This document summarizes key differences between the European Commission (E.C.) and U.S. approaches to analyzing the competitive effects of conglomerate mergers, particularly regarding digital platforms. The E.C. has been more active in challenging conglomerate mergers based on various economic theories, while the U.S. has not challenged such mergers due to lack of empirical evidence of harm and concerns about penalizing efficiency-enhancing mergers. The document discusses several recent E.C. cases involving conglomerate theories and investigations into digital platforms, as well as uncertainties around U.S. treatment of acquisitions of potential competitors after withdrawing guidelines on non-horizontal mergers.
The document discusses planning and procedures for statutory audits of bank branches, including pre-audit planning, audit acceptance, evaluation of internal controls, types of advances like cash credit, overdrafts, and loans, and expectations of central statutory auditors such as compliance with RBI/ICAI guidelines and timely completion of the audit.
A pull request is a way to propose changes to a repository on GitHub. By submitting a pull request, you can notify project maintainers about changes you've pushed to a branch in a fork of the original repository. Pull requests also allow maintainers to review and discuss proposed changes before incorporating them into the main project.
Paparan pelatihan lengkap Subdit Fasharkan Ditpolair Polda Jambi;AKBP H.DADANG DK,AMd Mar,SH,SIP,MH. Sengaja ditayangkan dalam rangka Ibadah, ilmu tidak dibawa sampai mati, dengan semboyan "BERBAGI ILMU ITU IBADAH & INDAH", amin
Easter Seals Midwest Kansas City 2017 - 10 Hidden Keys to Team, Time, and Ser...Tim Miles
The document discusses 10 keys to improving communication, including listening more, celebrating differences, using clear rather than clever language, managing overstimulation, coming together as a team, and committing to continuous improvement. The keys are presented through stories, quotes, and reflections on topics like autism, technology distraction, and building understanding between people.
Kevin Abdulrahman is a motivational speaker from the Middle East who inspires millions. He discusses how witnessing successful people live fully everyday further inspires him to be his best and bring out the best in others. He overcame adversity after losing everything in a crisis but chose to remain hungry and penniless to pursue his desire of making a lasting difference in society. Abdulrahman found his calling in motivational speaking and loves what he does, saying he is "all in" with his work.
This document discusses defining success and finding self-motivation. It begins by explaining how having a clear vision of success helps provide motivation and discipline. It then shares different definitions of success from famous people, emphasizing that success is personal and unique for each individual. The rest of the document provides advice on discovering your own definition of success, including by imagining what would be said about you at your funeral, in order to find purpose and motivation in life.
This document summarizes key differences between the European Commission (E.C.) and U.S. approaches to analyzing the competitive effects of conglomerate mergers, particularly regarding digital platforms. The E.C. has been more active in challenging conglomerate mergers based on various economic theories, while the U.S. has not challenged such mergers due to lack of empirical evidence of harm and concerns about penalizing efficiency-enhancing mergers. The document discusses several recent E.C. cases involving conglomerate theories and investigations into digital platforms, as well as uncertainties around U.S. treatment of acquisitions of potential competitors after withdrawing guidelines on non-horizontal mergers.
The document discusses planning and procedures for statutory audits of bank branches, including pre-audit planning, audit acceptance, evaluation of internal controls, types of advances like cash credit, overdrafts, and loans, and expectations of central statutory auditors such as compliance with RBI/ICAI guidelines and timely completion of the audit.
A pull request is a way to propose changes to a repository on GitHub. By submitting a pull request, you can notify project maintainers about changes you've pushed to a branch in a fork of the original repository. Pull requests also allow maintainers to review and discuss proposed changes before incorporating them into the main project.
Paparan pelatihan lengkap Subdit Fasharkan Ditpolair Polda Jambi;AKBP H.DADANG DK,AMd Mar,SH,SIP,MH. Sengaja ditayangkan dalam rangka Ibadah, ilmu tidak dibawa sampai mati, dengan semboyan "BERBAGI ILMU ITU IBADAH & INDAH", amin
Easter Seals Midwest Kansas City 2017 - 10 Hidden Keys to Team, Time, and Ser...Tim Miles
The document discusses 10 keys to improving communication, including listening more, celebrating differences, using clear rather than clever language, managing overstimulation, coming together as a team, and committing to continuous improvement. The keys are presented through stories, quotes, and reflections on topics like autism, technology distraction, and building understanding between people.
