Input speech to panel on ethics from Bram Stieltjes, University Hospital Basel at the DayOne Conference 2019 Shaping the future of Health September 9th 2019
Understanding the health data future - Deloitte Healthconnect, co-hosted by D...DayOne
In collaboration with Deloitte, we launched in 2020 the DayOne Health Data Scenario Project. Some 50 Experts coming together in three workshops for a total of more than 18 hours have identified 10 potential scenarios that will lead the way in creating a much-needed efficient and rewarding healthcare data ecosystem. We presented our results in an online joint event: “Understanding the health data future – Deloitte Healthconnect, co-hosted by DayOne”
“It’s cheaper to clean up a mess than to avoid a mess.” This mantra, coined by Alan Greenspan explaining why financial bubbles happen, stands very much at the core of how we as a society typically seem to deal with health: rather than nudging and rewarding people to conduct a healthier life and increase their immunity, the primary focus of efforts and resources is often on treating sickness.
How can this change? What role do health data, nutrition and immunity play in this? And what difference would it make? Find out at our next DayOne Experts Event, co-hosted by DSM Nutritional Products.
There are a couple of reasons why it is not an easy thing to successfully implement preventive measures. First of all, behavioral change is hard to accomplish. Secondly, in most cases it is challenging to show the scientific evidence that a certain measure works and is worth the effort. One key focus area is the importance of an optimal nutrient intake to support our health – with a focus on immunity and beyond. Last but not least, we need to consider a business and policy model that makes prevention less of a moral burden but a worthwhile experience that we are willing to apply in a smart way.
These are the big questions we will address at the DayOne Experts Event:
Will the rise of digital and data availability change the landscape – and if so to what extent?
What can we learn from the current pandemic?
Does nutrition play a role in supporting your immunity?
Which data should we take into consideration to shape the future?
This was our conversation. Read the conclusions here: https://www.dayone.swiss/as-shown-by-covid-19-making-prevention-smart-requires-a-mind-shift/
Our partner: DSM Nutritional Products
For the 5th year, we culminated the best of the DayOne Healthcare Innovation initiative: hot topics, open debates, smart insights, bright ideas, high energy personalities and tangible expertise. This will include the Open Innovation Session that brings together the Health Hack and is a springboard for the Accelerator. The panel sessions included: The patient centric approach + four bright ideas; How to make it happen; + The healthcare innovation journey.
This year’s conference joined forces with BioData Congress 2020 in a virtual format. Thank you to the partners Arcondis and Innosuisse, as well as all the mentors, coaches and behind the scenes work to pull this all together in a great event wtih over 800 participants.
Breathe - Empowering parents of children with asthmaDayOne
Presentation by Moritz Dietsche (Haako) at the DayOne Expert Event Legal challenges and opportunities for digital health innovation.
it is essential to address the legal aspects early on and make them part of the solution. This was shown by this start-up showcase:
Pioneering value & data driven healthcare for PatientsDayOne
Presentation by Michel Mohler (Lyfegen) at the DayOne Expert Event Legal challenges and opportunities for digital health innovation.
it is essential to address the legal aspects early on and make them part of the solution. This was shown by this start-up showcase:
Legal Framework for Digital Health Innovation - Data Protection and SecurityDayOne
Presentation by Monika Menz, Vossius & Partner at the DayOne Expert Event Legal challenges and opportunities for digital health innovation.
Data - GDPR still governs the data protection landscape and is here to stay. But GDPR is more than an implementation issue – innovators need to embrace its principles already when designing their products, not only to be compliant but also to gain the trust of customers and patients. As healthcare innovations are IT dependent and data driven, data and IT security are often neglected. But they are key to convincing investors and customers of the innovator’s business model, because the stakes are high, not only in terms of a start-up’s reputation and liability, but ultimately and most of all in terms of the patient’s interests as well.
EU regulatory frameworks - Legal challenges and opportunities for digital hea...DayOne
Presentation by Karin Schulze, Head of Medical Devices at SFL at the DayOne Expert Event Legal challenges and opportunities for digital health innovation
Regulation
Regarding the new MDR, the big question that arises is not only whether a piece of software falls under the definition of a medical device, but also who decides whether it does. At least in this regard the new regulation is clear: it is the regulator. Which means, according to Karin Shulze from SFL, that If a company offers an app which they do not consider a medical device themselves, but the regulator does, the distribution of this app will be stopped.
