Endocrine role of osteocalcin in homeostatic regulation of glucose metabolism
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Osteocalcin, a well-known bone formation marker, is secreted from osteoblasts and exists in fully carboxylated, partially carboxylated, and completely uncarboxylated forms. The endocrine involvement of uncarboxylated osteocalcin in glucose homeostasis has recently been confirmed. It has been demonstrated that double recessive osteocalcin mutant mice are hyperglycemic, hypoinsulinemic, and have reduced β cell numbers and insulin resistance. In contrast, leptin (an adipocyte-derived hormone) indirectly regulates the secretion of insulin in part through inhibition of osteocalcin conversion to uncarboxylated form via β2 adrenergic receptor signaling in osteoblasts. Because uncarboxylated osteocalcin is a secretagogue of insulin, which in turn positively regulates the bone formation, osteocalcin lies at the centre of the complex mechanism of glucose homeostasis and bone remodeling network.
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Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
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Describe the primary categories of smells and the concept of odor blindness.
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Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
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Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
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Stimulation of Olfactory Cells:
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Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
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Behavioral and emotional influences of smell.
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Receptors of Taste:
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Primary and Secondary Taste Sensations:
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Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
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Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
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Structure and Function of Taste Buds:
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Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
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Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
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Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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Acathocephalan of genus Raosentis are intestinal parasites of fresh water fishes. Subfamily Pallisentinae of order Gyracanthocephala includes four genera namely Acanthosentis (Verma & Datta,1929), Acanthogyrus (Thaper, 1927), Pallisentis (Van Cleave,1928) and Raosentis (Datta, 1947). The genus Raosentis was established By Datta (1947) with Raosentis podderi as its type species from a fresh water fish Mystus cavasius from Culcutta. The genus Raosentis differs from all the above genus in having proboscis armed with anterior two circle of hooks longer than posterior two circle with hook less space between second and third circle of hooks. The present study deals with the description of Raosentis lucknowensis n.sp.
On two new species of Acanthocephalan Genus Acanthosentis Verma and Dutta, 19...
The order Gyracanthocephala Van Cleave, 1936 includes family Quadrigyridae Van Cleave, 1920 divided into two sub-families Quadrigyrinae Van Cleave, 1920, with one genus Quadrigyrus from India and Pallisentinae Amin, 1985, with four genera Pallisentis Van Cleave, 1928; Acanthosenus Verma and Dutta, 1929; Acanthogyrus Thapar, 1927 and Raosentis Dutta, 1947) from India. Galvan (1959) synonymised Acanthosentis Verma and Dutta, 1929 with Acanthogyrus Thapar, 1927 and reduced Acanthoseniis to a subgenus further Galvan (l 994) reconsidered the generic status of Acanthosentis. Amin (2005) in agreement with Amin ( 1985) and Amin & Hendrix (1999) retained the status of Acanthosentis as sub-genus, most probably he has not got access of literature of Verma and Dutta, 1929. Bhattacharya (2007) in agreement with Verma and Dutta, 1925 given Acanthosentis to full generic status with proper justification supported by key, and authors are also in agreement with this. The type species Acanthosentis antespinus Verma & Dutta, 1929 was reported from fish Mystus gulio at Calcutta, India. Other species reported from India are A. duttai Podder, 1938; A. sircari Podder, 1941; A. giuris Soota and Sen, 1954; A. betwai Tripathi, 1959; A. indicus Tripathi, 1959; A. cameroni Gupta and Kajaji, 1969; A. thapari Prashad et al. 1969; A. bacailai Verma, 1973; A. vittatusi Verma, 1973; A. golvani Gupta & Jain, 1980; A. shuklai Agrawal & Singh, 1982; A. vancleavi Gupta & Fatma 1985; A. bilaspurensis Chowhan er al, 1987; A. gobindi Chowhan et al. 1987; A. putitorae Chowhan et al. 1988 and A. seenghalae Chowhan et al, 1988. In this paper we have described two new species of Genus Acanthosentis Verma and Dutta, 1929 recovered from the intestine of fish Channa punctatus (Bloch.) of river Gomti at Lucknow. India.
µCT analysis reveals that Cissus quadrangularis L. Stem and Trigonella foenum...
Cissus quadrangularis L. (hadjod) and Trigonella foenum-graecum L. (fenugreek) plant parts are used for fracture healing and as an antidiabetic agent, respectively in traditional medicine. This study aimed to investigate the efficacy of C. quadrangularis stem bark extract (CQ) and T. foenum-graecum seed extract (TFG) therapy for the treatment of type I diabetes induced osteopenia. Alloxan (dissolved in 0.1 M citrate buffer (pH = 4.5); intraperitoneally injected @ 130 mg/kg body weight) induced type I diabetic rats were treated with individual and combined doses of ethanol extracts of CQ and TFG for consecutive 30 days @ 250 and 500 mg per kg body weight, orally. Insulin (0.5 IU/kg body weight) was chosen as standard. Body weight and fasting blood glucose were recorded. Two-dimensional (2D) and three-dimensional (3D) analysis of the femur and tibia were performed using micro-computed tomography (µCT) scan to measure histomorphometric parameters of trabecular and cortical regions and bone mineral density (BMD). Elevated level of fasting blood glucose was restored to the vehicle-treated group after treatment with CQ and TFG. Both the extracts significantly improved trabecular histomorphometric parameters, viz. BMD, percent bone volume, trabecular number, trabecular separation, connection density. Cortical mean total cross-sectional bone area, cross-sectional thickness, mean total cross-sectional tissue area were comparable to the vehicle-treated group. CQ and TFG combination therapy showed a marked improvement in bone microarchitecture and can be given together as a potential alternative medicine to insulin for prevention of type I diabetes induced osteopathy. Therefore, it can be considered in the management of diabetic osteopathy in humans.