Kevin Abdulrahman is a motivational speaker from the Middle East who inspires millions. He discusses how witnessing successful people live fully everyday further inspires him to be his best and bring out the best in others. He overcame adversity after losing everything in a crisis but chose to remain hungry and penniless to pursue his desire of making a lasting difference in society. Abdulrahman found his calling in motivational speaking and loves what he does, saying he is "all in" with his work.
This document discusses defining success and finding self-motivation. It begins by explaining how having a clear vision of success helps provide motivation and discipline. It then shares different definitions of success from famous people, emphasizing that success is personal and unique for each individual. The rest of the document provides advice on discovering your own definition of success, including by imagining what would be said about you at your funeral, in order to find purpose and motivation in life.
The document provides background on how the author ended up homeless in the 1970s in Dallas, Texas. As a teenager, he wanted to be an author and moved to Dallas to pursue his dreams. However, he was scammed out of his life savings by a fraudulent company that promised him pipeline work, leaving him stranded and homeless in Dallas with no money or resources.
The document provides background on how the author ended up homeless in the 1970s in Dallas, Texas. As a teenager, he wanted to be an author and moved to Dallas to pursue his dreams. However, he was scammed out of his life savings by a fraudulent company that promised him pipeline work, leaving him stranded and homeless in Dallas with no money.
This document is an introduction to the book "No Excuses! The Power of Self-Discipline for Success in Your Life" by Brian Tracy. It discusses how self-discipline is the key to success and achievement. Most people make excuses for why they have not achieved their goals, but self-discipline allows one to overcome excuses and obstacles to achieve great things. The development and practice of self-discipline can change one's life by enabling them to accomplish more than they ever thought possible.
Xem thêm nhiều sách nói và ebook tại đây: (đợi 5s và click vào "skip ads" - "Bỏ qua quảng cáo" trên góc phải màn hình)
http://adf.ly/7180338/businessbook
http://adf.ly/7180338/kho-sach-noi-full
I'm so sorry to hear about the difficult situation you found yourself in. While losing all of your savings must have felt devastating at the time, sharing your story can help others avoid similar scams. Every experience, no matter how challenging, has the potential to help us grow in wisdom and compassion. I'm glad you were able to turn things around and achieve great success through positive means. Your story of perseverance and transformation offers hope.
This document is the table of contents for the book "177 Mental Toughness Secrets of the World Class" by Steve Siebold. It outlines some of the thought processes, habits, and philosophies that champions employ according to the author's research and experience coaching world-class performers. Some of the topics covered in the book include operating from objective reality, developing world-class beliefs before becoming a champion, embracing relativity, and compartmentalizing emotions. The document provides an overview of the concepts that will be discussed and analyzed in greater depth within the chapters of the book.
This document discusses limiting beliefs and how to eliminate them. It describes how limiting beliefs form in childhood from messages absorbed from caregivers and experiences. These beliefs reside unconsciously and influence behaviors and ability to achieve goals. The author shares experiencing a limiting belief around money after undergoing a process with an NLP trainer to uncover buried beliefs. Daily dream discussion with a partner about having already achieved goals can help replace limiting beliefs with empowering beliefs by vibrating at the frequency of the desired outcome. Burning a written description of a limiting belief and keeping a description of the desired situation can also help release limiting beliefs.
Mindset presentation currie cluster jan 2015curriechs
This document summarizes a teacher in-service on fostering a growth mindset in students. It discusses how a growth mindset believes intelligence can be developed through effort and learning from mistakes or setbacks. A fixed mindset believes intelligence is innate and cannot change. The in-service provides examples of how praise, strategies for success, dealing with failure, and role models can influence a growth versus fixed mindset. The goal for schools is to promote a growth mindset in students to increase motivation, resilience, and achievement.
This document is the foreword, preface, and introduction to the book "100 Ways to Improve Your Life Today" by W. Todd Smith. Brian Tracy writes in the foreword that small, consistent efforts over time are key to success and increasing the likelihood of achieving your goals. The preface discusses how personal development and the habits you build are crucial for achieving your goals, both personally and professionally. The introduction outlines that the book contains 100 short lessons to help the reader become the type of person needed to succeed.
Grow rich! with peace of mind - the law of attractionCHIRAGCHAUHAN72
Think and Grow Rich was written by Napoleon Hill in 1937 and promoted as a personal development and self-improvement book. He claimed to be inspired by a suggestion from business magnate and later-philanthropist Andrew Carnegie. It remains the biggest seller of Napoleon Hill's books.
2logical - 20 Life Lessons I Wish Someone Would Have Taught Me in My 20sDavid Naylor
1. The document provides 23 life lessons that the author wishes someone had taught him in his 20s to help with personal and professional development.
