What Is Cytomegalovirus (CMV)?
Structure of Human CMV
CMV: The Most Common Virus Few People
Have Heard Of
CMV Life Cycle and Pathogenesis
CMV Burden and Epidemiology
CMV Establishes Lifelong Latency
Clinical Manifestations of CMV Vary Based on
Immune Status
CMV Is Transmitted From Person to Person
Through Bodily Fluids
Main Sources of CMV Acquisition
Seroprevalence of CMV Varies by Population
and Assessment
CMV Seroprevalence Increases With Age
Risk Factors for CMV Seropositivity
CMV Infection During Pregnancy
Estimated Global Prevalence of cCMV
cCMV Prevalence Varies by Geographic
Region
Regional and Maternal Factors That Correlate
With cCMV Rate
cCMV Prevalence Varies by Race/Ethnicity
and SES
cCMV Risk During Pregnancy
How CMV Differs From Other Congenitally
Transmitted Viruses
cCMV Risk With Primary vs Nonprimary CMV
Infection
cCMV Risk With Primary vs Nonprimary CMV
Infection
cCMV Risk With Primary vs Nonprimary CMV
Infection
Risks of CMV Infection During Pregnancy
Infants and Young Children Are Often Carriers
of CMV
Maternal CMV Disease Is Difficult to Diagnose
Maternal CMV Disease Is Difficult to Diagnose
Imaging Can Help Identify a Fetus With cCMV
Gestational Age at Maternal CMV Acquisition
Affects Vertical Transmission Risk and Predicts
cCMV Severity
Gestational Age at Maternal CMV Acquisition
Affects Vertical Transmission Risk and Predicts
cCMV Severity
cCMV Sequelae in Fetuses and Children
Prognostic Assessments in a CMV-Infected
Fetus
Findings Consistent With a Fetal CMV
Infection
Findings Consistent With a Fetal CMV
Infection
cCMV Manifests a Spectrum of Outcomes
cCMV Is Broadly Categorized as Symptomatic
or Asymptomatic
cCMV Is Broadly Categorized as Symptomatic
or Asymptomatic
cCMV Can Cause Lifelong Morbidity
Regardless of Whether Neonates Are
Symptomatic or Asymptomatic at Birth
cCMV Can Cause Lifelong Morbidity
Regardless of Whether Neonates Are
Symptomatic or Asymptomatic at Birth
The Role of Antiviral Treatment in cCMV
Benefits and Risks/Limitations of Antiviral Use
Observations From Two Phase 3 Randomized
Trials in cCMV
Benefits and Risks/Limitations of Antiviral Use
Observations From Two Phase 3 Randomized
Trials in cCMV
Benefits and Risks/Limitations of Antiviral Use
Observations From Two Phase 3 Randomized
Trials in cCMV
Benefits and Risks/Limitations of Antiviral Use
Observations From Two Phase 3 Randomized
Trials in cCMV
Reducing the Prevalence of cCMV
Strategies for Reducing the Burden of cCMV
Clinical Studies of Hyperimmune Globulin
(HIG) to Prevent cCMV
Antivirals to Prevent Intrauterine Transmission
of CMV
Routine Prenatal Serology Testing for CMV Is
Not Advised
Hygiene Practices Can Help Prevent Maternal
CMV Infection
Other Recommendations to Reduce the
Burden of cCMV
Vaccine Research
Platforms of Candidate CMV Vaccines in
Clinical Trials
Candidate CMV Vaccines With Partial Efficacy
in Clinical Trials
Improving Efficacy of Candidate CMV Vaccines
Improving Efficacy of Candidate CMV Vaccines
Improving Efficacy of Candidate CMV Vaccines
Improving Efficacy of Candidate CMV Vaccines
Summary of Current Prevention Strategies
The CMV "Knowledge Vaccine" or
"Information Immunization"
The First Component Is an Ounce of
Awareness
Add in These 3 Hygiene Practices for Pregnant
Women During Interactions With Young
Children
Conclusions
cytomegalovirus , better understanding.pptx

cytomegalovirus , better understanding.pptx