telemonitoring market and mHealth market. The report provides the competitive landscape of global healthcare IT market, global EMR market and global PACS market. The report also discusses major trends and developments in the global mHealth and Healthcare IT market, company profile players, and the cause and effect relationship between industry factors and global healthcare IT market prospects. The future projections included in the report provide an insight on the prospects in the Global healthcare IT market, EMR market, mHealth market, telemedicine market, telemonitoring market and PACS market.
For more information on the industry research report please refer to the below mentioned link:
http://www.ammindpower.com/report.php?A=302&T=D&S=91
The Indian Innerwear Market Outlook to 2015 - Growth Opportunity for Internat...AMMindpower
The report provides a comprehensive analysis of market size of men’s and women’s innerwear on the basis of value and volume, market segmentation by organized, unorganized, low, economy, medium, premium, super premium and average selling price.
For more information on the industry research report please refer to the below mentioned link:
http://www.ammindpower.com/report.php?A=301&T=D&S=95
Brazil petroleum and natural gas market outlook to 2016 executive summaryAMMindpower
The report titled “Brazil Petroleum and Natural Gas Market Outlook to 2016 - Opportunities in Pre-Salt Region” provides a comprehensive analysis of market size of petroleum and natural gas industry on the basis of petroleum industry and natural gas industry.
Indian auto components industry outlook edition 2012AMMindpower
The report Focus on Automotive Chains’ OEM and Replacement Market” focuses on several growth aspects of the industry and various factors which pose challenges.
Europe crop protection industry outlook to 2016 sample reportAMMindpower
The present title analyses market size of herbicides, fungicide, insecticides and bio-pesticides, micro-nutrients and adjuvant segments in the Europe region with major focus on France, Germany, Italy and Spain. It highlights company profiles, future outlook of the industry and major driving forces.
Europe crop protection industry outlook to 2016 sample reportAMMindpower
The present title analyses market size of herbicides, fungicide, insecticides and bio-pesticides, micro-nutrients and adjuvant segments in the Europe region with major focus on France, Germany, Italy and Spain. It highlights company profiles, future outlook of the industry and major driving forces.
The us pharmaceutical industry outlook to 2016 sample reportAMMindpower
The present report gives a detailed analysis on the Pharmaceutical market in the US covering various aspects such as market size of the pharmaceutical industry, market segmentation by Branded and Generic drugs, and Prescribed and OTC drugs and Biologics and specialty drugs segments.
The us replacement tires industry outlook to 2016 sample reportAMMindpower
The present report offer detailed analysis on the US replacement tire industry with market size by value & volume, segmentation, regulations, competition and players profiling. Industry forecasting is an important part of the report which may help industry players to make strategies accordingly.
China pharmaceutical industry research & forecast to 2016 sample reportAMMindpower
The present title on “China Pharmaceutical Industry Research and Forecast to 2016” offer detailed study on drugs market in terms of OTC, Patent and Generic drugs. Also assess industry performance in terms of recent developments, driving forces, regulatory structure, economy environment and political situation.
Middle east real estate market outlook sample reportAMMindpower
The present report provides a comprehensive study on the Middle East’s real estate market with a focus on the reduced household budget allocation of the tenants. The report covers seven countries such as Saudi Arabia, Egypt, UAE (including Northern Emirates, Dubai and Abu Dhabi), Jordan, Oman Kuwait and Qatar on the basis of supply and revenue. It also discusses the segments of the market, competitive landscape and profile of major players.
Asia has taken a Lead as One of The Most Preferred Destination for Medical To...AMMindpower
The report titled “Asia Medical Tourism Industry Outlook to 2015 - The Destination for Foreign Patients” highlights the above mentioned fact along with the detailed analysis of the various aspects of the medical tourism such as number of foreign patients, cost of treatment, foreign patient’s revenue and medical tourists.
For more information please refer to the below mentioned link:
http://www.ammindpower.com/report.php?A=240
The European Golf Industry is Benefiting from Rising Golf Participation Rate ...AMMindpower
According to a report titled “Global Golf Industry, Participation and Growth Forecast” which provides a comprehensive analysis on the golf industry in the US, Europe and Asia.
A Major Portion of the Demand for Golf Equipment is Coming from Western Part ...AMMindpower
The report titled “Global Golf Industry, Participation and Growth Forecast” highlights the above mentioned fact along with the detailed analysis of the various aspects of the golf industry in the US, Europe and Asia, golf course revenues, equipment supplies, rounds played and number of golfers.
For more information please refer to the below mentioned link:
http://www.ammindpower.com/report.php?A=231&T=D&S=95
India’s total Gems and Jewelry Sales is expected to Register a Growth of 7.1%...AMMindpower
The report titled “India Gems and Jewelry Industry Outlook to 2015” highlights the above mentioned fact along with the detailed analysis of the various aspects such as gems and jewelry industry, total jewelry retail sales, imports and exports and information on various segments.
For more information please refer to the below mentioned link:
http://www.ammindpower.com/report.php?A=242
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
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Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection