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Name- Mohammad Asim
Roll no- 20/MPH/DIPSAR/2019
Supervisor- Dr Meenakshi K. Chauhan
Date-
Subject- Pharmaceutics practical II (MPH 205P)
Reference
 E. Touitou, N. Dayan, L. Bergelson, B. Godin, M. Eliaz,
Ethosomes — novel vesicular carriers for enhanced delivery:
characterization and skin penetration properties, Journal of
Controlled Release 65 (2000) 403–418.
Chemicals
required
• Lecithin
• Ethanol
• Distilled water
Apparatus
required
• Round bottom flask
• Magnetic stirrer
• Bath sonicator
• Nicomp® Nano DLS/ZLS zeta sizer
Theory
• Ethosomes are soft lipid vesicles made up of phospholipids, ethanol
and water.
• It can entrap drug molecules of various physical and chemical
characteristics i.e., hydrophilic, lipophilic or amphiphilic.
• The size range of ethosomes may vary from 10 nanometers to
microns.
• In 1996, Touitou discovered and investigated lipid vesicular system
containing ethanol in concentration range 10-50%.
• These are non invasive delivery carriers that enable drugs to reach the
deep skin layers and/or systemic circulation.
Advantages vs
disadvantages
Advantages
• Delivery of large molecules
is possible (peptides, protein
molecules)
• Enhanced permeation of
drug through skin for
transdermal drug delivery.
• High patient compliance.
• Simple method for drug
delivery.
• It is passive, non invasive
and is available for
immediate
commercialization.
Disadvantages
• May not be economical, poor
yield.
• Drugs that require high blood
levels cannot be administered
– limited to only potent
drugs, those requiring a daily
dose of 10 mg or less.
• Coalescence of ethosomes
may occur.
Mechanism of
penetrati
onof
ethosomes
 Ethanol effect
• Ethanol acts as penetration
enhancer through skin.
• Ethanol penetrates into
intercellular lipids and
increases the fluidity of cell
membrane lipids and
decrease the density of lipid
multilayer of cell membrane.
 Ethosome effect
• Increased cell membrane
lipid fluidity due to ethanol.
• Increased skin permeability.
• So the ethosomes permeated
very easily inside the deep
skin layers, where it gets
fused with skin lipids and
releases the drugs.
Ethosomes - formulation and evaluation
Class Use
Phospholipid Vesicle forming component
Alcohol For providing softness for vesicle
membrane also as a penetration
enhancer
Polyglycol As a skin penetration enhancer
cholesterol Enhances the stability and
entrapment efficiency of drugs
Composition
of ethosomes
Formulation of
ethosomes
• Ethosomes were prepared by taking lecithin (3% w/v) in a small
round bottom flask and solubilized with ethanol (50% v/v) under
mixing with a magnetic stirrer at 30°C.
• The round bottom flask was covered to avoid ethanol evaporation.
• Distilled water was added slowly with continuous stirring at 700
rpm to obtain the ethosomal colloidal suspensions.
• Finally it was sonicated for 15 minutes.
Ethanol + Phospholipid
(at 30°C)
Distilled water
(at 30°C)
At 700 rpm Ethosomes of irregular
size range were
obtained
Ethosomes of regular
size range were
obtained
Sonicated
for 15
minutes
Particle size
determination
• Nicomp® Nano DLS/ZLS System was used for particle size
determination.
• Small amount of sample was run for particle size
determination and the particle size of ethosome was found to
be 762 nm.
Ethosomes - formulation and evaluation
Conclusion
and result
• Ethosomes were successfully formulated.
• Particle size of ethosomes was found to be 762 nm.

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Ethosomes - formulation and evaluation

  • 1. Name- Mohammad Asim Roll no- 20/MPH/DIPSAR/2019 Supervisor- Dr Meenakshi K. Chauhan Date- Subject- Pharmaceutics practical II (MPH 205P)
  • 2. Reference  E. Touitou, N. Dayan, L. Bergelson, B. Godin, M. Eliaz, Ethosomes — novel vesicular carriers for enhanced delivery: characterization and skin penetration properties, Journal of Controlled Release 65 (2000) 403–418.
  • 4. Apparatus required • Round bottom flask • Magnetic stirrer • Bath sonicator • Nicomp® Nano DLS/ZLS zeta sizer
  • 5. Theory • Ethosomes are soft lipid vesicles made up of phospholipids, ethanol and water. • It can entrap drug molecules of various physical and chemical characteristics i.e., hydrophilic, lipophilic or amphiphilic. • The size range of ethosomes may vary from 10 nanometers to microns. • In 1996, Touitou discovered and investigated lipid vesicular system containing ethanol in concentration range 10-50%. • These are non invasive delivery carriers that enable drugs to reach the deep skin layers and/or systemic circulation.
  • 6. Advantages vs disadvantages Advantages • Delivery of large molecules is possible (peptides, protein molecules) • Enhanced permeation of drug through skin for transdermal drug delivery. • High patient compliance. • Simple method for drug delivery. • It is passive, non invasive and is available for immediate commercialization. Disadvantages • May not be economical, poor yield. • Drugs that require high blood levels cannot be administered – limited to only potent drugs, those requiring a daily dose of 10 mg or less. • Coalescence of ethosomes may occur.
  • 7. Mechanism of penetrati onof ethosomes  Ethanol effect • Ethanol acts as penetration enhancer through skin. • Ethanol penetrates into intercellular lipids and increases the fluidity of cell membrane lipids and decrease the density of lipid multilayer of cell membrane.  Ethosome effect • Increased cell membrane lipid fluidity due to ethanol. • Increased skin permeability. • So the ethosomes permeated very easily inside the deep skin layers, where it gets fused with skin lipids and releases the drugs.
  • 9. Class Use Phospholipid Vesicle forming component Alcohol For providing softness for vesicle membrane also as a penetration enhancer Polyglycol As a skin penetration enhancer cholesterol Enhances the stability and entrapment efficiency of drugs Composition of ethosomes
  • 10. Formulation of ethosomes • Ethosomes were prepared by taking lecithin (3% w/v) in a small round bottom flask and solubilized with ethanol (50% v/v) under mixing with a magnetic stirrer at 30°C. • The round bottom flask was covered to avoid ethanol evaporation. • Distilled water was added slowly with continuous stirring at 700 rpm to obtain the ethosomal colloidal suspensions. • Finally it was sonicated for 15 minutes.
  • 11. Ethanol + Phospholipid (at 30°C) Distilled water (at 30°C) At 700 rpm Ethosomes of irregular size range were obtained Ethosomes of regular size range were obtained Sonicated for 15 minutes
  • 12. Particle size determination • Nicomp® Nano DLS/ZLS System was used for particle size determination. • Small amount of sample was run for particle size determination and the particle size of ethosome was found to be 762 nm.
  • 14. Conclusion and result • Ethosomes were successfully formulated. • Particle size of ethosomes was found to be 762 nm.