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Energy sources in surgery
DR.UMA
Types of energy in operating room
• Monopolar radiofrequency energy
• Bipolar radiofrequency energy
• Ultrasonic energy
• Thunder beat
• Plasma energy
• Laser
• Radiofrequency energy abalation
• Microwave
• Radiosurgery
• Cryotherapy
• Photodynamic therapy
• CUSA
• Vessel ligation technology
History
• William bovie developed the first
electrosurgical device
• First usage started at 1926 at peter bent
bringham hospital in bostan
• Cushing first published series of 5000
neurosurgeries performed with an
electrocautery device by bovie
Electrocautery & Electrosurgery
• Electrocautery refers to direct current whereas
electrosurgery refers to alternate current
• During electro cautery current donot enter
patients body and only heated wire comes in
contact with tissue whereas in electrosurgery
patient is included in circuit and currents
enters patients body
Electrosurgery
• Electrosurgery is passage of high frequency
electric current through tissue to create a
desired clinical effect
• Basic principle of electricity is it seeks the
path of least resistance
Properties of electricity
• POWER(W)=VOLTS * AMPERE
• CURRENT(A)= VLOTS/ IMPEDENCE
• W= Energy produced over time
• V=pressure required to push electron
• A= rate at which electron flow
• Impedence = resistance to flow of
current(ohms)
Fundamental of electrosurgey
• In radiofrequency electrosurgery
electromagnetic energy is converted into
kinetic energy then to thermal energy
• Medium of current is high frequency AC
current as low frequency cause stimulation of
neuromuscular system causing fasciculations
• Because the frequency used is in excess of
300kHz they are called radiofrequency
• Galvanic effect:
– When direct current is used anions and cations
disperse towards their respective oppositely
charged electrodes and serves no medical
purpose
– Whereas AC current is applied they migrate
towards opposite poles but cannot maintain single
orientation within cell and they oscillate in
conjugation with differing polarity
• Faradic effect:
– When low frequency AC (20-30kHz ) is used It
cause depolarization & stimulation of nerve and
muscle causing fasciculation and pain
• when an high frequency alternating current is
applied across cell membrane, pulse duration is so
short that sodium and potassium channel is not even
opened and electromagnetic energy is converted into
mechanical energy then into thermal energy with the
help of friction forces
• Joules law:
– when an AC/ DC flows through the resistor heat is
generated (i.e)due to impedance provided to flow
of current & thermal energy is generated
Components of electrosurgery
• Radiofrequency electrosurgical generator or
unit ESU
• Electrosurgical radio frequency instruments
– Active electrode
– Dispersive electrode
Principle of diathermy
• When electric current pass through conductor
some of energy appears as heat and it
depends on:
– Intensity of current
– Waveform of current
– Electrical property of tissue through which energy
passes
– Relative size of two electrodes
Principle of monopolar
• Alternating current produced by generator
and passed to patient via an active electrode
which has a very small surface area
• Then the current passes through the tissue
and returns via a large surface plate back to
earth pole
• As surface area of electrode is small the
current produce heat at operative site
• The large surface area of patient plate spreads
the returning current over a wide and surface
area so it is less concentrated and produce
less heat
Principle of bipolar
• Two active electrodes are usually represented
by limbs of pair of diathermy
• Both forceps ends are active and therefore
current flows through them heats only the
tissue between them
Effects of diathemy
• Coagulation: sealing of blood vessel
– High voltage low current mode
• Fulguration: the destructive coagulation of
tissues with charring
– High voltage , low current mode
• Cutting: to divide tissue during bloodless
surgery
– Low voltage , high current
Tissue effects with waveform
modification
• Cutting
– Uses constant waveform
– Current flow is 100% of cycle
– Low voltage produces intense heat
– Contact mode cause dehydration of tissue
– Non contact mode cause vapourisation and
cutting
• Coagulation:
– Uses intermittent waveform so ‘on’ time( duty
cycle is reduced)
– Produce less heat
– Current flow 6% of cycle
– Uses high voltage low flow current
• Blend:
– Is not a mixture of both cutting and coagulation
– It is modification of duty cycle( on time)
– Duty cycle is progressively reduced from blend 1
to blend 3
– Low duty cycle produce less heat
– Blend 1 vaporise tissue with less hemostasis and
vicecersa
Variables impacting tissue effects
• Waveforms
• Size of electrode: smaller is the electrode the
higher the current concentration
• Time : the longer the generator is active more
heat is produced
• Manipulation of electrode: in contact or away
from tissue
• Type of tissue: which varies in resistance
• Eschar :electrodes free of eschar have enhanced
performance
