1. Hypertension
•Transdermal Delivery
Multiple Sclerosis
• Immunotherapy
Cancer
• LHRH Peptides
Company Profile
Eldrug S.A is a spin off Biotechnology Company
established in January 2007, with expertise in Drug
Discovery and Development. It is located at the Patras
Science Park nearby the University of Patras. The
company was financed mainly by VIANEX S.A and by
GSRT of Ministry of Development towards the
development of active peptides and mimetics for
Clinical investigation.
2. Myelin Research
Networking
•Department of Chemistry, University of Patras, Greece
•Department of Medicine, University of Patras, Greece
•Pasteur Institute, Athens, Greece
•Department of Medicine, University of Thessaloniki, Greece
•Burnet-Austin Research Institute, Australia
•University of Florence, Italy
•University of Tubingen, Germany
•Temple University, Pennsylvania, USA
•University of Cardiff, UK
3. Angiotensin Research
Networking
•Department of Chemistry, University of Patras, Greece
•Department of Medicine, University of Patras, Greece
•University of Cardiff, UK
•National Hellenic Research Foundation (NHRF) Athens, Greece
•University of Exeter, UK
•University of Calgary, Alberta, Canada
•Medical School, University of Crete, Greece
•Department of Chemistry, University of Athens, Greece
•Institute of Organic Chemistry And Biochemistry, Academy of
Sciences of The Czech Republic
•Department of Internal Medicine, “Attikon” University Hospital,
Athens, Greece
4. • UPLC-MS/MS
• Alliance HPLC
• Preparative HPLC
• Liberty Peptide Synthesizer- CEM
• Freeze Dryer
• Water purification System
• Hydrogenolysis Apparatus
• Drying oven
• Centrifuge Eppendorf 5424
• Analytical balances
• Rotavapors
Equipment
5. UPLC/MS/MS: Acquity Waters UPLC system
TQD MS/MS Waters Detector, Empower and Mass Lynx Software
Equipment
APPLICATIONS:
•Physical and Chemical
Characterization of pharmaceutical
products
•Analysis and identification of
peptides and organic molecules
•Identification of impurities
•Development of analytical
methods (drug analysis in
biological samples)
•ESI and APCI probe for polar and
less polar compounds respectively
•Quantitation analysis
6. Waters Preparative HPLC
PDA Detector, Empower Software
Equipment
APPLICATIONS:
•Purification intermediate and
final products (small and large
scale)
•Isolation of impurities in
pharmaceutical products
7. Waters Alliance HPLC
PDA Detector, Empower Software
Equipment
APPLICATIONS:
•Chromatographic analysis of
intermediate scaffolds and
pharmaceutical products
•Development of analytical
methods (drug analysis in
biological samples)
•Quantitation analysis
8. Liberty Microwave Peptide Synthesizer
Discover Pressurized Microwave System, CEM
Equipment
APPLICATION:
•Microwave Assisted Solid Phase
Peptide Synthesis (MW-SPPS) of
linear and cyclic peptides (small
scale for research purposes).
9. Organic Synthesis
Eldrug provides specific Medicinal Chemistry services for drug
development process. Our Medicinal Chemists undertake synthesis
of scaffolds and organic molecules (small scale, non GMP synthesis for
research purposes).
Peptide Technology – Custom Peptides Synthesis
Eldrug’s Peptide chemists design and synthesize peptides in small and
large scale. We synthesize high yield of linear and cyclic peptides by
conventional or Microwave methods in solid phase.
Services
10. Analytical services
In our laboratory, we offer chromatographic analyses (HPLC, UPLC-
MS/MS) and services specializing particularly in the analysis and
identification of peptides and organic molecules
• Physical and Chemical Characterization
• Purification of Peptides and Organic Molecules
• Method Development and Validation
Services
Quality management
Eldrug has been certified with ISO 9001:2008 quality management system
from TUV. Our lab pays attention on every simple detail in it's production
process, continually improving on the methodology so as to meet the needs of
our collaborators and customers and produce the best quality of it's services
and end products.
11. ΠΡΑΞΕ Α: Ανταγωνιστικότητα
Ministry of Development
Title: “Αξιοποίηση Kαινοτόµου Aντι-υπερτασικού προϊόντος Εlsartan και Τεχνολογίας Μιµητών Πεπτιδίων µέσω Σύστασης
Εταιρείας Εlfar για την Ανάπτυξη των”
ΠΡΑΞΕ Β
Ministry of Development
Title: “Υποστήριξη ερευνητικών Μονάδων για την προτυποποίηση και την εµπορική εκµετάλλευση ερευνητικών αποτελεσµάτων.
