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Ms Dan Jiang*
Hallam Institute of TCM, UK
*Corresponding author: Ms Dan Jiang, Hallam Institute of TCM, 439 Glossop Road Sheffield S10 2PR, UK.
Submission: December 04, 2017; Published: January 22, 2018
Protecting Embryo with Chinese Herbal
Medicine for Treating Habitual Miscarriages-----
4 Cases Study Enclosed
Case Report Perceptions Reprod Med
Copyright © All rights are reserved by Freddy Andrés Barrios Arroyave.
CRIMSONpublishers
http://www.crimsonpublishers.com
Case Report
It is almost impossible to protect the embryo, ladies
successfully complete pregnancy, and have healthy babies, if they
are going through vaginal bleeding, abdominal cramp and showing
some other signs at the early month of pregnancy, which will
normally end in miscarriages before TCM enters the West. Since the
beginning of my practice of TCM (Acupuncture and Chinese herbal
medicine) in UK, I have been using TCM for protecting embryo and
terminating signs of miscarriage effectively in order to help ladies
naturally complete their pregnancies and get healthy babies and
there are more and more successful cases. I will share a few of
the cases and my experience in treating miscarriage with Chinese
herbal medicine and acupuncture as below:
Case 1
After 3 times of spontaneous abortions, her embryo was
successfully protected with TCM treatment at the early time of
pregnancy and she labored a healthy baby boy: Ms. S J, 38 years
old of IT technician, started her menstrual bleeding at 4 weeks
after her last period, but she already found a positive result after
pregnancy test. She recognized that she might have a miscarriage
again, because she has experienced these vaginal bleeding for three
times in two years, all of which resulted in abortion in 7-8 weeks of
her pregnancies after a gradually increased vaginal bleeding. She
started her bleeding early this time, so she urgently went to see her
GP requiring an Ultrasound to prove her pregnancy and a suitable
treatment. She was refused an Ultrasound due to the reason that a
regular one should be done at the 8th week of pregnancy and not
any available treatment was given. When she visited me in anxiety,
I checked that she had a vaginal bleeding in average amount with
fresh blood, without clotting, or any solid substances in the blood,
and abdominal cramp for 2-3 days. Last period of hers was 34 days
ago, and the bleeding started 2 days ago without overreaction
symptoms of pregnancy. Pregnancy test was positive that morning.
Light red tongue with less white coating; Rolling and fine pulse.
Diagnosis of Conventional western medicine:
A. The early signs of miscarriage
B. The 4th
of weeks of pregnancy
C. Differentiation of syndrome by TCM: deficiency of both
spleen and Kidney
D. Weak embryo
E. Treating principle: Reinforcing kidney and spleen,
Strengthening embryo
F. Herbal medical prescription: Shudihuang (Radix
Rehmanniae Praeparata) 10, Huangqi (Radix Astragali)15, Baizhu
(RhizomaAtractylodis Macrocephalae) 10, Aiye(Folium Artemisiae
Argyi)10Sangjisheng(Herba Taxilli) 10,Xuduan (RadixDipsaci)10,
Sharen(Fructus Amomi) 10, Ejiao (Colla Corii Asini) 10, Huangqin
(Radix Scutellariae) 10, Chaihu (Radix Bupleuri) 10, Dangshen
(Radix Codonopsis Pilosulae) 10, Fuling (Poria )10, Zhigancao
(Radix Glycyrrhizae Praeparata) 5
Above herbal prescription was decocted into herbal juice, and
she drank the juice, twice daily.
Result: After she drank the herbal juice for two days, her
vaginal bleeding started to reduce until it completely stopped in
two weeks; her abdominal cramp eased after her taking this herbal
juice for a month. She was given an ultrasound in the 8th
week of
her pregnancy by her GP which reported that she was in a normal
pregnancy procedure. She remained well with a strong rolling pulse
and without abnormal symptoms until 12th
weeks of her pregnancy;
she went forward in her normal procedure after I ended the herbal
medicine and labored a healthy baby boy in the full term.
Case 2
Due to 3 times of spontaneous abortions caused by high
prolactin, she labored a baby girl after acupuncture and herbal
medicinetreatment:Mrs.CF,33yearsoldofsecretory,sufferedfrom
vaginal bleeding at the 8th
weeks in the third of her pregnancies, and
she was terminated again with drug due to occurring spontaneous
ISSN: 2640-9666
How to cite this article: Ms Dan J. Protecting Embryo with Chinese Herbal Medicine for Treating Habitual Miscarriages-----4 Cases Study Enclosed. Perceptions
Reprod Med. 1(3). PRM.000515. 2018. DOI: 10.31031/PRM.2018.01.000515
Perceptions in Reproductive Medicine
2/6
Perceptions Reprod Med
vaginal bleeding. Her gynecological consultant did all of relevant
examinations for her, and a high prolactin was confirmed to be the
reason for her multiple spontaneous abortions. Due to the many
emotional symptoms she was suffering from, she was referred to
see me---a TCM practitioner by her gynecological consultant.
Current figures: she was weepy with continuous tears and
couldn’t control her moodiness, bad depression, abdominal cramp.
Due to the drug she was taking for cleaning her uterus the day
before, she still had a bit of spotty blood, headache, insomnia,
anxiety, loose bowel and fatigues. Red tongue, worse at tip and
sides with less thin coating; Wiry-fine pulse. Prolactin 901miu/I,
repeat prolactin 839miu/I Rest of hormonal test: normal. Diagnosis
of conventional western medicine:
A. Habitual Miscarriage
B. High prolactin
C. Differentiation of syndrome by TCM: Liver Qi stagnation and
spleen deficiency
D. Liver fire flaring up
E. Acupuncture treatment: Du20 (Baihui), Du24 (Shenting),
St8 (Touwei, Emotion area in Scalp acupuncture), Sj5 (Waiguan)
Gb41 (Zulinqi), Li4 (Hegu), Liv3 (Taichong), Ren3 (Zhongji), Ren6
(Qihai), Ext (Zigong), Sp9 (Yinlingquan)
F. Chinese herbal medicine: The first step: to release the
accumulated blood from the uterus, to expel stagnated liver Qi and
to clear excessive Liver heat.
