1. www.ppscreeningcentre.com
Pivot Park OssVan target tot markt
25-Sep-2014
Helma Rutjes

2. Contents
•Pivot Park Life Sciences Community
•Pivot Park Screening Centre
•Organisatie
•Mogelijkhedenvoorsamenwerkingen
•ELF

4. Opening Oss Life Sciences Park 2012

5. Voornametrend in innovatieveentrepreneurship wereldwijd!
Faciliterenvan open innovatie
Pivot Park
Gesloteninnovatie
Open innovatie
Van gesloten…
•Solo-creatie
•Transacties
•IP legaldrive
•Academischresearch middelsfondsenvanuitindustrie
•Grote bedrijvenbepalenmarkttoegangvoorinnovatie
… naaropen innovatie:
•Co-creatie
•Netwerk/Relationships
•Entrepreneurial drive
•Commerciele& Academischeresearch samenwerkingen
•SMEs versnellenmarkttoegangin innovatie

6. Pivot Park OrganisatieChart
ELF project management
Screening
manager
Screening operations
Assay development
Assay Dev manager
CSO
CEO
CFO
COO
CCO
Business Development
EHS management
Facility management
Account management

7. Pivot Park
Analytics
HTS
uHTS
Compounds
Pilot Plant
Animal
facilities
Lab & Office facilities
Unique Facilities, Equipment, Knowledge and Approach
•Fully equipped labs
•Open Access labs
•Flex labs
•Nuclear Magnetic Resonance
•Liquid Chromatography
•Mass Spectrometry
•Open Access HTS
•Flexible uHTS
•Hit / Lead optimization
•Up to 10 kg
•GMP standard
•Small molecules
•Hosted by BioXpert

8. Pivot Park Community (September 2014)

9. 14-PPALG0055
Pivot Park Community Interactome2013

10. Focus op vroegestadia medicijnontwikkeling
Target ID
Hit / Lead discovery
Lead Optimization
Pre clinical development
Clinical phase I
Clinical phase II
Project management, Drug dev. Plan
Suppliers: Pivot Park Based bedrijvenplus anderen
Partners
Preferred suppliers
Top academenresearch partners
High throughput
Screening
PPSC
High content
Screening
NKI
HubrechtInst
Univ. Nijmegen
Univ. Leiden
Partner per indicatie
BioXB.V.
BioTB.V.
Partners
Core focus op ontwikkelingsfase

11. Pivot Park, 25 juni2014
Pivot Park 2.0 concept

12. Pivot Park 2.0
Uitbreiding faciliteiten: state-of-the-art pilot plant en laboratoriumfaciliteiten

13. Contents
•Pivot Park Life Sciences Community
•Pivot Park Screening Centre
•Organisatie
•Mogelijkhedenvoorsamenwerkingen
•ELF

14. PPSC: Uw partner voor Screening
30-9-2014
Screening faciliteiten
Automatiserings -en assay
development specialisten
Data processing
Compounds

15. 1995
2000
2005
2010
2015
IntroductieMTS & HTS
Biochemischeencellulairescreening
ASPIRE: Geintegreerdin-vitro screening platform
uHTS: capaciteit& miniaturisatie
Sluitingresearch @ Oss
NieuweSME 2012
Systeemaanname& overdracht2012
1stHTS in april2013
Screening Historiein Oss

16. IndrukwekkendegroeibinnenPPSC
0
20
40
2012
2013
2014
•Opening Pivot Park
•Nieuwrobot systeem
•2 fte
•Volledigoperationeel
•Start van ELF
•18 fte
•13 HTS
•Uitbouwensamenwerkingen
•HCA enFLIPR
•18+ fte
•30 HTS verwacht
2012
2013
2014
#HTS