Grounded electrosurgical system
• Originally generators used grounded current
• It was assumed that current entered the
patients body would return to ground
through patient return electrode
• But electricity will always seek path of least
resistance and as many conductive objects
touching patient , the current will enter this
pathway to ground leading to alternate site
burns
RF Current division
• The current may split and follow more than one
path to ground
• Patients are exposed to alternate site burns
• Reasons :
– Currents flows through easiest pathway
– Any grounded object not just generator complete the
circuit
– Surgical environment offers many alternate route
– If resistance of alternate pathway is least the current
flowing through this pathway is sufficient to cause
burns
Isolated electrosurgical system
• Isolated generators isolate the therapeutic
current from grounded by referencing with
the generator circuit
• Even though ground objects remain in OR
electrosurgical current from isolated
generators will not recognise these objects
Deactivated isolated system
• If the circuit to patient return electrode is
broken an isolated generator will deactivate
because current cannot return to its source
• Isolated system can mitigate alternate site
burns but donot protect from return electrode
burns
Return electrode
• They are not inactive or passive and the only
difference between active electrode and
return electrode is size and relative
conductivity
• The function of return electrode or dispersive
electrode is to safely remove current from
patients body
• The return electrode should present a large
and low impedence contact area to patient
• If the surface area is reduced or impedance of
contact is increased it results in burns
• When surface area is reduced large amount of
current is concentrated in small area produce
heat
• Impedance increases when it is attached to
hairy area, adipose tissue, bony prominence ,
scar tissue adhesive failure, fluid invasion
Return electrode monitering
technology
• Quality monitering to protect patients from
burns due to inadequate contact of return
electrode
• REM equipped generators actively moniter the
amount of impedance at the patient pad
interface
• The system is designed to deactivate before an
injury occurs if it detects dangerous level of
impedance
Bipolar diathermy
• Advantages :
– Precise
– Safe
– Used in endoscopic surgery
– Unintentional burns avoided
– Less distrubances to other electronic devices
connected to patient
•Disadvantage :
•Only small amount of tissue can be handeled
•Cutting possible only with microprocessor controlled machine
Complication of diathermy:
• Fire :
– For fire to occur 3 elements must be present
– Heat( surgical energy), fuel( alcohol based
preperation), oxygen
– Rescue patient or staff
– Alert- activate fire alarm
– Confine- isolate fire by closing doors
– Evacuate the incident room and entire surgical
suite
• Antenna coupling
– Radiofrequency energy from wire or cable of
monopolar device can transmit into air and
nearby conductors
– Prevention:
• separate active and dispersive electrodes from other
nearby wires
• Minimize voltage
• Avoid usage of monopolar in single incision laproscopic
surgery
• Insulation failure
– Most common cause of thermal injury
– Common in monopolar
– Prevention:
• Careful inspection of instrument prior to use
• Maximize visualisation of entire instrument during activation to
indentify abberent energy arcs
• Residual heat
– Is defined as increased instrument temperature after
energy activation is complete
– Causes injury to tissue when reapplied prior to complete
heat dissipation
– Prevention: resue after 5 seconds of cooling
• Direct application:
– Unintentional activation of device during device use
– Eg: when surgeon leans on monopolar it activates and
burns patient skin
• Interaction with electronic devices
– Radiofrequency energy transmitted through air interferes
with nearby monitering devises like ECG leads, implanted
cardiac devices
– Eg: during activatio of monopolar cardiac defibrilator
sensitize dysrythmia and administer shock
– Prevention:utilize low power and avoid use of energy
devise near or parallel to implantable devise
• Direct coupling:
– Intentional when surgeon touches monopolar to
forceps to coagulate a tissue
– Unintentional when it is not under vision
– Prevention: avoid contact with other conductive
instruments, have complete visualisation before
activation
• Capacitive coupling
• capacitance is stored electric charges
when two conductors are seperated by an
insulator
• the stored energy can be transferred
through intact insulation into nearby
conductors like bowel producing injury
• prevention:
– use of low voltage
– Avoid usage of combined plastic and metal lap trocars
– Maintain complete visualisation of instrument
Channeling
• Occurs if current passes through a narrow
channel or a pedicle to active electrode,
enough heat may be generated to coagulate
tissue
– Coagulation of penis in children undergoing
circumcision
– Coagulation of spermatic cord when the electrode
is applied for testis
Ultrasonic energy