Legal framework for digital health innvoation - Protection through patents, d...DayOne
Presentation by Philipp Marchand and Birgitte Bieler, Vossius & Partner at the DayOne Expert Event Legal challenges and opportunities for digital health innovation
Philipp Marchand from Vossius & Partner and co-host of the event said: “Technological developments, especially in the digital space, brought up completely new issues which lack clear definition. So, as lawyers and regulatory advisers, we have to be innovative and also come up with new solutions. This is a learning curve we have to go through together with entrepreneurs, industry and regulatory bodies“.
In other words, instead of being a French garden à la Versaille, the legal landscape has become a rather rough terrain to navigate. The uncertainty can be seen as a threat and show killer. A more entrepreneurial attitude, however, would be to see it as an opportunity, if not an invitation, to pursue more of a greenfield approach. But in order to make this happen, it is essential to address the legal aspects early on and make them part of the solution.
Protection
Accustomaed as it is to a science and engineering-driven approach, the healthcare industry has to change its mindset when it comes to protecting its business. As it is reasonable to patent a digital solution and to protect medical devices as well as mobile app interfaces by means of design and trademark rights, the legal framework is becoming more important. So, developing a great technological solution and then having it beautified later on will not suffice. Those capabilities have to be built in from day one to ensure freedom to operate and to generate added value from the digital solutions.
Understanding the health data future - Deloitte Healthconnect, co-hosted by D...DayOne
In collaboration with Deloitte, we launched in 2020 the DayOne Health Data Scenario Project. Some 50 Experts coming together in three workshops for a total of more than 18 hours have identified 10 potential scenarios that will lead the way in creating a much-needed efficient and rewarding healthcare data ecosystem. We presented our results in an online joint event: “Understanding the health data future – Deloitte Healthconnect, co-hosted by DayOne”
“It’s cheaper to clean up a mess than to avoid a mess.” This mantra, coined by Alan Greenspan explaining why financial bubbles happen, stands very much at the core of how we as a society typically seem to deal with health: rather than nudging and rewarding people to conduct a healthier life and increase their immunity, the primary focus of efforts and resources is often on treating sickness.
How can this change? What role do health data, nutrition and immunity play in this? And what difference would it make? Find out at our next DayOne Experts Event, co-hosted by DSM Nutritional Products.
There are a couple of reasons why it is not an easy thing to successfully implement preventive measures. First of all, behavioral change is hard to accomplish. Secondly, in most cases it is challenging to show the scientific evidence that a certain measure works and is worth the effort. One key focus area is the importance of an optimal nutrient intake to support our health – with a focus on immunity and beyond. Last but not least, we need to consider a business and policy model that makes prevention less of a moral burden but a worthwhile experience that we are willing to apply in a smart way.
These are the big questions we will address at the DayOne Experts Event:
Will the rise of digital and data availability change the landscape – and if so to what extent?
What can we learn from the current pandemic?
Does nutrition play a role in supporting your immunity?
Which data should we take into consideration to shape the future?
This was our conversation. Read the conclusions here: https://www.dayone.swiss/as-shown-by-covid-19-making-prevention-smart-requires-a-mind-shift/
Our partner: DSM Nutritional Products
For the 5th year, we culminated the best of the DayOne Healthcare Innovation initiative: hot topics, open debates, smart insights, bright ideas, high energy personalities and tangible expertise. This will include the Open Innovation Session that brings together the Health Hack and is a springboard for the Accelerator. The panel sessions included: The patient centric approach + four bright ideas; How to make it happen; + The healthcare innovation journey.
This year’s conference joined forces with BioData Congress 2020 in a virtual format. Thank you to the partners Arcondis and Innosuisse, as well as all the mentors, coaches and behind the scenes work to pull this all together in a great event wtih over 800 participants.