On Wardianum witenbergi n. sp. (Digenea: Cyclocoelidae) from Numenius arquata...
During the study of the helminth parasites of birds from the Lucknow, specimens of an undescribed species of Wardianum (Family Cylcocoelidae Kossack, 1911) were collected from Eurasian Curlew, Numenius arquata Linn. The Genus Wardianum Witenberg, 1923 including the trematodes of air sacs of birds. Body of these parasites markedly tapered anteriorly, caeca without diverticules, testes juxtaposed inside caecal arch, ovary just pretesticular, median or submedian. Vitellaria directly lateral to caeca, not united posteriorly.
Longicollum dattai n. sp. (Acanthocephala: Pomphorhynchidae Yamaguti, 1939) f...
During examination of intestine of marine fish, Drepane punctata (Cuv. & Val.) collected from Deegha, West Bengal, three specimens of an acanthocephalan parasite belonging to the genus Longicollum Yamaguti (1939), including two female and one male, were recovered from the intestine of the host. On subsequent study, the worm appears to be new and is described here in as new species.
On a new species of the genus Tenuiproboscis meyeri from a marine fish Scatop...
Acanthocephalans are among the most important and injurious groups of parasites infesting the fishes of India. It has been estimated that out of 800 reported species of acanthocephalans, 229 species are from India (Alfred, 1998). Fishes seem to tolerate high intensity of worms without showing pronounced symptoms of infection, and its complications (Taraschewski, 2000). Due to lack of symptoms in early stage of acanthocephalan infection in fishes, no diagnostic tool is available except postmortem investigations and identification by a helminth taxonomist. In the present paper, an account of a new acanthocephalan parasite recovered from the intestine of a marine fish Scatophague argus (Cuv. and Val.) from Deegha, West Bengal, has been given.
Diabetes mellitus: The Pandemic of 21st Century!
Diabetes mellitus is a major global metabolic disorder of 21 st century. This is due to its broad spectrum of associated complications with risks, like cardiac and renal disorders. The rapid growth of diabetes is becoming a major burden upon healthcare facilities in all affected countries. Due to lack of definitive preventative measures of diabetes, we must be aware of this pandemic and follow a disciplined lifestyle to limit it. In this communication, recent advances in diabetes management and current preventative measures have been concluded.
More from RahulGupta2015 (7)
On a new Acanthocephalan Raosentis (Patta, 1928) Recovered from intestine of ...
On a new Acanthocephalan Raosentis (Patta, 1928) Recovered from intestine of ...
On two new species of Acanthocephalan Genus Acanthosentis Verma and Dutta, 19...
On two new species of Acanthocephalan Genus Acanthosentis Verma and Dutta, 19...
µCT analysis reveals that Cissus quadrangularis L. Stem and Trigonella foenum...
µCT analysis reveals that Cissus quadrangularis L. Stem and Trigonella foenum...
On Wardianum witenbergi n. sp. (Digenea: Cyclocoelidae) from Numenius arquata...
On Wardianum witenbergi n. sp. (Digenea: Cyclocoelidae) from Numenius arquata...
Longicollum dattai n. sp. (Acanthocephala: Pomphorhynchidae Yamaguti, 1939) f...
Longicollum dattai n. sp. (Acanthocephala: Pomphorhynchidae Yamaguti, 1939) f...
On a new species of the genus Tenuiproboscis meyeri from a marine fish Scatop...
On a new species of the genus Tenuiproboscis meyeri from a marine fish Scatop...
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Hemodialysis: Chapter 3, Dialysis Water Unit - Dr.Gawad
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
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The POPPY STUDY (Preconception to post-partum cardiovascular function in prim...
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Physiology of Chemical Sensation of smell.pdf
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
ANATOMY AND PHYSIOLOGY OF URINARY SYSTEM.pptx
Valuable Content of Human Anatomy and Physiology of Urinary system as per PCI Syllabus for Pharmacy and PharmD Students.
The hemodynamic and autonomic determinants of elevated blood pressure in obes...
Christopher Hearon
The University of Texas Southwestern Medical Center
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Charaka Samhita Sutra sthana Chapter 15 Upakalpaniyaadhyaya
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Physiology of Special Chemical Sensation of Taste
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
KDIGO 2024 guidelines for diabetologists
KDIGO guidelines 2024 for evaluation and management of CKD, related to diabetes and management of diabetic kidney disease
How to Give Better Lectures: Some Tips for Doctors
Talk given to Koronadal Internists Society, Marbel, South Cotabato as part of the Continuing Medical Education (CME) series.
The Normal Electrocardiogram - Part I of II
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Evaluation of antidepressant activity of clitoris ternatea in animals
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Surat @ℂall @Girls ꧁❤8527049040❤꧂@ℂall @Girls Service Vip Top Model Safe
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Couples presenting to the infertility clinic- Do they really have infertility...
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Flu Vaccine Alert in Bangalore Karnataka
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
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