• Converts low voltage energy into high-
frequency mechanical vibrations via
piezoeletric crystals
• Rapid vibrations generate friction that heats
tissues, degenerate proteins(coagulate) and
creates tissue seperations (cuts) at
temperature below boiling point
• Advantage
– minimal charring,
– decrease operative time,
– seal vasculature upto 3mm,
– excellent hemostasis,
– minimal lateral thermal damage,
– low smoke,
– no risk of electrical current passage into patient
• Disadvantage: high cost
Thunderbeat
• Integration of ultrasonic and bipolar energy
simultaneously from a single instrument
• Ability to cut tissue with ultrasonic energy and
ability to create reliable vessel seals with
bipolar energy
• Advantage:
– 7mm sealing
– Minimal thermal spread
– Reduces mist formation
Plasma energy
• Radiofrequency energy is applied is carried
into tissue by an inert gas (argon)
• Used for superficial coagulation of diffuse
bleeding tissue like liver and spleen
• Disadvantage : intravascular embolism of
insoluble argon resulted in cardiac arrest and
death
Laser
• Generates heat by focusing beam of light on
tissue
• Can be used for both cutting and coagulation
• Can be used in dental, opthal, cosmetic and
gynecological procedure
• Common type: argon, Nd-YAG
• Penetration : Nd-Yag>CO2>argon
• Drawback: high cost
Radiofrequency energy abalation
• Basic method: placing a electrode on target tissue
to transmit high frequency alternating current to
tissue @ 300-500kHz- where kinetic energy is
converted into heat
• Has built in sensor for automatically terminating
transmission of current at a particular set point to
prevent unwanted collateral damage
• Used in tumor of liver, pancreas, thyroid, breast,
bone
Microwave abalation
• Uses generator to transmit microwave energy
at frequency of 2450MHz via probe placed
within target organ under image guidance
• Application : liver, partial nephrectomy,
prostatic hyperplasia, endometrial bleeding
• Only small area is abalated so it needs
mulitple insertion of probe to treat single
lesion
Radiosurgery
• Principle in neurosurgery
• Tool is gamma knife
• Allows more than 200 separate source of high
energy gamma radiation to be focused onto a
minute area in brain
• Ability to destroy minute area in brain and
used in treatment of benign and malignant
neoplasm, AV malformations and epilepsy
Cryotherapy
• Destroy cells by freezing and thawing
• With liquid nitrogen or argon circulating
through probe placed over or within lesion
tissue can be frozen to temperature of -35
degree
• Used for cutaneous lesion., tumor of head and
neck, cervix and rectum, prostate
• Major disadvantage: cost
Photodynamic therpy
• Administration of target specific photo
sensitizer in target tissue
• Photosensitizing agent is then activated with
wavelength specific light source – leads to
generation of free radicals cytotoxic to target
tissue
• Used in early pancreatic cancer, SCC, BCC,
chest involvement in breast cancer, chest wall
recurrence in breast cancer
CUSA
• Cavitron ultrasonic surgical aspirator
• Dissecting device that uses low ultrasonic
frequencies to fragment tissue
• Utilizing hollow titanium tip that vibrates and
cause fragmentation of susceptible tissue,
while concurrently irrigating and aspirating
material from surgical site
• Selectively abalates tissue with high water
content
• Advantage:
– Less blood loss
– Improved visibility
– Reduced collateral tissue injury
– Useful in removing non ressectable brain and
spine tumor, non cirrhotic liver and pancreatic
tumor
Vessel sealing technology
• Ligasure :
– Combination of pressure and energy-> denaturate collagen
and elastin –> permanent seal
– Seals upto 7mm vessel and withstand 3 times normal SBP
• Enseal :
– Small electrode technology : Uses million of nano
conductive particles each with discrete thermostatic
switch
– Particle interupts current flow when temperature rises and
turns back on when temperature falls
– Vessel wall fuses by compression and protein denaturation
REFERENCE
• FISCHER’S MASTER OF SURGERY
• BAILEY AND LOVE
• SABISTON
THANK U

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electrical energy in general surgery.pptx

  • 1. Energy sources in surgery DR.UMA
  • 2. Types of energy in operating room • Monopolar radiofrequency energy • Bipolar radiofrequency energy • Ultrasonic energy • Thunder beat • Plasma energy • Laser • Radiofrequency energy abalation • Microwave • Radiosurgery • Cryotherapy • Photodynamic therapy • CUSA • Vessel ligation technology
  • 3. History • William bovie developed the first electrosurgical device • First usage started at 1926 at peter bent bringham hospital in bostan • Cushing first published series of 5000 neurosurgeries performed with an electrocautery device by bovie
  • 4. Electrocautery & Electrosurgery • Electrocautery refers to direct current whereas electrosurgery refers to alternate current • During electro cautery current donot enter patients body and only heated wire comes in contact with tissue whereas in electrosurgery patient is included in circuit and currents enters patients body
  • 5.