G. Herbal prescription: Chaihu (Radix Bupleuri) 10, Zhiqiao
(FructusAurantii) 10, Chishao (Radix Paeoniae Rubra) 10, Ezhu
(Rhizoma Curcumae) 10,Yimucao (Herba Leonuri) 10, Taoren
(Semen Persicae) 10,Honghua (FlosCarthami) 10, Huanglian
(Rhizoma Coptidis) 6, Zhizi (Fructus Gardeniae) 10, Suanzaoren
(Semen Ziziphi Spinosae) 10, Fushen (Poria) 10, Chuanxiong (Radix
Chuanxiong) 10
After she took the above herbal decocted juice, twice daily for
a week, she recovered from last miscarriage: all of the bleeding
stopped, her emotion calmed down, she had better sleep quality.
The secondary step: to release the stagnated Liver Qi and to
strengthen the spleen; to regulate menstrual circles, and to promote
conception. Same acupuncture treatment once per week and patent
herbal medicine: Chaihushugan Pill [1] and Renshenguipi Pill [2]
were taken in the first two weeks of menstrual circles; Xiaoyao Pill
[3] and Jinkuishenqi Pills [4] were taken in the last two weeks of
menstrual circles.
Result: she had a normal prolactin after she took above
treatment for three months; her natural pregnancy happened again
in another month, and she started worry again as soon as she knew
her pregnancy. She had minor symptoms of pregnancy reaction,
nausea, vomiting, and minor vaginal bleeding, and she was given
patent herbal Jiaweixiaoyao Pills [5] and Jinkuishenqi Pills [4] for
stabilizing her emotion and easing vaginal bleeding until the 12th
weeks of her pregnancy. She went forward into a normal pregnancy
procedure after 12th
week and naturally labored a healthy baby girl
in the full term (Figure 1).
Figure 1
Case 3
Lady with Immune infertility met vaginal bleeding in pregnancy,
but labored a baby boy from protected embryo by TCM treatment:
Mrs. CC, a 27 year old spot trainer, couldn’t conceive after living
with her partner for 8 years. She was given a diagnosis of immune
infertility, which means she possessed the positive antibody in her
cervix which was against the sperm of her partner when she visited
Infertility expert. They were told IVF was the only available way
to result in pregnancy for them. They were in the waiting list for
their IVF, and during this time she came to me and wanted to try
TCM to see whether it can supply a miracle result. Current figures:
quite fit as a spot trainer with regular menstrual circles, only
minor depression. Light red tongue with thin white coating and
wiry pulse. Diagnosis of Conventional western medicine: Immune
Infertility Differentiation of syndrome by TCM: Liver Qi stagnation
and Spleen deficiency.
Treatment
A. Acupuncture: Du20 (Baihui), Gb20 (Fengchi), Ren4
(Guanyuan), Ren6 (Qihai) Sp9 (Yinlingquan), Sp6 (Sanyinjiao), St
36 (Zusanli), Sj5 (Waiguan), Gb41 (Zulinqi)
B. Patent herbal medicine: Jiaweixiaoyao pills [5] and
Buzhongyiqi Pills [6].
Above acupuncture was given once per week for a month, then
once for two weeks; Patent herbs were taken twice daily. Mr. AC,
32 years old of IT technician, who was found lower activity in his
sperm, was give Chinese herbal medicine for promoting the quality
of his sperm: Jiaweixiaoyao Pills [5] and Wuziyanzong Pills [7].
Result: when Mrs. C gotpregnant naturally, this couple was
very excited, but she experienced a vaginal bleeding when she was
the 6th week of pregnancy. Due to light spotty blood and some
pregnancy symptoms she suffered, I had to continue my treatment
for miscarriage prevention.
A regular acupuncture and patent herbal medicine:
Xiangshayangwei Pills [8] and Jinkuishenqi Pills [4] were given to
How to cite this article: Ms Dan J. Protecting Embryo with Chinese Herbal Medicine for Treating Habitual Miscarriages-----4 Cases Study Enclosed. Perceptions
Reprod Med. 1(3). PRM.000515. 2018. DOI: 10.31031/PRM.2018.01.000515
3/6
Perceptions Reprod MedPerceptions in Reproductive Medicine
her until the 12th
of weeks of her pregnancy. She labored a baby girl
in the full term (Figure 2).
Figure 2
Case 4
The lady with Infertility caused by Erythema Lupus, was
pregnant and herembryo protected, pregnancy procedure managed
by TCM until her having a healthy baby by a caesarean:
Mrs. R B, 38 years old of officer, suffered from active Erythema
Lupus for 10 years and kept taking oral steroid treatment which
couldn’t be stopped, otherwise she might experience recurring
palpitationandachingingeneraljoints.Shewasstayinginthestable
state under the control of 10g Progesterone daily. Since her immune
system were staying in an active state as a result of the medication,
she couldn’t get pregnant: she lived with her stalwart husband for
near 10 years of expecting their baby, but no positive result. Due to
their expectation, she was gradually reducing her steroid dose and
was referred to me for accepting a TCM treatment, and observed
by Rheumatoid-immune and Gynecological consultants. Current
figures: because she had just stopped the Progesterone, she felt
aching in general joints, fatigue, anxiety, and she was also nervous
and restless; she had regular menstrual circles with a normal blood
amount and no pain, but many symptoms of pre-menstrual tension;
loose bowel 2-3 times daily, disturbed sleep. Red tongue without
coating, Wiry-fine pulse. Diagnosis of Conventional western
medicine:
a) Erythema Lupus (in activity)
b) Infertility
c) Differentiation of syndromes by TCM: Liver Qi stagnation
and Spleen deficiency
d) Dampness accumulated throughout three burners
Treatment
Acupuncture: Moxi: Ren8 (Shenque) Du20 (Baihui), Gb20
(Fengchi), Li11 (Quchi), Lu7 (Lieque), Sp10 (Xuehai), Sp9
(Yinlingquan), Sp6 (Sanyinjiao), Ki3 (Taixi), Ki2 (Xingjian), Ki6
(Zhaohai)
Among of them: Li11 and Sp10 were given special handle
technique for expelling excessive dampness throughout three
burners. In the first step of her herbal treatment:
a) Treating principle: to release excessive dampness from
meridians and collateral channels; to expel out accumulated Liver
Qi and to reinforce spleen.
b) Chinese herbal medicine in the concentrated herbal
powder form is prescribed as below: Qianghuo (Radix EtRhizoma
Notopterygii) 15, Duhuo (Radix Angelicae Pubescentis) 10,
Rendongteng (Caulis Lonicerae) 15, Fuling (Poria) 10, Chaihu(Radix
Bupleuri) 10, Baizhu (RhizomaAtractylodisMacrocephalae)
10, Dangui (Radix AngelicaeSinensis) 10, Chuanxiong (Radix
Chuanxiong) 10, Chishao (Radix PaeoniaeRubra) 10, Zhishi
(FructusAurantiiImmaturus) 10, Jixueteng (Caulis Millettiae; Caulis
Spatholobi) 20, Zhigancao (Radix GlycyrrhizaePraeparata) 5.
