The document summarizes the typical drug discovery process in 6 steps:
1) Discovery and screening of 10,000-20,000 candidate drugs through high-throughput screening and target validation.
2) Lead optimization through combinatorial chemistry and structure-based drug design.
3) Testing for absorption, distribution, metabolism, excretion, and toxicity (ADMET).
4) Clinical trials in humans.
5) New drug application (NDA) approval by regulatory agencies.
6) Marketing of an average of 1 new drug.
Abstract
Background: Salt is an important component for normal function of cells. However, we consume more than 10 times the salt that is required. This high salt content affects the renin–angiotensin–aldosterone system (RAAS) that regulates blood pressure (BP) and water content of our body. Angiotensinogen is an oligopeptide hormone precursor serving as a substrate for renin in the formation of angiotensin I. Angiotensin I is converted to angiotensin II that causes vasoconstriction and a subsequent increase in BP. We hypothesized that angiotensinogen secretions increases in the kidney and urine with intake of high salt diet.
Methods: Dahl salt sensitive (SS) and salt resistant (SR) male rats (8 weeks old) were fed with high salt (HS) and low salt (LS) diet along with or without aldosterone (ALDO); aldosterone antagonist, eplerenone (EPL); and NADPH oxidase inhibitor, apocynin (APC) for 21 days. Urine samples and kidney were collected; total proteins isolated, and quantified using the microassay procedure and analyzed by western blot for angiotensinogen.
Results: Angiotensinogen was detected in the kidney samples of Dahl SS rat when fed either low or high salt diet, whereas angiotensinogen was detected in kidney samples of Dahl SR rats when fed with high salt diets. Angiotensinogen was not detected in urine samples.
Conclusions: In conclusion, consuming a high salt diet increases Angiotensinogen that lead to an increase in angiotensin II which may cause an increase in BP.
Acknowledgements: Vivien Thomas Summer Research Program, Morehouse School of Medicine, Atlanta, GA, USA.
Abstract
Background: Salt is an important component for normal function of cells. However, we consume more than 10 times the salt that is required. This high salt content affects the renin–angiotensin–aldosterone system (RAAS) that regulates blood pressure (BP) and water content of our body. Angiotensinogen is an oligopeptide hormone precursor serving as a substrate for renin in the formation of angiotensin I. Angiotensin I is converted to angiotensin II that causes vasoconstriction and a subsequent increase in BP. We hypothesized that angiotensinogen secretions increases in the kidney and urine with intake of high salt diet.
Methods: Dahl salt sensitive (SS) and salt resistant (SR) male rats (8 weeks old) were fed with high salt (HS) and low salt (LS) diet along with or without aldosterone (ALDO); aldosterone antagonist, eplerenone (EPL); and NADPH oxidase inhibitor, apocynin (APC) for 21 days. Urine samples and kidney were collected; total proteins isolated, and quantified using the microassay procedure and analyzed by western blot for angiotensinogen.
Results: Angiotensinogen was detected in the kidney samples of Dahl SS rat when fed either low or high salt diet, whereas angiotensinogen was detected in kidney samples of Dahl SR rats when fed with high salt diets. Angiotensinogen was not detected in urine samples.
Conclusions: In conclusion, consuming a high salt diet increases Angiotensinogen that lead to an increase in angiotensin II which may cause an increase in BP.
Acknowledgements: Vivien Thomas Summer Research Program, Morehouse School of Medicine, Atlanta, GA, USA.
Kubernetes & AI - Beauty and the Beast !?! @KCD Istanbul 2024Tobias Schneck
As AI technology is pushing into IT I was wondering myself, as an “infrastructure container kubernetes guy”, how get this fancy AI technology get managed from an infrastructure operational view? Is it possible to apply our lovely cloud native principals as well? What benefit’s both technologies could bring to each other?
Let me take this questions and provide you a short journey through existing deployment models and use cases for AI software. On practical examples, we discuss what cloud/on-premise strategy we may need for applying it to our own infrastructure to get it to work from an enterprise perspective. I want to give an overview about infrastructure requirements and technologies, what could be beneficial or limiting your AI use cases in an enterprise environment. An interactive Demo will give you some insides, what approaches I got already working for real.
Connector Corner: Automate dynamic content and events by pushing a buttonDianaGray10
Here is something new! In our next Connector Corner webinar, we will demonstrate how you can use a single workflow to:
Create a campaign using Mailchimp with merge tags/fields
Send an interactive Slack channel message (using buttons)
Have the message received by managers and peers along with a test email for review
But there’s more:
In a second workflow supporting the same use case, you’ll see:
Your campaign sent to target colleagues for approval
If the “Approve” button is clicked, a Jira/Zendesk ticket is created for the marketing design team
But—if the “Reject” button is pushed, colleagues will be alerted via Slack message
Join us to learn more about this new, human-in-the-loop capability, brought to you by Integration Service connectors.
And...
Speakers:
Akshay Agnihotri, Product Manager
Charlie Greenberg, Host
UiPath Test Automation using UiPath Test Suite series, part 3DianaGray10
Welcome to UiPath Test Automation using UiPath Test Suite series part 3. In this session, we will cover desktop automation along with UI automation.
