EHL Bio is an R&D center established to find ways to overcome various diseases and aging. We lead the development of stem cell therapies (stem cell isolation, storage, culture, etc.), which are the core of future regenerative medicine. commercialization of therapies, and development of immune cell therapies. EHL Bio's research centers on the treatment of diseases such as neurological diseases, osteoarthritis, circulatory diseases, metabolic diseases, autoimmune diseases such as neurological diseases, osteoarthritis, circulatory diseases, metabolic diseases, and autoimmune diseases, as well as anti-aging and health improvement, Alopecia cure, Esthetic care, etc. for the purpose of regenerative medicine. We continuously improve the expertise of our research personnel, and innovate stem cell application technologies to contribute to the improvement of human health around the world. to improve the health of humanity around the world. Contact 📞+82-2-532-9855 🎀HP : http://www.ehlbio.co.kr/eng 📸Insta : https://www.instagram.com/ehlbio_official/ 📱Facebook : https://www.facebook.com/EHLBiocellcenter/ 💛Kakao : https://pf.kakao.com/_Kxklxgb ✅Blog : https://blog.naver.com/ehlbio9883

1. ABOUT COMPANY

2. Vision
Whatwedo
Stemcell
Immunecell
Stemcellconditionedmedia
Philosophy
Mission
History
Direction
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The time in EHL flows
for your happiness
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3. EHL
BIO
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Esthetic
Health
Longevity

4. Find the Future in the EHL
EHL is making a strong leap to become a bio company
that the world is paying attention to.
EHL
BIO
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EHL Bio is an R&D Institute established to search for solutions against diverse
diseases and aging to live a healthy life and extend the human life span.
EHL Bio leads the practical use of innovative treatments based on the development
of stem cell and immune cell therapeutics and clinical experiences.
EHL Bio strives to cure diverse diseases including neurological, osteoarthritis,
circulatory, metabolic, and autoimmune diseases, anti-aging, health promotion, hair
loss treatment, and cosmetic dermatology through research and development of
regenerative medicine.

5. EHL
BIO
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6. Life science makes tomorrow
We create the power of tomorrow that never stops
with infinite thoughts and possibilities.
The future is not about waiting, but about pioneering.
EHL Bio will protect you from fear with infinite thoughts and possibilities
to make the most shining moments of your life stay longer.
EHL
BIO
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EHL
BIO

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EHL
BIO
What we do
EHL Protects your life.
사진
Apply to all diseases caused by poor
function of organ or tissue function
(cirrhosis, diabetes, hypertension,
Parkinson’s, rheumatoid arthritis, etc.)
Anti-aging treatment
Advantages in kidney and genitourinary
disease treatment.
Published the world’s first paper to
identify the klotho secretion from UDSCs.
The world’s first phase 1 clinical trial of
autologous urine-derived stem cell
(UDSC) for chronic kidney disease (CKD).
Immune cells (NK, T, DC) remove foreign
substances and wastes and destroy
cancer cells
The world’s first phase 2 clinical trials
of autologous adipose-derived stem
cell intravenous injections for atopic
dermatitis
The world’s first phase 1 clinical trial of
autologous urine-derived stem cell
(UDSC) for chronic kidney disease (CKD)
Autoimmune disease treatment
(rheumatoid arthritis, etc.)
EHL-STEM™ contains various growth
factors, and cytokines such as EGF, FGF,
VEGF, fibronectin, and collagen useful
for skin rejuvenation. (supply to over 50
domestic and international countries)
SupremeX™ provides an optimal
formulation for culturing various types of
stem cells and immune cells
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Adipose-derived stem cell Urine-derived stem cell Immune cells Development of
Cell therapeutics
Stem Cell Conditioned
Media / Cell Culture
Media
Regenerative medicine Regenerative medicine Immunotherapy
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9. EHL
BIO
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Stem cells are undifferentiated cells that have the capability to self-renew
and differentiate into many types of cells with specific functions.
Stem cell
What is stem cell?
Wound
Healing
Immune
regulation
Tissue
differentiation
Homeostasis Homing Effect
Angiogenesis
The Characteristics of Stem Cell
The Functions of Stem Cell
•Self-Renewal : Stem cells can multiply into cells with the same shape and ability.
•Multipotential : Depending on the needs of the human body, stem cells in an undifferentiated state can differentiate into various tissues and organs, such as the heart, bone, nerves, skin, and liver.
•Homing Effect : Stem cells that are administered to the human body can self-locate and regenerate damaged parts of the body.
•Wound healing : Regeneration of damaged cells.
•Differentiation : Stem cells are differentiated and regenerated into various cells.
•Growth factor activation : The growth factors of hormones, collagen, etc., are promoted to regenerate tissue in the body.
•Immune regulation : The immune system function is improved by increasing the immunity of immune system organs.
•Cell death prevention : Cell death is prevented in the body.
•Angiogenesis : Regeneration of damaged blood vessels to help blood supply.