Above acupuncture was given once per week, herbal powders
were taken twice daily for two months, as a result she had no
joint pain, and she had regular menstrual circle, calm mood and
balance in general body. In the second step of her treatment:
Treating principle: to regulate the menstrual circles and to
promote pregnancy. Acupuncture was similar to the last step and
herbal powders were prescribed as below: Shengdihuang (Radix
Rehmanniae) 30, Mudanpi (Cortex Moutan ) 10, Shanzhuyu(Fructus
Corni) 10, Shanyao (Rhizoma Dioscoreae) 10, Baizhu(Rhizoma
Atractylodis Macrocephalae) 10, Zexie (Rhizoma Alismatis) 10,
Fuling (Poria) 10, Rendongteng(Caulis Lonicerae) 10, Yimucao
(HerbaLeonuri) 10, Chishao (Radix PaeoniaeRubra) 10, Chuanxiong
(Radix Chuanxiong;) 10, Zelan (Herba Lycopi) 10, Xiangfu (Rhizoma
Cyperi) 10, Taoren (Semen Persicae) 10, Honghua(Flos Carthami)
10, were added in prescription in the secondary week; Xianmao
(Rhizoma Curculiginis) 10, Yinyanghuo (Herba Epimedii) 15 and
Sharen(Fructus Amomi) 10 were added in prescription from 3rd
to
4th
week.
After a regular treatment for two months, Mrs. R B disappeared
and stopped coming for treatment. In the third step for her
treatment: When she came back after four months, I was told that
she was pregnant, and she believed she had a successful pregnancy,
so stopped accepting her TCM treatment as soon as she was
pregnant, but she experienced miscarriage after vaginal bleeding
for a few days when she was 8th weeks in pregnancy. After three
months of rest, she came again for another attempt.
After TCM treatment of strengthening spleen and kidney,
regulating menstrual circles and promoting pregnancy for
two months, she was pregnant again. We had to continue TCM
treatment during her pregnancy and monitor her Erythema
Lupus and immune system. Her prescription of herbal powder
was as below: Shudihuang(Radix Rehmanniae Praeparata)
30, Huangqi (Radix Astragali) 30, Sangjisheng (Herba Taxilli)
10, Xuduan (Radix Dipsaci) 10, Baizhu (Rhizoma Atractylodis
Macrocephalae) 10, Gouqizi (Fructus Lycii) 10, Huangqin(Radix
Scutellariae) 10, Sharen(FructusAmomi) 10, Ejiao (Colla Corii
Asini) 10, Banxia(Rhizoma Pinelliae ) 10, Chenpi(Pericarpium Citri
Reticulatae) 10, Fuling(Poria) 10, Zhigancao (Radix Glycyrrhizae
Praeparata) 5.
How to cite this article: Ms Dan J. Protecting Embryo with Chinese Herbal Medicine for Treating Habitual Miscarriages-----4 Cases Study Enclosed. Perceptions
Reprod Med. 1(3). PRM.000515. 2018. DOI: 10.31031/PRM.2018.01.000515
Perceptions in Reproductive Medicine
4/6
Perceptions Reprod Med
I made a bit of modification each time according to her state
until 12th
weeks, and she still manifested some abdominal cramp,
general joint pains, unstable ESR levels, fatigue, anxiety, nausea and
relevant symptoms more or less sometimes, so I adjusted the herbs
to match her symptoms. I was giving her TCM treatment under
the observation of both Rheumatoid-immune and Gynecological
consultants, but they only observed to guarantee that she was
staying in a reasonable condition. She was given a caesarean
when she experienced an increasing ESR in the 32th
of weeks
which resulted in a possible aggravation of her immune system;
Gynecological consultant thought the baby was big enough for a
healthy life, so a caesarean was conducted. After terminating her
pregnancy, her immune system gradually recovered, and she never
used steroid anymore and remained in a good state. Both of the
consultants appreciated the effective complementary effects of
TCM (Table 1).
Table 1: Ingredients of the patent herbal formulae in paper.
No
Names of patent herbal
formulae
Ingredients of formulae in
Chinese spelling names
Ingredients of formulae in Latin name Dose
1 Chaihushugan Pills
Fuling Poria 12.6
Zhiqiao FructusAurantii 10
Baidoukou Fructus Amomi Cardamomi 9
Baishao Paeonia Lactiflora Pall 5.4
Xiangfu RhizomaCyperi 3.6
Chenpi Pericarpium Citri Reticulatae 3.6
Jiegeng Radix Platycodi 3.6
Shanzha Fructus Crataegi 3.6
Shenqu Massa Fermentata Medicinalis 3.6
Chaihu Radix Bupleuri 3.6
Huangqin Radix Scutellariae 3.6
Bohe Herba Menthae 3.6
Zisugeng Caulis Perillae 3.6
Sanleng Rhizoma Sparganii 3.6
Dahuang Radix Et Rhizoma Rhei 3.6
Qingpi Pericarpium Citri Reticulatae Viride 3.6
Danggui Radix Angelicae Sinensis 3.6
Ezhu RhizomaCurcumae 3.6
Fangfeng Radix Saposhnikoviae Divaricatae 9
Gancao Radix Glycyrrhizae 3.6
2 Renshenguipi Pills
Renshen Radix Ginseng 15.25
Baizhu Rhizoma Atractylodis Macrocephalae 10.17
Huangqi Radix Astragali 10.17
Fushen Poria 10.17
Yuanzhi Radix Polygalae 10.17
Suanzaoren Semen Ziziphi Spinosae 10.17
Longyanrou Arillus Longan 10.17
Danggui Radix Angelicae Sinensis 10.17
Dazao Fructus Zizyphi Jujubae 10.17
Zhigancao Radix Glycyrrhizae 3.39
3 Xiaoyao Pills
Chaihu Radix Bupleuri 16.67
Dangui Radix AngelicaeSinensis 16.67
Baishao Radix Paeoniae Alba 16.67
Baizhu Rhizoma Atractylodis Macrocephalae 16.67
Fuling Poria 16.67
Bohe HerbaMenthae 3.32
Zhigancao Radix Glycyrrhizae 13.33