2. The lessons include topics like embracing new experiences through travel, getting comfortable with failure and discomfort, focusing on high-payoff activities, cherishing relationships over money, and focusing on positive thoughts.
3. The author hopes sharing these lessons will help guide his son and others entering their 20s on their life journey.
2logical - 20 Life Lessons I Wish Someone Would Have Taught Me in My 20sDavid Naylor
In this article, 2logical's EVP of Global Learning reflects on his career and life, and provides valuable insight on how to be successful professionally as well as personally.
Week 7 Data InterviewsWow, what a great experience. I intervladonnacamplin
Week 7 Data Interviews
Wow, what a great experience. I interviewed two highly respected individuals in financial services. I quickly came to realize that their knowledge and expertise was immediately recognized. I could tell from both that the passion, and desire is there to help teach people about financial literacy. I found that they both were very knowledgeable on the concept and their answers flowed seamlessly. As I played the audio back, I feel I should have been more involved with my responses, but was scared to “steal the show.” I also found that he way I ask questions matters. It is tempting to focus on what I want to know rather than how I ask it. I noticed that I risked interjecting my opinions into the interview process even though I was not aware. The interview process made me aware of my own biases and as you mentioned in my last assignment, I must be aware of that. I also found myself anxious to get to the next question in regards to time. I need to remove that. Part of being an effective interviewer is being a good listener. Part of being a good listener, is to know when to be quiet. I may get anxious or excited when anticipating someone else’s answer, but it is important to slow down and not interject (Mckenna, 2017). I also recognized the importance of preparing for the interview. The importance of accurate preparation on behalf of the interviewer should not be underestimated and includes conceptual and practical preparations (Brinkmann & Kvale, 2005). Successful interviews start with careful planning that considers the focus and scope of the research question. Overall, I noticed that it is so easy to start interjecting or wanting to answer for them and I must remain to listen. This experience has been so rewarding and I look to forward to conducting many interviews as I go through this journey.
Brinkmann S, Kvale S. (2005). Confronting the ethics of qualitative research. J Constr Psychol. 18:157–181
Mckenna, K. (2017). Improve Your Research by Improving Your Interview Skills. Retrieved https://www.portent.com/blog/copywriting/content-strategy/improve-research-with-interview-skills.htm
Jennifer Vitale: 00:00 So hello today we are sitting here, uh, myself and Mr. Roosevelt who I will be interviewing. And just so you are aware, Roosevelt, the purpose of this interview is to be able to view financial literacy from a varying standpoint or perspective. This is such requires the contribution of parties who are familiar in this field of practice. And I know that you are familiar in this field and in a minute, I guess you can tell us how you are familiar in this field, but please ensure that the information provided is as accurate as possible because it helps reflect the perspective regarding the topic. So Roosevelt, if you could just take a minute, tell us about yourself and how you are familiar in this field of practice.
Roosevelt Desir: 00:45 Well, thank you. I appreciate the opportunity. Um, my name is Roosevelt. Obviously ...
Lessons I learnt from the greatest teacher - LIFE.Milind Jadhav
The document provides life lessons learned from experience. It advises to make mistakes early to grow, as life's tests come before lessons. Success comes from attitude, not just skills. It's important to follow your heart's intelligence. The goal is personal growth, not just achievement. Teamwork helps accomplish more. Respect yourself for others to respect you. Most successful people don't follow rules strictly and make their own. With time and effort, what seems impossible can become possible. Financial skills are as important as academic skills for long term wealth. Question assumptions and never stop learning. Stand up for your beliefs despite opposition. Take initiative to seize opportunities rather than waiting passively. Have the courage to change things you don't like.
When you start doing really well you begin to see a lot of people close to you acting very irrational. A lot of this is due to the fact that your success is threatening to them. Allow them to be irrational but do not allow it to affect you. Do not stress about it.
This chapter discusses the importance of belief in achieving success. It argues that believing you can succeed is essential for actually succeeding. Having faith in your abilities allows you to overcome obstacles and achieve your goals. The chapter encourages developing a positive mindset by truly believing in yourself and your capabilities. It asserts that with belief, you can accomplish great things and realize your full potential in life.
The document discusses the idea of shifting away from experts and towards embracing diverse perspectives and disagreement. It argues that Wikipedia exemplifies considering multiple viewpoints to gain understanding rather than making definitive decisions. Experts are seen more as fellow investigators rather than authorities, and disagreement can be appreciated rather than something to defeat. The role of experts may change to assembling many elements into new ways of looking at issues, like DJs, rather than making secret judgments. This represents a shift towards weighing opinions dispassionately to understand issues rather than requiring decisions.