Topics covered:
UI automation Introduction,
UI automation Sample
Desktop automation flow
Pradeep Chinnala, Senior Consultant Automation Developer @WonderBotz and UiPath MVP
Deepak Rai, Automation Practice Lead, Boundaryless Group and UiPath MVP
Generating a custom Ruby SDK for your web service or Rails API using Smithyg2nightmarescribd
Have you ever wanted a Ruby client API to communicate with your web service? Smithy is a protocol-agnostic language for defining services and SDKs. Smithy Ruby is an implementation of Smithy that generates a Ruby SDK using a Smithy model. In this talk, we will explore Smithy and Smithy Ruby to learn how to generate custom feature-rich SDKs that can communicate with any web service, such as a Rails JSON API.
Dev Dives: Train smarter, not harder – active learning and UiPath LLMs for do...UiPathCommunity
💥 Speed, accuracy, and scaling – discover the superpowers of GenAI in action with UiPath Document Understanding and Communications Mining™:
See how to accelerate model training and optimize model performance with active learning
Learn about the latest enhancements to out-of-the-box document processing – with little to no training required
Get an exclusive demo of the new family of UiPath LLMs – GenAI models specialized for processing different types of documents and messages
This is a hands-on session specifically designed for automation developers and AI enthusiasts seeking to enhance their knowledge in leveraging the latest intelligent document processing capabilities offered by UiPath.
Speakers:
👨🏫 Andras Palfi, Senior Product Manager, UiPath
👩🏫 Lenka Dulovicova, Product Program Manager, UiPath
LF Energy Webinar: Electrical Grid Modelling and Simulation Through PowSyBl -...DanBrown980551
Do you want to learn how to model and simulate an electrical network from scratch in under an hour?
Then welcome to this PowSyBl workshop, hosted by Rte, the French Transmission System Operator (TSO)!
During the webinar, you will discover the PowSyBl ecosystem as well as handle and study an electrical network through an interactive Python notebook.
PowSyBl is an open source project hosted by LF Energy, which offers a comprehensive set of features for electrical grid modelling and simulation. Among other advanced features, PowSyBl provides:
- A fully editable and extendable library for grid component modelling;
- Visualization tools to display your network;
- Grid simulation tools, such as power flows, security analyses (with or without remedial actions) and sensitivity analyses;
The framework is mostly written in Java, with a Python binding so that Python developers can access PowSyBl functionalities as well.
What you will learn during the webinar:
- For beginners: discover PowSyBl's functionalities through a quick general presentation and the notebook, without needing any expert coding skills;
- For advanced developers: master the skills to efficiently apply PowSyBl functionalities to your real-world scenarios.
Key Trends Shaping the Future of Infrastructure.pdfCheryl Hung
Keynote at DIGIT West Expo, Glasgow on 29 May 2024.
Cheryl Hung, ochery.com
Sr Director, Infrastructure Ecosystem, Arm.
The key trends across hardware, cloud and open-source; exploring how these areas are likely to mature and develop over the short and long-term, and then considering how organisations can position themselves to adapt and thrive.
JMeter webinar - integration with InfluxDB and GrafanaRTTS
Watch this recorded webinar about real-time monitoring of application performance. See how to integrate Apache JMeter, the open-source leader in performance testing, with InfluxDB, the open-source time-series database, and Grafana, the open-source analytics and visualization application.
In this webinar, we will review the benefits of leveraging InfluxDB and Grafana when executing load tests and demonstrate how these tools are used to visualize performance metrics.
Length: 30 minutes
Session Overview
-------------------------------------------
During this webinar, we will cover the following topics while demonstrating the integrations of JMeter, InfluxDB and Grafana:
- What out-of-the-box solutions are available for real-time monitoring JMeter tests?
- What are the benefits of integrating InfluxDB and Grafana into the load testing stack?
- Which features are provided by Grafana?
- Demonstration of InfluxDB and Grafana using a practice web application
To view the webinar recording, go to:
https://www.rttsweb.com/jmeter-integration-webinar
Neuro-symbolic is not enough, we need neuro-*semantic*Frank van Harmelen
Neuro-symbolic (NeSy) AI is on the rise. However, simply machine learning on just any symbolic structure is not sufficient to really harvest the gains of NeSy. These will only be gained when the symbolic structures have an actual semantics. I give an operational definition of semantics as “predictable inference”.
All of this illustrated with link prediction over knowledge graphs, but the argument is general.
UiPath Test Automation using UiPath Test Suite series, part 4DianaGray10
Welcome to UiPath Test Automation using UiPath Test Suite series part 4. In this session, we will cover Test Manager overview along with SAP heatmap.
The UiPath Test Manager overview with SAP heatmap webinar offers a concise yet comprehensive exploration of the role of a Test Manager within SAP environments, coupled with the utilization of heatmaps for effective testing strategies.
