ESnet6 provides an ultra-fast and reliable network that enables new smart instruments for 21st century science. The network capacity has increased dramatically over time, with 2022 bandwidth being 500,000 times greater than 1993. This network allows rapid data transfer between facilities, such as replicating 7 petabytes of climate data between three labs. It also enables fast assembly and use of new instruments like high energy diffraction microscopy that can perform an analysis in 31 seconds. The integrated research infrastructure provided by Globus further supports use of remote resources and smart instruments that will drive scientific discovery.