The document discusses phase 1 of detoxification, which involves biochemical processes that render toxins less harmful so they can be excreted from the body. The major organ responsible is the liver. Toxins can be endogenous from metabolism or exogenous from diet, drugs, microbes, or occupation. Phase 1 involves oxidation, reduction, and hydrolysis reactions in the liver. Oxidation introduces hydroxyl groups and is catalyzed by cytochrome P450 enzymes, making toxins more polar and able to be excreted. Reduction and hydrolysis also convert some toxins to forms that can be more easily excreted. The overall goal is to increase water solubility of toxins to facilitate their removal from the body