Breathe - Empowering parents of children with asthmaDayOne
Presentation by Moritz Dietsche (Haako) at the DayOne Expert Event Legal challenges and opportunities for digital health innovation.
it is essential to address the legal aspects early on and make them part of the solution. This was shown by this start-up showcase:
Pioneering value & data driven healthcare for PatientsDayOne
Presentation by Michel Mohler (Lyfegen) at the DayOne Expert Event Legal challenges and opportunities for digital health innovation.
it is essential to address the legal aspects early on and make them part of the solution. This was shown by this start-up showcase:
Legal Framework for Digital Health Innovation - Data Protection and SecurityDayOne
Presentation by Monika Menz, Vossius & Partner at the DayOne Expert Event Legal challenges and opportunities for digital health innovation.
Data - GDPR still governs the data protection landscape and is here to stay. But GDPR is more than an implementation issue – innovators need to embrace its principles already when designing their products, not only to be compliant but also to gain the trust of customers and patients. As healthcare innovations are IT dependent and data driven, data and IT security are often neglected. But they are key to convincing investors and customers of the innovator’s business model, because the stakes are high, not only in terms of a start-up’s reputation and liability, but ultimately and most of all in terms of the patient’s interests as well.
EU regulatory frameworks - Legal challenges and opportunities for digital hea...DayOne
Presentation by Karin Schulze, Head of Medical Devices at SFL at the DayOne Expert Event Legal challenges and opportunities for digital health innovation
Regulation
Regarding the new MDR, the big question that arises is not only whether a piece of software falls under the definition of a medical device, but also who decides whether it does. At least in this regard the new regulation is clear: it is the regulator. Which means, according to Karin Shulze from SFL, that If a company offers an app which they do not consider a medical device themselves, but the regulator does, the distribution of this app will be stopped.
Legal framework for digital health innvoation - Protection through patents, d...DayOne
Presentation by Philipp Marchand and Birgitte Bieler, Vossius & Partner at the DayOne Expert Event Legal challenges and opportunities for digital health innovation
Philipp Marchand from Vossius & Partner and co-host of the event said: “Technological developments, especially in the digital space, brought up completely new issues which lack clear definition. So, as lawyers and regulatory advisers, we have to be innovative and also come up with new solutions. This is a learning curve we have to go through together with entrepreneurs, industry and regulatory bodies“.
In other words, instead of being a French garden à la Versaille, the legal landscape has become a rather rough terrain to navigate. The uncertainty can be seen as a threat and show killer. A more entrepreneurial attitude, however, would be to see it as an opportunity, if not an invitation, to pursue more of a greenfield approach. But in order to make this happen, it is essential to address the legal aspects early on and make them part of the solution.
Protection
Accustomaed as it is to a science and engineering-driven approach, the healthcare industry has to change its mindset when it comes to protecting its business. As it is reasonable to patent a digital solution and to protect medical devices as well as mobile app interfaces by means of design and trademark rights, the legal framework is becoming more important. So, developing a great technological solution and then having it beautified later on will not suffice. Those capabilities have to be built in from day one to ensure freedom to operate and to generate added value from the digital solutions.
Expert Event Legal challenges and opportunities for digital health innovationDayOne
Introduction by Thomas Brenzikofer, DayOne, Basel Area Business & Innovation
Greenfield or jungle? Navigating the legal landscape for digital healthcare innovation
At first sight, it’s hard not to agree that dealing with the legal aspects of creating healthcare innovation is — although necessary — a rather unsexy topic. So it comes as no surprise that the DayOne Experts Event “Legal challenges and opportunities for healthcare innovation”, held online on September 30, attracted a slightly smaller audience than when the talks usually concern revolutionary new pieces of digital technology ready to disrupt healthcare as we know it — for the better.
Future of aging day one 20200630 zaynakhayatDayOne
What comes to mind when you think of an older person? Who are they? Where do they live? What does their day look like? How do they want to live their life, make money, spend money, experience services and leave a legacy?
These are just some among the many provocative questions that were researched in the new book “The Future of Aging” by Zayna Khayat. The book provides a much needed «reboot» of the perspective on how society needs to engage with the aging population. It is also a reminder of the limits to current approaches to aging. The vision Zayna Khayat proposes is intended to help individuals and organizations of all types and from all sectors position themselves as long-term partners on whom aging adults can depend as they navigate their experiences of aging.
