danielspower
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The document discusses various topics related to employment such as harassment, resigning from a job, losing a job, and drug testing. It defines sexual harassment and notes that if an employee feels harassed, they should report it to their supervisor or human resources. Common reasons for losing a job include drug use and failing to get along with others. Employers may require drug testing to ensure employees are responsible and dependable. Maintaining good work ethics such as arriving on time and completing assignments helps create a positive work environment and quality of life for patients.
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acne vulgaris -Mpharm (2nd semester) Cosmetics and cosmeceuticals
cosmetics and cosmeceuticals
Muskan
mpharm
2nd semester
Guru Gobind Singh college of pharmacy, yamunanagar, haryana
The Nervous and Chemical Regulation of Respiration
These lecture slides, by Dr Sidra Arshad, offer a simplified look into the mechanisms involved in the regulation of respiration:
Learning objectives:
1. Describe the organisation of respiratory center
2. Describe the nervous control of inspiration and respiratory rhythm
3. Describe the functions of the dorsal and respiratory groups of neurons
4. Describe the influences of the Pneumotaxic and Apneustic centers
5. Explain the role of Hering-Breur inflation reflex in regulation of inspiration
6. Explain the role of central chemoreceptors in regulation of respiration
7. Explain the role of peripheral chemoreceptors in regulation of respiration
8. Explain the regulation of respiration during exercise
9. Integrate the respiratory regulatory mechanisms
10. Describe the Cheyne-Stokes breathing
Study Resources:
1. Chapter 42, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 36, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 13, Human Physiology by Lauralee Sherwood, 9th edition
Alzheimer’s Disease Case Conference: Gearing Up for the Expanding Role of Neu...
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Co-Chairs, Val J. Lowe, MD, and Cyrus A. Raji, MD, PhD, prepared useful Practice Aids pertaining to Alzheimer’s disease for this CME/AAPA activity titled “Alzheimer’s Disease Case Conference: Gearing Up for the Expanding Role of Neuroradiology in Diagnosis and Treatment.” For the full presentation, downloadable Practice Aids, and complete CME/AAPA information, and to apply for credit, please visit us at https://bit.ly/3PvVY25. CME/AAPA credit will be available until June 28, 2025.Breast cancer: Post menopausal endocrine therapy
Breast cancer in postmenopausal women with hormone receptor-positive (HR+) status is a common and complex condition that necessitates a multifaceted approach to management. HR+ breast cancer means that the cancer cells grow in response to hormones such as estrogen and progesterone. This subtype is prevalent among postmenopausal women and typically exhibits a more indolent course compared to other forms of breast cancer, which allows for a variety of treatment options.
Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
Histololgy of Female Reproductive System.pptx
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danielspower
- 2. To TROUBLE , TORMENT, OFFEND , or WORRY a person by one’s behavior or comments I NVOLVES AGE RACE ETHNIC BACKGROUND RELIGION DISABILITY
- 3. SEXUAL HARRASMENT SEXUAL HARASSMENT INVOVES UNWANTED SEXUAL BEHAVIORS BY ANOTHER. SOME REMARKS, COMMENTS, AND TOUCHING ARE SEXUAL. THE BEHAVIOR AFFECT THE PERSON’S WORK AND COMFORT PATIENTS AND CO-WORKERS CAN BOTH BE VICTIMS IF YOU FEEL THAT YOU ARE BEING HARASSED, REPORT THE MATTER TO YOUR SUPERVISOR AND HUMAN RESOURCE OFFICER
- 4. DISRESPECTFUL SAYING REMARKS SUCH AS THIS IS
- 5. A JOB IS A PRIVILEGE!! FAILURE TO DO SO WOULD RESULT TO TERMINATION FAILURE TO GET ALONG WITH OTHERS WOULD ALSO RESULT TO TERMINATION
- 6. COMMON REASONS FOR LOSING A JOB
- 7. DRUG TESTING Those who use drugs or alcohol are late to work or absent more often than staff members who do not use such substance HEALTH CENTERS ONLY LOOK FOR PEOPLE THAT ARE RESPOSIBILE AND DEPENDABLE SO THEY ASK FOR YOU TO TAKE A DRUG TEST
- 10. THE END…