This is the final poster for my Fall 2009 design project. We created a model that was used for teaching students the difference between HIV and other viruses, and the ensuing immunological consequences of HIV are.

2. Incompatible binding sites for other viruses

6. Easily transported from car to classroom

7. Visible to a class of 30 students (approx. 6m away)

8. Three dimensional and color-coded

9. Intended for undergraduate students with minimal scientific knowledge

10. Demonstrates the process of HIV infection

11. Shows difference between the effects of HIV and other viruses

12. Minimize amount of loose pieces

13. Manual control of each step

15. 2 switches

16. 1-5k ohm potentiometer

17. 8” (20.3cm) foam spheres

19. Clear tubing and syringe

20. Plaster and clay

21. Vinyl and paint

22. Foam display boardsModel Construction References Motivation HIV Replication Cycle Figure 1 – Step 1: HIV binds to CD4 receptor on helper T cell Step 2: Injection of viral RNA and incorporation into host DNA Step 3: Replication and budding of mature HIV viruses Budget Figure 3 – Red LEDs on. Death of human Figure 2 – White LEDs on. Immune system strong Figure 5 – Completed final design including illuminating immune system, cells modeling HIV binding, injection and lysis in response to HIV infection Client – Marge Sutinen Advisor – Professor Wan-Ju Li Circuits Help – AmitNimunkar, Professor Leon McCaughan HIV Information – Professor David Abbott Figure 4 – Light Controls HIV is transmitted through contact of infected bodily fluids, most often during sexual contact. The best way to stop AIDS is to prevent the spread of the virus by educating people about methods and personal protection against HIV. Current models trying to explain the basic principles of HIV replication are often too detailed and advanced for most people to understand. A more effective way of reaching the target audience is to present a very simplistic demonstration of how HIV is more deadly than a normal virus which the body can fight off. Cell Supplies: $51.79 Nucleus: $2.09 Crafter’s Foam Sphere: $17.03 Hardware and vinyl: $8.11 Circuit Supplies: $28.58 TOTAL: $107.60 [1] “The Human Immune System: Our Defense Mechanism.” Davidson College. 5 October 2009. <http://www.bio.davidson.edu/Courses/Molbio/MolStudents/spring2003/Cobain/geneprotein.html> [2] Cichocki, M. “The HIV Life Cycle” about.com. Medical Review Board. 5 October 2009. <http://aids.about.com/od/newlydiagnosed/ss/livecycle.htm> [3] “Computer Generated Model of HIV in Bloodstream.” Getty Images. 5 October 2009. <cache.gettyimages.com> [4] Noble, Rob. “HIV Structure and Life Style.” Avert. 18 September 2009.<http://www.avert.org/hiv-virus.htm> [5] Poeschla, E. M. “The HIV-1 Life Cycle.” Mayo Clinic. 5 October 2009. <http://mayoresearch.mayo.edu/mayo/research/poeschla/life_cycle.cfm> [6] “Replication Cycle of HIV.” National Institute of Allergies and Infectious Diseases. 5 October 2009. <www3.niaid.nih.gov/topics/HIVAIDS/Understanding/How+HIV+Causes+AIDS/howhiv.htm>