10. EHL
BIO
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EHL focuses on
the autologous stem cells
and immune cells
It is important to check that “stem cell therapeutics” have undergone clinical
trials for safe use. because, unlike autologous stem cells, allogenic stem cells
have a risk of immune rejection.

11. EHL
BIO
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Immune
The immune system can defeat invading disease-causing germs (or pathogens), such as bacteria, viruses, parasites as well as cancer cells.
But, an underactive immune system allows for chronic infection and cancers, and an overactive immune system leads to allergies or autoimmune diseases.
Immune cells are divided into innate immunity (macrophages, NK cells) and acquired immunity (T cell, B cell), and dendritic cells and gamma delta T cells act as the link between those two immunities.
Attack cells infected with
viruses, or tumor cells
The most potent antigen-
presenting cells against
cancer cells
Recognize specific antigens
specifically targeting cancer
cells and attack
Antibody production
•Phagocytosis of bacteria
•Remove foreign substances and
wastes
•Antigen presentation/anti-viral
•Anti-cancer
•Boosts the immune system
•Allow immune cells to attack
cancer cells.
NK cell
Immune cells
Immune cells are defenders of one’s body against foreign substances
such as invading pathogens, viruses, and other substances.
Immune cells
Macrophage Dendritic Cell B lymphocyte iNKT T lymphocyte

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EHL Protects you
from cancer and
diseases.
We long for the same dream.
Our path is to be with you for your better health.

13. EHL
BIO
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Skin
Regeneration
Skin elasticity
Improvement
Hydration Skin structure
Wrinkle
Improvement
Anti-aging
Key growth factors in Stem Cell Conditioned media
Growth
differentiation
factor 11
(GDF11)
Hepatocyte
growth factor
(HGF)
vascular
endothelial
growth factor
(VEGF)
Fibroblast
growth factor-2
(FGF-2)
Epidermal
growth factor
(EGF)
Transforming
growth factor-beta
(TGF-b)
Keratinocyte
growth factor
(KGF)
Platelet-derived
growth factor
(PDGF)
Stem cell conditioned media
Stem cell conditioned media is produced during stem cells culture
and It is in the spotlight as a high-end cosmetic raw material because
it contains various growth factors, and cytokines such as EGF, FGF,
VEGF, fibronectin, and collagen which are useful for skin rejuvenation.
What is stem cell
conditioned media?

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EHL promises
a better tomorrow.
Face your rejuvenated skin.
The magic of various benefit factors in stem cell conditioned media.
Promise your brighter tomorrow

15. EHL
BIO
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Asia No.1
Bio-Technology
Leader
Contribute to
humanity
Social
activity
Technique
Absolute
Value
Life
quality
SALT UP
Philosophy
EHL hopes to become the salt of the world with the goal of becoming
a 200-year company. EHL will always be with you in your time,
creating a future through communication and cooperation/autonomy,
and accountability/professionality.
We promise to be an
enterprise for 200 years.
Enterprise for
200 years

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BIO
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Business Support
Recruit cooperator
Consulting
Trial/Proof
Distribution
Attracting investment
Local partnering
Local employee training
Local start-up support
Dispatch specialists
Establish overseas base
International Conference
Localization support
Work Space GMP
Verification center
Training center
Equipment/.Network
Exhibition/ Networking
Conference/Seminars
Information portal development
Guideline development
Fact-finding survey
Employee Training
Investor Training
Base Expansion
Research and Development
Clinical Trial
New Drug Development
Law-abiding business
management
Bio-policy research
Biotechnology Market Research
Commercialization
R&D
Infrastructure
Human Resources
Overseas Expansion
Review of Law and Legal Institutions
Policy search Information Exchange
Mission
Biotechnology is changing the scene of the pharmaceutical
and medical industries. EHL will contribute to the growth of
pharmaceutical and medical industries by establishing bio-industry
infrastructure by analyzing current business models and discovering
promising future models.
Build infrastructure for
200 years enterprise