This document discusses developing strong character and work ethic. It provides tips for self-improvement, including chiseling away excess to find your core values, developing emotional strength through challenges, and filling your mind with positive thoughts. Key aspects of character include commitment, perseverance, and contributing value through service to others. The document emphasizes creating a future vision to guide your goals and taking action through continuous learning and skill development. Overall it promotes developing a growth mindset and philosophy of success based on inner strength and serving the greater good.
Steve Virgadamo-Dynamics Of Face-To-Face Solicitation For Major Gift Steven Virgadamo
Steve Virgadamo recently gave an in-depth speech and presentation in Florida regarding face-to-face solicitation for major gift. This is Steve's exact presentation and he takes great pride in it. Hope you enjoy and feel free to check back again soon for more updates.
Histololgy of Female Reproductive System.pptxAyeshaZaid1
Dive into an in-depth exploration of the histological structure of female reproductive system with this comprehensive lecture. Presented by Dr. Ayesha Irfan, Assistant Professor of Anatomy, this presentation covers the Gross anatomy and functional histology of the female reproductive organs. Ideal for students, educators, and anyone interested in medical science, this lecture provides clear explanations, detailed diagrams, and valuable insights into female reproductive system. Enhance your knowledge and understanding of this essential aspect of human biology.
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The document provides background on how the author ended up homeless in the 1970s in Dallas, Texas. As a teenager, he wanted to be an author and moved to Dallas to pursue his dreams. However, he was scammed out of his life savings by a fraudulent company that promised him pipeline work, leaving him stranded and homeless in Dallas with no money or resources.
The document provides background on how the author ended up homeless in the 1970s in Dallas, Texas. As a teenager, he wanted to be an author and moved to Dallas to pursue his dreams. However, he was scammed out of his life savings by a fraudulent company that promised him pipeline work, leaving him stranded and homeless in Dallas with no money.
This document is an introduction to the book "No Excuses! The Power of Self-Discipline for Success in Your Life" by Brian Tracy. It discusses how self-discipline is the key to success and achievement. Most people make excuses for why they have not achieved their goals, but self-discipline allows one to overcome excuses and obstacles to achieve great things. The development and practice of self-discipline can change one's life by enabling them to accomplish more than they ever thought possible.
Xem thêm nhiều sách nói và ebook tại đây: (đợi 5s và click vào "skip ads" - "Bỏ qua quảng cáo" trên góc phải màn hình)
http://adf.ly/7180338/businessbook
http://adf.ly/7180338/kho-sach-noi-full
I'm so sorry to hear about the difficult situation you found yourself in. While losing all of your savings must have felt devastating at the time, sharing your story can help others avoid similar scams. Every experience, no matter how challenging, has the potential to help us grow in wisdom and compassion. I'm glad you were able to turn things around and achieve great success through positive means. Your story of perseverance and transformation offers hope.
This document is the table of contents for the book "177 Mental Toughness Secrets of the World Class" by Steve Siebold. It outlines some of the thought processes, habits, and philosophies that champions employ according to the author's research and experience coaching world-class performers. Some of the topics covered in the book include operating from objective reality, developing world-class beliefs before becoming a champion, embracing relativity, and compartmentalizing emotions. The document provides an overview of the concepts that will be discussed and analyzed in greater depth within the chapters of the book.
This document discusses limiting beliefs and how to eliminate them. It describes how limiting beliefs form in childhood from messages absorbed from caregivers and experiences. These beliefs reside unconsciously and influence behaviors and ability to achieve goals. The author shares experiencing a limiting belief around money after undergoing a process with an NLP trainer to uncover buried beliefs. Daily dream discussion with a partner about having already achieved goals can help replace limiting beliefs with empowering beliefs by vibrating at the frequency of the desired outcome. Burning a written description of a limiting belief and keeping a description of the desired situation can also help release limiting beliefs.
Mindset presentation currie cluster jan 2015curriechs
This document summarizes a teacher in-service on fostering a growth mindset in students. It discusses how a growth mindset believes intelligence can be developed through effort and learning from mistakes or setbacks. A fixed mindset believes intelligence is innate and cannot change. The in-service provides examples of how praise, strategies for success, dealing with failure, and role models can influence a growth versus fixed mindset. The goal for schools is to promote a growth mindset in students to increase motivation, resilience, and achievement.
