Epidemic diseases are spread by insects passing on microorganisms like bacteria, viruses, and protozoa when they feed or bite. Mosquitoes in particular spread serious epidemic diseases such as malaria, yellow fever, African sleeping sickness, and West Nile virus. Malaria is one of the deadliest diseases worldwide, spread by the bite of the Anopheles mosquito between dusk and dawn across over 100 countries. Yellow fever is also spread by mosquitoes and causes varied symptoms with most improving after a few days but some experiencing liver and kidney failure. Vaccines exist for these diseases but are not always accessible in developing areas.