17. EHL
BIO
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2017 2021
Make a headway
2015
Be Encouraged
March
-Certifiedasaventurecompany
July
-CertifiedforCPCbyMHLW (Japan)
January
-CertifiedforHumancellManagementFacilitybyKFDA
(1stinKorea)
2019
Lead the market
January
-Appliedphase2clinicaltrialsusingADSTEMInj.(Thefirstin
Korea,Autologousadipose-derivedstemcell,intravenous
injection)
March
-Completionof2ndGMP(500LOTpermonthcanbe
cultured.)
-OpeningaCambodianbranchandahospitalspecializingin
celltherapy(Jointcompany)
September
-Phase2clinicaltrialapprovalforADSTEMInj.(World’s
first,autologous,adipose-derived,intravenousinjectio)
2016
Prove ability
March
-CertifiedforGMPFacilitybyKFDA
May
-ApprovedPhase1clinicaltrialforatopicdermatitis
November
-SelectedforStart-upGrowth TechnologyDevelopment
ProjectbytheMinistryofSMEs(Smalland Medium-sized
Enterprises)and startups
November
-Expandandrelocatetheresearchinstitute
-Completedconstructionof GMPfacilities
November
-EstablishmentoftherepresentativeofficeinVietnam March
-CertifiedforCellProcessingFacilitybyKFDA
December
-Appliedforaclinicaltrial(Autologousadipose-derived
stemcells/intravenousinjection/Atopicdermatitis)
December
-Completedphase1clinicaltrialusingADSTEMInj. May
-SignedMOUforAdvancedRegenerativeMedicinewith
DangookUniversityHospital
June
-SignedMOUforAdvancedRegenerativeMedicinewith
ChungnamUniversityHospital
2012
Great First
February
-Establishedaninstituteofcellbiologyandregenerative
medicine. (EHLBIO.Co.Ltd)
January
-EstablishmentofEHLBIOCellCenter(Seoul)
May
-SignedCMOforcelltherapeuticwithATEMs
June
-SignedCMOforcelltherapeuticwithPaean
2020
Challenging
implementation
From the beginning
to the best
History
EHL took its first step as a bio company in 2012 and has grown
significantly by facing and overcoming every change.
Looking forward to tomorrow with pleasant excitement of change.
Looking forward to
every Morning.

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2022 2023 2025
2024
February
-CompletedpreclinicalstudyforCTLcells
-InitiateUDSCphase1clinicaltrial
-Applyphase3clinicaltrialforAtopicdermatitis
-ApplyIPO
-EstablishCPCinIndonesiaandVietnam
-Finnishphase3clinicaltrialsandapplyNDA
-Start phase3clinicaltrials/Applyphase3clinicaltrialsin
theUnitedStates
-EnterKOSDAC
-EstablishCPCinCIScountries
March
-FundedbytheKoreangovernmentforKDSTEMTM
development
July
-Completedpreclinicalfordendriticcells
September
-RelocationofCellTreatmentCentertoGangnam,Seoul
August
-Completed patientregistrationforphase2clinicaltrialfor
ADSTEM
-Appliedphase1clinicaltrialforchronicheartdiseasein
KDSC
World Class Bio
Memorable 10th
Anniversary
Leap for 200 years
company
From Innovation to
Standard

19. EHL
BIO
We listen to everything even little,
with invisible delicate technology.
The technology of handling cells brings different results depending on the researcher’s ability and experiences.
EHL set up a control tower and even listen to micro changes.
EHL’s biggest strength is that each researcher performs their best and harmony with each other.
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21. EHL
BIO
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Doctors and scientists at the EHL conduct research and clinical trials together to
achieve a common goal. It is the biggest strength that can result in better quality
and speed. Experience advanced medical services at EHL, which co-operates with
cell therapy hospitals and research institutes.
The Meeting of medical and science
With a sense of duty as a doctor to patients,
we empathize with their hardships and design a healthier future.
History
The Synergies between
Science and Medical

