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1. What We Talk About When We Talk
About Real-world Data?
Nevena Veljkovic

2. Principal research scientist, Vinca Institute of Nuclear Sciences, University of
Belgrade, National institute of Republic of Serbia
Chief Scientific Officer, Heliant doo
Founder and CEO, Genial doo
PhD Chemistry and chemical engineering, University of Belgrade
Professional interests: computational biology and chemistry, analyses of
clinical data and biomarkers
About me

3. About HELIANT
HELIANT is a software company
focused on IT solutions for
healthcare and well-being.
HELIANT is leader in the
Western Balkan market.
280
institutions
6
million
prescriptions
per month 5
million
examinations
per month
100 000
users
120
employees

4. STAKEHOLDERS
• Individuals, patients and families
• Healthcare providers
• Governments & policy makers
• Industry
• Research & educators
and many more…
INDUSTRIES
• Drugs
• Medical Equipment
• Insurance
• Healthcare Facilities
• IT
and many more…
Healthcare ecosystem

5. Digitalization is changing healthcare
Let’s turn knowledge into innovations for seamless digital patient journeys.

6. Big Data & Healthcare Analytics
Tan Tock Seng Hospital's operations command center

7. REAL WORLD DATA (RWD)
&
REAL WORLD EVIDENCE (RWE)

8. Real World Data (RWD) are the data
relating to patient health status and/or
the delivery of health care routinely
collected from a variety of sources.
Real-World Evidence (RWE) is the clinical
evidence about the usage and potential
benefits or risks of a medical product
derived from analysis of RWD.

9. USE of RWD
Patient Identification
Resources Management
Scientific Research
Clinical Trials
Precision Public Health
AI & ML Models

10. Sources of RWD
Wearable devices
Mobile devices
Claims and billing
activities
Electronic Health
records (EHRs)
Disease
registries
Social Media Patient reported Molecular profiling Enviromental

11. An electronic medical record (EMR) is a
patient’s medical history that is
maintained electronically by a single
provider. It is a digital version of a
patient's paper chart.
An electronic health record (EHR) is a
patient’s medical history that is
maintained electronically by multiple
providers.

12. TYPES of DATA
• Contact and demographic
information
• Information about visits to
healthcare professionals
• Allergies
• Insurance information
• Family history
• Immunization status
• Information about any
conditions or diseases
• A list of medications
• Records of hospitalization

13. Disease registries
• Global
• Regional
• National
• Intra-Hospital
Disease Registry a database that stores
detailed information about people with a
specific disease or condition

14. CHALLENGES & OPPORTUNITIES

15. Characteristics of RWD
Sub-optimal Data Quality that requires
intensive pre-processing
Unstructured and structured
Inconsistent
Voluminous and dynamic
Incomplete and often missing crucial end points
Subject to bias and measurement errors
Missingness rate is high
Multiple events overlap

16. Challenges
Data Quality Efficient and practical ML
and statistical procedures
Explainability and
interpretability
Reproducibility and
replicability
Privacy, data sharing Diversity, Equity, Algorithmic
fairness, and Transparency
(DEAT)

17. Challenges
Adapted from Liu & Panagiotakos, 2022

18. How to harness the value of data?
Patient data anonymization
Data standards
Standardized Analytics
Regulate data sharing

19. Opportunities
How to harness the value of data?
Patient data anonymization
Data standards
Standardized Analytics
Regulate data sharing

20. What We Need to Keep Moving Forward?
Identifying
stakeholders
who can drive
the change
Data Access
Protection
Anonymization
Data Exchange
Data Security
Education
Public Trust
TECHNICAL
POLITICAL REGULATORY CULTURAL

21. When We Talk About Real-World Data We Talk About
Real-world hold great potential for answering
questions that may not be addressed otherwise.
…rich health data sources beyond the confines
of traditional studies.
…data source that can make savings in cost
and time in evidence generation.
...routinely collected data that can be used to
make regulatory decisions.

22. Thank you.
nevena.veljkovic@heliant.rs