This document is the foreword, preface, and introduction to the book "100 Ways to Improve Your Life Today" by W. Todd Smith. Brian Tracy writes in the foreword that small, consistent efforts over time are key to success and increasing the likelihood of achieving your goals. The preface discusses how personal development and the habits you build are crucial for achieving your goals, both personally and professionally. The introduction outlines that the book contains 100 short lessons to help the reader become the type of person needed to succeed.
Grow rich! with peace of mind - the law of attractionCHIRAGCHAUHAN72
Think and Grow Rich was written by Napoleon Hill in 1937 and promoted as a personal development and self-improvement book. He claimed to be inspired by a suggestion from business magnate and later-philanthropist Andrew Carnegie. It remains the biggest seller of Napoleon Hill's books.
2logical - 20 Life Lessons I Wish Someone Would Have Taught Me in My 20sDavid Naylor
1. The document provides 23 life lessons that the author wishes someone had taught him in his 20s to help with personal and professional development.
2. The lessons include topics like embracing new experiences through travel, getting comfortable with failure and discomfort, focusing on high-payoff activities, cherishing relationships over money, and focusing on positive thoughts.
3. The author hopes sharing these lessons will help guide his son and others entering their 20s on their life journey.
2logical - 20 Life Lessons I Wish Someone Would Have Taught Me in My 20sDavid Naylor
In this article, 2logical's EVP of Global Learning reflects on his career and life, and provides valuable insight on how to be successful professionally as well as personally.
Week 7 Data InterviewsWow, what a great experience. I intervladonnacamplin
Week 7 Data Interviews
Wow, what a great experience. I interviewed two highly respected individuals in financial services. I quickly came to realize that their knowledge and expertise was immediately recognized. I could tell from both that the passion, and desire is there to help teach people about financial literacy. I found that they both were very knowledgeable on the concept and their answers flowed seamlessly. As I played the audio back, I feel I should have been more involved with my responses, but was scared to “steal the show.” I also found that he way I ask questions matters. It is tempting to focus on what I want to know rather than how I ask it. I noticed that I risked interjecting my opinions into the interview process even though I was not aware. The interview process made me aware of my own biases and as you mentioned in my last assignment, I must be aware of that. I also found myself anxious to get to the next question in regards to time. I need to remove that. Part of being an effective interviewer is being a good listener. Part of being a good listener, is to know when to be quiet. I may get anxious or excited when anticipating someone else’s answer, but it is important to slow down and not interject (Mckenna, 2017). I also recognized the importance of preparing for the interview. The importance of accurate preparation on behalf of the interviewer should not be underestimated and includes conceptual and practical preparations (Brinkmann & Kvale, 2005). Successful interviews start with careful planning that considers the focus and scope of the research question. Overall, I noticed that it is so easy to start interjecting or wanting to answer for them and I must remain to listen. This experience has been so rewarding and I look to forward to conducting many interviews as I go through this journey.
Brinkmann S, Kvale S. (2005). Confronting the ethics of qualitative research. J Constr Psychol. 18:157–181
Mckenna, K. (2017). Improve Your Research by Improving Your Interview Skills. Retrieved https://www.portent.com/blog/copywriting/content-strategy/improve-research-with-interview-skills.htm
Jennifer Vitale: 00:00 So hello today we are sitting here, uh, myself and Mr. Roosevelt who I will be interviewing. And just so you are aware, Roosevelt, the purpose of this interview is to be able to view financial literacy from a varying standpoint or perspective. This is such requires the contribution of parties who are familiar in this field of practice. And I know that you are familiar in this field and in a minute, I guess you can tell us how you are familiar in this field, but please ensure that the information provided is as accurate as possible because it helps reflect the perspective regarding the topic. So Roosevelt, if you could just take a minute, tell us about yourself and how you are familiar in this field of practice.
Roosevelt Desir: 00:45 Well, thank you. I appreciate the opportunity. Um, my name is Roosevelt. Obviously ...
Lessons I learnt from the greatest teacher - LIFE.Milind Jadhav
The document provides life lessons learned from experience. It advises to make mistakes early to grow, as life's tests come before lessons. Success comes from attitude, not just skills. It's important to follow your heart's intelligence. The goal is personal growth, not just achievement. Teamwork helps accomplish more. Respect yourself for others to respect you. Most successful people don't follow rules strictly and make their own. With time and effort, what seems impossible can become possible. Financial skills are as important as academic skills for long term wealth. Question assumptions and never stop learning. Stand up for your beliefs despite opposition. Take initiative to seize opportunities rather than waiting passively. Have the courage to change things you don't like.