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BIO
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Discovery and
Develop
Discovery and
Develop
Preclinical Preclinical
Phase 1 Phase 1
Phase 2 Phase 2
Phase 3 Phase 3
Atopic Dermatitis(ADSTEM) : Enter Phase 3 in 2023 NK cell + Opdivo : implement Advanced Regenerative medicine in 2023
Chronic kidney disease : Initiate phase 1 in 2023 Dendritic cell : implement Advanced Regenerative medicine in 2023
Rotator cuff tear : Initiate preclinical in 2021 T cell : implement Advanced Regenerative medicine in 2023
Rotator cuff tear : Initiate phase 1 in 2023 DC+NK : implement Advanced Regenerative medicine in 2023
Strength
To extend healthy life, it is important to do stem/immune cell
treatment and to diagnose disease or gene mutation early.
EHL is a leading company that supplies almost all kinds of stem cells
and immune cells that customers require. Experience advanced stable
cell therapy at EHL
Pipelines

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BIO
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Hardware
Cutting-edge facility
Lipid extraction, isolation, separation, culture,
and storage according to KGMP standards
State-of-the-art aseptic facilities
Extract essential immune cells using Apheresis
Separately isolate and bank
NK cells, Dendritic cells and T cells
Cryopreservation system
High quality GMP
Software
Optimized operational know-how
Strength
Good manufacturing practice (GMP) is a system that ensures medical
products are consistently produced and controlled according to the
quality standards that the government requested.
EHL has the best manufacturing facility that meets the GMP standard
and its annual production capacity is 10,000 lots.
High quality GMP Facilities
and optimized operational
know-how

24. EHL
BIO
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Title Registration Date Registration No.
Domestic
patent
Thiazolidinedione Derivative and Use Thereof 2012.08.02 10-2011-7017782
Fat extraction and SVF isolation kit 2016.01.20 10-2016-0007049
Composition comprising cells treated with 15-PGDH inhibitor or culture thereof and use thereof 2016.10.26 10-2016-0139967
Composition comprising cells treated with 15-PGDH inhibitor or culture thereof and use thereof 2018.01.04 10-2018-0001149
Cosmetic composition comprising a stem-cell culture fluid, and method for preparing the stem-cell cultee fluid 2018.03.16 10-2018-0030906
Culture medium composition for culturing urine-derived stem cells, and method for culturing urine-derived stem cells by using same 2019.11.04 10-2019-0139702
Culture method of adipose-derived stem cell proliferation expressing anti-aging factors 2020.02.03 10-2020-0012437
Skin-regenerative, whitening, antioxidant, or wound healing composition containing exosome as active ingredient derived from stem cells and its use 2021.02.17 10-2021-0021026
Culture medium composition for culturing urine-derived stem cells, method for dividing and culturing urine-derived stem cells by using same, Urine-
derived stem cells having improved kidney diseases therapeutic potential and cell therapeutic composition comprising the same
2021.09.29 10-2021-0129299
International
patent
Skin-regenerative, whitening, antioxidant, or wound healing composition containing exosome as active ingredient derived from stem cells and its use 2022.02.07 PCT/KR2022/001851
Culture medium composition for culturing urine-derived stem cells, method for dividing and culturing urine-derived stem cells by using same, Urine-
derived stem cells having improved kidney diseases therapeutic potential and cell therapeutic composition comprising the same
2021.04.19 PCT/KR2022/005579
Strength
By playing a critical role in developing national science and
technology in the field of new drug development, we are expanding
advanced research equipment, attracting great talent resources,
presenting outstanding research achievements, and inducing patent
registration through advanced new technology.
Patent application and
Registration through
continuous research

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BIO
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-Secured know-how and patents for cell culture
technology
-Secured Independent cell proliferation and know-
how
-Superior stem cell number and activity compared to
other competitors
-More than 1,000 times higher stem cell harvest rate
than other competitors
-Minimization of stem cell death rate after
cryopreservation
Strength
EHL has been approved for human cell management & cell processing
facility by KFDA for the first time in Korea. Therefore, these certified
facilities can supply various stem and immune cells as raw materials to
biopharmaceutical companies and hospitals.
Certified for Human cell Management
& Cell processing Facility /
Certified for CPC by MHLW (Japan)