How to cite this article: Ms Dan J. Protecting Embryo with Chinese Herbal Medicine for Treating Habitual Miscarriages-----4 Cases Study Enclosed. Perceptions
Reprod Med. 1(3). PRM.000515. 2018. DOI: 10.31031/PRM.2018.01.000515
5/6
Perceptions Reprod MedPerceptions in Reproductive Medicine
4 Jinkuishenqi Pills
Shudihuang Rehmannia Glutinosa, Libosch 28.1
Shanyao Dioscorea OppositaThunb 7.1
Shanzhuyu Fructus Corni 7.1
Mudanpi Cortex Moutan 7.1
Zexie Rhizoma Alismatis 7.1
Fuling Poria 21
Guizhi Ramulus Cinnamomi 7.1
Rougui Cortex Cinnamomi 1.2
Niuxi Radix Achyranthis Bidentatae 7.1
Cheqianzi Semen Plantaginis 7.1
5 Jiaweixiaoyao Pills
Chaihu Bupleurum Chinese DC 11
Dangui Radix AngelicaeSinensis 11
Baishao Paeonia Lactiflora Pall 11
Baizhu Rhizoma Atractylodis Macrocephalae 11
Fuling Poria 11
Mudanpi Cortex Moutan 17
Zhizi Gardenia Jasminoides Sllis 17
Bohe Herba Menthae 2
Gancao Glycyrrhizae Uralensis Fisch. 9
6 Buzhongyiqi Pills
Huangqi Radix Astragali 30
Dangshen Radix Codonopsis Pilosulae 10
Baizhu Altractylodes Macrocephala Koidz 9
Danggui Radix Angelicae Sinensis 9
Shengma Rhizoma Cimicifugae 9
Chaihu Bupleurum Chinese DC 9
Chenpi Pericarpium Citri Reticulatae 9
Zhigancao Glycyrrhizae Uralensis Fisch. 15
7 Wuziyanzong Pills
Gouqizi Fructus Lycii 34.78
Tusizi Semen Cuseutae; Semen Cuseutae 34.78
Fupenzi Fructus Rubi 17.39
Wuweizi Fructus Schisandrae 4.35
Chqianzi Herba Plantaginis 8.7
8 Xiangshayangwei Pills
Juye Folium CitriTangerinae 7.6
Sharen FructusAmomi 7.6
Baizhu Rhizoma Atractylodis Macrocephalae 10.87
Chenpi Pericarpium Citri Reticulatae 10.87
Fuling Poria 10.87
Banxia Rhizoma Pinelliae 10.87
Xiangfu Rhizoma Cyperi 7.6
Zhishi Fructus AurantiiImmaturus 7.6
Doukou Fructus Amomi Card amomi 7.6
Houpo Cortex Magnoliae Officinalis 7.6
Huoxiang Herba Agastaches 7.6
Gancao Radix Glycyrrhizae 3.32
How to cite this article: Ms Dan J. Protecting Embryo with Chinese Herbal Medicine for Treating Habitual Miscarriages-----4 Cases Study Enclosed. Perceptions
Reprod Med. 1(3). PRM.000515. 2018. DOI: 10.31031/PRM.2018.01.000515
Perceptions in Reproductive Medicine
6/6
Perceptions Reprod Med
Analysis
There are accurate effects from traditional Chinese herbal
medicine for protection of embryo and treatment of miscarriage
as observed from above cases. We can explore the advantages and
shortcomings of TCM treatment from these cases:
A. For those spontaneous miscarriages for which no causes are
found by conventional western medicine, they can occur from pre-
clinical state. TCM believe that might be a result of Qi and blood
deficiency. For example, the lady might be pregnant when she is
in a weaker body state; or reconceive in the short time after last
miscarriage; or does not have enough rest for complete recovery
from a disease…… due to above conditions, cervix may be too loose
to hold the embryo, and after a bit of movement, the placenta and
embryo can be released to cause a miscarriage. TCM will play an
effective role in helping with these conditions, like in case 1.
B. For ladies’ miscarriage caused by emotional or psychological
disorders, or high prolactin, which is always accompanied with
psychological symptoms, or immune disorder, TCM can offer an
effective treatment. Like case2, 3 and 4.
C. The ladies who became pregnant assisted from TCM
promotion or IVF support may easily experience miscarriages,
especially for the cases when the ladies conceive very quickly, since
the Qi and blood deficiency of these ladies have not been reinforced
enough, so we should continue TCM treatment in order to prevent
miscarriage’s occurrence and help ladies go forward in their
pregnancy peacefully.
D. For the ladies with miscarriage related with Gene disorder
or abnormal Chromosome, TCM cannot present a satisfactory
effect. This may need a longer time of observation and treatment
to sort out.
References
1.	 Li X, Zhang M, Wang B, Li Y, Wang L, et al. (2013) Shenghua Decoction
reduces uterine bleeding and regulates T-cell paradigm in human
deciduas of RU486 medical abortion. J Ethnopharmacol 150(3): 907-
917.
2.	 Hullender Rubin L, Cantor Dand Marx BL (2013) Recurrent Pregnancy
Loss and Traditional Chinese Medicine. Med Acupunct 25(3): 232-237.
3.	 Gao J and Luo SP (2011) Kidney-tonifying and abortion preventing
effects of Shou Tai Wan by different extracted methods on rats. Zhong
Yao Cai 34(8): 1251-1255.
4.	 Sun Fand, Yu J (1999) Effect of TCM on plasma beta-endorphin and
placental endocrine in threatened abortion. Zhongguo Zhong Xi Yi Jie He
Za Zhi 19(2): 87-89.
5.	 Wang QM, Yao DY, Yang YF (1994) Experimental study on anti-abortion
effect of Yunkang oral liquid. Zhongguo Zhong Xi Yi Jie He Za Zhi 14(7):
418-420.
6.	 Zhao LQ (2013) The treatment of recurrent spontaneous miscarriage.
Medical condition overview. The Journal of Chinese Medicine 16(101):
13.
7.	 Dan Jiang, Lily Li, Bai-Yun Zeng (2017) Treatment of Chinese Herbal
Medicine for Female Infertility. In: Bai-Yun Zeng, Kaicun Zhao (Eds.),
International Review of Neurobiology. Academic Press, Burlington, USA,
Vol 135, pp. 233-247.