When you start doing really well you begin to see a lot of people close to you acting very irrational. A lot of this is due to the fact that your success is threatening to them. Allow them to be irrational but do not allow it to affect you. Do not stress about it.
This chapter discusses the importance of belief in achieving success. It argues that believing you can succeed is essential for actually succeeding. Having faith in your abilities allows you to overcome obstacles and achieve your goals. The chapter encourages developing a positive mindset by truly believing in yourself and your capabilities. It asserts that with belief, you can accomplish great things and realize your full potential in life.
The document discusses the idea of shifting away from experts and towards embracing diverse perspectives and disagreement. It argues that Wikipedia exemplifies considering multiple viewpoints to gain understanding rather than making definitive decisions. Experts are seen more as fellow investigators rather than authorities, and disagreement can be appreciated rather than something to defeat. The role of experts may change to assembling many elements into new ways of looking at issues, like DJs, rather than making secret judgments. This represents a shift towards weighing opinions dispassionately to understand issues rather than requiring decisions.
This document discusses developing strong character and work ethic. It provides tips for self-improvement, including chiseling away excess to find your core values, developing emotional strength through challenges, and filling your mind with positive thoughts. Key aspects of character include commitment, perseverance, and contributing value through service to others. The document emphasizes creating a future vision to guide your goals and taking action through continuous learning and skill development. Overall it promotes developing a growth mindset and philosophy of success based on inner strength and serving the greater good.
Steve Virgadamo-Dynamics Of Face-To-Face Solicitation For Major Gift Steven Virgadamo
Steve Virgadamo recently gave an in-depth speech and presentation in Florida regarding face-to-face solicitation for major gift. This is Steve's exact presentation and he takes great pride in it. Hope you enjoy and feel free to check back again soon for more updates.
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Histololgy of Female Reproductive System.pptxAyeshaZaid1
Dive into an in-depth exploration of the histological structure of female reproductive system with this comprehensive lecture. Presented by Dr. Ayesha Irfan, Assistant Professor of Anatomy, this presentation covers the Gross anatomy and functional histology of the female reproductive organs. Ideal for students, educators, and anyone interested in medical science, this lecture provides clear explanations, detailed diagrams, and valuable insights into female reproductive system. Enhance your knowledge and understanding of this essential aspect of human biology.
Breast cancer: Post menopausal endocrine therapyDr. Sumit KUMAR
Breast cancer in postmenopausal women with hormone receptor-positive (HR+) status is a common and complex condition that necessitates a multifaceted approach to management. HR+ breast cancer means that the cancer cells grow in response to hormones such as estrogen and progesterone. This subtype is prevalent among postmenopausal women and typically exhibits a more indolent course compared to other forms of breast cancer, which allows for a variety of treatment options.
Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
5-hydroxytryptamine or 5-HT or Serotonin is a neurotransmitter that serves a range of roles in the human body. It is sometimes referred to as the happy chemical since it promotes overall well-being and happiness.
It is mostly found in the brain, intestines, and blood platelets.
5-HT is utilised to transport messages between nerve cells, is known to be involved in smooth muscle contraction, and adds to overall well-being and pleasure, among other benefits. 5-HT regulates the body's sleep-wake cycles and internal clock by acting as a precursor to melatonin.
It is hypothesised to regulate hunger, emotions, motor, cognitive, and autonomic processes.
These lecture slides, by Dr Sidra Arshad, offer a simplified look into the mechanisms involved in the regulation of respiration:
Learning objectives:
1. Describe the organisation of respiratory center
2. Describe the nervous control of inspiration and respiratory rhythm
3. Describe the functions of the dorsal and respiratory groups of neurons
4. Describe the influences of the Pneumotaxic and Apneustic centers
5. Explain the role of Hering-Breur inflation reflex in regulation of inspiration
6. Explain the role of central chemoreceptors in regulation of respiration
7. Explain the role of peripheral chemoreceptors in regulation of respiration
8. Explain the regulation of respiration during exercise
9. Integrate the respiratory regulatory mechanisms
10. Describe the Cheyne-Stokes breathing
Study Resources:
1. Chapter 42, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 36, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 13, Human Physiology by Lauralee Sherwood, 9th edition
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low birth weight presentation. Low birth weight (LBW) infant is defined as the one whose birth weight is less than 2500g irrespective of their gestational age. Premature birth and low birth weight(LBW) is still a serious problem in newborn. Causing high morbidity and mortality rate worldwide. The nursing care provide to low birth weight babies is crucial in promoting their overall health and development. Through careful assessment, diagnosis,, planning, and evaluation plays a vital role in ensuring these vulnerable infants receive the specialize care they need. In India every third of the infant weight less than 2500g.