Εντοπισµός και αξιοποίηση ερευνητικών αποτελεσµάτων µε δηµιουργία νέων επιχειρήσεων (Spin off). Φάση Β’”
VIANEX SA
Title: “Development of Elmyelin and Elsartan”
Cooperation
Ministry of Development
Title: “Pre-clinical and Toxicology Evaluation of Immunodominant Myelin Peptides/Mimetics Conjugated with Mannan towards
Clinical Phase I-II Studies: A Potential Therapeutic Vaccine Drug in the Treatment of Multiple Sclerosis (MS).”
«Ανταγωνιστικότητα & Επιχειρηµατικότητα: Υποστήριξη Νέων Επιχειρήσεων για ∆ραστηριότητες Έρευνας &
Τεχνολογικής Ανάπτυξης»
Ministry of Development
Title: “Σύνθεση και Προκλινική Αξιολόγηση της ∆ραστικής Αντιϋπερτασικής Ένωσης BV6 για έγκριση Κλινικών ∆οκιµών και
Προώθηση του Προϊόντος στην Αγορά ”
Total Funding: ~ 6.000.000€
Other funding in support of Eldrug’s R&D
ΕΠΕΑΕΚ, ΕΠΑΝ ΥΒ 76, ΕΠΑΝ ΥΒ 84
Funding
12. “Η ΕΛΛΑ∆Α ΚΑΙΝΟΤΟΜΕΙ”, ΣΕΒ – Eurobank
∆ύο προτάσεις της Eldrug µεταξύ των 10 τελικών προκριθέντων:
• Ανάπτυξη Θεραπευτικού Εµβολίου για την Σκλήρυνση κατά Πλάκας (Ελµυελίνη)
• Ανάπτυξη ∆ιαδερµικού Αντιυπερτασικού Προϊόντος (Ελσαρτάνη)
“INNOVATION PROJECT”, ΣΦΕΕ (Σύνδεσµος Φαρµακευτικών Εταιρειών Ελλάδος)
Τρεις προτάσεις της Eldrug µεταξύ των 20 τελικών προκριθέντων:
• Εξατοµικευµένη Ανοσοθεραπεία της Σκλήρυνσης Κατά Πλάκας µε χορήγηση ex-vivo
∆ενδριτικών Κυττάρων ασθενών, ενεργοποιηµένων από Αντιγονικά Πεπτίδια.
• Ανάπτυξη Ελµυελίνης, εν δυνάµει Θεραπευτικό Εµβόλιο, στην Ανοσοθεραπεία της
Σκλήρυνσης Κατά Πλάκας.
• ∆ιαδερµική Χορήγηση Σαρτανών, Λοσαρτάνης, Βαλσαρτάνης και Σαρτάνης V8COOH:
Μια νέα Προσέγγιση στη Θεραπεία της Υπέρτασης.
Awards - Distinctions
13. ELDRUGELDRUGELDRUGELDRUG---- VIANEX PatentsVIANEX PatentsVIANEX PatentsVIANEX Patents
Patent ApplicationsPatent ApplicationsPatent ApplicationsPatent Applications
Pending and GrantedPending and GrantedPending and GrantedPending and Granted
Myelin Patents (Europe, USA, China, Australia)
"Peptide analogues of Myelin Basic Protein epitopes in the treatment
of Experimental Autoimmune Encephalomyelitis (EAE) and Multiple
Sclerosis (MS)".
"Immunotherapy of Multiple Sclerosis using MBP83-99 peptide
analogues and mannan".
"Immunotherapy of Multiple Sclerosis using mannosylated peptides as
Therapeutic Vaccines".
Angiotensin Patents (Europe, USA, China)
“ Novel Sartans in the treatment of hypertension, transdermally”.
14. Visitors in Eldrug S.A.
Investors – Vianex S.A. James Watson
Jean-Marie Lehn Andrew V. Schally
(Nobel in Medicine)
(Nobel in Medicine)(Nobel in Chemistry)
15. Visitors in Eldrug S.A.
Investors – Vianex S.A. James Watson
Ada Yonath Kyriakos Nicolaou
(Nobel in Medicine)
(Nobel in Chemistry)