8.	 Dan Jiang, Alberto Coscione, Lily Li, Bai-Yun Zeng (2017) Effect of Chinese
Herbal Medicine on Male Infertility. In: Bai-Yun Zeng, Kaicun Zhao (Eds.),
International Review of Neurobiology. Academic Press, Burlington, USA,
Vol 135, pp. 297-311.

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Crimson Publishers- Protecting Embryo with Chinese Herbal Medicine for Treating Habitual Miscarriages-----4 Cases Study Enclosed

  • 1. 1/6 Ms Dan Jiang* Hallam Institute of TCM, UK *Corresponding author: Ms Dan Jiang, Hallam Institute of TCM, 439 Glossop Road Sheffield S10 2PR, UK. Submission: December 04, 2017; Published: January 22, 2018 Protecting Embryo with Chinese Herbal Medicine for Treating Habitual Miscarriages----- 4 Cases Study Enclosed Case Report Perceptions Reprod Med Copyright © All rights are reserved by Freddy Andrés Barrios Arroyave. CRIMSONpublishers http://www.crimsonpublishers.com Case Report It is almost impossible to protect the embryo, ladies successfully complete pregnancy, and have healthy babies, if they are going through vaginal bleeding, abdominal cramp and showing some other signs at the early month of pregnancy, which will normally end in miscarriages before TCM enters the West. Since the beginning of my practice of TCM (Acupuncture and Chinese herbal medicine) in UK, I have been using TCM for protecting embryo and terminating signs of miscarriage effectively in order to help ladies naturally complete their pregnancies and get healthy babies and there are more and more successful cases. I will share a few of the cases and my experience in treating miscarriage with Chinese herbal medicine and acupuncture as below: Case 1 After 3 times of spontaneous abortions, her embryo was successfully protected with TCM treatment at the early time of pregnancy and she labored a healthy baby boy: Ms. S J, 38 years old of IT technician, started her menstrual bleeding at 4 weeks after her last period, but she already found a positive result after pregnancy test. She recognized that she might have a miscarriage again, because she has experienced these vaginal bleeding for three times in two years, all of which resulted in abortion in 7-8 weeks of her pregnancies after a gradually increased vaginal bleeding. She started her bleeding early this time, so she urgently went to see her GP requiring an Ultrasound to prove her pregnancy and a suitable treatment. She was refused an Ultrasound due to the reason that a regular one should be done at the 8th week of pregnancy and not any available treatment was given. When she visited me in anxiety, I checked that she had a vaginal bleeding in average amount with fresh blood, without clotting, or any solid substances in the blood, and abdominal cramp for 2-3 days. Last period of hers was 34 days ago, and the bleeding started 2 days ago without overreaction symptoms of pregnancy. Pregnancy test was positive that morning. Light red tongue with less white coating; Rolling and fine pulse. Diagnosis of Conventional western medicine: A. The early signs of miscarriage B. The 4th of weeks of pregnancy C. Differentiation of syndrome by TCM: deficiency of both spleen and Kidney D. Weak embryo E. Treating principle: Reinforcing kidney and spleen, Strengthening embryo F. Herbal medical prescription: Shudihuang (Radix Rehmanniae Praeparata) 10, Huangqi (Radix Astragali)15, Baizhu (RhizomaAtractylodis Macrocephalae) 10, Aiye(Folium Artemisiae Argyi)10Sangjisheng(Herba Taxilli) 10,Xuduan (RadixDipsaci)10, Sharen(Fructus Amomi) 10, Ejiao (Colla Corii Asini) 10, Huangqin (Radix Scutellariae) 10, Chaihu (Radix Bupleuri) 10, Dangshen (Radix Codonopsis Pilosulae) 10, Fuling (Poria )10, Zhigancao (Radix Glycyrrhizae Praeparata) 5 Above herbal prescription was decocted into herbal juice, and she drank the juice, twice daily. Result: After she drank the herbal juice for two days, her vaginal bleeding started to reduce until it completely stopped in two weeks; her abdominal cramp eased after her taking this herbal juice for a month. She was given an ultrasound in the 8th week of her pregnancy by her GP which reported that she was in a normal pregnancy procedure. She remained well with a strong rolling pulse and without abnormal symptoms until 12th weeks of her pregnancy; she went forward in her normal procedure after I ended the herbal medicine and labored a healthy baby boy in the full term. Case 2 Due to 3 times of spontaneous abortions caused by high prolactin, she labored a baby girl after acupuncture and herbal medicinetreatment:Mrs.CF,33yearsoldofsecretory,sufferedfrom vaginal bleeding at the 8th weeks in the third of her pregnancies, and she was terminated again with drug due to occurring spontaneous ISSN: 2640-9666
  • 2. How to cite this article: Ms Dan J. Protecting Embryo with Chinese Herbal Medicine for Treating Habitual Miscarriages-----4 Cases Study Enclosed. Perceptions Reprod Med. 1(3). PRM.000515. 