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8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptxHolistified Wellness
We’re talking about Vedic Meditation, a form of meditation that has been around for at least 5,000 years. Back then, the people who lived in the Indus Valley, now known as India and Pakistan, practised meditation as a fundamental part of daily life. This knowledge that has given us yoga and Ayurveda, was known as Veda, hence the name Vedic. And though there are some written records, the practice has been passed down verbally from generation to generation.
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptx
Denis Waitley Answers 7 Questions On How To Develop The Winner's Edge
1. Denis Waitley Answers 7
Questions On How To Develop
The Winner's Edge
I sat down with personal growth pioneer, Denis Waitley, to ask for his advice on
how to become a winner, raise children, and make your career your passion.
The legendary Denis Waitley published The Psychology of Winning in the
1980s, which then went on to become the bestselling audiobook in
history, bringing in $100 million and 2 million students.
Denis Waitley is not only perhaps the greatest coach America has ever produced,
he’s also the most humble.
As one of the most-listened-to voices in personal development and growth,
with The Psychology of Winning audiobook selling out to over 2 million people
and raking in over $100 million dollars, Denis Waitley has good reason to tout his
own success.
After all, he’s a pioneer in the field of personal growth.
He’s worked alongside the early greats and met men before they were giants:
Zig Ziglar, Norman Vincent Peale, Earl Nightingale, a dashing 17-year-old Tony
Robbins. . . And he’s been responsible for the creation of champions as the
Chairman of Psychology for US Olympics team and as the performance coach of
Astronauts.
However, when you meet him, you’ll find a man that surprises you with his
humility, his story, his insight, and brilliant wisdom.
Unlike his friend Zig Ziglar, Dennis Waitley is not a salesman. He’s not a self-
promoter and he’s not a marketer.
2. Denis Waitley is a teacher, a poet, a patriot — and he knows how to train your
brain to unleash your inner champion.
That’s why I sat down with him last Tuesday to ask him to share his journey and
ask him about how to become unstoppable, how to raise children, and
his Mindvalley Quest, The New Psychology of Winning.
Waitley on Larry King Live.
Interview With Denis Waitley
Mindvalley: Let's start with your origin story. How did you become the leading
expert in peak performance and and the author of the bestselling audiobook in
history?
Denis Waitley: Well, it's actually something that you would not expect.
I grew up in a dysfunctional poor family in San Diego. My mother worked in a
factory and my father worked in a car dealership, but he had a lot of drinking and
smoking issues.
3. In order to find love and compassion, I rode my bike 20 miles to my
grandmother's home in Mission Hills and gardened with her every Saturday.
She really gave me the first feelings of worth by telling me whatever you put in
the soil and nurture will come up. And she told me, "You need to concentrate on
planting seeds of greatness. You need to model yourself after people with proven
track records of success rather than people who just yell and shout.”
But because we were at war with North Korea, everyone in my class got drafted.
I then became a Navy pilot. And I didn't mind defending my country, but I wanted
to do more to actually develop people's potential.
I was not successful for a 10-year period other than local talks and going out and
building a speaking career, little by little. But my military career and my interest in
personal development allowed me to finally get into the astronaut training
program. And then in 1980 I was appointed Chairman of Psychology for the
United States Olympics.
So that was the beginning.
4. Mindvalley: Why did you write The Psychology of Winning?
Denis Watley: I wrote The Psychology of Winning at the worst time of my life as a
result of what I wasn't doing.
I wrote for myself, to explain to me what I wasn't doing, why I was losing, why I
could not stay on top, why I only had temporary success. So I had no idea that it
would end up more successful… I would say that in The Psychology of
Winning: The 10 Traits of The Total Winner every trait was one that I needed to
develop in myself at the time.
Mindvalley: So it was almost like journaling, actually, in a way?
Denis Waitley: Yes, it was. And it was also part of a doctoral thesis. In the book, I
explain why no American prisoner ever escaped from a minimum-security campus
5. because they had no purpose. Only the leaders who were in maximum security
escaped from the prison camps. I became a cerebral researcher. I used anecdotal
evidence coming from prisoners of war or from people who, in the military, who
had gone through tremendous trauma.
I learned a lot from people who were not succeeding but were surviving.
Mindvalley: Tell me more about what people learn from your program. How
does it change their lives? How did it change your life?
Denis Waitley: It changed my life because I had to look inside. The very beginning
of this whole process is self-awareness.