Participants will gain insights into the responsibilities, challenges, and best practices associated with test management in SAP projects. Additionally, the webinar delves into the significance of heatmaps as a visual aid for identifying testing priorities, areas of risk, and resource allocation within SAP landscapes. Through this session, attendees can expect to enhance their understanding of test management principles while learning practical approaches to optimize testing processes in SAP environments using heatmap visualization techniques
What will you get from this session?
1. Insights into SAP testing best practices
2. Heatmap utilization for testing
3. Optimization of testing processes
4. Demo
Topics covered:
Execution from the test manager
Orchestrator execution result
Defect reporting
SAP heatmap example with demo
Speaker:
Deepak Rai, Automation Practice Lead, Boundaryless Group and UiPath MVP
UiPath Test Automation using UiPath Test Suite series, part 4
Drug discovery strategy design 7 powerpoint ppt slides.
1. Drug Discovery Process – Style 7
10,000 – 20,000 candidate drugs
Discovery &
Screening Step 1
High throughput
screening & target
validation Lead Optimization
Step 2 combinatorial
chemistry/ structure-
based drug design
ADMET
Adsorption, distribution, Step 3
metabolism, excretion,
toxicity studies
Step 4 Clinical Trials
Step 5
NDA Approved
1 Drug to
Market
www.slideteam.net Your Logo
2. Drug Discovery Process – Style 7
Discovery &
Step 1 Screening
High throughput
screening & target
Your Text Here
validation
Step 2 Your Text Goes here. Download
this awesome diagram
• Your Text Goes here
Step 3
• Download this awesome
diagram
Step 4 • Bring your presentation to life
• Capture your audience’s
attention
Step 5
• All images are 100% editable in
PowerPoint
• Pitch your ideas convincingly
• Your Text Goes here
Step 6
www.slideteam.net Your Logo
3. Drug Discovery Process – Style 7
Step 1
Put Text Here
Lead Optimization
Step 2 combinatorial
Your Text Goes here. Download
chemistry/ structure- this awesome diagram
based drug design
• Your Text Goes here
Step 3
• Download this awesome
diagram
Step 4 • Bring your presentation to life
• Capture your audience’s
attention
Step 5
• All images are 100% editable in
PowerPoint
• Pitch your ideas convincingly
• Your Text Goes here
• All images are 100% editable in
Step 6 PowerPoint
• Pitch your ideas convincingly
www.slideteam.net Your Logo
4. Drug Discovery Process – Style 7
Step 1
Your Text Goes Here
Step 2 Your Text Goes here. Download
this awesome diagram
ADMET
Adsorption, • Your Text Goes here
Step 3
distribution, • Download this awesome
metabolism, excretion, diagram
Step 4 toxicity studies
• Bring your presentation to life
• Capture your audience’s
attention
Step 5
• All images are 100% editable in
PowerPoint
• Pitch your ideas convincingly
• Your Text Goes here
• All images are 100% editable in
Step 6 PowerPoint
• Pitch your ideas convincingly
www.slideteam.net Your Logo
5. Drug Discovery Process – Style 7
Step 1
Put Your Text Here
Step 2 Your Text Goes here. Download
this awesome diagram
• Your Text Goes here
Step 3
• Download this awesome
diagram
Step 4 Clinical Trials
• Bring your presentation to life
• Capture your audience’s
attention
Step 5
• All images are 100% editable in
PowerPoint
• Pitch your ideas convincingly
• Your Text Goes here
• All images are 100% editable in
Step 6 PowerPoint
• Pitch your ideas convincingly
www.slideteam.net Your Logo
6. Drug Discovery Process – Style 7
Step 1
Your Text Here
Step 2 Your Text Goes here. Download
this awesome diagram
• Your Text Goes here
Step 3
• Download this awesome
diagram
Step 4 • Bring your presentation to life
• Capture your audience’s
attention
Step 5 NDA Approved
• All images are 100% editable in
PowerPoint
• Pitch your ideas convincingly
• Your Text Goes here
Step 6
www.slideteam.net Your Logo
7. Drug Discovery Process – Style 7
Step 1
Your Text Goes Here
Step 2 Your Text Goes here. Download
this awesome diagram
• Your Text Goes here
Step 3
• Download this awesome
diagram
Step 4 • Bring your presentation to life
• Capture your audience’s
attention
Step 5
• All images are 100% editable in
PowerPoint
• Pitch your ideas convincingly
• Your Text Goes here
1 Drug to
Market
www.slideteam.net Your Logo
8. All images are 100% editable in PowerPoint
“Change color, size and orientation of any icon to your liking”
www.slideteam.net
9. Ungrouping the object
2
1
3
1. Right click the object.
2. Choose Group and then Ungroup.
3. Click beside the object and drag the arrow over it.
www.slideteam.net
10. Edit Color
2 3
1
1. Select the shape to change the color and Right click the object( click any object which you
want to change color)
2. Choose Format Shape in the dialog box.
3. Choose “Fill” in the Format Shape box then “Solid” or “Gradient” depending on the
appearance of the object. Change colour as shown in the picture.
www.slideteam.net