  • 6.
  • 7. Electrosurgery • Electrosurgery is passage of high frequency electric current through tissue to create a desired clinical effect • Basic principle of electricity is it seeks the path of least resistance
  • 8. Properties of electricity • POWER(W)=VOLTS * AMPERE • CURRENT(A)= VLOTS/ IMPEDENCE • W= Energy produced over time • V=pressure required to push electron • A= rate at which electron flow • Impedence = resistance to flow of current(ohms)
  • 9. Fundamental of electrosurgey • In radiofrequency electrosurgery electromagnetic energy is converted into kinetic energy then to thermal energy • Medium of current is high frequency AC current as low frequency cause stimulation of neuromuscular system causing fasciculations • Because the frequency used is in excess of 300kHz they are called radiofrequency
  • 10. • Galvanic effect: – When direct current is used anions and cations disperse towards their respective oppositely charged electrodes and serves no medical purpose – Whereas AC current is applied they migrate towards opposite poles but cannot maintain single orientation within cell and they oscillate in conjugation with differing polarity
  • 11.
  • 12. • Faradic effect: – When low frequency AC (20-30kHz ) is used It cause depolarization & stimulation of nerve and muscle causing fasciculation and pain • when an high frequency alternating current is applied across cell membrane, pulse duration is so short that sodium and potassium channel is not even opened and electromagnetic energy is converted into mechanical energy then into thermal energy with the help of friction forces
  • 13. • Joules law: – when an AC/ DC flows through the resistor heat is generated (i.e)due to impedance provided to flow of current & thermal energy is generated
  • 14.
  • 15. Components of electrosurgery • Radiofrequency electrosurgical generator or unit ESU • Electrosurgical radio frequency instruments – Active electrode – Dispersive electrode
  • 16. Principle of diathermy • When electric current pass through conductor some of energy appears as heat and it depends on: – Intensity of current – Waveform of current – Electrical property of tissue through which energy passes – Relative size of two electrodes
  • 17. Principle of monopolar • Alternating current produced by generator and passed to patient via an active electrode which has a very small surface area • Then the current passes through the tissue and returns via a large surface plate back to earth pole • As surface area of electrode is small the current produce heat at operative site
  • 18. • The large surface area of patient plate spreads the returning current over a wide and surface area so it is less concentrated and produce less heat
  • 19.
  • 20. Principle of bipolar • Two active electrodes are usually represented by limbs of pair of diathermy • Both forceps ends are active and therefore current flows through them heats only the tissue between them
  • 21. Effects of diathemy • Coagulation: sealing of blood vessel – High voltage low current mode • Fulguration: the destructive coagulation of tissues with charring – High voltage , low current mode • Cutting: to divide tissue during bloodless surgery – Low voltage , high current
  • 22. Tissue effects with waveform modification • Cutting – Uses constant waveform – Current flow is 100% of cycle – Low voltage produces intense heat – Contact mode cause dehydration of tissue – Non contact mode cause vapourisation and cutting
  • 23. • Coagulation: – Uses intermittent waveform so ‘on’ time( duty cycle is reduced) – Produce less heat – Current flow 6% of cycle – Uses high voltage low flow current
  • 24. • Blend: – Is not a mixture of both cutting and coagulation – It is modification of duty cycle( on time) – Duty cycle is progressively reduced from blend 1 to blend 3 – Low duty cycle produce less heat – Blend 1 vaporise tissue with less hemostasis and vicecersa
  • 25.
