EWMA 2013-Ep429-THE USE OF CELLULAR TECHNOLOGY IN TREATMENT OF CHILDREN WITH DEEP BURNS

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THE USE OF CELLULAR TECHNOLOGY IN TREATMENT OF CHILDREN WITH DEEP BURNS Budkevich Ludmila1, Koroleva Tatiana1 1Moscow Scientific Institute of Pediatrics and Children Surgery (Moscow, Russia).

Moscow Scientific Institute of Pediatrics and Children
Surgery
Speransky Children Hospital, Moscow, Russia
THE USE OF CELLULAR
TECHNOLOGY IN TREATMENT
OF CHILDREN WITH DEEP
BURNS
Ludmila Budkevich, Tatyana Koroleva

Cellular technologies (grown autologous
keratinocytes, allofibroblasts)
 Difficulties with cultivation of cell layers
 High percentage of complications
 Shortcoming of legal using in Russia

ReCell®
Device for receipt autologous cells:
 Keratinocytes
 Melanocytes
 Fibroblasts
 Langerhans cells
Suspension time preparation : 20-30 minutes
Area of coverage max 320 cm2
Biopsy size : 1-4 cm2

2011-2012 years
10 children with deep dermal burns with hot liquid
Age from 8 months to 3 years
From 3 to 25% TBSA
Sex
Boys
Girls
6
4

Location of deep dermal burns:
Chest 4
Stomach 4
Upper extremities 6
Lower extremities 2
TBSA of deep dermal
burns:
1-10% (78 – 320 cm2)

Performed surgical operation:
Tangential necrectomy
+
Skin grafting of a 1:4 meshed
+
Transplantation of autocells with «ReCell®»
technology

Results:
 Mean time of full epithelization of burn wounds
9 day after operation
 Total hospital bed-days: 15 days
 No local infectious complications
 On follow-up - minimal scars
 Pigmentation of scars was close to healthy skin

A child aged 1-year old with
deep dermal burn 10% TBSA
7 days after
operation
6 months
after
operation
A burn wound Transplantation
autocells

A child aged 1-year old with deep
dermal burn 10% TBSA
A burn wound Transplantation
autocells
11 days after
operation
8 months
after
operation

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Maggot Therapy

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This document discusses the history and modern use of maggot therapy in medicine. Maggot therapy involves using fly larvae to clean infected and necrotic wounds. Maggots secrete enzymes that eat away dead tissue while leaving healthy tissue intact. They also secrete antibacterial compounds. This "debridement" action helps disinfect wounds and stimulate healing. While widely used in the early 20th century, maggot therapy fell out of favor after antibiotics were discovered. However, it is seeing renewed interest due to antibiotic-resistant infections. The FDA now regulates the use of medicinal maggots to treat chronic wounds.

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EWMA 2013-Ep429-THE USE OF CELLULAR TECHNOLOGY IN TREATMENT OF CHILDREN WITH DEEP BURNS

1. Moscow Scientific Institute of Pediatrics and Children Surgery Speransky Children Hospital, Moscow, Russia THE USE OF CELLULAR TECHNOLOGY IN TREATMENT OF CHILDREN WITH DEEP BURNS Ludmila Budkevich, Tatyana Koroleva

2. Cellular technologies (grown autologous keratinocytes, allofibroblasts)  Difficulties with cultivation of cell layers  High percentage of complications  Shortcoming of legal using in Russia

3. ReCell® Device for receipt autologous cells:  Keratinocytes  Melanocytes  Fibroblasts  Langerhans cells Suspension time preparation : 20-30 minutes Area of coverage max 320 cm2 Biopsy size : 1-4 cm2

4. 2011-2012 years 10 children with deep dermal burns with hot liquid Age from 8 months to 3 years From 3 to 25% TBSA Sex Boys Girls 6 4

5. Location of deep dermal burns: Chest 4 Stomach 4 Upper extremities 6 Lower extremities 2 TBSA of deep dermal burns: 1-10% (78 – 320 cm2)

6. Performed surgical operation: Tangential necrectomy + Skin grafting of a 1:4 meshed + Transplantation of autocells with «ReCell®» technology

7. Results:  Mean time of full epithelization of burn wounds 9 day after operation  Total hospital bed-days: 15 days  No local infectious complications  On follow-up - minimal scars  Pigmentation of scars was close to healthy skin

8. A child aged 1-year old with deep dermal burn 10% TBSA 7 days after operation 6 months after operation A burn wound Transplantation autocells

9. A child aged 1-year old with deep dermal burn 10% TBSA A burn wound Transplantation autocells 11 days after operation 8 months after operation

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