2018. DOI: 10.31031/PRM.2018.01.000515 Perceptions in Reproductive Medicine 2/6 Perceptions Reprod Med vaginal bleeding. Her gynecological consultant did all of relevant examinations for her, and a high prolactin was confirmed to be the reason for her multiple spontaneous abortions. Due to the many emotional symptoms she was suffering from, she was referred to see me---a TCM practitioner by her gynecological consultant. Current figures: she was weepy with continuous tears and couldn’t control her moodiness, bad depression, abdominal cramp. Due to the drug she was taking for cleaning her uterus the day before, she still had a bit of spotty blood, headache, insomnia, anxiety, loose bowel and fatigues. Red tongue, worse at tip and sides with less thin coating; Wiry-fine pulse. Prolactin 901miu/I, repeat prolactin 839miu/I Rest of hormonal test: normal. Diagnosis of conventional western medicine: A. Habitual Miscarriage B. High prolactin C. Differentiation of syndrome by TCM: Liver Qi stagnation and spleen deficiency D. Liver fire flaring up E. Acupuncture treatment: Du20 (Baihui), Du24 (Shenting), St8 (Touwei, Emotion area in Scalp acupuncture), Sj5 (Waiguan) Gb41 (Zulinqi), Li4 (Hegu), Liv3 (Taichong), Ren3 (Zhongji), Ren6 (Qihai), Ext (Zigong), Sp9 (Yinlingquan) F. Chinese herbal medicine: The first step: to release the accumulated blood from the uterus, to expel stagnated liver Qi and to clear excessive Liver heat. G. Herbal prescription: Chaihu (Radix Bupleuri) 10, Zhiqiao (FructusAurantii) 10, Chishao (Radix Paeoniae Rubra) 10, Ezhu (Rhizoma Curcumae) 10,Yimucao (Herba Leonuri) 10, Taoren (Semen Persicae) 10,Honghua (FlosCarthami) 10, Huanglian (Rhizoma Coptidis) 6, Zhizi (Fructus Gardeniae) 10, Suanzaoren (Semen Ziziphi Spinosae) 10, Fushen (Poria) 10, Chuanxiong (Radix Chuanxiong) 10 After she took the above herbal decocted juice, twice daily for a week, she recovered from last miscarriage: all of the bleeding stopped, her emotion calmed down, she had better sleep quality. The secondary step: to release the stagnated Liver Qi and to strengthen the spleen; to regulate menstrual circles, and to promote conception. Same acupuncture treatment once per week and patent herbal medicine: Chaihushugan Pill [1] and Renshenguipi Pill [2] were taken in the first two weeks of menstrual circles; Xiaoyao Pill [3] and Jinkuishenqi Pills [4] were taken in the last two weeks of menstrual circles. Result: she had a normal prolactin after she took above treatment for three months; her natural pregnancy happened again in another month, and she started worry again as soon as she knew her pregnancy. She had minor symptoms of pregnancy reaction, nausea, vomiting, and minor vaginal bleeding, and she was given patent herbal Jiaweixiaoyao Pills [5] and Jinkuishenqi Pills [4] for stabilizing her emotion and easing vaginal bleeding until the 12th weeks of her pregnancy. She went forward into a normal pregnancy procedure after 12th week and naturally labored a healthy baby girl in the full term (Figure 1). Figure 1 Case 3 Lady with Immune infertility met vaginal bleeding in pregnancy, but labored a baby boy from protected embryo by TCM treatment: Mrs. CC, a 27 year old spot trainer, couldn’t conceive after living with her partner for 8 years. She was given a diagnosis of immune infertility, which means she possessed the positive antibody in her cervix which was against the sperm of her partner when she visited Infertility expert. They were told IVF was the only available way to result in pregnancy for them. They were in the waiting list for their IVF, and during this time she came to me and wanted to try TCM to see whether it can supply a miracle result. Current figures: quite fit as a spot trainer with regular menstrual circles, only minor depression. Light red tongue with thin white coating and wiry pulse. Diagnosis of Conventional western medicine: Immune Infertility Differentiation of syndrome by TCM: Liver Qi stagnation and Spleen deficiency. Treatment A. Acupuncture: Du20 (Baihui), Gb20 (Fengchi), Ren4 (Guanyuan), Ren6 (Qihai) Sp9 (Yinlingquan), Sp6 (Sanyinjiao), St 36 (Zusanli), Sj5 (Waiguan), Gb41 (Zulinqi) B. Patent herbal medicine: Jiaweixiaoyao pills [5] and Buzhongyiqi Pills [6]. Above acupuncture was given once per week for a month, then once for two weeks; Patent herbs were taken twice daily. Mr. AC, 32 years old of IT technician, who was found lower activity in his sperm, was give Chinese herbal medicine for promoting the quality of his sperm: Jiaweixiaoyao Pills [5] and Wuziyanzong Pills [7]. Result: when Mrs. C gotpregnant naturally, this couple was very excited, but she experienced a vaginal bleeding when she was the 6th week of pregnancy. Due to light spotty blood and some pregnancy symptoms she suffered, I had to continue my treatment for miscarriage prevention. A regular acupuncture and patent herbal medicine: Xiangshayangwei Pills [8] and Jinkuishenqi Pills [4] were given to
  • 3. How to cite this article: Ms Dan J. Protecting Embryo with Chinese Herbal Medicine for Treating Habitual Miscarriages-----4 Cases Study Enclosed. Perceptions Reprod Med. 1(3). PRM.000515. 2018. DOI: 10.31031/PRM.2018.01.000515 3/6 Perceptions Reprod MedPerceptions in Reproductive Medicine her until the 12th of weeks of her pregnancy. She labored a baby girl in the full term (Figure 2). Figure 2 Case 4 The lady with Infertility caused by Erythema Lupus, was pregnant and herembryo protected, pregnancy procedure managed by TCM until her having a healthy baby by a caesarean: Mrs. R B, 38 years old of officer, suffered from active Erythema Lupus for 10 years and kept taking oral steroid treatment which couldn’t be stopped, otherwise she might experience recurring palpitationandachingingeneraljoints.Shewasstayinginthestable state under the control of 10g Progesterone daily. Since her immune system were staying in an active state as a result of the medication, she couldn’t get pregnant: she lived with her stalwart husband for near 10 years of expecting their baby, but no positive result. Due to their expectation, she was gradually reducing her steroid dose and was referred to me for accepting a TCM treatment, and observed by Rheumatoid-immune and Gynecological consultants. Current figures: because she had just stopped the Progesterone, she felt aching in general joints, fatigue, anxiety, and she was also nervous and restless; she had regular menstrual circles with a normal blood amount and no pain, but many symptoms of pre-menstrual tension; loose bowel 2-3 times daily, disturbed sleep. Red tongue without coating, Wiry-fine pulse. Diagnosis of Conventional