  • 26.
  • 27. Variables impacting tissue effects • Waveforms • Size of electrode: smaller is the electrode the higher the current concentration • Time : the longer the generator is active more heat is produced • Manipulation of electrode: in contact or away from tissue • Type of tissue: which varies in resistance • Eschar :electrodes free of eschar have enhanced performance
  • 28. Grounded electrosurgical system • Originally generators used grounded current • It was assumed that current entered the patients body would return to ground through patient return electrode • But electricity will always seek path of least resistance and as many conductive objects touching patient , the current will enter this pathway to ground leading to alternate site burns
  • 29.
  • 30. RF Current division • The current may split and follow more than one path to ground • Patients are exposed to alternate site burns • Reasons : – Currents flows through easiest pathway – Any grounded object not just generator complete the circuit – Surgical environment offers many alternate route – If resistance of alternate pathway is least the current flowing through this pathway is sufficient to cause burns
  • 31. Isolated electrosurgical system • Isolated generators isolate the therapeutic current from grounded by referencing with the generator circuit • Even though ground objects remain in OR electrosurgical current from isolated generators will not recognise these objects
  • 32.
  • 33. Deactivated isolated system • If the circuit to patient return electrode is broken an isolated generator will deactivate because current cannot return to its source • Isolated system can mitigate alternate site burns but donot protect from return electrode burns
  • 34. Return electrode • They are not inactive or passive and the only difference between active electrode and return electrode is size and relative conductivity • The function of return electrode or dispersive electrode is to safely remove current from patients body • The return electrode should present a large and low impedence contact area to patient
  • 35. • If the surface area is reduced or impedance of contact is increased it results in burns • When surface area is reduced large amount of current is concentrated in small area produce heat • Impedance increases when it is attached to hairy area, adipose tissue, bony prominence , scar tissue adhesive failure, fluid invasion
  • 36. Return electrode monitering technology • Quality monitering to protect patients from burns due to inadequate contact of return electrode • REM equipped generators actively moniter the amount of impedance at the patient pad interface • The system is designed to deactivate before an injury occurs if it detects dangerous level of impedance
  • 37. Bipolar diathermy • Advantages : – Precise – Safe – Used in endoscopic surgery – Unintentional burns avoided – Less distrubances to other electronic devices connected to patient •Disadvantage : •Only small amount of tissue can be handeled •Cutting possible only with microprocessor controlled machine
  • 38. Complication of diathermy: • Fire : – For fire to occur 3 elements must be present – Heat( surgical energy), fuel( alcohol based preperation), oxygen – Rescue patient or staff – Alert- activate fire alarm – Confine- isolate fire by closing doors – Evacuate the incident room and entire surgical suite
  • 39. • Antenna coupling – Radiofrequency energy from wire or cable of monopolar device can transmit into air and nearby conductors – Prevention: • separate active and dispersive electrodes from other nearby wires • Minimize voltage • Avoid usage of monopolar in single incision laproscopic surgery
  • 40. • Insulation failure – Most common cause of thermal injury – Common in monopolar – Prevention: • Careful inspection of instrument prior to use • Maximize visualisation of entire instrument during activation to indentify abberent energy arcs • Residual heat – Is defined as increased instrument temperature after energy activation is complete – Causes injury to tissue when reapplied prior to complete heat dissipation – Prevention: resue after 5 seconds of cooling
  • 41.
  • 42. • Direct application: – Unintentional activation of device during device use – Eg: when surgeon leans on monopolar it activates and burns patient skin • Interaction with electronic devices – Radiofrequency energy transmitted through air interferes with nearby monitering devises like ECG leads, implanted cardiac devices – Eg: during activatio of monopolar cardiac defibrilator sensitize dysrythmia and administer shock – Prevention:utilize low power and avoid use of energy devise near or parallel to implantable devise
  • 43.
  • 44. • Direct coupling: – Intentional when surgeon touches monopolar to forceps to coagulate a tissue – Unintentional when it is not under vision – Prevention: avoid contact with other conductive instruments, have complete visualisation before activation
  • 45.
  • 46. • Capacitive coupling • capacitance is stored electric charges when two conductors are seperated by an insulator • the stored energy can be transferred through intact insulation into nearby conductors like bowel producing injury • prevention: – use of low voltage – Avoid usage of combined plastic and metal lap trocars – Maintain complete visualisation of instrument
  • 47.