17. ASPIRE systeem: Flexibeleautomatisering

18. State-of-the-art Equipment enWorkflows consistenteenhogekwaliteitdata

19. ●19

20. MogelijkhedenbinnenPPSC
•Assay ontwikkeling
•Celkweek
•Sample handling
•Screening (Low, medium en high throughput)
•Biochemische en cellulaire assays(High content)
•Automatisering van in-vitroexperimenten
•Optimalisatie en validatie van geautomatiseerde protocollen
•Geautomatiseerde data processing
30-9-2014 High Throughput Screening Facility

21. Velesamenwerkingengestart
•Cancer Drug Discovery Initiative
•NederlandsKankerInstituutenLeiden Universiteit
•Gezamenlijkprogrammaom klinischekandidatenin oncologieteontwikkelen
•Academischesamenwerkingenin Europa
•C.elegansscreening/Horizon2020 aanvragen
•Pivot Park bedrijven
•NTRC screening projecten
•Lab vooropen innovatie
•Vroegeresearch samenwerkingenmet meerderebedrijven
•European Lead Factory
•30 partners, 7 EFPIA
•120 HTS programma’sin 5 jaar

23. Disclaimer
23
Dear Reader,
Only the official and formally signed contractual documents in relation to the EU Lead Factory (the Project Agreement, Grant Agreement, the Description of Work, and Third Party Access Agreements) have a binding value in relation to the subject matter covered in these slides.
Any information contained in these slides is not binding upon the parties and can in no event be used to interpret or complement the formally signed contractual documents referred to above.
The EU Lead Factory Team

24. Made Possible by
24
EU Lead Factory
combines
innovationof Academia,
agility of SMEs, and
experienceof Pharma
and fundingfrom

25. Medicijnenonderzoekende waardeketen
25
Waardevan compound
Target
Hit finding
Hit to lead
Lead series
Phase I & II
Phase II & registrate
Sales €€
Years
3
5
6
8
11
13
25

26. A Large-Scale Controlled Experiment
26
Shared Useof Compound Collections
Crowd- SourcingInnovation from Biology & Chemistry
Partneringof Public Target Programmes
Value Generation from Publicly- funded Initiative

27. Collaborative Drug Discovery
27
Molecular
Targets
European
Screening
Centre
EFPIA contribution
(>300.000 cpds)
Public contribution
(up to 200.000 cpds)
Joint
European
Compound
Library
Compounds
uHTS
Compound logistics
Hit triage
Medicinal Chemistry

28. Target Programme Collaboration
28
EU Lead Factory Experts
supporting and pavingthe way
You
in the lead
Flying start
drug discovery research

29. Assay development / uHTS
29
0
2
4
6
8
10
0
1
2
3
4
5
6
0
5
10
15
384-wells
1536-wells
0
5
10
15
20
biochemical
cellular
Number of platesscreened per day
Technologiesprogrammes
Plate format
Assay typeprogrammes

30. Publieke Target Programma’s Voortgang
30
Submitted
68
Accepted
31
Assay
development
24
uHTS
14
Hit
Follow-up
13
QHL
4
Molecular
Targets
Sept 2014

31. www.ppscreeningcentre.com
●31
Eenmooietoekomst!
30-9-2014 High Throughput Screening Facility
•Oss herbergtHETEuropeseScreening Centrum
•Europesefunding tot jan.2018
•ELF is eeninnovatiefbusiness model voorPharma onderzoek
•Samenwerkingin consortium leidttot nieuweopportunities

32. www.ppscreeningcentre.com
●32
Business Opportunity
Pivot Park
•Perfectelocatie, goedbereikbaar
•Goedeatmosfeer: community
•Starterspakketvoorlabinrichting
•Van target tot markt
•Van starter tot middelgrootbedrijf
Pivot Park Screening Centre
•Kwaliteit
•Efficienteenvolledigeautomatisering
•Flexibeleklant-georienteerdeservice
•Samenwerkingen: improvement cycle
•KansenvoorELF assays

33. www.ppscreeningcentre.com Molenstraat 110 • 5342 CC Oss • The Netherlands • +31 (0) 412 71 25 11
Bedankt voor uw aandacht!