Innovation for the future of aging will include new policies, services, products, technologies, living spaces, and even approaches to shaping inter-generational communities—all of which will be transformative for the lives of older adults. The potential societal and economic returns from innovation for the future of aging are immense, and therefore need to be prioritized.
It’s time to redefine what it means to age.
We are proud to host Zayna Khayat for the DayOne LabTalk to discuss innovation opportunities for the future of aging!
This event is part of our Aging Well Catalyst project by DayOne: a journey which will seek out innovative solutions that can help with both functional and psycho-social well-being. Learn more at Dayone.swiss
Value-based Healthcare - Towards a systems approach in chronic diseasesnDayOne
Role of patient journey in science, predictive modeling and high-risk patients in early stages of disease progression, in real world context. Presented by Michael Rebhan, Novartis at the DayOne Basel event in June 2020
Value-based Healthcare today and tomorrow by Deloitte.DayOne
There is an increasing need for a value-based Healthcare based on holistic patient and health system outcomes. Success can only be reached by a genuinely collaborative approach.
Presented at the DayOne Expert event in Basel
The slides in this deck are what were discussed in the first of five Aging Well workshops. This first workshop focused on mobility for aging adults. Take a look.
How can digital bridge the mental health gaps?
Mental health is a story of gaps. This was made clear by all the speakers and panelists at DayOne’s most recent Expert Meeting titled “Measuring the Unmeasurable - will digital pave the way for new treatments in mental health?” which took place in Basel. Check out the slides from the event here.
20191203 DOE Data Driven Healthcare- Expert EventDayOne
DayOne Experts - Data-driven healthcare – are we ready?
Data is transforming healthcare. Health data from multiple sources such as electronic health records, genomic testing, imaging and digital tools, combined with advanced analytics can be used to deliver more personalised care, improve outcomes, empower patients and make healthcare more sustainable and efficient. But is the industry ready for these new approaches? What is needed on the policy level and in the regulatory field to enable a new era of data driven health solutions? How will their business models look like?
This is what we discussed at this DayOne Expert Event, which was proudly presented in close collaboration with the Embassy of the Netherlands, fostering the exchange between two world leading healthcare innovation ecosystems.
Healthcare delivery in the periphery workshop outputDayOne
A tri-national (CH, D, F) group of healthcare and labor experts came together at the DayOne lab to brainstorm on common initiatives to tackle the challenges of Healthcare delivery in our region. Please find attached the output of our workshop here.
What does “patient centricity” really mean and how is it actually done? This was the driving question of the DayOne Experts Meeting in Basel, co-hosted by Arcondis.
Input speech to panel on ethics from Evelyne Bischof, Shanghai University of Medicine & Health Sciences University Hospital Basel at the DayOne Conference 2019 Shaping the future of Health September 9th 2019
How start-up funding in digital health can workDayOne
Input speech to panel on future financing from Andreas Igel from Arcondis at the DayOne Conference 2019 Shaping the future of Health September 9th 2019
Input speech to panel on future financing by Julien Salaberry from Galen Growth Asia at introduce the DayOne Conference 2019 Shaping the future of Health September 9th 2019
Day one conference projects with journey mapsDayOne
DayOne Conference 2019 projects and journey maps. 30 ventures presented their solutions and together with conference participants built a journey map of their future.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Expert Event Legal challenges and opportunities for digital health innovationDayOne
Introduction by Thomas Brenzikofer, DayOne, Basel Area Business & Innovation
Greenfield or jungle? Navigating the legal landscape for digital healthcare innovation
At first sight, it’s hard not to agree that dealing with the legal aspects of creating healthcare innovation is — although necessary — a rather unsexy topic. So it comes as no surprise that the DayOne Experts Event “Legal challenges and opportunities for healthcare innovation”, held online on September 30, attracted a slightly smaller audience than when the talks usually concern revolutionary new pieces of digital technology ready to disrupt healthcare as we know it — for the better.
Future of aging day one 20200630 zaynakhayatDayOne
What comes to mind when you think of an older person? Who are they? Where do they live? What does their day look like? How do they want to live their life, make money, spend money, experience services and leave a legacy?
