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New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
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3. The slide title goes here!
Do you know what helps you make your point clear?
Lists like this one:
● They’re simple
● You can organize your ideas clearly
● You’ll never forget to buy milk!
And the most important thing: the audience won’t miss
the point of your presentation
4. About the disease
Diagnosis
Pathology
Treatment
01
02 You can describe the topic of the
section here
04 You can describe the topic of the
section here
05 You can describe the topic of the
section here
Table of contents
You can describe the topic of the
section here
03 You can describe the topic of the
section here
06 You can describe the topic of the
section here
Recommendations Conclusions
6. Introduction
Mercury is the closest planet to the Sun and the smallest one in the
Solar System—it’s only a bit larger than the Moon. This planet’s name
has nothing to do with the liquid metal, since Mercury was named after
the Roman messenger god
9. 333,000
9h 55m 23s
386,000 km
Jupiter’s rotation period
The Sun’s mass compared to Earth’s
Distance between Earth and the Moon
Key numbers
10. Mercury is the closest planet to the Sun and the smallest one in the entire
Solar System. This planet’s name has nothing to do with the liquid metal, since
Mercury was named after the Roman messenger god. Despite being closer to
the Sun than Venus, its temperatures aren't as terribly hot as that planet’s. Its
surface is quite similar to that of Earth’s Moon, which means there are a lot of
craters and plains. Speaking of craters, many of them were named after artists
or authors who made significant contributions to their respective fields
Mercury takes a little more than 58 days to complete its rotation, so try to
imagine how long days must be there! Since the temperatures are so extreme,
albeit not as extreme as on Venus, and the solar radiation is so high, Mercury
has been deemed to be non-habitable for humans. We’ve already mentioned
that Mercury is the smallest planet in the Solar System, but conversely, its core
has the same size as Earth's! What's more, since Mercury’s core contains so
much iron—more than any other planet in the Solar System
ENT disorders
11. Mars
Jupiter
Venus
Three areas
Mars is a very cold place. It’s full of iron oxide dust, which
gives the planet its reddish cast
Jupiter is the biggest planet in the Solar System and the
fourth-brightest object in the night sky
Venus has a beautiful name and is the second planet
from the Sun. It’s terribly hot
13. A picture always
reinforces the concept
Images reveal large amounts of data, so
remember: use an image instead of a long
text. Your audience will appreciate it
14. About some ENT diseases
Type
Type Saturn
It’s composed of
hydrogen and helium
Neptune
Neptune is the farthest
planet from the Sun
Mars
Mars is actually a very
cold place
Venus
Venus is the second
planet from the Sun
Mercury
It’s the smallest planet in
the Solar System
Jupiter
Jupiter is the biggest
planet of them all
01
02
15. Concept A Concept B Concept C
Neptune is the farthest
planet from the Sun and
the fourth-largest in the
Solar System
Mercury is the closest
planet to the Sun and
also the smallest one in
our Solar System
Concepts and typology
Despite being red, Mars
is a cold place. It’s full of
iron oxide dust, giving
the planet its red cast
16. Nose Throat
Mercury is the closest
planet to the Sun and
also the smallest one in
our Solar System
Despite being red, Mars
is a cold place. It’s full of
iron oxide dust, giving
the planet its red cast
17. Mercury
Venus
Mars
Jupiter
Mercury is the closest
planet to the Sun
Despite being red, Mars is
a cold place
Venus is the second
planet from the Sun
Jupiter is the biggest
planet of them all
Pathology
18. 02
Ear, nose and throat
You can describe the topic of the section here
19. Symptoms of some diseases
Mercury
Mercury is the closest
planet to the Sun
Venus
Venus is the second
planet from the Sun
Mars
Despite being red, Mars
is actually a cold place
01
02
03
20. Risk factors
Follow the link in the graph to modify its data and then paste the new one here. For more info, click here
Mars
Despite being red,
Mars is a cold place
Mercury
It’s the closest
planet to the Sun
50%
Risk factor 1
30%
Risk factor 2
20%
Risk factor 3
200
120
Saturn
It’s a gas giant and
has several rings
80
21. —Someone Famous
“This is a quote, words full of
wisdom that someone
important said and can make
the reader get inspired.”
23. Recommendations
● You can describe what the
patient should do here
● You can describe what the
patient should do here
● You can describe what the
patient should do here
What to do What not to do
● You can describe what the
patient shouldn’t do here
● You can describe what the
patient shouldn’t do here
● You can describe what the
patient shouldn’t do here
24. Prevention
Treatments Recommendations
Studies A Venus is the second planet
from the Sun
● You can describe what the patient
should do here
● You can describe what the patient
should do here
● You can describe what the patient
should do here
Studies B Jupiter is the biggest
planet in the Solar System
Studies C Despite being red, Mars is
a very cold place
25. 01
03 04
02
Treatment
Venus
Venus is the second
planet from the Sun
Mercury
Mercury is the closest
planet to the Sun
Mars
Despite being red,
Mars is a cold place
Saturn
Saturn is a gas giant
and has several rings
26. ENT disorders timeline
Mercury
Mercury the closest
planet to the Sun
01
Venus
Venus is the second
planet from the Sun
02
Jupiter
Jupiter is the biggest
planet of them all
03
Saturn
Saturn is composed of
hydrogen and helium
04
Neptune
Neptune is very far
away from the Sun
05
27. Prevalence
High
Venus has a
beautiful name
Moderate
Mercury is quite a
small planet
Follow the link in the graph
to modify its data and then
paste the new one here. For
more info, click here
30+
20-29
28. Mercury is the closest planet to the Sun and
the smallest one in the Solar System
Conclusion 1
Earth is the third planet from the Sun and the
only one that harbors life
Conclusion 2
Mars is a cold place. It’s full of iron oxide dust,
which gives the planet its reddish cast
Conclusion 3
29. Our team
John Doe
Sarah James
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● Author (Year). Title of the publication. Publisher
● Author (Year). Title of the publication. Publisher
● Author (Year). Title of the publication. Publisher
● Author (Year). Title of the publication. Publisher
● Author (Year). Title of the publication. Publisher
● Author (Year). Title of the publication. Publisher
References
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