Self-awareness is the ability to step back from the campus of your life and do an
audit. And the audit is, "What are my natural gifts? How do I know? What are my
positive personality traits and what are the ones that are holding me back?"
Because if it's true that the brain is the GPS system, first, you crank in your
starting point where you are today and then you crank in your destination. You
can't get anywhere unless you know where you are.
So in The Psychology of Winning, they'll save a lot of time, a lot of anguish, by
learning what they really have to offer. And they'll learn from the people who
are already champions.
That's what every good golfer does from a golf coach and every good Olympian
does. They learn from the coach the correct sling. Because you can't play the
inner game of anything until you learn the correct swing. And then you repeat, so
that over time it internalizes into reflex.
Winning is 90% reflex at the highest level. So champions, astronauts, Olympians,
top entrepreneurs, don't think about it anymore. It's a natural reflex action that
they have developed through two years of this kind of activity.
6. Mindvalley Founder Vishen Lakhiani interviewing Denis Waitley
Mindvalley: How do you measure success after working with people like that?
Denis Waitley: A winner is someone who takes the potential that they've been
given and the experiences, skills they have since developed, and applies it to a
fulfilling and happy life that benefits other people as well as themselves. They
take what they've been given, develop it fully into something they love to do, and
achieve their highest goals in a way that benefits others as well as themselves.
A loser would not be somebody impoverished in a poor country, somebody who
couldn't get enough to eat.
A loser would be somebody in an abundant country with every opportunity for
education, every opportunity to read, but someone who can read but doesn't
read. A loser would be somebody who would like to look like, be like, earn like,
and be somebody else, but is not willing to pay the price of success and put in the
work.
Mindvalley: And what is the greatest mistake that people make in pursuit of
success?
7. Dennis Waitley: Expecting success to arrive as a result of somebody doing
something for you — and believing you have to look out for number one at the
expense of others. Those are the two main problems that people have.
People get stuck in the having to provide income, and therefore they are not
willing to risk bailing or risk being a fool.
But the only thing I can say there is that they should be taking their free time to
chase their passion. You don't have to take all the risk by yourself, but the
greatest risk is seeking security. And the greatest security is being able to seek
risk that will actually set you free.
Denis Waitley having dinner with Jim Rohn and Brian Tracy.
Mindvalley: How does someone go from scarcity and security-seeking mindset
to mustering up the courage and self-confidence to pursue their dreams?
Denis Watley: The best way is to attend, watch, listen, network, read of people
who've overcome enormous handicaps and obstacles to become successful. And
history is full of average and below average people who've become extraordinary
successes.
And it gives one, a person like me who grew up with marginal self-esteem, the
courage to try it knowing that all these people who are ordinary did extraordinary
8. things. You have to get out of the blame game, and get into the game of, "Why
not me?" Instead of, "Why me, Lord?"
Mindvalley: I'm sure that you discovered a lot about resilience from Prisoners of
War. What did you learn from the POWs you interviewed?
Denis Waitley: The most. I've learned the most.
I've learned that when everything is taken from you and you don't know whether
you're going to survive, there's two kinds of people at that moment. Those who
are afraid and will do anything to stay alive. They will compromise any belief they
have as long as no one gives them pain.
And then there are those who are leaders.
People who know where they are going, where they came from, what they stand
for, what they're fighting for, and they will not break under either intimidation or
in being given special privileges. Those are the ones that tapped down the pipes,
Morse code, and kept their faith. And those are the people who exhibit winning
characteristics.
9. Mindvalley: And how can parents teach their children to be successful?
Denis Waitley: The problem is that many parents are attempting to relive their
lives in their children. Parents give their children money instead of time, they give
them indulgence, and they want to be their children's best friend when they
should be their mentor, their role model.
Now children are actually losing the ability to take responsibility for the outcomes
in their lives. And they're unable to handle very simple setbacks because they
never had to handle those all throughout their childhood and all throughout high
school and university.
And not until they got into the real world and they got their first major rejection
did they finally experience that life is full of noise and barriers.
10. So I think the greatest thing that holds our children back is by not giving them
authentic value and praise, just indulging them with things. It's important to give
praise for specific accomplishments. And I always say, "Let a child experiment, but
keep them safe." Let them experience the consequences of their own actions as
long as it doesn't damage them emotionally or personally.
Mindvalley: Last question. What's the one message you'd want to share with
every generation on the world right now?
Denis Waitley: The future belongs to the optimist because imagination rules the
world. It isn't what we know, it's what we imagine that counts. And that's why we
should be optimistic — there's enough for everyone. We can give without giving
up anything. We haven't lost anything just because we're sharing the abundance.