This document discusses the challenge of interoperability between health systems and the role open source can play in addressing this challenge. It notes that open source software and specifications allow systems to avoid vendor lock-in, but that open source applications alone do not ensure interoperability unless everyone uses the same system. It argues that the strength of open source lies in open infrastructure components, not just applications. An open platform based on common open standards and information models could substantially accelerate app development and lower barriers to the market while avoiding lock-in.