western medicine: a) Erythema Lupus (in activity) b) Infertility c) Differentiation of syndromes by TCM: Liver Qi stagnation and Spleen deficiency d) Dampness accumulated throughout three burners Treatment Acupuncture: Moxi: Ren8 (Shenque) Du20 (Baihui), Gb20 (Fengchi), Li11 (Quchi), Lu7 (Lieque), Sp10 (Xuehai), Sp9 (Yinlingquan), Sp6 (Sanyinjiao), Ki3 (Taixi), Ki2 (Xingjian), Ki6 (Zhaohai) Among of them: Li11 and Sp10 were given special handle technique for expelling excessive dampness throughout three burners. In the first step of her herbal treatment: a) Treating principle: to release excessive dampness from meridians and collateral channels; to expel out accumulated Liver Qi and to reinforce spleen. b) Chinese herbal medicine in the concentrated herbal powder form is prescribed as below: Qianghuo (Radix EtRhizoma Notopterygii) 15, Duhuo (Radix Angelicae Pubescentis) 10, Rendongteng (Caulis Lonicerae) 15, Fuling (Poria) 10, Chaihu(Radix Bupleuri) 10, Baizhu (RhizomaAtractylodisMacrocephalae) 10, Dangui (Radix AngelicaeSinensis) 10, Chuanxiong (Radix Chuanxiong) 10, Chishao (Radix PaeoniaeRubra) 10, Zhishi (FructusAurantiiImmaturus) 10, Jixueteng (Caulis Millettiae; Caulis Spatholobi) 20, Zhigancao (Radix GlycyrrhizaePraeparata) 5. Above acupuncture was given once per week, herbal powders were taken twice daily for two months, as a result she had no joint pain, and she had regular menstrual circle, calm mood and balance in general body. In the second step of her treatment: Treating principle: to regulate the menstrual circles and to promote pregnancy. Acupuncture was similar to the last step and herbal powders were prescribed as below: Shengdihuang (Radix Rehmanniae) 30, Mudanpi (Cortex Moutan ) 10, Shanzhuyu(Fructus Corni) 10, Shanyao (Rhizoma Dioscoreae) 10, Baizhu(Rhizoma Atractylodis Macrocephalae) 10, Zexie (Rhizoma Alismatis) 10, Fuling (Poria) 10, Rendongteng(Caulis Lonicerae) 10, Yimucao (HerbaLeonuri) 10, Chishao (Radix PaeoniaeRubra) 10, Chuanxiong (Radix Chuanxiong;) 10, Zelan (Herba Lycopi) 10, Xiangfu (Rhizoma Cyperi) 10, Taoren (Semen Persicae) 10, Honghua(Flos Carthami) 10, were added in prescription in the secondary week; Xianmao (Rhizoma Curculiginis) 10, Yinyanghuo (Herba Epimedii) 15 and Sharen(Fructus Amomi) 10 were added in prescription from 3rd to 4th week. After a regular treatment for two months, Mrs. R B disappeared and stopped coming for treatment. In the third step for her treatment: When she came back after four months, I was told that she was pregnant, and she believed she had a successful pregnancy, so stopped accepting her TCM treatment as soon as she was pregnant, but she experienced miscarriage after vaginal bleeding for a few days when she was 8th weeks in pregnancy. After three months of rest, she came again for another attempt. After TCM treatment of strengthening spleen and kidney, regulating menstrual circles and promoting pregnancy for two months, she was pregnant again. We had to continue TCM treatment during her pregnancy and monitor her Erythema Lupus and immune system. Her prescription of herbal powder was as below: Shudihuang(Radix Rehmanniae Praeparata) 30, Huangqi (Radix Astragali) 30, Sangjisheng (Herba Taxilli) 10, Xuduan (Radix Dipsaci) 10, Baizhu (Rhizoma Atractylodis Macrocephalae) 10, Gouqizi (Fructus Lycii) 10, Huangqin(Radix Scutellariae) 10, Sharen(FructusAmomi) 10, Ejiao (Colla Corii Asini) 10, Banxia(Rhizoma Pinelliae ) 10, Chenpi(Pericarpium Citri Reticulatae) 10, Fuling(Poria) 10, Zhigancao (Radix Glycyrrhizae Praeparata) 5.
  • 4. How to cite this article: Ms Dan J. Protecting Embryo with Chinese Herbal Medicine for Treating Habitual Miscarriages-----4 Cases Study Enclosed. Perceptions Reprod Med. 1(3). PRM.000515. 2018. DOI: 10.31031/PRM.2018.01.000515 Perceptions in Reproductive Medicine 4/6 Perceptions Reprod Med I made a bit of modification each time according to her state until 12th weeks, and she still manifested some abdominal cramp, general joint pains, unstable ESR levels, fatigue, anxiety, nausea and relevant symptoms more or less sometimes, so I adjusted the herbs to match her symptoms. I was giving her TCM treatment under the observation of both Rheumatoid-immune and Gynecological consultants, but they only observed to guarantee that she was staying in a reasonable condition. She was given a caesarean when she experienced an increasing ESR in the 32th of weeks which resulted in a possible aggravation of her immune system; Gynecological consultant thought the baby was big enough for a healthy life, so a caesarean was conducted. After terminating her pregnancy, her immune system gradually recovered, and she never used steroid anymore and remained in a good state. Both of the consultants appreciated the effective complementary effects of TCM (Table 1). Table 1: Ingredients of the patent herbal formulae in paper. No Names of patent herbal formulae Ingredients of formulae in Chinese spelling names Ingredients of formulae in Latin name Dose 1 Chaihushugan Pills Fuling Poria 12.6 Zhiqiao FructusAurantii 10 Baidoukou Fructus Amomi Cardamomi 9 Baishao Paeonia Lactiflora Pall 5.4 Xiangfu RhizomaCyperi 3.6 Chenpi Pericarpium Citri Reticulatae 3.6 Jiegeng Radix Platycodi 3.6 Shanzha Fructus Crataegi 3.6 Shenqu Massa Fermentata Medicinalis 3.6 Chaihu Radix Bupleuri 3.6 Huangqin Radix Scutellariae 3.6 Bohe Herba Menthae 3.6 Zisugeng Caulis Perillae 3.6 Sanleng Rhizoma Sparganii 3.6 Dahuang Radix Et Rhizoma Rhei 3.6 Qingpi Pericarpium Citri Reticulatae Viride 3.6 Danggui Radix Angelicae Sinensis 3.6 Ezhu RhizomaCurcumae 3.6 Fangfeng Radix Saposhnikoviae Divaricatae 9 Gancao Radix Glycyrrhizae 3.6 2 Renshenguipi Pills Renshen Radix Ginseng 15.25 Baizhu Rhizoma Atractylodis Macrocephalae 10.17 Huangqi Radix Astragali 10.17 Fushen Poria 10.17 Yuanzhi Radix Polygalae 10.17 Suanzaoren Semen Ziziphi Spinosae 10.17 Longyanrou Arillus Longan 10.17 Danggui Radix Angelicae Sinensis 10.17 Dazao Fructus Zizyphi Jujubae 10.17 Zhigancao Radix Glycyrrhizae 3.39 3 Xiaoyao Pills Chaihu Radix Bupleuri 16.67 Dangui Radix AngelicaeSinensis 16.67 Baishao Radix Paeoniae Alba 16.67 Baizhu Rhizoma Atractylodis Macrocephalae 16.67 Fuling Poria 16.67 Bohe HerbaMenthae 3.32 Zhigancao Radix Glycyrrhizae 13.33
