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Network neuroscience: where the brain and social
networks works the same
Ilya Zakharov, Brainify.AI
Graph theory
How can you walk across all seven bridges of Königsberg,
without going through any of them twice?
Euler, 1736
Doctrina de la neurona, Ramón y Cajal , 1906
Brain “network”
Brain “connectivity”
Brain “connectivity”
“Architecture” of brain networks
Felleman, D. J., & Van Essen, D. C. (1991). Distributed hierarchical processing in the
primate cerebral cortex. Cerebral cortex (New York, NY: 1991), 1(1), 1-47.
How to analyze
complex networks
Universality of graphs
One of the first images of the structure of social
connections in the form of a network. Connection -
the presence of friendships in the school class.
Triangles depict boys, circles depict girls (1930s)
Graph theory for science
Sociology
Moreno, J. L. (1934). Who shall survive?: A new approach to
the problem of human interrelations.
Graph theory for science
Graph theory for science
6 handshakes theory
Hub
Hub
Hub
6 handshakes theory
Hub
Hub
Hub
6 handshakes theory
Back to
the brain
Van Den Heuvel, M. P., & Sporns, O. (2011). Rich-club organization of
the human connectome. Journal of Neuroscience, 31(44), 15775-
15786.
“Rich-club” architecture
“A hub is a place where something
is collected and distributed. For
example, transport hub, USB hub,
network hub.”
Neural efficiency theory
People with higher scores on
intelligence tests show less brain
activation when solving problems
Haier, R. J., Siegel Jr, B. V., Nuechterlein, K. H., Hazlett, E., Wu, J. C., Paek, J., ... &
Buchsbaum, M. S. (1988). Cortical glucose metabolic rate correlates of abstract
reasoning and attention studied with positron emission tomography. Intelligence,
12(2), 199-217.
The strength of weak ties
Weak ties are more important than strong ties
in interpersonal communication.
Granovetter, M. S. (1973). The strength of weak ties. American
journal of sociology, 78(6), 1360-1380.
Weak ties: experimental data
From: Rajkumar, K., Saint-Jacques, G., Bojinov, I., Brynjolfsson, E., & Aral, S. (2022). A
causal test of the strength of weak ties. Science, 377(6612), 1304-1310.
Weak ties in the brain
Red - strong but short connections between regions, green - weak and long
connections. Green ties explain up to 37% of the variance in intelligence tests.
Santarnecchi, E., Galli, G., Polizzotto, N. R., Rossi, A., & Rossi, S. (2014). Efficiency of weak brain connections support general cognitive
functioning. Human brain mapping, 35(9), 4566-4582.
Mental health conditions - alternative
stable states of strongly connected
symptom networks
Borsboom, D. (2017). A network theory of mental
disorders. World psychiatry, 16(1), 5-13.
Ties in and the Mental Health
Psychology Neuroscience
Pan, Y., Liu, Z., Xue, Z., Sheng, Y., Cai, Y., Cheng, Y., & Chen, X. (2022).
Abnormal network properties and fiber connections of DMN across
major mental disorders: a probability tracing and graph theory
study. Cerebral Cortex, 32(15), 3127-3136.
Thanks for your attention!
Ready for Q and A :)

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[DSC Europe 23][DigiHealth] Ilya Zakharov - NETWORK NEUROSCIENCE WHERE THE BRAIN AND SOCIAL NETWORKS WORKS THE SAME

  • 1. Network neuroscience: where the brain and social networks works the same Ilya Zakharov, Brainify.AI
  • 2. Graph theory How can you walk across all seven bridges of Königsberg, without going through any of them twice? Euler, 1736
  • 3. Doctrina de la neurona, Ramón y Cajal , 1906 Brain “network”
  • 6. “Architecture” of brain networks Felleman, D. J., & Van Essen, D. C. (1991). Distributed hierarchical processing in the primate cerebral cortex. Cerebral cortex (New York, NY: 1991), 1(1), 1-47.
  • 9. One of the first images of the structure of social connections in the form of a network. Connection - the presence of friendships in the school class. Triangles depict boys, circles depict girls (1930s) Graph theory for science Sociology Moreno, J. L. (1934). Who shall survive?: A new approach to the problem of human interrelations.
  • 10. Graph theory for science
  • 11. Graph theory for science
  • 16. Van Den Heuvel, M. P., & Sporns, O. (2011). Rich-club organization of the human connectome. Journal of Neuroscience, 31(44), 15775- 15786. “Rich-club” architecture “A hub is a place where something is collected and distributed. For example, transport hub, USB hub, network hub.”
  • 17. Neural efficiency theory People with higher scores on intelligence tests show less brain activation when solving problems Haier, R. J., Siegel Jr, B. V., Nuechterlein, K. H., Hazlett, E., Wu, J. C., Paek, J., ... & Buchsbaum, M. S. (1988). Cortical glucose metabolic rate correlates of abstract reasoning and attention studied with positron emission tomography. Intelligence, 12(2), 199-217.
  • 18. The strength of weak ties Weak ties are more important than strong ties in interpersonal communication. Granovetter, M. S. (1973). The strength of weak ties. American journal of sociology, 78(6), 1360-1380.
  • 19. Weak ties: experimental data From: Rajkumar, K., Saint-Jacques, G., Bojinov, I., Brynjolfsson, E., & Aral, S. (2022). A causal test of the strength of weak ties. Science, 377(6612), 1304-1310.
  • 20. Weak ties in the brain Red - strong but short connections between regions, green - weak and long connections. Green ties explain up to 37% of the variance in intelligence tests. Santarnecchi, E., Galli, G., Polizzotto, N. R., Rossi, A., & Rossi, S. (2014). Efficiency of weak brain connections support general cognitive functioning. Human brain mapping, 35(9), 4566-4582.
  • 21. Mental health conditions - alternative stable states of strongly connected symptom networks Borsboom, D. (2017). A network theory of mental disorders. World psychiatry, 16(1), 5-13. Ties in and the Mental Health Psychology Neuroscience Pan, Y., Liu, Z., Xue, Z., Sheng, Y., Cai, Y., Cheng, Y., & Chen, X. (2022). Abnormal network properties and fiber connections of DMN across major mental disorders: a probability tracing and graph theory study. Cerebral Cortex, 32(15), 3127-3136.
  • 22. Thanks for your attention! Ready for Q and A :)