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EMULSION PROCESSING
JOSHITA DJAJADISASTRA
EMULSION PROCESSING
Yang mempengaruhi distribusi ukuran
tetesan, viskositas dan stabilitas emulsi :
• Metode penambahan
• Kecepatan penambahan
• Suhu masing2 fase
• Kecepatan pendinginan setelah
pencampuran fase
Emulsi o/w
• Fase minyak ditambahkan ke dalam fase
air
• Teknik inversi:fase air dimasukkan ke
dalam fase minyak – awalnya terbentuk w/
o, kmd viskositas naik karena volume fase
internal naik sampai titik inversi –
terbentuk o/w
Emulsi w/o
• Fase air ditambahkan ke dalam fase
minyak dengan pengadukan konstan, lalu
dihomogenkan, digiling untuk mengecilkan
ukuran partikel fase internal utk
meningkatkan stabilitas dan memperbaiki
kilatnya emulsi
Metode konvensional
• Memanaskan fase minyak +yg terlarut didalamnya
sampai 5-10o di atas ttk leleh tertinggi dari komponen
fase minyak
• Memanaskan fase air pada suhu yang sama jangan >
85oC
• Satu fase ditambahkan pada fase lain dengan
pengadukan konstan selama proses penambahan
• Kecepatan pendinginan adalah sangat penting untuk
mendapatkan tekstur dan konsistensi emulsi – karena
tipe kristalisasi komponen yg BM tinggi spt: beeswax,
asam stearat, cetyl alkohol dan GMS
• Dlm skala produksi – scale up dari skala labor, proses
pengadukan dan pendinginan perlu dipelajari dengan
cermat
• Gunakan peralatan jacket untuk pembuatan emulsi skala
besar untuk mengontrol suhu pemanasan dan
pendinginan
Tambahan
• Penambahan gum
• Peralatan
• Penyiapan untuk evaluasi dan uji klinik dlm batch 2,5-25
kg adalah kesempatan untuk mengamati, mengoreksi
dan memperbaiki
• Mixing dan Stirring adalah proses penyiapan yang kritis
dalam membuat emulsi
• Waktu, suhu dan kerja mesin penting dalam
pembuatan emulsi semisolid di pabrik.Ketiga faktor ini
saling berinteraksi dan harus dikontrol dengan hati2 jika
batch berkualitas tinggi akan diproduksi berulangkali
• Diperlukan peralatan yg dapat mengontrol secara
otomatis suhu dalam jaket, regulasi waktu pencampuran
dan kecepatan pengadukan
• Ketel harus bersih sebelum digunakan kembali-
mencegah kontaminasi yang dpt mempengaruhi
kestabilan
Tambahan
• Komponen minyak ditempatkan dalam ketel stainless
steel berjaket uap air, disini dilelehkan dan dicampur
• Dipindahkan ke dalam ketel pencampuran emulsi
dengan pompa yang dindingnya sudah dipanaskan
untuk menghindari pembekuan kembali
• Fase air dan komponen yang terlarut didalamnya
disiapkan dengan air murni dan disaring
• Dicampurkan pada suhu 70-72 oC
• Pendinginan biasanya umumnya lambat agar dapat
terus dicampur selagi bahan emulsi masih cair
• Penambahan obat dilakukan dalam keadaan terlarut
• Mencukupkan volume akhir
PERALATAN EMULSIFIKASI
• Pengadukan mekanik
• Homogenisasi
• Penggilingan
• Penghilangan busa dan udara
SIFAT EMULSI
• Penampilan dan perabaan
• Ukuran partikel
• pH
• Viskositas
STABILITAS EMULSI
• Creaming dan sedimentasi
• Agregasi dan Koalesensi
• Stres Testing

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Emulsionprocessing

  • 2. EMULSION PROCESSING Yang mempengaruhi distribusi ukuran tetesan, viskositas dan stabilitas emulsi : • Metode penambahan • Kecepatan penambahan • Suhu masing2 fase • Kecepatan pendinginan setelah pencampuran fase
  • 3. Emulsi o/w • Fase minyak ditambahkan ke dalam fase air • Teknik inversi:fase air dimasukkan ke dalam fase minyak – awalnya terbentuk w/ o, kmd viskositas naik karena volume fase internal naik sampai titik inversi – terbentuk o/w
  • 4. Emulsi w/o • Fase air ditambahkan ke dalam fase minyak dengan pengadukan konstan, lalu dihomogenkan, digiling untuk mengecilkan ukuran partikel fase internal utk meningkatkan stabilitas dan memperbaiki kilatnya emulsi
  • 5. Metode konvensional • Memanaskan fase minyak +yg terlarut didalamnya sampai 5-10o di atas ttk leleh tertinggi dari komponen fase minyak • Memanaskan fase air pada suhu yang sama jangan > 85oC • Satu fase ditambahkan pada fase lain dengan pengadukan konstan selama proses penambahan • Kecepatan pendinginan adalah sangat penting untuk mendapatkan tekstur dan konsistensi emulsi – karena tipe kristalisasi komponen yg BM tinggi spt: beeswax, asam stearat, cetyl alkohol dan GMS • Dlm skala produksi – scale up dari skala labor, proses pengadukan dan pendinginan perlu dipelajari dengan cermat • Gunakan peralatan jacket untuk pembuatan emulsi skala besar untuk mengontrol suhu pemanasan dan pendinginan
  • 6. Tambahan • Penambahan gum • Peralatan • Penyiapan untuk evaluasi dan uji klinik dlm batch 2,5-25 kg adalah kesempatan untuk mengamati, mengoreksi dan memperbaiki • Mixing dan Stirring adalah proses penyiapan yang kritis dalam membuat emulsi • Waktu, suhu dan kerja mesin penting dalam pembuatan emulsi semisolid di pabrik.Ketiga faktor ini saling berinteraksi dan harus dikontrol dengan hati2 jika batch berkualitas tinggi akan diproduksi berulangkali • Diperlukan peralatan yg dapat mengontrol secara otomatis suhu dalam jaket, regulasi waktu pencampuran dan kecepatan pengadukan • Ketel harus bersih sebelum digunakan kembali- mencegah kontaminasi yang dpt mempengaruhi kestabilan
  • 7. Tambahan • Komponen minyak ditempatkan dalam ketel stainless steel berjaket uap air, disini dilelehkan dan dicampur • Dipindahkan ke dalam ketel pencampuran emulsi dengan pompa yang dindingnya sudah dipanaskan untuk menghindari pembekuan kembali • Fase air dan komponen yang terlarut didalamnya disiapkan dengan air murni dan disaring • Dicampurkan pada suhu 70-72 oC • Pendinginan biasanya umumnya lambat agar dapat terus dicampur selagi bahan emulsi masih cair • Penambahan obat dilakukan dalam keadaan terlarut • Mencukupkan volume akhir
  • 8. PERALATAN EMULSIFIKASI • Pengadukan mekanik • Homogenisasi • Penggilingan • Penghilangan busa dan udara
  • 9. SIFAT EMULSI • Penampilan dan perabaan • Ukuran partikel • pH • Viskositas
  • 10. STABILITAS EMULSI • Creaming dan sedimentasi • Agregasi dan Koalesensi • Stres Testing