  • 5. How to cite this article: Ms Dan J. Protecting Embryo with Chinese Herbal Medicine for Treating Habitual Miscarriages-----4 Cases Study Enclosed. Perceptions Reprod Med. 1(3). PRM.000515. 2018. DOI: 10.31031/PRM.2018.01.000515 5/6 Perceptions Reprod MedPerceptions in Reproductive Medicine 4 Jinkuishenqi Pills Shudihuang Rehmannia Glutinosa, Libosch 28.1 Shanyao Dioscorea OppositaThunb 7.1 Shanzhuyu Fructus Corni 7.1 Mudanpi Cortex Moutan 7.1 Zexie Rhizoma Alismatis 7.1 Fuling Poria 21 Guizhi Ramulus Cinnamomi 7.1 Rougui Cortex Cinnamomi 1.2 Niuxi Radix Achyranthis Bidentatae 7.1 Cheqianzi Semen Plantaginis 7.1 5 Jiaweixiaoyao Pills Chaihu Bupleurum Chinese DC 11 Dangui Radix AngelicaeSinensis 11 Baishao Paeonia Lactiflora Pall 11 Baizhu Rhizoma Atractylodis Macrocephalae 11 Fuling Poria 11 Mudanpi Cortex Moutan 17 Zhizi Gardenia Jasminoides Sllis 17 Bohe Herba Menthae 2 Gancao Glycyrrhizae Uralensis Fisch. 9 6 Buzhongyiqi Pills Huangqi Radix Astragali 30 Dangshen Radix Codonopsis Pilosulae 10 Baizhu Altractylodes Macrocephala Koidz 9 Danggui Radix Angelicae Sinensis 9 Shengma Rhizoma Cimicifugae 9 Chaihu Bupleurum Chinese DC 9 Chenpi Pericarpium Citri Reticulatae 9 Zhigancao Glycyrrhizae Uralensis Fisch. 15 7 Wuziyanzong Pills Gouqizi Fructus Lycii 34.78 Tusizi Semen Cuseutae; Semen Cuseutae 34.78 Fupenzi Fructus Rubi 17.39 Wuweizi Fructus Schisandrae 4.35 Chqianzi Herba Plantaginis 8.7 8 Xiangshayangwei Pills Juye Folium CitriTangerinae 7.6 Sharen FructusAmomi 7.6 Baizhu Rhizoma Atractylodis Macrocephalae 10.87 Chenpi Pericarpium Citri Reticulatae 10.87 Fuling Poria 10.87 Banxia Rhizoma Pinelliae 10.87 Xiangfu Rhizoma Cyperi 7.6 Zhishi Fructus AurantiiImmaturus 7.6 Doukou Fructus Amomi Card amomi 7.6 Houpo Cortex Magnoliae Officinalis 7.6 Huoxiang Herba Agastaches 7.6 Gancao Radix Glycyrrhizae 3.32
  • 6. How to cite this article: Ms Dan J. Protecting Embryo with Chinese Herbal Medicine for Treating Habitual Miscarriages-----4 Cases Study Enclosed. Perceptions Reprod Med. 1(3). PRM.000515. 2018. DOI: 10.31031/PRM.2018.01.000515 Perceptions in Reproductive Medicine 6/6 Perceptions Reprod Med Analysis There are accurate effects from traditional Chinese herbal medicine for protection of embryo and treatment of miscarriage as observed from above cases. We can explore the advantages and shortcomings of TCM treatment from these cases: A. For those spontaneous miscarriages for which no causes are found by conventional western medicine, they can occur from pre- clinical state. TCM believe that might be a result of Qi and blood deficiency. For example, the lady might be pregnant when she is in a weaker body state; or reconceive in the short time after last miscarriage; or does not have enough rest for complete recovery from a disease…… due to above conditions, cervix may be too loose to hold the embryo, and after a bit of movement, the placenta and embryo can be released to cause a miscarriage. TCM will play an effective role in helping with these conditions, like in case 1. B. For ladies’ miscarriage caused by emotional or psychological disorders, or high prolactin, which is always accompanied with psychological symptoms, or immune disorder, TCM can offer an effective treatment. Like case2, 3 and 4. C. The ladies who became pregnant assisted from TCM promotion or IVF support may easily experience miscarriages, especially for the cases when the ladies conceive very quickly, since the Qi and blood deficiency of these ladies have not been reinforced enough, so we should continue TCM treatment in order to prevent miscarriage’s occurrence and help ladies go forward in their pregnancy peacefully. D. For the ladies with miscarriage related with Gene disorder or abnormal Chromosome, TCM cannot present a satisfactory effect. This may need a longer time of observation and treatment to sort out. References 1. Li X, Zhang M, Wang B, Li Y, Wang L, et al. (2013) Shenghua Decoction reduces uterine bleeding and regulates T-cell paradigm in human deciduas of RU486 medical abortion. J Ethnopharmacol 150(3): 907- 917. 2. Hullender Rubin L, Cantor Dand Marx BL (2013) Recurrent Pregnancy Loss and Traditional Chinese Medicine. Med Acupunct 25(3): 232-237. 3. Gao J and Luo SP (2011) Kidney-tonifying and abortion preventing effects of Shou Tai Wan by different extracted methods on rats. Zhong Yao Cai 34(8): 1251-1255. 4. Sun Fand, Yu J (1999) Effect of TCM on plasma beta-endorphin and placental endocrine in threatened abortion. Zhongguo Zhong Xi Yi Jie He Za Zhi 19(2): 87-89. 5. Wang QM, Yao DY, Yang YF (1994) Experimental study on anti-abortion effect of Yunkang oral liquid. Zhongguo Zhong Xi Yi Jie He Za Zhi 14(7): 418-420. 6. Zhao LQ (2013) The treatment of recurrent spontaneous miscarriage. Medical condition overview. The Journal of Chinese Medicine 16(101): 13. 7. Dan Jiang, Lily Li, Bai-Yun Zeng (2017) Treatment of Chinese Herbal Medicine for Female Infertility. In: Bai-Yun Zeng, Kaicun Zhao (Eds.), International Review of Neurobiology. Academic Press, Burlington, USA, Vol 135, pp. 233-247. 8. Dan Jiang, Alberto Coscione, Lily Li, Bai-Yun Zeng (2017) Effect of Chinese Herbal Medicine on Male Infertility. In: Bai-Yun Zeng, Kaicun Zhao (Eds.), International Review of Neurobiology. Academic Press, Burlington, USA, Vol 135, pp. 297-311.