These are just some among the many provocative questions that were researched in the new book “The Future of Aging” by Zayna Khayat. The book provides a much needed «reboot» of the perspective on how society needs to engage with the aging population. It is also a reminder of the limits to current approaches to aging. The vision Zayna Khayat proposes is intended to help individuals and organizations of all types and from all sectors position themselves as long-term partners on whom aging adults can depend as they navigate their experiences of aging.
Innovation for the future of aging will include new policies, services, products, technologies, living spaces, and even approaches to shaping inter-generational communities—all of which will be transformative for the lives of older adults. The potential societal and economic returns from innovation for the future of aging are immense, and therefore need to be prioritized.
It’s time to redefine what it means to age.
We are proud to host Zayna Khayat for the DayOne LabTalk to discuss innovation opportunities for the future of aging!
This event is part of our Aging Well Catalyst project by DayOne: a journey which will seek out innovative solutions that can help with both functional and psycho-social well-being. Learn more at Dayone.swiss
Value-based Healthcare - Towards a systems approach in chronic diseasesnDayOne
Role of patient journey in science, predictive modeling and high-risk patients in early stages of disease progression, in real world context. Presented by Michael Rebhan, Novartis at the DayOne Basel event in June 2020
Value-based Healthcare today and tomorrow by Deloitte.DayOne
There is an increasing need for a value-based Healthcare based on holistic patient and health system outcomes. Success can only be reached by a genuinely collaborative approach.
Presented at the DayOne Expert event in Basel
The slides in this deck are what were discussed in the first of five Aging Well workshops. This first workshop focused on mobility for aging adults. Take a look.
How can digital bridge the mental health gaps?
Mental health is a story of gaps. This was made clear by all the speakers and panelists at DayOne’s most recent Expert Meeting titled “Measuring the Unmeasurable - will digital pave the way for new treatments in mental health?” which took place in Basel. Check out the slides from the event here.
20191203 DOE Data Driven Healthcare- Expert EventDayOne
DayOne Experts - Data-driven healthcare – are we ready?
Data is transforming healthcare. Health data from multiple sources such as electronic health records, genomic testing, imaging and digital tools, combined with advanced analytics can be used to deliver more personalised care, improve outcomes, empower patients and make healthcare more sustainable and efficient. But is the industry ready for these new approaches? What is needed on the policy level and in the regulatory field to enable a new era of data driven health solutions? How will their business models look like?
This is what we discussed at this DayOne Expert Event, which was proudly presented in close collaboration with the Embassy of the Netherlands, fostering the exchange between two world leading healthcare innovation ecosystems.
Healthcare delivery in the periphery workshop outputDayOne
A tri-national (CH, D, F) group of healthcare and labor experts came together at the DayOne lab to brainstorm on common initiatives to tackle the challenges of Healthcare delivery in our region. Please find attached the output of our workshop here.
What does “patient centricity” really mean and how is it actually done? This was the driving question of the DayOne Experts Meeting in Basel, co-hosted by Arcondis.
Input speech to panel on ethics from Evelyne Bischof, Shanghai University of Medicine & Health Sciences University Hospital Basel at the DayOne Conference 2019 Shaping the future of Health September 9th 2019
How start-up funding in digital health can workDayOne
Input speech to panel on future financing from Andreas Igel from Arcondis at the DayOne Conference 2019 Shaping the future of Health September 9th 2019
Input speech to panel on future financing by Julien Salaberry from Galen Growth Asia at introduce the DayOne Conference 2019 Shaping the future of Health September 9th 2019
Day one conference projects with journey mapsDayOne
DayOne Conference 2019 projects and journey maps. 30 ventures presented their solutions and together with conference participants built a journey map of their future.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
2. Dürrenmatt
• Who is struggling with data availability in Medicine?
• Who has read Durrenmatt's Physicists?
“What is thought, cannot be undone” …and will
inevitably lead to its ultimate thinkable consequence
3. Is Dürrenmatt too sinister?
Atomic energy, Atomic bomb, Atomic warfare
4. Questions
• Should we stop ourselves?
• Can we stop ourselves?
• Regulations vs. moral standard
• Global vs. local actions
5. Considerations
• We will suffer from a status quo bias!1
Bostrom et al., Ethics 2006
• Contributing data vs money (sharing is no option)
• Counteract neo-liberal thinking when it comes to
healthcare
• Use technology to make this shift efficient