Memi Beltrame's talk at FrontendConf 2014 discusses the inadequacies of modern web design, particularly the lack of focus on function and data. He advocates for data-driven design (DDD) that simulates user interactions with actual data, emphasizing the need for realistic prototypes that meet user expectations. Beltrame also evaluates various prototyping tools, concluding that while simpler tools handle basic designs efficiently, more complex tools like Protostrap better manage intricate designs and large amounts of data.