26. EHL
BIO
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Clinical trial implementation
hospital
Seoul National University Hospital , Seoul Boramae Hospital , Korea University Ansan Hospital , KyungHee University Hospital , Chung-Ang
University Hospital , Chungnam National University Hospital
Business partner Hospital
Chungnam National University Hospital , Dankook University Hospital , Chonnam National University Hospital , Hwasun Chonnam National
University Hospital , Yonsei University Gangnam Severance Hospital , Wonkwang University Hospital , Seoul Songdo Hospital, Madi Sarang Hospital
Affiliated hospital Japan Nagoya Gobayashi clinic, Fukuoka Danaka clinic, Vietnam An Viet hospital, etc. (over 50 domestic and international)
Mission
We are actively collaborating with many domestic and international
partners under the common goal of the future values of life. At the
same time, we also share knowledge and human resources to serve as
a leading bio company
Competitive
Research Network

27. EHL
BIO
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Developed an optimum media compatible with the current trend using minimum or none of the animal serum.
Discovered factors capable of inducing cell proliferation corresponding to MesenPro culture media which is commercially used for adipose stem cell culture.
Cell
proliferation
Rate (%)
Stem cell
related gene
expression
Development 1
ADSC Culture Media
Development 1
UDSC Culture Media
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•Price competitiveness with a performance that can compete with expensive imported culture media through
the development and commercialization of cell therapeutics to provide quality and reasonable price products
to customers.
•The practical effectiveness and reproducibility of the product are verified through blind tests and efficacy tests.
•Production of finally developed new culture media is in progress
Development of optimized exclusive culture media for UDSCs./ Excellence stemness and proliferative capacity of EHL-UDSCs.
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REF1 UDSC
OCT4
REF1 UDSC
SOX2
Passage 3 Passage 5
EHL-UDSC
NANOG
1325%
8.2
16.2
397.6
16.2
582%
1.3
1.8
17.05
582%
374%
1 1 1
374%
1805%
*REF 1 : HS Kang et al.,2015
*REF 2 : Qian Wan et al.,2018
Strength
Development and supply of
stem cell culture media

28. Proliferation assay
Human Dermal Fibroblasts Keratinocytes
Wound healing assay
Premium
Exosome
KLOSOMETM
KLOSOMETM
45.5%
improvement
48.1%
improvement
KLOSOMETM
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Exosomes are nano-sized small extracellular vehicles (EVs) produced in most cells. They carry various bioactive substances to play a role in the body’s physiological and
pathological processes and create communication paths between cells. Especially, stem cell-derived exosomes are known as potential factors for skin regeneration and
other diseases treatment because of their regenerative and differentiation abilities
Klosome is a premium exosome containing anti-aging protein that prolongs cells’ life and protects cells from various stress.
General Exosome General Exosome
Skin-regenerative, whitening, antioxidant, or wound healing
composition containing exosome as active ingredient derived
from stem cells and its use
Patent (No.10-2341375)
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Proliferation
rate
(%)
Proliferation
rate
(%)
Wound
healing
rate
(%)
400 400
80
100 6 hours later 12 hours later 18 hours later
Best Wound
Regeneration
300 300
60
200 200
40
100
20
0 0 0
Parent Cell
MVB
Microvesicles
(200㎚-1㎛)
Exosome
(30㎚-150㎚)
Tetraspanins
Lipid-rafts
Enzymes
Cytoskeletal proteins
Proteins associated with
MVB formation
mRNAs
IncRNAs
Annexins
Immunoregulatory
molecules
Nucleus
CYTOKINE
miRNAs
Active substances in
Exosome
Strength
Customized cosmetics made with stem cell conditioned media are
effective in skin whitening, wrinkle improvement, and skin barrier
protection. Stem cell conditioned media created through continuous
research contains various factors that help anti-aging and collagen
production.
Stem cell conditioned media / Culture media / Exosome
The world’s first kidney-derived Exosome (Klosome)
GROWTH
FACTORS

29. Protect your life
EHL BIO
People who have been unwell
know how precious and
enjoyable their daily life is.
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EHL Cell Center
EHL Building, 136, Apgujeong-ro,
Gangnam-gu, Seoul, Republic of Korea
TEL +82-2-532-9855 | FAX +82-2-514-8027
Hyundai High school
Indeogwon High school
Indeogwon Elementary school
Indeogwon Middle school
Hannam Bridge
Dongho Bridge
Apgujeong station
Indeogwon station
Subway Line 3
Subway Line 4
Sinsa Middle school
3
Headquarters & Research Institute
B 207, Indeogwon IT Valley, 40 Imi-ro,
Uiwang-si, Gyeonggi-do
TEL 02-535-9883~4
TEL +82-2-535-9883~4 | FAX +82-70-4009-6979

31. www.ehlbio.co.kr