  • 48. Channeling • Occurs if current passes through a narrow channel or a pedicle to active electrode, enough heat may be generated to coagulate tissue – Coagulation of penis in children undergoing circumcision – Coagulation of spermatic cord when the electrode is applied for testis
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  • 50.
  • 51.
  • 52.
  • 53.
  • 54. Ultrasonic energy • Converts low voltage energy into high- frequency mechanical vibrations via piezoeletric crystals • Rapid vibrations generate friction that heats tissues, degenerate proteins(coagulate) and creates tissue seperations (cuts) at temperature below boiling point
  • 55.
  • 56. • Advantage – minimal charring, – decrease operative time, – seal vasculature upto 3mm, – excellent hemostasis, – minimal lateral thermal damage, – low smoke, – no risk of electrical current passage into patient • Disadvantage: high cost
  • 57. Thunderbeat • Integration of ultrasonic and bipolar energy simultaneously from a single instrument • Ability to cut tissue with ultrasonic energy and ability to create reliable vessel seals with bipolar energy • Advantage: – 7mm sealing – Minimal thermal spread – Reduces mist formation
  • 58. Plasma energy • Radiofrequency energy is applied is carried into tissue by an inert gas (argon) • Used for superficial coagulation of diffuse bleeding tissue like liver and spleen • Disadvantage : intravascular embolism of insoluble argon resulted in cardiac arrest and death
  • 59. Laser • Generates heat by focusing beam of light on tissue • Can be used for both cutting and coagulation • Can be used in dental, opthal, cosmetic and gynecological procedure • Common type: argon, Nd-YAG • Penetration : Nd-Yag>CO2>argon • Drawback: high cost
  • 60. Radiofrequency energy abalation • Basic method: placing a electrode on target tissue to transmit high frequency alternating current to tissue @ 300-500kHz- where kinetic energy is converted into heat • Has built in sensor for automatically terminating transmission of current at a particular set point to prevent unwanted collateral damage • Used in tumor of liver, pancreas, thyroid, breast, bone
  • 61. Microwave abalation • Uses generator to transmit microwave energy at frequency of 2450MHz via probe placed within target organ under image guidance • Application : liver, partial nephrectomy, prostatic hyperplasia, endometrial bleeding • Only small area is abalated so it needs mulitple insertion of probe to treat single lesion
  • 62. Radiosurgery • Principle in neurosurgery • Tool is gamma knife • Allows more than 200 separate source of high energy gamma radiation to be focused onto a minute area in brain • Ability to destroy minute area in brain and used in treatment of benign and malignant neoplasm, AV malformations and epilepsy
  • 63. Cryotherapy • Destroy cells by freezing and thawing • With liquid nitrogen or argon circulating through probe placed over or within lesion tissue can be frozen to temperature of -35 degree • Used for cutaneous lesion., tumor of head and neck, cervix and rectum, prostate • Major disadvantage: cost
  • 64. Photodynamic therpy • Administration of target specific photo sensitizer in target tissue • Photosensitizing agent is then activated with wavelength specific light source – leads to generation of free radicals cytotoxic to target tissue • Used in early pancreatic cancer, SCC, BCC, chest involvement in breast cancer, chest wall recurrence in breast cancer
  • 65. CUSA • Cavitron ultrasonic surgical aspirator • Dissecting device that uses low ultrasonic frequencies to fragment tissue • Utilizing hollow titanium tip that vibrates and cause fragmentation of susceptible tissue, while concurrently irrigating and aspirating material from surgical site • Selectively abalates tissue with high water content
  • 66.
  • 67. • Advantage: – Less blood loss – Improved visibility – Reduced collateral tissue injury – Useful in removing non ressectable brain and spine tumor, non cirrhotic liver and pancreatic tumor
  • 68. Vessel sealing technology • Ligasure : – Combination of pressure and energy-> denaturate collagen and elastin –> permanent seal – Seals upto 7mm vessel and withstand 3 times normal SBP • Enseal : – Small electrode technology : Uses million of nano conductive particles each with discrete thermostatic switch – Particle interupts current flow when temperature rises and turns back on when temperature falls – Vessel wall fuses by compression and protein denaturation
  • 69. REFERENCE • FISCHER’S MASTER OF SURGERY • BAILEY AND LOVE • SABISTON